| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Syed F Kazim, Shih-Chieh Chuang, Wangfa Zhao, Robert K S Wong, Riccardo Bianchi, Khalid Iqba. Early-Onset Network Hyperexcitability in Presymptomatic Alzheimer's Disease Transgenic Mice Is Suppressed by Passive Immunization with Anti-Human APP/Aβ Antibody and by mGluR5 Blockade. Frontiers in aging neuroscience. vol 9. 2020-09-30. PMID:28392767. |
we thus evaluated seizure susceptibility and hippocampal network hyperexcitability at ~3 weeks of age [prior to amyloid beta (aβ) plaque deposition, neurofibrillary pathology, and cognitive impairment] in a triple transgenic mouse model of familial ad (3xtg-ad mouse) that harbors mutated human aβ precursor protein (app), tau and presenilin 1 (ps1) genes. |
2020-09-30 |
2023-08-13 |
mouse |
| Depei Yuan, Chuhua Zeng, Qianfeng Chen, Fengjie Wang, Lin Yuan, Yaoqian Zhu, Ziyang Shu, Ning Che. Root-Securing and Brain-Fortifying Liquid Upregulates Caveolin-1 in Cell Model with Alzheimer's Disease through Inhibiting Tau Phosphorylation. Neurology research international. vol 2017. 2020-09-30. PMID:29123923. |
in order to explore the effect of root-securing and brain-fortifying liquid- (rsbfl-) mediated caveolin-1 (cav-1) on phosphorylation of tau protein and to uncover underlying mechanisms of rsbfl for the prevention and treatment of alzheimer's disease (ad), hippocampal neurons isolated from neonatal sd rats and cultured in dmem-f12 medium were induced by exogenous a |
2020-09-30 |
2023-08-13 |
rat |
| Scott A Ferguson, Benoit C Mouzon, Cillian Lynch, Carlyn Lungmus, Alexander Morin, Gogce Crynen, Benjamin Carper, Gayle Bieler, Elliott J Mufson, William Stewart, Michael Mullan, Fiona Crawfor. Negative Impact of Female Sex on Outcomes from Repetitive Mild Traumatic Brain Injury in hTau Mice Is Age Dependent: A Chronic Effects of Neurotrauma Consortium Study. Frontiers in aging neuroscience. vol 9. 2020-09-30. PMID:29311903. |
pathologically, increases in iba-1 and gfap staining typically seen in this model of r-mtbi showed the expected increases with both injury and age, but phosphorylated tau stained with cp13 in the hippocampus (reduced in female sham mice compared to males) and phf1 in the cortex (reduced in female tbi mice compared to male tbi mice) showed the only histological signs of sex-dependent differences in these mice. |
2020-09-30 |
2023-08-13 |
mouse |
| Satoshi Okuyama, Tatsumi Nakashima, Kumi Nakamura, Wakana Shinoka, Maho Kotani, Atsushi Sawamoto, Mitsunari Nakajima, Yoshiko Furukaw. Inhibitory Effects of Auraptene and Naringin on Astroglial Activation, Tau Hyperphosphorylation, and Suppression of Neurogenesis in the Hippocampus of Streptozotocin-Induced Hyperglycemic Mice. Antioxidants (Basel, Switzerland). vol 7. issue 8. 2020-09-30. PMID:30126250. |
inhibitory effects of auraptene and naringin on astroglial activation, tau hyperphosphorylation, and suppression of neurogenesis in the hippocampus of streptozotocin-induced hyperglycemic mice. |
2020-09-30 |
2023-08-13 |
mouse |
| Satoshi Okuyama, Tatsumi Nakashima, Kumi Nakamura, Wakana Shinoka, Maho Kotani, Atsushi Sawamoto, Mitsunari Nakajima, Yoshiko Furukaw. Inhibitory Effects of Auraptene and Naringin on Astroglial Activation, Tau Hyperphosphorylation, and Suppression of Neurogenesis in the Hippocampus of Streptozotocin-Induced Hyperglycemic Mice. Antioxidants (Basel, Switzerland). vol 7. issue 8. 2020-09-30. PMID:30126250. |
both compounds inhibited astroglial activation and the hyperphosphorylation of tau at 231 of threonine in neurons, and also recovered the suppression of neurogenesis in the dentate gyrus of the hippocampus in hyperglycemic mice. |
2020-09-30 |
2023-08-13 |
mouse |
| Michael F Almeida, Rodrigo S Chaves, Carolliny M Silva, Juliana C S Chaves, Karla P Melo, Merari F R Ferrar. BDNF trafficking and signaling impairment during early neurodegeneration is prevented by moderate physical activity. IBRO reports. vol 1. 2020-09-30. PMID:30135925. |
in the present study it was found that early neurodegeneration is accompanied by decrease in bdnf signaling, in the absence of hyperphosphorylated tau aggregation, in hippocampus of 11 months old lewis rats exposed to rotenone. |
2020-09-30 |
2023-08-13 |
rat |
| Rodrigo S Chaves, Amajad I Kazi, Carolliny M Silva, Michael F Almeida, Raquel S Lima, Daniel C Carrettiero, Marilene Demasi, Merari F R Ferrar. Presence of insoluble Tau following rotenone exposure ameliorates basic pathways associated with neurodegeneration. IBRO reports. vol 1. 2020-09-30. PMID:30135926. |
to better understand the biological role of the protein aggregation with regard its effects in cellular homeostasis, the present study investigated the role of insoluble tau and tau aggregates on crucial cellular parameters such as redox homeostasis, proteasome activity and autophagy in hippocampal cell cultures and hippocampus of aged lewis rats using a rotenone-induced aggregation model. |
2020-09-30 |
2023-08-13 |
rat |
| Yu-Te Lin, Yi-Chung Wu, Gwo-Ching Sun, Chiu-Yi Ho, Tzyy-Yue Wong, Ching-Huang Lin, Hsin-Hung Chen, Tung-Chen Yeh, Chia-Jung Li, Ching-Jiunn Tseng, Pei-Wen Chen. Effect of Resveratrol on Reactive Oxygen Species-Induced Cognitive Impairment in Rats with Angiotensin II-Induced Early Alzheimer's Disease Journal of clinical medicine. vol 7. issue 10. 2020-09-30. PMID:30301188. |
furthermore, losartan inhibition of hippocampal tau |
2020-09-30 |
2023-08-13 |
rat |
| Carmen Romero-Molina, Victoria Navarro, Raquel Sanchez-Varo, Sebastian Jimenez, Juan J Fernandez-Valenzuela, Maria V Sanchez-Mico, Clara Muñoz-Castro, Antonia Gutierrez, Javier Vitorica, Marisa Vizuet. Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology. Frontiers in cellular neuroscience. vol 12. 2020-09-30. PMID:30487735. |
in the hippocampus of ad patients, where tau pathology is more prominent than amyloid-beta pathology, a microglial degenerative process has been reported. |
2020-09-30 |
2023-08-13 |
mouse |
| Davide Bruno, Michel J Grothe, Jay Nierenberg, Stefan J Teipel, Henrik Zetterberg, Kaj Blennow, Nunzio Pomar. The relationship between CSF tau markers, hippocampal volume and delayed primacy performance in cognitively intact elderly individuals. Alzheimer's & dementia (Amsterdam, Netherlands). vol 1. issue 1. 2020-09-29. PMID:26258161. |
the relationship between csf tau markers, hippocampal volume and delayed primacy performance in cognitively intact elderly individuals. |
2020-09-29 |
2023-08-13 |
Not clear |
| Davide Bruno, Michel J Grothe, Jay Nierenberg, Stefan J Teipel, Henrik Zetterberg, Kaj Blennow, Nunzio Pomar. The relationship between CSF tau markers, hippocampal volume and delayed primacy performance in cognitively intact elderly individuals. Alzheimer's & dementia (Amsterdam, Netherlands). vol 1. issue 1. 2020-09-29. PMID:26258161. |
since presence of neurofibrillary tangles is an early sign of ad-related pathology, we set out to test whether cerebrospinal fluid (csf) levels of tau had an effect on delayed primacy performance, while controlling for hippocampal volume and csf aβ 1-42 levels. |
2020-09-29 |
2023-08-13 |
Not clear |
| Teresa Neri-Gómez, Judith Espinosa-Raya, Sofía Díaz-Cintra, Julia Segura-Uribe, Sandra Orozco-Suárez, Juan Manuel Gallardo, Christian Guerra-Araiz. Tibolone modulates neuronal plasticity through regulating Tau, GSK3β/Akt/PI3K pathway and CDK5 p35/p25 complexes in the hippocampus of aged male mice. Neural regeneration research. vol 12. issue 4. 2020-09-29. PMID:28553339. |
tibolone modulates neuronal plasticity through regulating tau, gsk3β/akt/pi3k pathway and cdk5 p35/p25 complexes in the hippocampus of aged male mice. |
2020-09-29 |
2023-08-13 |
mouse |
| Teresa Neri-Gómez, Judith Espinosa-Raya, Sofía Díaz-Cintra, Julia Segura-Uribe, Sandra Orozco-Suárez, Juan Manuel Gallardo, Christian Guerra-Araiz. Tibolone modulates neuronal plasticity through regulating Tau, GSK3β/Akt/PI3K pathway and CDK5 p35/p25 complexes in the hippocampus of aged male mice. Neural regeneration research. vol 12. issue 4. 2020-09-29. PMID:28553339. |
the aim of this work was to evaluate the long-term effects of tib (0.01 mg/kg and 1 mg/kg, intragastrically for 12 weeks) on the content of total and hyperphosphorylated tau (phf-1) proteins and the regulation of gsk3β/akt/pi3k pathway and cdk5/p35/p25 complexes in the hippocampus of aged male mice. |
2020-09-29 |
2023-08-13 |
mouse |
| Cai Shi, Jia Zeng, Zixi Li, Qingjie Chen, Weijian Hang, Liangtao Xia, Yue Wu, Juan Chen, Anbing Sh. Melatonin Mitigates Kainic Acid-Induced Neuronal Tau Hyperphosphorylation and Memory Deficits through Alleviating ER Stress. Frontiers in molecular neuroscience. vol 11. 2020-09-29. PMID:29416502. |
by using primary hippocampal neurons and mouse brain, we showed that ka treatment specifically induced er stress and activated gsk-3β and cdk5, two major kinases responsible for tau phosphorylation. |
2020-09-29 |
2023-08-13 |
mouse |
| Rodolfo Pinto-Almazan, Julia J Segura-Uribe, Marvin A Soriano-Ursúa, Eunice D Farfán-García, Juan M Gallardo, Christian Guerra-Araiz. Effect of tibolone pretreatment on kinases and phosphatases that regulate the expression and phosphorylation of Tau in the hippocampus of rats exposed to ozone. Neural regeneration research. vol 13. issue 3. 2020-09-29. PMID:29623928. |
effect of tibolone pretreatment on kinases and phosphatases that regulate the expression and phosphorylation of tau in the hippocampus of rats exposed to ozone. |
2020-09-29 |
2023-08-13 |
rat |
| Christian Griñán-Ferré, Vanesa Izquierdo, Eduard Otero, Dolors Puigoriol-Illamola, Rubén Corpas, Coral Sanfeliu, Daniel Ortuño-Sahagún, Mercè Pallà. Environmental Enrichment Improves Cognitive Deficits, AD Hallmarks and Epigenetic Alterations Presented in 5xFAD Mouse Model. Frontiers in cellular neuroscience. vol 12. 2020-09-29. PMID:30158856. |
neurodegenerative markers as β-ctf and tau hyperphosphorylation, reduced protein levels whiles appα, postsynaptic density 95 (psd95) and synaptophysin (syn) protein levels increased protein levels in the hippocampus of 5xfad-ee mice group. |
2020-09-29 |
2023-08-13 |
mouse |
| Lili Zhong, Hong Liu, Weijia Zhang, Xu Liu, Bo Jiang, Hongxin Fei, Zhongren Su. Ellagic acid ameliorates learning and memory impairment in APP/PS1 transgenic mice via inhibition of β-amyloid production and tau hyperphosphorylation. Experimental and therapeutic medicine. vol 16. issue 6. 2020-09-29. PMID:30542451. |
hippocampal regions were examined for the presence of amyloid plaques, neuronal apoptosis and tau phosphorylation. |
2020-09-29 |
2023-08-13 |
mouse |
| Emrah Düzel, David Berron, Hartmut Schütze, Arturo Cardenas-Blanco, Coraline Metzger, Matthew Betts, Gabriel Ziegler, Yi Chen, Laura Dobisch, Daniel Bittner, Wenzel Glanz, Martin Reuter, Annika Spottke, Janna Rudolph, Frederic Brosseron, Katharina Buerger, Daniel Janowitz, Klaus Fliessbach, Michael Heneka, Christoph Laske, Martina Buchmann, Peter Nestor, Oliver Peters, Dominik Diesing, Siyao Li, Josef Priller, Eike Jakob Spruth, Slawek Altenstein, Alfredo Ramirez, Anja Schneider, Barbara Kofler, Oliver Speck, Stefan Teipel, Ingo Kilimann, Martin Dyrba, Jens Wiltfang, Claudia Bartels, Steffen Wolfsgruber, Michael Wagner, Frank Jesse. CSF total tau levels are associated with hippocampal novelty irrespective of hippocampal volume. Alzheimer's & dementia (Amsterdam, Netherlands). vol 10. 2020-09-29. PMID:30555890. |
csf total tau levels are associated with hippocampal novelty irrespective of hippocampal volume. |
2020-09-29 |
2023-08-13 |
Not clear |
| Tomas Smolek, Veronika Cubinkova, Veronika Brezovakova, Bernadeta Valachova, Peter Szalay, Norbert Zilka, Santosh Jadha. Genetic Background Influences the Propagation of Tau Pathology in Transgenic Rodent Models of Tauopathy. Frontiers in aging neuroscience. vol 11. 2020-09-28. PMID:31920624. |
in this study we investigated whether genetic background has an influence in the spread of tau pathology, using hippocampal inoculations of insoluble tau from ad brains in rodent models of tauopathy with either a spontaneously hypertensive (shr72) or wistar-kyoto (wky72) genetic background. |
2020-09-28 |
2023-08-13 |
human |
| Tomas Smolek, Veronika Cubinkova, Veronika Brezovakova, Bernadeta Valachova, Peter Szalay, Norbert Zilka, Santosh Jadha. Genetic Background Influences the Propagation of Tau Pathology in Transgenic Rodent Models of Tauopathy. Frontiers in aging neuroscience. vol 11. 2020-09-28. PMID:31920624. |
we observed that insoluble tau from human ad induced at8-positive neurofibrillary structures in the hippocampus of both lines. |
2020-09-28 |
2023-08-13 |
human |