| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pranav Vemula, Yu Jing, Hu Zhang, Jerry B Hunt, Leslie A Sandusky-Beltran, Daniel C Lee, Ping Li. Altered brain arginine metabolism in a mouse model of tauopathy. Amino acids vol 51 issue 3 2019 30604097 |
using high-performance liquid chromatographic and mass spectrometric assays, the present study systematically determined the tissue concentrations of l-arginine and its nine downstream metabolites in the frontal cortex, hippocampus, parahippocampal region, striatum, thalamus, and cerebellum in male ps19 mice-bearing human tau p301s mutation at 4, 8, and 12-14\xc2\xa0months of age. |
2019-07-24 |
2023-01-26 |
mouse |
| Zhi-Tao Hou, Yu-Sheng Han, Yi-Tian Liu, Yu Xing, Meng Wang, Jing Che. [Effects of Sagacious Confucius' Pillow Elixir on cognitive function in type 2 diabetic rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica vol 43 issue 22 2019 30593246 |
the results showed that the sagacious confucius' pillow elixir could improve the learning and memory ability of stz injected rats, reduce the level of a beta content both in hippocampus and serum, effectively reduce tau protein phosphorylation degree, and also significantly alleviate hippocampal pathological injury, blood glucose, insulin and other basic indicators. |
2019-07-23 |
2023-01-26 |
rat |
| Elisa R Zanier, Ilaria Bertani, Eliana Sammali, Francesca Pischiutta, Maria Antonietta Chiaravalloti, Gloria Vegliante, Antonio Masone, Alessandro Corbelli, Douglas H Smith, David K Menon, Nino Stocchetti, Fabio Fiordaliso, Maria-Grazia De Simoni, William Stewart, Roberto Chies. Induction of a transmissible tau pathology by traumatic brain injury. Brain : a journal of neurology vol 141 issue 9 2019 30084913 |
brain homogenates from these mice, when inoculated into the hippocampus and overlying cerebral cortex of na\xc3\xafve mice, induced widespread tau pathology, synaptic loss, and persistent memory deficits. |
2019-07-17 |
2023-01-26 |
mouse |
| Ilse Eidhof, Jonathan Baets, Erik-Jan Kamsteeg, Tine Deconinck, Lisa van Ninhuijs, Jean-Jacques Martin, Rebecca Sch\\xc3\\xbcle, Stephan Z\\xc3\\xbcchner, Peter De Jonghe, Annette Schenck, Bart P van de Warrenbur. GDAP2 mutations implicate susceptibility to cellular stress in a new form of cerebellar ataxia. Brain : a journal of neurology vol 141 issue 9 2019 30084953 |
neuropathological examination showed degenerative changes in the cerebellum, olive inferior, thalamus, substantia nigra, and pyramidal tracts, as well as tau pathology in the hippocampus and amygdala. |
2019-07-17 |
2023-01-26 |
drosophila_melanogaster |
| Kristen M Craven, William R Kochen, Carlos M Hernandez, Jane M Flin. Zinc Exacerbates Tau Pathology in a Tau Mouse Model. Journal of Alzheimer's disease : JAD vol 64 issue 2 2019 29914030 |
zinc supplementation in tau mice also increased tangle numbers in the hippocampus while decreasing free-zinc levels, demonstrating that tangles were sequestering zinc. |
2019-07-15 |
2023-01-26 |
mouse |
| Eric M Gold, Vitaly Vasilevko, Jonathan Hasselmann, Casey Tiefenthaler, Danny Hoa, Kasuni Ranawaka, David H Cribbs, Brian J Cumming. Repeated Mild Closed Head Injuries Induce Long-Term White Matter Pathology and Neuronal Loss That Are Correlated With Behavioral Deficits. ASN neuro vol 10 issue 2019 29932344 |
in human tau transgenic mice, rmchi induced increases in hyperphosphorylated paired helical filament 1 tau in the hippocampus. |
2019-07-11 |
2023-01-26 |
mouse |
| Robert A Whittington, L\\xc3\\xa1szl\\xc3\\xb3 Vir\\xc3\\xa1g, Maud Gratuze, Hilana Lewkowitz-Shpuntoff, Mehdi Cheheltanan, Franck Petry, Isabelle Poitras, Fran\\xc3\\xa7oise Morin, Emmanuel Plane. Administration of the benzodiazepine midazolam increases tau phosphorylation in the mouse brain. Neurobiology of aging vol 75 issue 2019 30508732 |
in c57bl/6 mice, chronic midazolam administration immediately increased hippocampal tau phosphorylation, and this effect was more pronounced in older mice. |
2019-07-11 |
2023-01-26 |
mouse |
| Robert A Whittington, L\\xc3\\xa1szl\\xc3\\xb3 Vir\\xc3\\xa1g, Maud Gratuze, Hilana Lewkowitz-Shpuntoff, Mehdi Cheheltanan, Franck Petry, Isabelle Poitras, Fran\\xc3\\xa7oise Morin, Emmanuel Plane. Administration of the benzodiazepine midazolam increases tau phosphorylation in the mouse brain. Neurobiology of aging vol 75 issue 2019 30508732 |
interestingly, in young c57bl/6 mice, chronic midazolam administration induced hippocampal tau hyperphosphorylation, which persisted for 1\xc2\xa0week. |
2019-07-11 |
2023-01-26 |
mouse |
| Robert A Whittington, L\\xc3\\xa1szl\\xc3\\xb3 Vir\\xc3\\xa1g, Maud Gratuze, Hilana Lewkowitz-Shpuntoff, Mehdi Cheheltanan, Franck Petry, Isabelle Poitras, Fran\\xc3\\xa7oise Morin, Emmanuel Plane. Administration of the benzodiazepine midazolam increases tau phosphorylation in the mouse brain. Neurobiology of aging vol 75 issue 2019 30508732 |
in htau mice, chronic midazolam administration increased hippocampal tau phosphorylation and, although this was not associated with proaggregant changes, this correlated with a decreased capacity of tau to bind to preassembled microtubules. |
2019-07-11 |
2023-01-26 |
mouse |
| Caoyi Chen, Jianlan Gu, Gustavo Basurto-Islas, Nana Jin, Feng Wu, Cheng-Xin Gong, Khalid Iqbal, Fei Li. Up-regulation of casein kinase 1\\xce\\xb5 is involved in tau pathogenesis in Alzheimer's disease. Scientific reports vol 7 issue 1 2019 29044200 |
overexpression of ck1\xce\xb5 in the mouse hippocampus increased tau phosphorylation and impaired spontaneous alternation behavior. |
2019-07-01 |
2023-01-26 |
mouse |
| Hugo Botha, William G Mantyh, Melissa E Murray, David S Knopman, Scott A Przybelski, Heather J Wiste, Jonathan Graff-Radford, Keith A Josephs, Christopher G Schwarz, Walter K Kremers, Bradley F Boeve, Ronald C Petersen, Mary M Machulda, Joseph E Parisi, Dennis W Dickson, Val Lowe, Clifford R Jack, David T Jone. FDG-PET in tau-negative amnestic dementia resembles that of autopsy-proven hippocampal sclerosis. Brain : a journal of neurology vol 141 issue 4 2019 29538658 |
we evaluated the utility of 18f-fdg-pet to differentiate flortaucipir tau pet negative from flortaucipir positive amnestic mild cognitive impairment and dementia and used an autopsy confirmed cohort to test the hypothesis that hippocampal sclerosis might account for the observed pattern. |
2019-06-28 |
2023-01-26 |
human |
| Michaeline L Hebron, Monica Javidnia, Charbel E-H Mouss. Tau clearance improves astrocytic function and brain glutamate-glutamine cycle. Journal of the neurological sciences vol 391 issue 2019 30103978 |
to obtain an animal model that expresses tau in the brainstem, we bred hemizygous mice that express p301l tau (taup301l) and detected hyper-phosphorylated tau (p-tau) predominantly in the hippocampus, cortex, brainstem and thalamus. |
2019-06-27 |
2023-01-26 |
mouse |
| Bension Shlomo Tilley, Colin Smith, Nicola Pavese, Johannes Attem. Rare histotype of sporadic Creutzfeldt-Jakob disease, clinically suspected as corticobasal degeneration. BMJ case reports vol 12 issue 3 2019 30850568 |
hyperphosphorylated tau was only found in the entorhinal cortex and hippocampus. |
2019-06-24 |
2023-01-26 |
Not clear |
| Tomas Smolek, Santosh Jadhav, Veronika Brezovakova, Veronika Cubinkova, Bernadeta Valachova, Petr Novak, Norbert Zilk. First-in-Rat Study of Human Alzheimer's Disease Tau Propagation. Molecular neurobiology vol 56 issue 1 2019 29770957 |
by using specific monoclonal antibodies, we were able to monitor the spreading of tau isolated from human brain directly in the rat hippocampus. |
2019-06-11 |
2023-01-26 |
rat |
| Catia M Teixeira, Noem\\xc3\\xad Pallas-Bazarra, Marta Bol\\xc3\\xb3s, Julia Terreros-Roncal, Jes\\xc3\\xbas \\xc3\\x81vila, Mar\\xc3\\xada Llorens-Mart\\xc3\\xad. Untold New Beginnings: Adult Hippocampal Neurogenesis and Alzheimer's Disease. Journal of Alzheimer's disease : JAD vol 64 issue s1 2019 29562522 |
importantly, it has been revealed that gsk-3\xce\xb2 and tau proteins, which are two of the main players driving ad pathology, are cornerstones of adult hippocampal neurogenesis regulation. |
2019-06-11 |
2023-01-26 |
Not clear |
| Yvonne S Davidson, Andrew Robinson, Vee P Prasher, David M A Man. The age of onset and evolution of Braak tangle stage and Thal amyloid pathology of Alzheimer's disease in individuals with Down syndrome. Acta neuropathologica communications vol 6 issue 1 2019 29973279 |
tau pathology usually commenced after 35\xc2\xa0years of age, initially involving not only entorhinal areas and hippocampus but also subcortical regions such as locus caeruleus (lc) and dorsal raphe nucleus (drn). |
2019-06-04 |
2023-01-26 |
Not clear |
| Yvonne S Davidson, Andrew Robinson, Vee P Prasher, David M A Man. The age of onset and evolution of Braak tangle stage and Thal amyloid pathology of Alzheimer's disease in individuals with Down syndrome. Acta neuropathologica communications vol 6 issue 1 2019 29973279 |
we found no evidence that tau pathology might commence within the brain in ds before amyloid deposition had occurred, but there was limited data that suggests tau pathology in lc or drn might predate that in entorhinal areas and hippocampus or at least be coincident. |
2019-06-04 |
2023-01-26 |
Not clear |
| Iv\\xc3\\xa1n M\\xc3\\xa9ndez-L\\xc3\\xb3pez, Idoia Blanco-Luquin, Javier S\\xc3\\xa1nchez-Ruiz de Gordoa, Amaya Urd\\xc3\\xa1noz-Casado, Miren Rold\\xc3\\xa1n, Blanca Acha, Carmen Echavarri, Victoria Zelaya, Ivonne Jeric\\xc3\\xb3, Maite Mendioro. Hippocampal International journal of molecular sciences vol 20 issue 4 2019 30781626 |
here, we examined a-type and b-type lamin expression levels by rt-qpcr in alzheimer's disease (ad) patients and controls in the hippocampus, the core of tau pathology in the brain. |
2019-05-31 |
2023-01-26 |
Not clear |
| Biswanath Dinda, Manikarna Dinda, Goutam Kulsi, Ankita Chakraborty, Subhajit Dind. Therapeutic potentials of plant iridoids in Alzheimer's and Parkinson's diseases: A review. European journal of medicinal chemistry vol 169 issue 2019 30877973 |
ad is characterized by deposition of extracellular beta-amyloid (a\xce\xb2) proteins and intracellular neurofibrillary tangles (nft), composed of hyperphosphorylated tau proteins in the neurons located particularly in hippocampus and cerebral cortex regions of brain, resulting the neuronal loss, while pd is characterized by deposition of intraneuronal aggregates of mostly composed of alpha-synuclein gene as lewy bodies (lb) in the striatal region, known as substantia nigra pars compacta (snpc) of brain, leading to the death of dopaminergic neurons. |
2019-05-28 |
2023-01-26 |
Not clear |
| Isidro Ferrer, Meritxell Aguil\\xc3\\xb3 Garc\\xc3\\xada, Irene L\\xc3\\xb3pez Gonz\\xc3\\xa1lez, Daniela Diaz Lucena, Aina Roig Villalonga, Margarita Carmona Tech, Franc Llorens, Paula Garcia-Esparcia, Alejandra Martinez-Maldonado, Margalida Frau Mendez, Benjam\\xc3\\xadn Torrej\\xc3\\xb3n Escribano, Joan Josep Bech-Serra, Eduard Sabido, Carolina de la Torre G\\xc3\\xb3mez, Jos\\xc3\\xa9 Antonio Del Ri. Aging-related tau astrogliopathy (ARTAG): not only tau phosphorylation in astrocytes. Brain pathology (Zurich, Switzerland) vol 28 issue 6 2019 29396893 |
finally, present results show for the first time that tau seeding is produced in neurons of the hippocampal complex, astrocytes, oligodendroglia and along fibers of the corpus callosum, fimbria and fornix following inoculation into the hippocampus of wild type mice of sarkosyl-insoluble fractions enriched in hyper-phosphorylated tau from selected artag cases. |
2019-05-28 |
2023-01-26 |
mouse |