| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gabriel Keine Kuga, Vitor Rosetto Mu\\xc3\\xb1oz, Rafael Calais Gaspar, Susana Castelo Branco Ramos Nakandakari, Adelino Sanchez Ramos da Silva, Jos\\xc3\\xa9 Diego Botezelli, Jos\\xc3\\xa9 Alexandre Curiacos de Almeida Leme, Ricardo Jos\\xc3\\xa9 Gomes, Leandro Pereira de Moura, Dennys Esper Cintra, Eduardo Rochete Ropelle, Jos\\xc3\\xa9 Rodrigo Paul. Impaired insulin signaling and spatial learning in middle-aged rats: The role of PTP1B. Experimental gerontology vol 104 issue 2019 29421605 |
in this context, our study aims to investigate the age-related changes in ptp1b content, insulin signaling, \xce\xb2-amyloid content, and tau phosphorylation in the hippocampus of middle-aged rats. |
2019-02-19 |
2023-01-26 |
rat |
| Gabriel Keine Kuga, Vitor Rosetto Mu\\xc3\\xb1oz, Rafael Calais Gaspar, Susana Castelo Branco Ramos Nakandakari, Adelino Sanchez Ramos da Silva, Jos\\xc3\\xa9 Diego Botezelli, Jos\\xc3\\xa9 Alexandre Curiacos de Almeida Leme, Ricardo Jos\\xc3\\xa9 Gomes, Leandro Pereira de Moura, Dennys Esper Cintra, Eduardo Rochete Ropelle, Jos\\xc3\\xa9 Rodrigo Paul. Impaired insulin signaling and spatial learning in middle-aged rats: The role of PTP1B. Experimental gerontology vol 104 issue 2019 29421605 |
also, the aging process increased tau phosphorylation and \xce\xb2-amyloid content in the hippocampus region. |
2019-02-19 |
2023-01-26 |
rat |
| Edna Maria Camelo Chaves, Jose Eduardo Ribeiro Hon\\xc3\\xb3rio-J\\xc3\\xbanior, Caren N\\xc3\\xa1dia Soares Sousa, Vald\\xc3\\xa9cio Silveira Monteiro, Dayanne Terra Ten\\xc3\\xb3rio Nonato, Leonardo Pimentel Dantas, Ana Silvia Suassuna Carneiro L\\xc3\\xbacio, Jos\\xc3\\xa9 Maria Barbosa-Filho, Manoel Cl\\xc3\\xa1udio Azevedo Patroc\\xc3\\xadnio, Glauce Socorro Barros Viana, Silv\\xc3\\xa2nia Maria Mendes Vasconcelo. The anxiolytic-like effect of 6-styryl-2-pyrone in mice involves GABAergic mechanism of action. Metabolic brain disease vol 33 issue 1 2019 29086102 |
after behavioral tests, these animals were sacrificed and had their prefrontal cortex (pfc), hippocampus (hc) and striatum (st) dissected for assaying amino acids (aspartate- asp, glutamate- glu, glycine- gly, taurine- tau and gamma-aminobutyric acid- gaba). |
2019-01-31 |
2023-01-26 |
mouse |
| Kristen R Montgomery, A S C Louis Sam Titus, Lulu Wang, Santosh R D'Mell. Elevated MeCP2 in Mice Causes Neurodegeneration Involving Tau Dysregulation and Excitotoxicity: Implications for the Understanding and Treatment of MeCP2 Triplication Syndrome. Molecular neurobiology vol 55 issue 12 2019 29637441 |
mecp2-tg mice display elevated gfap and tau expression within the hippocampus and cortex followed by neuronal loss in these brain regions. |
2019-01-18 |
2023-01-26 |
mouse |
| Andrew Arner, Edward Rockenstein, Michael Mante, Jazmin Florio, Deborah Masliah, Bahar Salehi, Anthony Adame, Cassia Overk, Eliezer Masliah, Robert A Rissma. Increased Vulnerability of the Hippocampus in Transgenic Mice Overexpressing APP and Triple Repeat Tau. Journal of Alzheimer's disease : JAD vol 61 issue 3 2019 29332037 |
increased vulnerability of the hippocampus in transgenic mice overexpressing app and triple repeat tau. |
2019-01-17 |
2023-01-26 |
mouse |
| Andrew Arner, Edward Rockenstein, Michael Mante, Jazmin Florio, Deborah Masliah, Bahar Salehi, Anthony Adame, Cassia Overk, Eliezer Masliah, Robert A Rissma. Increased Vulnerability of the Hippocampus in Transgenic Mice Overexpressing APP and Triple Repeat Tau. Journal of Alzheimer's disease : JAD vol 61 issue 3 2019 29332037 |
we found that even in young animals we found that the presence of app/a\xce\xb2 increased the accumulation of 3r tau in the neocortex and hippocampus. |
2019-01-17 |
2023-01-26 |
mouse |
| Siddhartha Mondrag\\xc3\\xb3n-Rodr\\xc3\\xadguez, Anah\\xc3\\xad Salas-Gallardo, Perla Gonz\\xc3\\xa1lez-Pereyra, Mart\\xc3\\xadn Mac\\xc3\\xadas, Benito Ordaz, Fernando Pe\\xc3\\xb1a-Ortega, Azucena Aguilar-V\\xc3\\xa1zquez, Erika Orta-Salazar, Sof\\xc3\\xada D\\xc3\\xadaz-Cintra, George Perry, Sylvain William. Phosphorylation of Tau protein correlates with changes in hippocampal theta oscillations and reduces hippocampal excitability in Alzheimer's model. The Journal of biological chemistry vol 293 issue 22 2019 29632073 |
phosphorylation of tau protein correlates with changes in hippocampal theta oscillations and reduces hippocampal excitability in alzheimer's model. |
2019-01-16 |
2023-01-26 |
mouse |
| Yuetao Wen, Qingyuan Wu, Quanhong Shi, Yanfeng Xie, Wei Dan, YangMei Chen, Limin M. UCH-L1 inhibition aggravates mossy fiber sprouting in the pentylenetetrazole kindling model. Biochemical and biophysical research communications vol 503 issue 4 2019 29964011 |
our results suggest that uch-l1 may be associated with hippocampal msf followed the epileptogenesis through mediating phosphorylation of tau. |
2019-01-14 |
2023-01-26 |
rat |
| Xinghua Liu, Kuan Zeng, Mengzhu Li, Qun Wang, Rong Liu, Bin Zhang, Jian-Zhi Wang, Xiji Shu, Xiaochuan Wan. Expression of P301L-hTau in mouse MEC induces hippocampus-dependent memory deficit. Scientific reports vol 7 issue 1 2019 28634382 |
interestingly, expression of the mutant tau in mec induces endogenous tau hyperphosphorylation and accumulation in hippocampus and cortex, and inhibits neuronal activity with attenuated pp-dg synapse plasticity, leading to hippocampus-dependent memory deficit with intact olfactory function. |
2019-01-11 |
2023-01-26 |
mouse |
| Ang\\xc3\\xa9lica Maria Sabogal-Gu\\xc3\\xa1queta, Luis Carrillo-Hormaza, Edison Osorio, Gloria Patricia Cardona-G\\xc3\\xb3me. Effects of biflavonoids from Garcinia madruno on a triple transgenic mouse model of Alzheimer's disease. Pharmacological research vol 129 issue 2019 29229355 |
the bf treatment reduced \xce\xb2a deposition in different regions of the brain (the hippocampus, entorhinal cortex and amygdala), reduced \xce\xb2a1-40 and \xce\xb2a1-42 levels, bace1-mediated cleavage of app (ctf\xce\xb2), tau pathology, astrogliosis and microgliosis in the brains of aged 3xtg-ad mice. |
2019-01-04 |
2023-01-26 |
mouse |
| Ramesh Kandimalla, Maria Manczak, Xiangling Yin, Rui Wang, P Hemachandra Redd. Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer's disease. Human molecular genetics vol 27 issue 1 2019 29040533 |
hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of alzheimer's disease. |
2019-01-02 |
2023-01-26 |
mouse |
| Ramesh Kandimalla, Maria Manczak, Xiangling Yin, Rui Wang, P Hemachandra Redd. Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer's disease. Human molecular genetics vol 27 issue 1 2019 29040533 |
the purpose of our study was to understand the toxic effects of hippocampal phosphorylated tau in tau mice. |
2019-01-02 |
2023-01-26 |
mouse |
| Ramesh Kandimalla, Maria Manczak, Xiangling Yin, Rui Wang, P Hemachandra Redd. Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer's disease. Human molecular genetics vol 27 issue 1 2019 29040533 |
mwm and rotarod tests revealed that hippocampal learning and memory and motor learning and coordination were impaired in tau mice relative to wild-type (wt) mice. |
2019-01-02 |
2023-01-26 |
mouse |
| Ramesh Kandimalla, Maria Manczak, Xiangling Yin, Rui Wang, P Hemachandra Redd. Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer's disease. Human molecular genetics vol 27 issue 1 2019 29040533 |
these findings suggest that hippocampal accumulation of phosphorylated tau is responsible for abnormal mitochondrial dynamics and reducing dendritic protein map2 and dendritic spines and hippocampal based learning and memory impairments, and mitochondrial structural and functional changes in tau mice. |
2019-01-02 |
2023-01-26 |
mouse |
| Ramesh Kandimalla, Maria Manczak, Xiangling Yin, Rui Wang, P Hemachandra Redd. Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer's disease. Human molecular genetics vol 27 issue 1 2019 29040533 |
based on these observations, we propose that reduced hippocampal phosphorylated tau is an important therapeutic strategy for ad and other tauopathies. |
2019-01-02 |
2023-01-26 |
mouse |
| An Phu Tran Nguyen, Guillaume Daniel, Pamela Vald\\xc3\\xa9s, Md Shariful Islam, Bernard L Schneider, Darren J Moor. G2019S LRRK2 enhances the neuronal transmission of tau in the mouse brain. Human molecular genetics vol 27 issue 1 2019 29088368 |
p301s-tau expression induces hippocampal tau pathology and marked degeneration of ca1 pyramidal neurons in mice, however, this occurs independently of endogenous or pathogenic lrrk2 expression. |
2019-01-02 |
2023-01-26 |
mouse |
| Nan Zhang, Marc L Gordo. Clinical efficacy and safety of donepezil in the treatment of Alzheimer's disease in Chinese patients. Clinical interventions in aging vol 13 issue 2018 30349215 |
based on these studies, donepezil has been shown to be effective and safe in chinese ad patients and may impact ad biomarkers, such as hippocampal atrophy, a\xce\xb2, and tau. |
2018-12-20 |
2023-01-26 |
human |
| Caterina Scuderi, Maria Rosanna Bronzuoli, Roberta Facchinetti, Lorenzo Pace, Luca Ferraro, Kevin Donald Broad, Gaetano Serviddio, Francesco Bellanti, Gianmauro Palombelli, Giulia Carpinelli, Rossella Canese, Silvana Gaetani, Luca Steardo, Luca Steardo, Tommaso Cassan. Ultramicronized palmitoylethanolamide rescues learning and memory impairments in a triple transgenic mouse model of Alzheimer's disease by exerting anti-inflammatory and neuroprotective effects. Translational psychiatry vol 8 issue 1 2018 29382825 |
moreover, it reduces a\xce\xb2 formation, the phosphorylation of tau proteins, and promotes neuronal survival in the ca1 subregion of the hippocampus. |
2018-12-12 |
2023-01-26 |
mouse |
| Lin-Na Ning, Teng Zhang, Jiang Chu, Na Qu, Li Lin, Ying-Yan Fang, Yan Shi, Peng Zeng, Er-Li Cai, Xiao-Ming Wang, Qun Wang, You-Ming Lu, Xin-Wen Zhou, Qi Zhang, Qing Tia. Gender-Related Hippocampal Proteomics Study from Young Rats After Chronic Unpredicted Mild Stress Exposure. Molecular neurobiology vol 55 issue 1 2018 28064424 |
further, the synapse-related proteins, cytoskeleton protein tau, and stress-related kinases in hippocampus were assayed by western blotting. |
2018-12-11 |
2023-01-26 |
rat |
| Christine L Tardif, Gabriel A Devenyi, Robert S C Amaral, Sandra Pelleieux, Judes Poirier, Pedro Rosa-Neto, John Breitner, M Mallar Chakravart. Regionally specific changes in the hippocampal circuitry accompany progression of cerebrospinal fluid biomarkers in preclinical Alzheimer's disease. Human brain mapping vol 39 issue 2 2018 29164798 |
however, there has been limited investigation of the structural integrity of the components of the hippocampal circuit, including subfields and extra-hippocampal white matter structure, in relation to the progression of well-accepted cerebrospinal fluid (csf) biomarkers of ad, amyloid-\xce\xb2 1-42 (a\xce\xb2) and total-tau (tau). |
2018-12-11 |
2023-01-26 |
human |