| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Patrick H Lim, Stephanie L Wert, Elif Tunc-Ozcan, Robert Marr, Adriana Ferreira, Eva E Rede. Premature hippocampus-dependent memory decline in middle-aged females of a genetic rat model of depression. Behavioural brain research vol 353 issue 2018 29490235 |
hippocampal expression of ad-related genes, such as amyloid precursor protein, amyloid beta 42, beta secretase, synucleins, total and dephosphorylated tau, and synaptophysin, did not differ between wlis and wmis in either age group. |
2018-11-26 |
2023-01-26 |
rat |
| Ryszard Pluta, Anna Bogucka-Kocka, Marzena U\\xc5\\x82amek-Kozio\\xc5\\x82, Jacek Bogucki, S\\xc5\\x82awomir Januszewski, Janusz Kocki, Stanis\\xc5\\x82aw J Czuczwa. Ischemic tau protein gene induction as an additional key factor driving development of Alzheimer's phenotype changes in CA1 area of hippocampus in an ischemic model of Alzheimer's disease. Pharmacological reports : PR vol 70 issue 5 2018 30096486 |
ischemic tau protein gene induction as an additional key factor driving development of alzheimer's phenotype changes in ca1 area of hippocampus in an ischemic model of alzheimer's disease. |
2018-11-16 |
2023-01-26 |
Not clear |
| Claudia Jara, Alejandra Ar\\xc3\\xa1nguiz, Waldo Cerpa, Cheril Tapia-Rojas, Rodrigo A Quintanill. Genetic ablation of tau improves mitochondrial function and cognitive abilities in the hippocampus. Redox biology vol 18 issue 2018 30077079 |
genetic ablation of tau improves mitochondrial function and cognitive abilities in the hippocampus. |
2018-11-05 |
2023-01-26 |
mouse |
| Claudia Jara, Alejandra Ar\\xc3\\xa1nguiz, Waldo Cerpa, Cheril Tapia-Rojas, Rodrigo A Quintanill. Genetic ablation of tau improves mitochondrial function and cognitive abilities in the hippocampus. Redox biology vol 18 issue 2018 30077079 |
our results showed that tau deletion had positive effects on hippocampal cells by decreasing oxidative damage, favoring a mitochondrial pro-fusion state, and inhibiting mitochondrial permeability transition pore (mptp) formation by reducing cyclophilin d (cyp-d) protein. |
2018-11-05 |
2023-01-26 |
mouse |
| Fatemeh Mirzaei, Mozafar Khazaei, Alireza Komaki, Iraj Amiri, Cyrus Jalil. Virgin coconut oil (VCO) by normalizing NLRP3 inflammasome showed potential neuroprotective effects in Amyloid-\\xce\\xb2 induced toxicity and high-fat diet fed rat. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association vol 118 issue 2018 29729307 |
the congo red, cresyl violet staining and immunohistochemistry (ihc) test revealed that vco improved hippocampus histological changes, reduced a\xce\xb2 plaques and phosphorylated tau. |
2018-10-24 |
2023-01-26 |
rat |
| Maria Joseph, Marta Anglada-Huguet, Katharina Paesler, Eckhard Mandelkow, Eva-Maria Mandelko. Anti-aggregant tau mutant promotes neurogenesis. Molecular neurodegeneration vol 12 issue 1 2018 29202785 |
previous work has shown that the expression of the pro-aggregant mutant tau repeat domain causes strong aggregation and pronounced neuronal loss in the hippocampus whereas the anti-aggregant form has no deleterious effects. |
2018-10-18 |
2023-01-26 |
Not clear |
| Yue Cao, Christian H\\xc3\\xb6lscher, Meng-Ming Hu, Ting Wang, Fang Zhao, Yu Bai, Jun Zhang, Mei-Na Wu, Jin-Shun Q. DA5-CH, a novel GLP-1/GIP dual agonist, effectively ameliorates the cognitive impairments and pathology in the APP/PS1 mouse model of Alzheimer's disease. European journal of pharmacology vol 827 issue 2018 29551659 |
we found that: (1) da5-ch administration effectively improved working-memory and long-term spatial memory of 9-month-old ad mice in y-maze and morris water maze tests; (2) da5-ch also reduced hippocampal amyloid senile plaques and phosphorylated tau protein levels; (3) da5-ch basically reversed the deficits in hippocampal late-phase long-term potentiation; (4) da5-ch up-regulated the levels of p-pi3k and p-akt growth factor kinases and prevented excessive activation of p-gsk3\xce\xb2 in the hippocampus of app/ps1 mice. |
2018-10-09 |
2023-01-26 |
mouse |
| Chao Wu, Wei-Gang Gong, Yan-Juan Wang, Jun-Jun Sun, Hong Zhou, Zhi-Jun Zhang, Qing-Guo Re. Escitalopram alleviates stress-induced Alzheimer's disease-like\\xc2\\xa0tau\\xc2\\xa0pathologies and cognitive deficits by reducing hypothalamic-pituitary-adrenal axis reactivity and insulin/GSK-3\\xce\\xb2\\xc2\\xa0signal pathway activity. Neurobiology of aging vol 67 issue 2018 29656013 |
the results showed that both depressive and resistant rats displayed spatial memory deficits and an accumulation of tau in the hippocampus. |
2018-10-04 |
2023-01-26 |
rat |
| Shuangyue Li, Lijun Yang, Yan Zhang, Cong Zhang, Jing Shao, Xiaohui Liu, Yachen Li, Fengyuan Pia. Taurine Ameliorates Arsenic-Induced Apoptosis in the Hippocampus of Mice Through Intrinsic Pathway. Advances in experimental medicine and biology vol 975 Pt 1 issue 2018 28849454 |
the aim of the present study was to clarify the protective capacity of taurine (tau) on as-induced neuronal apoptosis and the related mechanism in mouse hippocampus. |
2018-10-02 |
2023-01-26 |
mouse |
| Shuangyue Li, Lijun Yang, Yan Zhang, Cong Zhang, Jing Shao, Xiaohui Liu, Yachen Li, Fengyuan Pia. Taurine Ameliorates Arsenic-Induced Apoptosis in the Hippocampus of Mice Through Intrinsic Pathway. Advances in experimental medicine and biology vol 975 Pt 1 issue 2018 28849454 |
the results indicated that tau supplement markedly ameliorates as-induced apoptosis by mitochondria-related pathway in mouse hippocampus. |
2018-10-02 |
2023-01-26 |
mouse |
| Satoshi Okuyama, Wakana Shinoka, Kumi Nakamura, Maho Kotani, Atsushi Sawamoto, Kuniaki Sugawara, Masahiko Sudo, Mitsunari Nakajima, Yoshiko Furukaw. Suppressive effects of the peel of Citrus kawachiensis (Kawachi Bankan) on astroglial activation, tau phosphorylation, and inhibition of neurogenesis in the hippocampus of type 2 diabetic db/db mice. Bioscience, biotechnology, and biochemistry vol 82 issue 8 2018 29732953 |
suppressive effects of the peel of citrus kawachiensis (kawachi bankan) on astroglial activation, tau phosphorylation, and inhibition of neurogenesis in the hippocampus of type 2 diabetic db/db mice. |
2018-10-02 |
2023-01-26 |
mouse |
| Satoshi Okuyama, Wakana Shinoka, Kumi Nakamura, Maho Kotani, Atsushi Sawamoto, Kuniaki Sugawara, Masahiko Sudo, Mitsunari Nakajima, Yoshiko Furukaw. Suppressive effects of the peel of Citrus kawachiensis (Kawachi Bankan) on astroglial activation, tau phosphorylation, and inhibition of neurogenesis in the hippocampus of type 2 diabetic db/db mice. Bioscience, biotechnology, and biochemistry vol 82 issue 8 2018 29732953 |
moreover, the c. kawachiensis treatment inhibited astroglial activation in the hippocampus and the hyperphosphorylation of tau at 231 of threonine and 396 of serine in hippocampal neurons, and also relieved the suppression of neurogenesis in the dentate gyrus of the hippocampus in the db/db mice. |
2018-10-02 |
2023-01-26 |
mouse |
| Stergios Tsartsalis, Aikaterini Xekardaki, Patrick R Hof, Enik\\xc3\\xb6 K\\xc3\\xb6vari, Constantin Boura. Early Alzheimer-type lesions in cognitively normal subjects. Neurobiology of aging vol 62 issue 2018 29107845 |
to define whether amyloid \xce\xb2 protein deposits or tau protein lesions appear first during normal brain aging, we performed an immunohistological study on serial sections from 105 autopsy brains (age range: 40-104\xc2\xa0years) from patients free of clinical signs of cognitive decline, using anti-tau (at8) and anti-amyloid (4g8) antibodies in the hippocampus, entorhinal cortex, inferior temporal cortex (brodmann area 20), prefrontal cortex (brodmann area 9), occipital cortex (brodmann areas 17 and 18), and in the brainstem. |
2018-09-26 |
2023-01-26 |
human |
| Zhihui Gai, Donghong Su, Yawen Wang, Wenlong Li, Bo Cui, Kang Li, Xiaojun She, Rui Wan. Effects of chronic noise on the corticotropin-releasing factor system in the rat hippocampus: relevance to Alzheimer's disease-like tau hyperphosphorylation. Environmental health and preventive medicine vol 22 issue 1 2018 29228900 |
effects of chronic noise on the corticotropin-releasing factor system in the rat hippocampus: relevance to alzheimer's disease-like tau hyperphosphorylation. |
2018-09-04 |
2023-01-26 |
rat |
| Zhihui Gai, Donghong Su, Yawen Wang, Wenlong Li, Bo Cui, Kang Li, Xiaojun She, Rui Wan. Effects of chronic noise on the corticotropin-releasing factor system in the rat hippocampus: relevance to Alzheimer's disease-like tau hyperphosphorylation. Environmental health and preventive medicine vol 22 issue 1 2018 29228900 |
in this study, we explored the effects of long-term noise exposure on the corticotropin-releasing factor (crf) system in the hippocampus and its role in noise-induced tau phosphorylation. |
2018-09-04 |
2023-01-26 |
rat |
| Gabor G Kovacs, Linda K Kwong, Murray Grossman, David J Irwin, Edward B Lee, John L Robinson, Eunran Suh, Vivianna M Van Deerlin, Virginia M Lee, John Q Trojanowsk. Tauopathy with hippocampal 4-repeat tau immunoreactive spherical inclusions: a report of three cases. Brain pathology (Zurich, Switzerland) vol 28 issue 2 2018 28019685 |
tauopathy with hippocampal 4-repeat tau immunoreactive spherical inclusions: a report of three cases. |
2018-08-30 |
2023-01-26 |
human |
| Gabor G Kovacs, Linda K Kwong, Murray Grossman, David J Irwin, Edward B Lee, John L Robinson, Eunran Suh, Vivianna M Van Deerlin, Virginia M Lee, John Q Trojanowsk. Tauopathy with hippocampal 4-repeat tau immunoreactive spherical inclusions: a report of three cases. Brain pathology (Zurich, Switzerland) vol 28 issue 2 2018 28019685 |
common neuropathological features included neuronal loss in the hippocampus and dentate gyrus associated with spherical basophilic pick body-like inclusions showing 4r tau immunoreactivity, which was supported by the detection of predominantly 4r tau species by western blot examination. |
2018-08-30 |
2023-01-26 |
human |
| Gabor G Kovacs, Linda K Kwong, Murray Grossman, David J Irwin, Edward B Lee, John L Robinson, Eunran Suh, Vivianna M Van Deerlin, Virginia M Lee, John Q Trojanowsk. Tauopathy with hippocampal 4-repeat tau immunoreactive spherical inclusions: a report of three cases. Brain pathology (Zurich, Switzerland) vol 28 issue 2 2018 28019685 |
in addition, accumulation of tau immunoreactive argyrophilic astrocytes in the hippocampus and amygdala and oligodendroglial coiled bodies in the hippocampal white matter were observed. |
2018-08-30 |
2023-01-26 |
human |
| Gabor G Kovacs, Linda K Kwong, Murray Grossman, David J Irwin, Edward B Lee, John L Robinson, Eunran Suh, Vivianna M Van Deerlin, Virginia M Lee, John Q Trojanowsk. Tauopathy with hippocampal 4-repeat tau immunoreactive spherical inclusions: a report of three cases. Brain pathology (Zurich, Switzerland) vol 28 issue 2 2018 28019685 |
we suggest that this tauopathy variant with hippocampal 4r tau immunoreactive spherical inclusions might contribute to the cognitive deficits in the patients reported here. |
2018-08-30 |
2023-01-26 |
human |
| Anaclara Prada Jardim, Joan Liu, Jack Baber, Zuzanna Michalak, Cheryl Reeves, Matthew Ellis, Jan Novy, Jane de Tisi, Andrew McEvoy, Anna Miserocchi, Elza Marcia Targas Yacubian, Sanjay Sisodiya, Pamela Thompson, Maria Tho. Characterising subtypes of hippocampal sclerosis and reorganization: correlation with pre and postoperative memory deficit. Brain pathology (Zurich, Switzerland) vol 28 issue 2 2018 28380661 |
we also evaluated hippocampal regenerative activity (mcm2, nestin, olig2, calbindin), degeneration (at8/phosphorylated tau) and mossy-fiber pathway re-organization (znt3). |
2018-08-30 |
2023-01-26 |
Not clear |