| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hyemin Jang, Jongyun Park, Sookyoung Woo, Seonwoo Kim, Hee Jin Kim, Duk L Na, Samuel N Lockhart, Yeshin Kim, Ko Woon Kim, Soo Hyun Cho, Seung Joo Kim, Joon-Kyung Seong, Sang Won Se. Prediction of fast decline in amyloid positive mild cognitive impairment patients using multimodal biomarkers. NeuroImage. Clinical. vol 24. 2020-09-16. PMID:31376643. |
the associations of potential covariates (mci stage, apoe4 genotype, corrected hippocampal volume (hv), fdg pet suvr, av45 pet suvr, csf aβ, total tau (t-tau), and phosphorylated tau (p-tau)) with the outcome were tested and nomograms were constructed using logistic regression models in the training dataset (n=124, n of fast decliners=52). |
2020-09-16 |
2023-08-13 |
Not clear |
| Ran Ma, Li-Hong Kong, Feng-Jun Qi, Rui-Yang He, Qing Zheng, Wei Lu, Xiao-Ping F. [Effect of electroacupuncture on cyclin-dependent kinase 5 and Tau protein in hippocampus of SAMP8 mice]. Zhen ci yan jiu = Acupuncture research. vol 45. issue 7. 2020-09-16. PMID:32705825. |
[effect of electroacupuncture on cyclin-dependent kinase 5 and tau protein in hippocampus of samp8 mice]. |
2020-09-16 |
2023-08-13 |
mouse |
| Ran Ma, Li-Hong Kong, Feng-Jun Qi, Rui-Yang He, Qing Zheng, Wei Lu, Xiao-Ping F. [Effect of electroacupuncture on cyclin-dependent kinase 5 and Tau protein in hippocampus of SAMP8 mice]. Zhen ci yan jiu = Acupuncture research. vol 45. issue 7. 2020-09-16. PMID:32705825. |
to observe the effect of electroacupuncture (ea) and manual acupuncture (ma) on learning-memory ability, changes of ultrastructure of neurons and expression of cdk5 and tau proteins in hippocampus of samp8 mice，so as to explore its mechanisms underlying improvement of alzheimer's disease (ad)．. |
2020-09-16 |
2023-08-13 |
mouse |
| Dylan J Finneran, Dave Morgan, Marcia N Gordon, Kevin R Nas. CNS-Wide over Expression of Fractalkine Improves Cognitive Functioning in a Tauopathy Model. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 14. issue 2. 2020-09-11. PMID:30499006. |
these benefits were achieved without detectable reductions in tau hyperphosphorylation, hippocampal atrophy, or microglial cd45 expression. |
2020-09-11 |
2023-08-13 |
mouse |
| Zhen Wei, Yacoubou Abdoul Razak Mahaman, Feiqi Zhu, Mengjuan Wu, Yiyuan Xia, Kuan Zeng, Ying Yang, Rong Liu, Jian-Zhi Wang, Xiji Shu, Xiaochuan Wan. GSK-3β and ERK1/2 incongruously act in tau hyperphosphorylation in SPS-induced PTSD rats. Aging. vol 11. issue 18. 2020-09-08. PMID:31548435. |
we here show that employing single prolonged stress (sps), as a consensus ptsd model, induced a typical anxiety and abnormal hyperphosphorylation of tau at ser202/thr205 (at8) and ser404 but not at ser199 and ser396 in the hippocampus compared to the control rats. |
2020-09-08 |
2023-08-13 |
rat |
| S A Krivopalov, B G Yushkov, M Yu Bykova, K N Zabegalo. [Gender differences in the pool of free amino acid neurotransmitters in Krushinsky-Molodkina rats]. Biomeditsinskaia khimiia. vol 66. issue 2. 2020-09-08. PMID:32420892. |
the content of asp, glu, gaba, gly, and tau of the medulla oblongata, hippocampus and cerebral cortex were determined using high-performance liquid chromatography (hplc) in intact km rats, km rats exposed to a series of epileptiform seizures, and wistar rats (control group). |
2020-09-08 |
2023-08-13 |
rat |
| S A Krivopalov, B G Yushkov, M Yu Bykova, K N Zabegalo. [Gender differences in the pool of free amino acid neurotransmitters in Krushinsky-Molodkina rats]. Biomeditsinskaia khimiia. vol 66. issue 2. 2020-09-08. PMID:32420892. |
the changes observed in male rats after the set of seizures included the increase in gaba concentration and a decrease in the gly level in all investigated brain parts, as well as the decrease of the tau content in the cortex and hippocampus. |
2020-09-08 |
2023-08-13 |
rat |
| Tauqeerunnisa Syeda, Rachel M Foguth, Emily Llewellyn, Jason R Canno. PhIP exposure in rodents produces neuropathology potentially relevant to Alzheimer's disease. Toxicology. vol 437. 2020-08-31. PMID:32169473. |
phip exposure for 16 weeks resulted in increased hippocampal oxidative damage, app, bace1, aβ aggregation, and tau phosphorylation. |
2020-08-31 |
2023-08-13 |
mouse |
| Yang Zhao, Haiyan Deng, Kun Li, Lijun Wang, Yongkang Wu, Xianwen Dong, Xingyu Wang, Yongjun Chen, Ying X. Trans-cinnamaldehyde improves neuroinflammation-mediated NMDA receptor dysfunction and memory deficits through blocking NF-κB pathway in presenilin1/2 conditional double knockout mice. Brain, behavior, and immunity. vol 82. 2020-08-25. PMID:31376499. |
we observed that tca treatment reversed abnormal expression of synaptic proteins and tau hyperphosphorylation in the hippocampus and prefrontal cortex of ps cdko mice. |
2020-08-25 |
2023-08-13 |
mouse |
| Heidi I L Jacobs, Jean C Augustinack, Aaron P Schultz, Bernard J Hanseeuw, Joseph Locascio, Rebecca E Amariglio, Kathryn V Papp, Dorene M Rentz, Reisa A Sperling, Keith A Johnso. The presubiculum links incipient amyloid and tau pathology to memory function in older persons. Neurology. vol 94. issue 18. 2020-08-21. PMID:32273431. |
to identify the hippocampal subregions linking initial amyloid and tau pathology to memory performance in clinically normal older individuals, reflecting preclinical alzheimer disease (ad). |
2020-08-21 |
2023-08-13 |
Not clear |
| Anna Mietelska-Porowska, Anna Gasiorowska, Ewelina Palasz, Dave J Koss, Gernot Riedel, Grazyna Niewiadomsk. Pore-former enabled seeding of tau in rats: Alleviation by memantine and lithium chloride. Journal of neuroscience methods. vol 319. 2020-08-19. PMID:30448465. |
wistar rats 3, 9 and 15 month-old were surgically prepared for hippocampal loading with pore-former polymeric 1,3-alkylpyridinium salts (poly-aps) and recombinant human tau including pharmacological inhibition of phosphatase activity by okadaic acid co-administration. |
2020-08-19 |
2023-08-13 |
mouse |
| Christopher D Morrone, Paolo Bazzigaluppi, Tina L Beckett, Mary E Hill, Margaret M Koletar, Bojana Stefanovic, JoAnne McLauri. Regional differences in Alzheimer's disease pathology confound behavioural rescue after amyloid-β attenuation. Brain : a journal of neurology. vol 143. issue 1. 2020-08-18. PMID:31782760. |
amyloid-β peptide attenuation reduced hippocampal tau pathology and rescued adult hippocampal neurogenesis and neuronal function, via improvements in cross-frequency coupling between theta and gamma bands. |
2020-08-18 |
2023-08-13 |
rat |
| Christopher D Morrone, Paolo Bazzigaluppi, Tina L Beckett, Mary E Hill, Margaret M Koletar, Bojana Stefanovic, JoAnne McLauri. Regional differences in Alzheimer's disease pathology confound behavioural rescue after amyloid-β attenuation. Brain : a journal of neurology. vol 143. issue 1. 2020-08-18. PMID:31782760. |
reduction of amyloid-β peptide in the entorhinal cortex had no effect on entorhinal tau pathology or entorhinal-hippocampal neuronal network dysfunction, as measured by an impairment in hippocampal response to entorhinal stimulation. |
2020-08-18 |
2023-08-13 |
rat |
| Sarah Gourmaud, Haochang Shou, David J Irwin, Kimberly Sansalone, Leah M Jacobs, Timothy H Lucas, Eric D Marsh, Kathryn A Davis, Frances E Jensen, Delia M Talo. Alzheimer-like amyloid and tau alterations associated with cognitive deficit in temporal lobe epilepsy. Brain : a journal of neurology. vol 143. issue 1. 2020-08-18. PMID:31834353. |
we examined these pathways, as well as amyloid-β and tau pathologies in the hippocampus and temporal lobe cortex of drug-resistant temporal lobe epilepsy patients who underwent temporal lobe resection (n = 19), in comparison with age- and region-matched samples from neurologically normal autopsy cases (n = 22). |
2020-08-18 |
2023-08-13 |
Not clear |
| Sarah Gourmaud, Haochang Shou, David J Irwin, Kimberly Sansalone, Leah M Jacobs, Timothy H Lucas, Eric D Marsh, Kathryn A Davis, Frances E Jensen, Delia M Talo. Alzheimer-like amyloid and tau alterations associated with cognitive deficit in temporal lobe epilepsy. Brain : a journal of neurology. vol 143. issue 1. 2020-08-18. PMID:31834353. |
pathological phosphorylation of two distinct tau species was also increased in both regions, but increases in amyloid-β1-42 peptide, the main component of amyloid plaques, were restricted to the hippocampus. |
2020-08-18 |
2023-08-13 |
Not clear |
| Sarah Gourmaud, Haochang Shou, David J Irwin, Kimberly Sansalone, Leah M Jacobs, Timothy H Lucas, Eric D Marsh, Kathryn A Davis, Frances E Jensen, Delia M Talo. Alzheimer-like amyloid and tau alterations associated with cognitive deficit in temporal lobe epilepsy. Brain : a journal of neurology. vol 143. issue 1. 2020-08-18. PMID:31834353. |
in temporal lobe epilepsy cases, hippocampal levels of phosphorylated amyloid precursor protein, its pro-amyloidogenic processing enzyme beta-site amyloid precursor protein cleaving enzyme 1, and both total and hyperphosphorylated tau expression, correlated with impaired preoperative executive function. |
2020-08-18 |
2023-08-13 |
Not clear |
| Lexiang Yu, Yao Chen, Yong Xu, Tao He, Yan Wei, Rongqiao H. D-ribose is elevated in T1DM patients and can be involved in the onset of encephalopathy. Aging. vol 11. issue 14. 2020-08-06. PMID:31307014. |
furthermore, advanced glycation end products (age), tau hyperphosphorylation and neuronal death in the hippocampal ca4/dg region were detected in t1dm rats. |
2020-08-06 |
2023-08-13 |
rat |
| Jessica Z K Caldwell, Jeffrey L Cummings, Sarah J Banks, Sebastian Palmqvist, Oskar Hansso. Cognitively normal women with Alzheimer's disease proteinopathy show relative preservation of memory but not of hippocampal volume. Alzheimer's research & therapy. vol 11. issue 1. 2020-08-06. PMID:31878968. |
we examined interactive effects of sex, diagnosis, and cerebrospinal fluid (csf) amyloid beta/phosphorylated tau ratio (aβ/p-tau) on verbal memory and hippocampal volumes. |
2020-08-06 |
2023-08-13 |
Not clear |
| Maud Gratuze, Nicolas Josset, Franck R Petry, Mathieu Pflieger, Laura Eyoum Jong, Geoffrey Truchetti, Isabelle Poitras, Jacinthe Julien, François Bezeau, Françoise Morin, Pershia Samadi, Francesca Cicchetti, Frédéric Bretzner, Emmanuel Plane. The toxin MPTP generates similar cognitive and locomotor deficits in hTau and tau knock-out mice. Brain research. vol 1711. 2020-08-04. PMID:30641037. |
mptp also induced a slight but significant increase in tau phosphorylation (thr205) in the hippocampus of htau mice, as well as a significant decrease in the soluble and insoluble tau fractions that correlated with the loss of dopaminergic neurons in the brainstem. |
2020-08-04 |
2023-08-13 |
mouse |
| Maxime Sartori, Tiago Mendes, Shruti Desai, Alessia Lasorsa, Adrien Herledan, Nicolas Malmanche, Petra Mäkinen, Mikael Marttinen, Idir Malki, Julien Chapuis, Amandine Flaig, Anaïs-Camille Vreulx, Marion Ciancia, Philippe Amouyel, Florence Leroux, Benoit Déprez, François-Xavier Cantrelle, Damien Maréchal, Laurent Pradier, Mikko Hiltunen, Isabelle Landrieu, Devrim Kilinc, Yann Herault, Jocelyn Laporte, Jean-Charles Lamber. BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr Acta neuropathologica. vol 138. issue 4. 2020-08-04. PMID:31065832. |
after killing the cohort at 18 months, immunohistochemistry revealed that bin1 overexpression prevents both tau mislocalization and somatic inclusion in the hippocampus, where an increase in bin1-tau interaction was also observed. |
2020-08-04 |
2023-08-13 |
mouse |