| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dong Liu, Hanbing Lu, Elliot Stein, Zhujuan Zhou, Yihong Yang, Mark P Mattso. Brain regional synchronous activity predicts tauopathy in\\xc2\\xa03\\xc3\\x97TgAD\\xc2\\xa0mice. Neurobiology of aging vol 70 issue 2019 30015035 |
compared to age-matched wild-type mice, 6- to 8-month-old 3\xc3\x97tgad mice exhibited increased regional homogeneity in the hippocampus and parietal and temporal cortices, regions with tau pathology but not a\xce\xb2 pathology at this age. |
2019-09-27 |
2023-01-26 |
mouse |
| Dong Liu, Hanbing Lu, Elliot Stein, Zhujuan Zhou, Yihong Yang, Mark P Mattso. Brain regional synchronous activity predicts tauopathy in\\xc2\\xa03\\xc3\\x97TgAD\\xc2\\xa0mice. Neurobiology of aging vol 70 issue 2019 30015035 |
by 18-24\xc2\xa0months of age, 3\xc3\x97tgad mice exhibited extensive tau and a\xce\xb2 pathologies involving the hippocampus and multiple functionally related brain regions, with a spatial expansion of increased local synchronous activity to include those regions. |
2019-09-27 |
2023-01-26 |
mouse |
| Yanning Li, Runtao Ding, Xinghua Ren, Gehua Wen, Zhibin Dong, Hui Yao, Yaqing Tan, Hao Yu, Xiaolong Wang, Xiaoni Zhan, Jun Yao, Yan Lu, Guohua Zhang, Xu W. Long-term ketamine administration causes Tau protein phosphorylation and Tau protein-dependent AMPA receptor reduction in the hippocampus of mice. Toxicology letters vol 315 issue 2019 31470060 |
long-term ketamine administration causes tau protein phosphorylation and tau protein-dependent ampa receptor reduction in the hippocampus of mice. |
2019-09-23 |
2023-01-26 |
mouse |
| Yanning Li, Runtao Ding, Xinghua Ren, Gehua Wen, Zhibin Dong, Hui Yao, Yaqing Tan, Hao Yu, Xiaolong Wang, Xiaoni Zhan, Jun Yao, Yan Lu, Guohua Zhang, Xu W. Long-term ketamine administration causes Tau protein phosphorylation and Tau protein-dependent AMPA receptor reduction in the hippocampus of mice. Toxicology letters vol 315 issue 2019 31470060 |
in this study, we established a model of long-term (6 months) ketamine administration in wild-type (c57bl/6) and tau knockout mice to investigate the effects of different doses of ketamine administration on tau protein expression and phosphorylation in the mouse hippocampus. |
2019-09-23 |
2023-01-26 |
mouse |
| John L Robinson, Maria M Corrada, Gabor G Kovacs, Myrna Dominique, Carrie Caswell, Sharon X Xie, Virginia M-Y Lee, Claudia H Kawas, John Q Trojanowsk. Non-Alzheimer's contributions to dementia and cognitive resilience in The 90+ Study. Acta neuropathologica vol 136 issue 3 2019 29916037 |
the diagnosis of alzheimer's disease (ad) in the oldest-old is complicated by the increasing prevalence of age-related neurofibrillary tangles, plaques and non-ad pathologies such as cerebrovascular disease (cvd), hippocampal sclerosis (hs), aging-related tau astrogliopathy (artag), as well as tdp-43 and lewy pathology. |
2019-09-17 |
2023-01-26 |
human |
| Mireille Moussaed, Sylvaine Huc-Brandt, Nicolas Cubedo, Michele Silhol, Samy Murat, Marie-Christine Lebart, Gabor Kovacs, Jean-Michel Verdier, Francoise Trousse, Mireille Rossel, Anne Marcilha. Regenerating islet-derived 1\\xce\\xb1 (REG-1\\xce\\xb1) protein increases tau phosphorylation in cell and animal models of tauopathies. Neurobiology of disease vol 119 issue 2019 30092268 |
first, reg-1\xce\xb1 and phosphorylated tau expression were assessed in tissue sections from the hippocampus, representing neurofibrillary tangles (nfts), from patients with ad, and from basal ganglia, representing subcortical nfts, from patients with progressive supranuclear palsy (psp). |
2019-09-17 |
2023-01-26 |
rat |
| Olga Pletnikova, Yusuke Kageyama, Gay Rudow, Katherine D LaClair, Marilyn Albert, Barbara J Crain, Jing Tian, David Fowler, Juan C Troncos. The spectrum of preclinical Alzheimer's disease pathology and its modulation by ApoE genotype. Neurobiology of aging vol 71 issue 2019 30099348 |
tau lesions were present in the hippocampus and entorhinal cortex in 7% of subjects aged <40\xc2\xa0years and increased steadily with age reaching near 70% in the 60- to 65-year age group. |
2019-09-11 |
2023-01-26 |
human |
| M K Schultz, R Gentzel, M Usenovic, C Gretzula, C Ware, S Parmentier-Batteur, J B Schachter, H A Zariwal. Pharmacogenetic neuronal stimulation increases human tau pathology and trans-synaptic spread of tau to distal brain regions in mice. Neurobiology of disease vol 118 issue 2019 30049665 |
we translated this approach to an in vivo model and used aav to express htau and the excitatory dreadd in the ventral hippocampus of wild type mice, p301l htau-expressing mice, or tau knockout mice. |
2019-09-09 |
2023-01-26 |
mouse |
| C\\xc3\\xa9line Laurenc\\xc3\\xa9, Narimane Zeghbib, Michael Rivard, Sonia Lehri-Boufala, Isabelle Lachaise, Caroline Barau, Philippe Le Corvoisier, Thierry Martens, Laure Garrigue-Antar, Christophe Mori. A new human pyridinium metabolite of furosemide, inhibitor of mitochondrial complex I, is a candidate inducer of neurodegeneration. Biochemical pharmacology vol 160 issue 2019 30537467 |
moreover, in mice, pof induced neurodegenerative diseases hallmarks like phospho-serine129 alpha-synuclein, tyrosine hydroxylase decrease in striatum, tau accumulation in hippocampus. |
2019-09-09 |
2023-01-26 |
mouse |
| Heidi Martini-Stoica, Allysa L Cole, Daniel B Swartzlander, Fading Chen, Ying-Wooi Wan, Lakshya Bajaj, David A Bader, Virginia M Y Lee, John Q Trojanowski, Zhandong Liu, Marco Sardiello, Hui Zhen. TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading. The Journal of experimental medicine vol 215 issue 9 2019 30108137 |
in vivo, induced tfeb expression in astrocytes reduces pathology in the hippocampus of ps19 tauopathy mice, as well as prominently attenuates tau spreading from the ipsilateral to the contralateral hippocampus in a mouse model of tau spreading. |
2019-09-04 |
2023-01-26 |
mouse |
| Mariane C Vicente, Maria C Almeida, K\\xc3\\xaania C B\\xc3\\xadcego, Daniel C Carrettiero, Luciane H Gargaglion. Hypercapnic and Hypoxic Respiratory Response During Wakefulness and Sleep in a Streptozotocin Model of Alzheimer's Disease in Rats. Journal of Alzheimer's disease : JAD vol 65 issue 4 2019 30124447 |
in addition, we performed western blot analyses for phosphorylated tau, total tau, and amyloid-\xce\xb2 (a\xce\xb2) peptide in the locus coeruleus (lc), retrotrapezoid nucleus, medullary raphe, pre-b\xc3\xb6tzinger/b\xc3\xb6tzinger complex, and hippocampus, and evaluated memory and learning acquisition using the barnes maze. |
2019-08-26 |
2023-01-26 |
rat |
| Michele M Comerota, Batbayar Tumurbaatar, Balaji Krishnan, Rakez Kayed, Giulio Taglialatel. Near Infrared Light Treatment Reduces Synaptic Levels of Toxic Tau Oligomers in Two Transgenic Mouse Models of Human Tauopathies. Molecular neurobiology vol 56 issue 5 2019 30120733 |
we found that a 4-week exposure to nir light (90\xc2\xa0s/day/5\xc2\xa0days a week) significantly reduced levels of endogenous total and oligomeric tau in both synaptosomes and total protein extracts from the hippocampus and cortex of htau mice and improved deteriorating memory function. |
2019-08-20 |
2023-01-26 |
mouse |
| Meng-Shan Tan, Ping Wang, Fang-Chen Ma, Jie-Qiong Li, Chen-Chen Tan, Jin-Tai Yu, Lan Ta. Common Variant in PLD3 Influencing Cerebrospinal Fluid Total Tau Levels and Hippocampal Volumes in Mild Cognitive Impairment Patients from the ADNI Cohort. Journal of Alzheimer's disease : JAD vol 65 issue 3 2019 30103332 |
common variant in pld3 influencing cerebrospinal fluid total tau levels and hippocampal volumes in mild cognitive impairment patients from the adni cohort. |
2019-08-19 |
2023-01-26 |
Not clear |
| Shengnuo Fan, Yuqiu Zheng, Xuan Liu, Wenli Fang, Xiaoyu Chen, Wang Liao, Xiuna Jing, Ming Lei, Enxiang Tao, Qiulan Ma, Xingmei Zhang, Rui Guo, Jun Li. Curcumin-loaded PLGA-PEG nanoparticles conjugated with B6 peptide for potential use in Alzheimer's disease. Drug delivery vol 25 issue 1 2019 30107760 |
the ex vivo assays including bielschowsky silver staining, immunostaining, and western blotting demonstrated that plga-peg-b6/cur could reduce hippocampal \xce\xb2-amyloid formation and deposit and tau hyperphosphorylation. |
2019-08-14 |
2023-01-26 |
mouse |
| Melinda Barkhuizen, Fleur J P van Dijck, Reint K Jellema, Ruth Gussenhoven, Imke Engelbertink, Ralph van Mechelen, Jack P M Cleutjens, Matthias Seehase, Harry W M Steinbusch, Luc J Zimmermann, A W Danilo Gavilanes, Boris W Krame. The influence of anesthetics on substantia nigra tyrosine hydroxylase expression and tau phosphorylation in the hypoxic-ischemic near-term lamb. Pediatric research vol 83 issue 6 2019 29741516 |
the overall microglial response and tau phosphorylation were also measured in the sn, surrounding the midbrain gray matter structures and the hippocampal white matter.resultsthe isoflurane-treated uco group had fewer tyrosine hydroxylase-expressing neurons in the sn at 8\xe2\x80\x89h after the insult than the propofol-treated uco or sham-operated groups (p<0.05). |
2019-08-12 |
2023-01-26 |
Not clear |
| Dawling A Dionisio-Santos, John A Olschowka, M Kerry O'Banio. Exploiting microglial and peripheral immune cell crosstalk to treat Alzheimer's disease. Journal of neuroinflammation vol 16 issue 1 2019 30953557 |
in rodent models, increased neuroinflammation promoted by overexpression of proinflammatory cytokines can cause an increase in hyperphosphorylated tau and a decrease in hippocampal function. |
2019-08-05 |
2023-01-26 |
Not clear |
| Pranav Vemula, Yu Jing, Hu Zhang, Jerry B Hunt, Leslie A Sandusky-Beltran, Daniel C Lee, Ping Li. Altered brain arginine metabolism in a mouse model of tauopathy. Amino acids vol 51 issue 3 2019 30604097 |
using high-performance liquid chromatographic and mass spectrometric assays, the present study systematically determined the tissue concentrations of l-arginine and its nine downstream metabolites in the frontal cortex, hippocampus, parahippocampal region, striatum, thalamus, and cerebellum in male ps19 mice-bearing human tau p301s mutation at 4, 8, and 12-14\xc2\xa0months of age. |
2019-07-24 |
2023-01-26 |
mouse |
| Zhi-Tao Hou, Yu-Sheng Han, Yi-Tian Liu, Yu Xing, Meng Wang, Jing Che. [Effects of Sagacious Confucius' Pillow Elixir on cognitive function in type 2 diabetic rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica vol 43 issue 22 2019 30593246 |
the results showed that the sagacious confucius' pillow elixir could improve the learning and memory ability of stz injected rats, reduce the level of a beta content both in hippocampus and serum, effectively reduce tau protein phosphorylation degree, and also significantly alleviate hippocampal pathological injury, blood glucose, insulin and other basic indicators. |
2019-07-23 |
2023-01-26 |
rat |
| Elisa R Zanier, Ilaria Bertani, Eliana Sammali, Francesca Pischiutta, Maria Antonietta Chiaravalloti, Gloria Vegliante, Antonio Masone, Alessandro Corbelli, Douglas H Smith, David K Menon, Nino Stocchetti, Fabio Fiordaliso, Maria-Grazia De Simoni, William Stewart, Roberto Chies. Induction of a transmissible tau pathology by traumatic brain injury. Brain : a journal of neurology vol 141 issue 9 2019 30084913 |
brain homogenates from these mice, when inoculated into the hippocampus and overlying cerebral cortex of na\xc3\xafve mice, induced widespread tau pathology, synaptic loss, and persistent memory deficits. |
2019-07-17 |
2023-01-26 |
mouse |
| Ilse Eidhof, Jonathan Baets, Erik-Jan Kamsteeg, Tine Deconinck, Lisa van Ninhuijs, Jean-Jacques Martin, Rebecca Sch\\xc3\\xbcle, Stephan Z\\xc3\\xbcchner, Peter De Jonghe, Annette Schenck, Bart P van de Warrenbur. GDAP2 mutations implicate susceptibility to cellular stress in a new form of cerebellar ataxia. Brain : a journal of neurology vol 141 issue 9 2019 30084953 |
neuropathological examination showed degenerative changes in the cerebellum, olive inferior, thalamus, substantia nigra, and pyramidal tracts, as well as tau pathology in the hippocampus and amygdala. |
2019-07-17 |
2023-01-26 |
drosophila_melanogaster |