All Relations between microtubule-associated protein tau and hippocampus

Publication Sentence Publish Date Extraction Date Species
Rodrigo A Quintanilla, Carola Tapia-Monsalves, Erick H Vergara, María José Pérez, Alejandra Arangui. Truncated Tau Induces Mitochondrial Transport Failure Through the Impairment of TRAK2 Protein and Bioenergetics Decline in Neuronal Cells. Frontiers in cellular neuroscience. vol 14. 2020-09-28. PMID:32848607. we expressed green fluorescent protein (gfp), gfp-full-length, and gpf-caspase-3-cleaved tau proteins in rat hippocampal neurons and immortalized cortical neurons (cn 1.4) and analyzed the expression and localization of these proteins involved in mitochondrial transport regulation. 2020-09-28 2023-08-13 rat
Rodrigo A Quintanilla, Carola Tapia-Monsalves, Erick H Vergara, María José Pérez, Alejandra Arangui. Truncated Tau Induces Mitochondrial Transport Failure Through the Impairment of TRAK2 Protein and Bioenergetics Decline in Neuronal Cells. Frontiers in cellular neuroscience. vol 14. 2020-09-28. PMID:32848607. we observed that hippocampal neurons expressing caspase-cleaved tau showed a significant accumulation of a mitochondrial population in the soma. 2020-09-28 2023-08-13 rat
Rodrigo A Quintanilla, Carola Tapia-Monsalves, Erick H Vergara, María José Pérez, Alejandra Arangui. Truncated Tau Induces Mitochondrial Transport Failure Through the Impairment of TRAK2 Protein and Bioenergetics Decline in Neuronal Cells. Frontiers in cellular neuroscience. vol 14. 2020-09-28. PMID:32848607. more critically, caspase-cleaved tau significantly decreased the expression of trak2 in immortalized and primary hippocampal neurons without affecting rhot1/t2 and syntaphilin levels. 2020-09-28 2023-08-13 rat
Yu-Wei Zhang, Xiao-Qian Li, Wen-Fei Tan, Bo Fang, Hong M. Postoperative 24-h Acute Sleep Deprivation Improves Learning and Memory Through Inhibition of Tau Phosphorylation in the Hippocampal Neurons of Splenectomized Rats. Nature and science of sleep. vol 12. 2020-09-28. PMID:32904483. postoperative 24-h acute sleep deprivation improves learning and memory through inhibition of tau phosphorylation in the hippocampal neurons of splenectomized rats. 2020-09-28 2023-08-13 rat
Kerstin Schlegel, Khader Awwad, Roland G Heym, David Holzinger, Annika Doell, Stefan Barghorn, Thomas R Jahn, Corinna Klein, Yulia Mordashova, Michael Schulz, Laura Gasparin. N368-Tau fragments generated by legumain are detected only in trace amount in the insoluble Tau aggregates isolated from AD brain. Acta neuropathologica communications. vol 7. issue 1. 2020-09-25. PMID:31722749. in brain soluble extracts, despite reduced uncleaved tau in ad, levels of n368-cleaved tau are comparable in ad and control hippocampus, suggesting that lgmn-mediated cleavage of tau is not altered in ad. 2020-09-25 2023-08-13 mouse
Kerstin Schlegel, Khader Awwad, Roland G Heym, David Holzinger, Annika Doell, Stefan Barghorn, Thomas R Jahn, Corinna Klein, Yulia Mordashova, Michael Schulz, Laura Gasparin. N368-Tau fragments generated by legumain are detected only in trace amount in the insoluble Tau aggregates isolated from AD brain. Acta neuropathologica communications. vol 7. issue 1. 2020-09-25. PMID:31722749. to assess the potential accumulation of n368-cleaved tau in insoluble tau aggregates, we analyzed sarkosyl-insoluble extracts from ad and control hippocampus. 2020-09-25 2023-08-13 mouse
Christy M Kelley, Sylvia E Perez, Elliott J Mufso. Tau pathology in the medial temporal lobe of athletes with chronic traumatic encephalopathy: a chronic effects of neurotrauma consortium study. Acta neuropathologica communications. vol 7. issue 1. 2020-09-25. PMID:31831066. the medial temporal lobe (mtl; i.e., hippocampus, subiculum, and entorhinal and perirhinal cortices) memory circuit displays tau lesions during the pathological progression of cte. 2020-09-25 2023-08-13 Not clear
Keiichi Kadoyama, Kenji Matsuura, Masaoki Takano, Koji Maekura, Yukari Inoue, Shogo Matsuyam. Changes in the expression of prefoldin subunit 5 depending on synaptic plasticity in the mouse hippocampus. Neuroscience letters. vol 712. 2020-09-23. PMID:31505240. in transgenic mice overexpressing human tau with n279 k mutation as a model of alzheimer's disease that showed impaired synaptic plasticity, the levels of pfdn5 mrna and protein in the hippocampus were significantly decreased in an age-dependent manner as compared with age-matched control. 2020-09-23 2023-08-13 mouse
M A Berezutsky, N A Durnova, T A Andronova, O V Sinichkin. [Alzheimer's disease: experimental and clinical researches of Chinese herbal medicine neurobiological effects (a review).] Advances in gerontology = Uspekhi gerontologii. vol 33. issue 2. 2020-09-22. PMID:32593241. various neurobiological effects of various herbal decoctions in the cells of hippocampus were demonstrated - the inhibition of amyloid β peptides aggregation, increasing of neurons quantity with normal morphology and decreasing of apoptotic cells, decreasing of inducible nitric oxide synthase (inos) production, decreasing of reactive expression level of rage and increasing reactive expression level of lrp-1, decreasing of tau protein phosphorylation at thr231 and ser422, inhibition of expression of gsk-3β and cdk-5, decreasing of activation and inflammation of microglia, production of 15 types of n-glycans in the cerebral cortex layers, which are absent in experimental animals. 2020-09-22 2023-08-13 mouse
Guo-Quan Wang, Peng Zhou, Dao-Jun Xie, Shu Ye, Hua-Wu Gao, Yan Wang, Zheng-Qing Fang, Biao Ca. [Effects of Huangpu Tongqiao Capsules on EGFR-PLCγ signal pathway of hippocampus in rats with Alzheimer's disease]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 9. 2020-09-17. PMID:32495567. rt-pcr results showed that the mrna levels of egfr, plcγ, ip3 r and tau in hippocampus of ad rats were significantly increased(p<0.01), and hptqc could reduce the mrna levels of egfr, plcγ, ip3 r and tau in ad rats(p<0.05). 2020-09-17 2023-08-13 rat
Gustavo A Rodriguez, Geoffrey M Barrett, Karen E Duff, S Abid Hussain. Chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces Aβ and tau pathology in the hippocampus. PLoS biology. vol 18. issue 8. 2020-09-17. PMID:32822389. chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces aβ and tau pathology in the hippocampus. 2020-09-17 2023-08-13 mouse
Gustavo A Rodriguez, Geoffrey M Barrett, Karen E Duff, S Abid Hussain. Chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces Aβ and tau pathology in the hippocampus. PLoS biology. vol 18. issue 8. 2020-09-17. PMID:32822389. using a novel transgenic mouse line to model the impact of human app (happ)/aβ accumulation on tauopathy in the entorhinal cortex-hippocampal (ec-hipp) network, we demonstrate that happ overexpression aggravates ec-tau aggregation and accelerates pathological tau spread into the hippocampus. 2020-09-17 2023-08-13 mouse
Gustavo A Rodriguez, Geoffrey M Barrett, Karen E Duff, S Abid Hussain. Chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces Aβ and tau pathology in the hippocampus. PLoS biology. vol 18. issue 8. 2020-09-17. PMID:32822389. chronic chemogenetic attenuation of ec neuronal hyperactivity led to reduced happ/aβ accumulation and reduced pathological tau spread into downstream hippocampus. 2020-09-17 2023-08-13 mouse
Emily L Munger, Melissa K Edler, William D Hopkins, John J Ely, Joseph M Erwin, Daniel P Perl, Elliott J Mufson, Patrick R Hof, Chet C Sherwood, Mary Ann Raghant. Astrocytic changes with aging and Alzheimer's disease-type pathology in chimpanzees. The Journal of comparative neurology. vol 527. issue 7. 2020-09-16. PMID:30578640. both prefrontal cortex layer i and hippocampal astrocytes exhibit a high degree of astrogliosis that is positively correlated with accumulation of amyloid beta and tau proteins. 2020-09-16 2023-08-13 chimpanzee
Hyemin Jang, Jongyun Park, Sookyoung Woo, Seonwoo Kim, Hee Jin Kim, Duk L Na, Samuel N Lockhart, Yeshin Kim, Ko Woon Kim, Soo Hyun Cho, Seung Joo Kim, Joon-Kyung Seong, Sang Won Se. Prediction of fast decline in amyloid positive mild cognitive impairment patients using multimodal biomarkers. NeuroImage. Clinical. vol 24. 2020-09-16. PMID:31376643. the associations of potential covariates (mci stage, apoe4 genotype, corrected hippocampal volume (hv), fdg pet suvr, av45 pet suvr, csf aβ, total tau (t-tau), and phosphorylated tau (p-tau)) with the outcome were tested and nomograms were constructed using logistic regression models in the training dataset (n=124, n of fast decliners=52). 2020-09-16 2023-08-13 Not clear
Ran Ma, Li-Hong Kong, Feng-Jun Qi, Rui-Yang He, Qing Zheng, Wei Lu, Xiao-Ping F. [Effect of electroacupuncture on cyclin-dependent kinase 5 and Tau protein in hippocampus of SAMP8 mice]. Zhen ci yan jiu = Acupuncture research. vol 45. issue 7. 2020-09-16. PMID:32705825. [effect of electroacupuncture on cyclin-dependent kinase 5 and tau protein in hippocampus of samp8 mice]. 2020-09-16 2023-08-13 mouse
Ran Ma, Li-Hong Kong, Feng-Jun Qi, Rui-Yang He, Qing Zheng, Wei Lu, Xiao-Ping F. [Effect of electroacupuncture on cyclin-dependent kinase 5 and Tau protein in hippocampus of SAMP8 mice]. Zhen ci yan jiu = Acupuncture research. vol 45. issue 7. 2020-09-16. PMID:32705825. to observe the effect of electroacupuncture (ea) and manual acupuncture (ma) on learning-memory ability, changes of ultrastructure of neurons and expression of cdk5 and tau proteins in hippocampus of samp8 mice,so as to explore its mechanisms underlying improvement of alzheimer's disease (ad).. 2020-09-16 2023-08-13 mouse
Dylan J Finneran, Dave Morgan, Marcia N Gordon, Kevin R Nas. CNS-Wide over Expression of Fractalkine Improves Cognitive Functioning in a Tauopathy Model. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 14. issue 2. 2020-09-11. PMID:30499006. these benefits were achieved without detectable reductions in tau hyperphosphorylation, hippocampal atrophy, or microglial cd45 expression. 2020-09-11 2023-08-13 mouse
Zhen Wei, Yacoubou Abdoul Razak Mahaman, Feiqi Zhu, Mengjuan Wu, Yiyuan Xia, Kuan Zeng, Ying Yang, Rong Liu, Jian-Zhi Wang, Xiji Shu, Xiaochuan Wan. GSK-3β and ERK1/2 incongruously act in tau hyperphosphorylation in SPS-induced PTSD rats. Aging. vol 11. issue 18. 2020-09-08. PMID:31548435. we here show that employing single prolonged stress (sps), as a consensus ptsd model, induced a typical anxiety and abnormal hyperphosphorylation of tau at ser202/thr205 (at8) and ser404 but not at ser199 and ser396 in the hippocampus compared to the control rats. 2020-09-08 2023-08-13 rat
S A Krivopalov, B G Yushkov, M Yu Bykova, K N Zabegalo. [Gender differences in the pool of free amino acid neurotransmitters in Krushinsky-Molodkina rats]. Biomeditsinskaia khimiia. vol 66. issue 2. 2020-09-08. PMID:32420892. the content of asp, glu, gaba, gly, and tau of the medulla oblongata, hippocampus and cerebral cortex were determined using high-performance liquid chromatography (hplc) in intact km rats, km rats exposed to a series of epileptiform seizures, and wistar rats (control group). 2020-09-08 2023-08-13 rat