| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wen Hu, Feng Wu, Yanchong Zhang, Cheng-Xin Gong, Khalid Iqbal, Fei Li. Expression of Tau Pathology-Related Proteins in Different Brain Regions: A Molecular Basis of Tau Pathogenesis. Frontiers in aging neuroscience. vol 9. 2020-10-01. PMID:29021756. |
the tau pathology starts from the entorhinal cortex (ec), spreads to the hippocampus and frontal and temporal cortices, and finally to all isocortex areas, but the cerebellum is spared from tau lesions. |
2020-10-01 |
2023-08-13 |
human |
| Wen Hu, Feng Wu, Yanchong Zhang, Cheng-Xin Gong, Khalid Iqbal, Fei Li. Expression of Tau Pathology-Related Proteins in Different Brain Regions: A Molecular Basis of Tau Pathogenesis. Frontiers in aging neuroscience. vol 9. 2020-10-01. PMID:29021756. |
in the rat brain, the expression level of tau with three microtubule-binding repeats (3r-tau) was comparable in the hippocampus, ec, fc, parietal-temporal cortex (ptc), occipital-temporal cortex (otc), striatum, thalamus, olfactory bulb (ob) and cerebellum. |
2020-10-01 |
2023-08-13 |
human |
| Liping Chen, Chunhui Huang, Jieyi Shentu, Minjun Wang, Sicheng Yan, Fei Zhou, Zaijun Zhang, Chuang Wang, Yifan Han, Qinwen Wang, Wei Cu. Indirubin Derivative 7-Bromoindirubin-3-Oxime (7Bio) Attenuates Aβ Oligomer-Induced Cognitive Impairments in Mice. Frontiers in molecular neuroscience. vol 10. 2020-10-01. PMID:29234273. |
the mean optical density (od) with hyper-phosphorylated tau (ptau), glial fibrillary acidic protein (gfap) and cd45 positive staining in the hippocampus of 7bio-treated mice were significantly decreased compared to those of aβ oligomer-treated mice. |
2020-10-01 |
2023-08-13 |
mouse |
| Lei Song, Xiaoping Li, Xiao-Xue Bai, Jian Gao, Chun-Yan Wan. Calycosin improves cognitive function in a transgenic mouse model of Alzheimer's disease by activating the protein kinase C pathway. Neural regeneration research. vol 12. issue 11. 2020-10-01. PMID:29239334. |
calycosin diminished hippocampal beta amyloid, tau protein, interleukin-1beta, tumor necrosis factor-alpha, acetylcholinesterase and malondialdehyde levels in a dose-dependent manner, and increased acetylcholine and glutathione activities. |
2020-10-01 |
2023-08-13 |
mouse |
| Misato Yoshikawa, Yoshiyuki Soeda, Makoto Michikawa, Osborne F X Almeida, Akihiko Takashim. Tau Depletion in APP Transgenic Mice Attenuates Task-Related Hyperactivation of the Hippocampus and Differentially Influences Locomotor Activity and Spatial Memory. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:29545742. |
tau depletion in app transgenic mice attenuates task-related hyperactivation of the hippocampus and differentially influences locomotor activity and spatial memory. |
2020-10-01 |
2023-08-13 |
mouse |
| Misato Yoshikawa, Yoshiyuki Soeda, Makoto Michikawa, Osborne F X Almeida, Akihiko Takashim. Tau Depletion in APP Transgenic Mice Attenuates Task-Related Hyperactivation of the Hippocampus and Differentially Influences Locomotor Activity and Spatial Memory. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:29545742. |
depletion of endogenous tau in an amyloid precursor protein (app) transgenic (j20) mouse line was shown to ameliorate hippocampal hyperactivity in j20 animals, tau depletion failed to reverse memory deficits associated with app/aβ overproduction. |
2020-10-01 |
2023-08-13 |
mouse |
| Hong-Bin Luo, Nan Shang, Wen-Zhi Xie, De-Jian Wen, Min Qu, Sheng Huang, Sha-Sha Fan, Wei Chen, Nan-Qiao Mou, Xiang-Yu Liu, Qin Chen, Feng-Feng Xie, Jun-Xu L. Neural regeneration research. vol 13. issue 5. 2020-10-01. PMID:29863023. |
western blot assay was used to detect the levels of tau protein and other factors involved in tau phosphorylation in the hippocampus. |
2020-10-01 |
2023-08-13 |
rat |
| Hong-Bin Luo, Nan Shang, Wen-Zhi Xie, De-Jian Wen, Min Qu, Sheng Huang, Sha-Sha Fan, Wei Chen, Nan-Qiao Mou, Xiang-Yu Liu, Qin Chen, Feng-Feng Xie, Jun-Xu L. Neural regeneration research. vol 13. issue 5. 2020-10-01. PMID:29863023. |
immunohistochemical staining was used to examine tau protein in the hippocampus. |
2020-10-01 |
2023-08-13 |
rat |
| Yuan Zhang, Yun-Luo Lv, Yan-Na Si, Jianwei Zhou, Yanning Qian, Hong-Guang Ba. α-lipoic acid attenuates spatial learning and memory impairment induced by hepatectomy. Experimental and therapeutic medicine. vol 17. issue 3. 2020-10-01. PMID:30867718. |
the expression levels of proteins, including cyclin-dependent kinase 5 (cdk5), tau, phosphorylated tau and amyloid β (aβ) were measured in the hippocampus. |
2020-10-01 |
2023-08-13 |
mouse |
| Yuan Zhang, Yun-Luo Lv, Yan-Na Si, Jianwei Zhou, Yanning Qian, Hong-Guang Ba. α-lipoic acid attenuates spatial learning and memory impairment induced by hepatectomy. Experimental and therapeutic medicine. vol 17. issue 3. 2020-10-01. PMID:30867718. |
furthermore, the expression levels of cdk5 and aβ, and the phosphorylation of tau in the hippocampus increased after the surgery in both wt and db/db mice. |
2020-10-01 |
2023-08-13 |
mouse |
| Yuan Zhang, Yun-Luo Lv, Yan-Na Si, Jianwei Zhou, Yanning Qian, Hong-Guang Ba. α-lipoic acid attenuates spatial learning and memory impairment induced by hepatectomy. Experimental and therapeutic medicine. vol 17. issue 3. 2020-10-01. PMID:30867718. |
treatment with ala protected the postoperative cognitive function and the structure of hippocampal neurons and synapses, and prevented the increase in protein expression levels of cdk5 and aβ, and the phosphorylation of tau in the hippocampus of wt but not db/db mice. |
2020-10-01 |
2023-08-13 |
mouse |
| Jin Miao, Ruirui Shi, Longfei Li, Feng Chen, Yan Zhou, Yunn Chyn Tung, Wen Hu, Cheng-Xin Gong, Khalid Iqbal, Fei Li. Pathological Tau From Alzheimer's Brain Induces Site-Specific Hyperphosphorylation and SDS- and Reducing Agent-Resistant Aggregation of Tau Frontiers in aging neuroscience. vol 11. 2020-10-01. PMID:30890929. |
in the present study, we injected hyperphosphorylated and oligomeric tau isolated from ad brain (ad p-tau) into hippocampus of human tau transgenic mice and found that in addition to tau aggregation/pathology, tau was hyperphosphorylated at ser202/thr205, thr212, ser214, thr217, ser262, and ser422 in ad p-tau injected hippocampus and at ser422 in the contralateral hippocampus and in the ipsilateral cortex. |
2020-10-01 |
2023-08-13 |
mouse |
| Jin Miao, Ruirui Shi, Longfei Li, Feng Chen, Yan Zhou, Yunn Chyn Tung, Wen Hu, Cheng-Xin Gong, Khalid Iqbal, Fei Li. Pathological Tau From Alzheimer's Brain Induces Site-Specific Hyperphosphorylation and SDS- and Reducing Agent-Resistant Aggregation of Tau Frontiers in aging neuroscience. vol 11. 2020-10-01. PMID:30890929. |
ad p-tau-induced ad-like high molecular weight aggregation of tau that was sds- and reducing agent-resistant and site-specifically hyperphosphorylated in the ipsilateral hippocampus. |
2020-10-01 |
2023-08-13 |
mouse |
| Gehua Wen, Hui Yao, Yanning Li, Runtao Ding, Xinghua Ren, Yaqing Tan, Weishu Ren, Hao Yu, Xiaoni Zhan, Xiaolong Wang, Enyu Xu, Jun Yao, Guohua Zhang, Yan Lu, Xu W. Regulation of Tau Protein on the Antidepressant Effects of Ketamine in the Chronic Unpredictable Mild Stress Model. Frontiers in psychiatry. vol 10. 2020-10-01. PMID:31114516. |
we used c57bl/6 and tau ko mice exposed to 42 days of chronic unpredictable mild stress (the cums model) to investigate the effect of ketamine on behavioral changes and synaptic functioning of the hippocampus. |
2020-10-01 |
2023-08-13 |
mouse |
| Gehua Wen, Hui Yao, Yanning Li, Runtao Ding, Xinghua Ren, Yaqing Tan, Weishu Ren, Hao Yu, Xiaoni Zhan, Xiaolong Wang, Enyu Xu, Jun Yao, Guohua Zhang, Yan Lu, Xu W. Regulation of Tau Protein on the Antidepressant Effects of Ketamine in the Chronic Unpredictable Mild Stress Model. Frontiers in psychiatry. vol 10. 2020-10-01. PMID:31114516. |
the abnormal behaviors were accompanied by increased levels of specific alterations of hyperphosphorylated tau protein in cytoplasm and synapse in the hippocampus of the c57bl/6 mice, but ketamine reduced the aggregation of hyperphosphorylated tau protein only in the synapse. |
2020-10-01 |
2023-08-13 |
mouse |
| Gehua Wen, Hui Yao, Yanning Li, Runtao Ding, Xinghua Ren, Yaqing Tan, Weishu Ren, Hao Yu, Xiaoni Zhan, Xiaolong Wang, Enyu Xu, Jun Yao, Guohua Zhang, Yan Lu, Xu W. Regulation of Tau Protein on the Antidepressant Effects of Ketamine in the Chronic Unpredictable Mild Stress Model. Frontiers in psychiatry. vol 10. 2020-10-01. PMID:31114516. |
however, the tau ko mice did not develop any stress-induced depressive behaviors or deficits of hippocampal function. |
2020-10-01 |
2023-08-13 |
mouse |
| Ambrose A Dunn-Meynell, Peter Dowling, Michelle Marchese, Esther Rodriguez, Benjamin Blumberg, Yun-Beom Choi, Deeya Gaindh, Wei L. Frontiers in aging neuroscience. vol 11. 2020-10-01. PMID:31572168. |
post mortem analysis showed the elevated luminescence was correlated with hyperphosphorylated tau deposition in the hippocampus of double transgenic mice. |
2020-10-01 |
2023-08-13 |
mouse |
| Marianna Alves, Aidan Kenny, Gioacchino de Leo, Edward H Beamer, Tobias Enge. Tau Phosphorylation in a Mouse Model of Temporal Lobe Epilepsy. Frontiers in aging neuroscience. vol 11. 2020-10-01. PMID:31780921. |
status epilepticus resulted in an immediate increase in total tau levels in the hippocampus, in particular, the dentate gyrus, and phosphorylation of the at8 epitope (ser202, thr205), with phosphorylated tau mainly localizing to the mossy fibers of the dentate gyrus. |
2020-10-01 |
2023-08-13 |
mouse |
| Marianna Alves, Aidan Kenny, Gioacchino de Leo, Edward H Beamer, Tobias Enge. Tau Phosphorylation in a Mouse Model of Temporal Lobe Epilepsy. Frontiers in aging neuroscience. vol 11. 2020-10-01. PMID:31780921. |
during epilepsy, abnormal phosphorylation of tau was detected again at the at8 epitope with lower total tau levels in the ca3 and ca1 subfields of the hippocampus. |
2020-10-01 |
2023-08-13 |
mouse |
| R A. Armstrong, P L. Lantos, N J. Cairn. The spatial patterns of pathological brain lesions in 12 patients with corticobasal degeneration. Pathophysiology : the official journal of the International Society for Pathophysiology. vol 8. issue 1. 2020-09-30. PMID:11476973. |
we studied the spatial patterns of the bn, tau positive neurons with inclusions (tau+ neurons), and tau positive plaques in the neocortex and hippocampus in 12 cases of cbd. |
2020-09-30 |
2023-08-12 |
Not clear |