| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Teresa Diaz-Perdigon, Francisco B Belloch, Ana Ricobaraza, Elghareeb E Elboray, Takayoshi Suzuki, Rosa M Tordera, Elena Puert. Early sirtuin 2 inhibition prevents age-related cognitive decline in a senescence-accelerated mouse model. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 2. 2020-12-28. PMID:31471557. |
samp8 showed hyperphosphorylation of tau protein and decrease levels of sirt1 in the hippocampus, which were not altered by 33i treatment. |
2020-12-28 |
2023-08-13 |
mouse |
| Hongli Ma, Tao Jiang, Wenxin Tang, Zhi Ma, Kairui Pu, Fuxing Xu, Haiqing Chang, Ge Zhao, Wei Gao, Yansong Li, Qiang Wan. Transplantation of platelet-derived mitochondria alleviates cognitive impairment and mitochondrial dysfunction in db/db mice. Clinical science (London, England : 1979). vol 134. issue 16. 2020-12-28. PMID:32794577. |
importantly, one month following mito-plt transplantation, daci was alleviated in db/db mice and the effect was accompanied with increased mitochondrial number, restored mitochondrial function, attenuated oxidative stress and neuronal apoptosis, as well as decreased accumulation of aβ and tau in the hippocampus. |
2020-12-28 |
2023-08-13 |
mouse |
| José J Jarero-Basulto, Martha C Rivera-Cervantes, Deisy Gasca-Martínez, Francisco García-Sierra, Yadira Gasca-Martínez, Carlos Beas-Zárat. Current Evidence on the Protective Effects of Recombinant Human Erythropoietin and Its Molecular Variants against Pathological Hallmarks of Alzheimer's Disease. Pharmaceuticals (Basel, Switzerland). vol 13. issue 12. 2020-12-26. PMID:33255969. |
ad is a degenerative disorder of the brain, characterized by an aberrant accumulation of amyloid β (aβ) and hyperphosphorylated tau (tau-p) proteins in the extracellular and intracellular space, respectively, leading to inflammation, oxidative stress, excitotoxicity, and other neuronal alterations that compromise cell viability, causing neurodegeneration in the hippocampus and the cerebral cortex. |
2020-12-26 |
2023-08-13 |
human |
| Seiko Ikezu, Kaitlin L Ingraham Dixie, Lacin Koro, Takashi Watanabe, Kozo Kaibuchi, Tsuneya Ikez. Tau-tubulin kinase 1 and amyloid-β peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models. Acta neuropathologica communications. vol 8. issue 1. 2020-12-23. PMID:32019603. |
tau tubulin kinase-1 (ttbk1) is a neuron-specific tau kinase and expressed in the ec and hippocampal regions in both human and mouse brains. |
2020-12-23 |
2023-08-13 |
mouse |
| Rosellina Guarascio, Dervis Salih, Marina Yasvoina, Frances A Edwards, Michael E Cheetham, Jacqueline van der Spu. Negative Regulator of Ubiquitin-Like Protein 1 modulates the autophagy-lysosomal pathway via p62 to facilitate the extracellular release of tau following proteasome impairment. Human molecular genetics. vol 29. issue 1. 2020-12-21. PMID:31691796. |
nub1 localized to cytosolic inclusions with pathological forms of tau, as well as lamp1 and p62 in the hippocampal neurons of tauopathy mice. |
2020-12-21 |
2023-08-13 |
mouse |
| Aida Muntsant, Lydia Giménez-Llor. Impact of Social Isolation on the Behavioral, Functional Profiles, and Hippocampal Atrophy Asymmetry in Dementia in Times of Coronavirus Pandemic (COVID-19): A Translational Neuroscience Approach. Frontiers in psychiatry. vol 11. 2020-12-18. PMID:33329110. |
hippocampal tau pathology was not modified, but asymmetric atrophy of the hippocampus, recently described in human patients with dementia and modeled here for the first time in an animal model of ad, was found to increase with isolation. |
2020-12-18 |
2023-08-13 |
mouse |
| Qing Tao, Xianhe Wang, Lei Liu, Yongsheng Ji, Qingli Luo, Jian Du, Li Yu, Jilong Shen, Deyong Ch. Toxoplasma gondii Chinese I genotype Wh6 strain infection induces tau phosphorylation via activating GSK3β and causes hippocampal neuron apoptosis. Acta tropica. vol 210. 2020-12-17. PMID:32492398. |
toxoplasma gondii chinese i genotype wh6 strain infection induces tau phosphorylation via activating gsk3β and causes hippocampal neuron apoptosis. |
2020-12-17 |
2023-08-13 |
mouse |
| Qing Tao, Xianhe Wang, Lei Liu, Yongsheng Ji, Qingli Luo, Jian Du, Li Yu, Jilong Shen, Deyong Ch. Toxoplasma gondii Chinese I genotype Wh6 strain infection induces tau phosphorylation via activating GSK3β and causes hippocampal neuron apoptosis. Acta tropica. vol 210. 2020-12-17. PMID:32492398. |
then we observed the formation of tissue cysts in the brain, the damage of neuron and the increased expression of phosphorylated tau (p-tau) in the hippocampal tissue of the mice. |
2020-12-17 |
2023-08-13 |
mouse |
| Qing Tao, Xianhe Wang, Lei Liu, Yongsheng Ji, Qingli Luo, Jian Du, Li Yu, Jilong Shen, Deyong Ch. Toxoplasma gondii Chinese I genotype Wh6 strain infection induces tau phosphorylation via activating GSK3β and causes hippocampal neuron apoptosis. Acta tropica. vol 210. 2020-12-17. PMID:32492398. |
in all, our results indicated that tgctwh6 infection not only led to phosphorylation of tau via activating gsk3β but also promoted hippocampal neuron apoptosis. |
2020-12-17 |
2023-08-13 |
mouse |
| Juliana C S Chaves, Felippe T Machado, Michael F Almeida, Tatiana B Bacovsky, Merari F R Ferrar. microRNAs expression correlates with levels of APP, DYRK1A, hyperphosphorylated Tau and BDNF in the hippocampus of a mouse model for Down syndrome during ageing. Neuroscience letters. vol 714. 2020-12-07. PMID:31605772. |
micrornas expression correlates with levels of app, dyrk1a, hyperphosphorylated tau and bdnf in the hippocampus of a mouse model for down syndrome during ageing. |
2020-12-07 |
2023-08-13 |
mouse |
| Juliana C S Chaves, Felippe T Machado, Michael F Almeida, Tatiana B Bacovsky, Merari F R Ferrar. microRNAs expression correlates with levels of APP, DYRK1A, hyperphosphorylated Tau and BDNF in the hippocampus of a mouse model for Down syndrome during ageing. Neuroscience letters. vol 714. 2020-12-07. PMID:31605772. |
in this study, we investigated the association among mirnas mir-17, -20a, -101, -106b, -199b, -26a, 26b and some of their target mrnas such as app, dyrk1a and bdnf, as well as the levels of hyperphosphorylated tau in the hippocampus of a 2 and 5 months old mice model of trisomy 21 (ts65dn). |
2020-12-07 |
2023-08-13 |
mouse |
| Tong-Yao Hou, Yang Zhou, Ling-Shuang Zhu, Xiong Wang, Pei Pang, Ding-Qi Wang, Zhen-Yu Liuyang, Hengye Man, Youming Lu, Ling-Qiang Zhu, Dan Li. Correcting abnormalities in miR-124/PTPN1 signaling rescues tau pathology in Alzheimer's disease. Journal of neurochemistry. vol 154. issue 4. 2020-12-07. PMID:31951013. |
we found that artificially replicating the abnormalities in mir-124/ptpn1 signaling induced ad-like tau pathology in the hippocampus of wild-type mice, including hyperphosphorylation at multiple sites, insolubility and somadendritic aggregation, as well as learning/memory deficits. |
2020-12-07 |
2023-08-13 |
mouse |
| Teodora Petrova, Camila Orellana, Vesna Jelic, Anne-Rita Oeksengaard, Jon Snaedal, Peter Høgh, Birgitte Bo Andersen, Mala Naik, Knut Engedal, Lars-Olof Wahlund, Daniel Ferreir. Cholinergic dysfunction, neurodegeneration, and amyloid-beta pathology in neurodegenerative diseases. Psychiatry research. Neuroimaging. vol 302. 2020-12-07. PMID:32505903. |
we investigated the association between the eeg-ach index and cerebrospinal fluid (csf) amyloid-beta, csf total tau, cortical thickness, and hippocampal volume from magnetic resonance imaging (mri), and cognition. |
2020-12-07 |
2023-08-13 |
Not clear |
| Teodora Petrova, Camila Orellana, Vesna Jelic, Anne-Rita Oeksengaard, Jon Snaedal, Peter Høgh, Birgitte Bo Andersen, Mala Naik, Knut Engedal, Lars-Olof Wahlund, Daniel Ferreir. Cholinergic dysfunction, neurodegeneration, and amyloid-beta pathology in neurodegenerative diseases. Psychiatry research. Neuroimaging. vol 302. 2020-12-07. PMID:32505903. |
cross-sectional sub-analyses based on a small sample suggests that the eeg-ach index increases the closest to ad dementia, downstream to amyloid-beta pathology, csf total tau, and hippocampal volume. |
2020-12-07 |
2023-08-13 |
Not clear |
| Zuntao Wu, Lin Bai, Runqi Tu, Lijie Zhang, Yue Ba, Huizhen Zhang, Xing Li, Xuemin Cheng, Wenjie Li, Hui Huan. Disruption of synaptic expression pattern and age-related DNA oxidation in a neuronal model of lead-induced toxicity. Environmental toxicology and pharmacology. vol 76. 2020-12-04. PMID:32058320. |
furthermore, the expression of bace1 protein and tau phosphorylation level in pfc and hippocampus increased, app mrnas in pfc and prolonged induction of bace1 in hippocampus. |
2020-12-04 |
2023-08-13 |
mouse |
| Natalia Dos Santos Tramontin, Sabrina da Silva, Rychard Arruda, Kellen Simon Ugioni, Paula Bortuluzzi Canteiro, Gustavo de Bem Silveira, Carolini Mendes, Paulo Cesar Lock Silveira, Alexandre Pastoris Mulle. Gold Nanoparticles Treatment Reverses Brain Damage in Alzheimer's Disease Model. Molecular neurobiology. vol 57. issue 2. 2020-11-25. PMID:31612296. |
oa increases tau phosphorylation in the cortex and hippocampus, while aunp treatment maintained it as normal. |
2020-11-25 |
2023-08-13 |
rat |
| Ryszard Pluta, Marzena Ułamek-Kozioł, Janusz Kocki, Jacek Bogucki, Sławomir Januszewski, Anna Bogucka-Kocka, Stanisław J Czuczwa. Expression of the Tau Protein and Amyloid Protein Precursor Processing Genes in the CA3 Area of the Hippocampus in the Ischemic Model of Alzheimer's Disease in the Rat. Molecular neurobiology. vol 57. issue 2. 2020-11-25. PMID:31713815. |
expression of the tau protein and amyloid protein precursor processing genes in the ca3 area of the hippocampus in the ischemic model of alzheimer's disease in the rat. |
2020-11-25 |
2023-08-13 |
rat |
| Ryszard Pluta, Marzena Ułamek-Kozioł, Janusz Kocki, Jacek Bogucki, Sławomir Januszewski, Anna Bogucka-Kocka, Stanisław J Czuczwa. Expression of the Tau Protein and Amyloid Protein Precursor Processing Genes in the CA3 Area of the Hippocampus in the Ischemic Model of Alzheimer's Disease in the Rat. Molecular neurobiology. vol 57. issue 2. 2020-11-25. PMID:31713815. |
data show that brain ischemia activates neuronal changes and death in the ca3 region of the hippocampus in a manner dependent on amyloid and tau protein, thus determining a new and important way to regulate the survival and/or death of ischemic neurons. |
2020-11-25 |
2023-08-13 |
rat |
| Brent Aulston, Qing Liu, Michael Mante, Jazmin Florio, Robert A Rissman, Shauna H Yua. Extracellular Vesicles Isolated from Familial Alzheimer's Disease Neuronal Cultures Induce Aberrant Tau Phosphorylation in the Wild-Type Mouse Brain. Journal of Alzheimer's disease : JAD. vol 72. issue 2. 2020-11-17. PMID:31594233. |
moreover, fad ev injected hippocampi contained significantly more tau inclusions in the ca1 hippocampal neuronal field than controls. |
2020-11-17 |
2023-08-13 |
mouse |
| Yanhua Jiang, Yongjian Zhou, Hong Ma, Xuezhao Cao, Zhe Li, Fengshou Chen, Hongnan Wan. Autophagy Dysfunction and mTOR Hyperactivation Is Involved in Surgery: Induced Behavioral Deficits in Aged C57BL/6J Mice. Neurochemical research. vol 45. issue 2. 2020-11-17. PMID:31865521. |
brain derived neurotrophic factor (bdnf), synaptophysin, and tau hyperphosphorylation (t396) in the hippocampus were also examined. |
2020-11-17 |
2023-08-13 |
mouse |