| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David Berron, Danielle van Westen, Rik Ossenkoppele, Olof Strandberg, Oskar Hansso. Medial temporal lobe connectivity and its associations with cognition in early Alzheimer's disease. Brain : a journal of neurology. vol 143. issue 4. 2020-07-31. PMID:32252068. |
furthermore, correlation analysis in this group revealed decreasing functional connectivity between bilateral perirhinal/entorhinal cortices, anterior hippocampus and posterior-medial regions with increasing levels of phosphorylated tau. |
2020-07-31 |
2023-08-13 |
human |
| Atsuko Kubo, Hiroaki Misonou, Makoto Matsuyama, Akane Nomori, Satoko Wada-Kakuda, Akihiko Takashima, Mitsuhiro Kawata, Shigeo Murayama, Yasuo Ihara, Tomohiro Miyasak. Distribution of endogenous normal tau in the mouse brain. The Journal of comparative neurology. vol 527. issue 5. 2020-07-28. PMID:30408165. |
interestingly, tau antibodies strongly labeled nonmyelinated axons such as hippocampal mossy fibers, while white matters generally exhibited low levels of immunoreactivity. |
2020-07-28 |
2023-08-13 |
mouse |
| A Ahnaou, C Walsh, N V Manyakov, S A Youssef, W H Drinkenbur. Early Electrophysiological Disintegration of Hippocampal Neural Networks in a Novel Locus Coeruleus Tau-Seeding Mouse Model of Alzheimer's Disease. Neural plasticity. vol 2019. 2020-07-27. PMID:31285742. |
here, a tau-seeding model in which preformed synthetic tau fibrils (k18) were unilaterally injected into the lc of p301l mice, equipped with multichannel electrodes for recording eeg in frontal cortical and ca1-ca3 hippocampal areas, was used to longitudinally quantify over 20 weeks of functional network dynamics in (1) power spectra; (2) fc using intra- and intersite phase-amplitude theta-gamma coupling (pac); (3) coherence, partial coherence, and global coherent network efficiency (eglob) estimates; and (4) the directionality of functional connectivity using extended partial direct coherence (pdc). |
2020-07-27 |
2023-08-13 |
mouse |
| A Ahnaou, C Walsh, N V Manyakov, S A Youssef, W H Drinkenbur. Early Electrophysiological Disintegration of Hippocampal Neural Networks in a Novel Locus Coeruleus Tau-Seeding Mouse Model of Alzheimer's Disease. Neural plasticity. vol 2019. 2020-07-27. PMID:31285742. |
the present results demonstrate early dysfunctional hippocampal networks, despite no spreading tau pathology to the hippocampus and frontal cortex. |
2020-07-27 |
2023-08-13 |
mouse |
| A Ahnaou, C Walsh, N V Manyakov, S A Youssef, W H Drinkenbur. Early Electrophysiological Disintegration of Hippocampal Neural Networks in a Novel Locus Coeruleus Tau-Seeding Mouse Model of Alzheimer's Disease. Neural plasticity. vol 2019. 2020-07-27. PMID:31285742. |
the ability of the k18 seed in the brainstem lc to elicit such robust functional alterations in distant hippocampal structures in the absence of pathology challenges the classic view that tau pathology spread to an area is necessary to elicit functional impairments in that area. |
2020-07-27 |
2023-08-13 |
mouse |
| Benoit Mouzon, Corbin Bachmeier, Joseph Ojo, Christopher Acker, Scott Ferguson, Gogce Crynen, Peter Davies, Michael Mullan, William Stewart, Fiona Crawfor. Chronic White Matter Degeneration, but No Tau Pathology at One-Year Post-Repetitive Mild Traumatic Brain Injury in a Tau Transgenic Model. Journal of neurotrauma. vol 36. issue 4. 2020-07-21. PMID:29993324. |
tau immunohistochemistry and enzyme-linked immunosorbent assay data suggest, however, only transient, injury-dependent increases in phosphorylated tau in the cerebral cortex beneath the impact site and in the ca1/ca3 subregion of the hippocampus after single or r-mtbi. |
2020-07-21 |
2023-08-13 |
mouse |
| Ramsey Najm, Antara Rao, Yadong Huan. Too Much Tau in Interneurons Impairs Adult Hippocampal Neurogenesis in Alzheimer's Disease. Cell stem cell. vol 26. issue 3. 2020-07-15. PMID:32142656. |
too much tau in interneurons impairs adult hippocampal neurogenesis in alzheimer's disease. |
2020-07-15 |
2023-08-13 |
mouse |
| René Andrade Machado, Vanesa Benjumea-Cuartas, José Fernando Zapata Berruecos, Piedad Matilde Agudelo-Flóres, Lina María Salazar-Peláe. Reelin, tau phosphorylation and psychiatric complications in patients with hippocampal sclerosis and structural abnormalities in temporal lobe epilepsy. Epilepsy & behavior : E&B. vol 96. 2020-07-07. PMID:31150999. |
reelin, tau phosphorylation and psychiatric complications in patients with hippocampal sclerosis and structural abnormalities in temporal lobe epilepsy. |
2020-07-07 |
2023-08-13 |
Not clear |
| Stavros Skouras, Jordi Torner, Patrik Andersson, Yury Koush, Carles Falcon, Carolina Minguillon, Karine Fauria, Francesc Alpiste, Kaj Blenow, Henrik Zetterberg, Juan D Gispert, José L Molinuev. Earliest amyloid and tau deposition modulate the influence of limbic networks during closed-loop hippocampal downregulation. Brain : a journal of neurology. vol 143. issue 3. 2020-07-06. PMID:32091109. |
earliest amyloid and tau deposition modulate the influence of limbic networks during closed-loop hippocampal downregulation. |
2020-07-06 |
2023-08-13 |
human |
| Stavros Skouras, Jordi Torner, Patrik Andersson, Yury Koush, Carles Falcon, Carolina Minguillon, Karine Fauria, Francesc Alpiste, Kaj Blenow, Henrik Zetterberg, Juan D Gispert, José L Molinuev. Earliest amyloid and tau deposition modulate the influence of limbic networks during closed-loop hippocampal downregulation. Brain : a journal of neurology. vol 143. issue 3. 2020-07-06. PMID:32091109. |
in this study, we aimed to identify the effects of amyloid-β peptide 42 (amyloid-β42) and phosphorylated tau on the patterns of functional connectomics involved in hippocampal downregulation. |
2020-07-06 |
2023-08-13 |
human |
| Stavros Skouras, Jordi Torner, Patrik Andersson, Yury Koush, Carles Falcon, Carolina Minguillon, Karine Fauria, Francesc Alpiste, Kaj Blenow, Henrik Zetterberg, Juan D Gispert, José L Molinuev. Earliest amyloid and tau deposition modulate the influence of limbic networks during closed-loop hippocampal downregulation. Brain : a journal of neurology. vol 143. issue 3. 2020-07-06. PMID:32091109. |
across subjects, our main findings during hippocampal downregulation were: (i) in the absence of abnormal biomarkers, age correlated with eigenvector centrality negatively in the insula and midcingulate cortex, and positively in the inferior temporal gyrus; (ii) abnormal csf amyloid-β42 (<1098) correlated negatively with eigenvector centrality in the anterior cingulate cortex and primary motor cortex; and (iii) abnormal csf phosphorylated tau levels (>19.2) correlated with eigenvector centrality positively in the ventral striatum, anterior cingulate and somatosensory cortex, and negatively in the precuneus and orbitofrontal cortex. |
2020-07-06 |
2023-08-13 |
human |
| Grace I Hallinan, Mariana Vargas-Caballero, Jonathan West, Katrin Deinhard. Tau Misfolding Efficiently Propagates between Individual Intact Hippocampal Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 48. 2020-07-02. PMID:31658988. |
tau misfolding efficiently propagates between individual intact hippocampal neurons. |
2020-07-02 |
2023-08-13 |
Not clear |
| David Berron, Arturo Cardenas-Blanco, Daniel Bittner, Coraline D Metzger, Annika Spottke, Michael T Heneka, Klaus Fliessbach, Anja Schneider, Stefan J Teipel, Michael Wagner, Oliver Speck, Frank Jessen, Emrah Düze. Higher CSF Tau Levels Are Related to Hippocampal Hyperactivity and Object Mnemonic Discrimination in Older Adults. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 44. 2020-06-29. PMID:31541019. |
higher csf tau levels are related to hippocampal hyperactivity and object mnemonic discrimination in older adults. |
2020-06-29 |
2023-08-13 |
human |
| David Berron, Arturo Cardenas-Blanco, Daniel Bittner, Coraline D Metzger, Annika Spottke, Michael T Heneka, Klaus Fliessbach, Anja Schneider, Stefan J Teipel, Michael Wagner, Oliver Speck, Frank Jessen, Emrah Düze. Higher CSF Tau Levels Are Related to Hippocampal Hyperactivity and Object Mnemonic Discrimination in Older Adults. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 44. 2020-06-29. PMID:31541019. |
importantly, csf tau levels were associated with increased fmri activity in the hippocampus, and both increased hippocampal activity as well as tau levels were associated with mnemonic discrimination of objects, but again not scenes. |
2020-06-29 |
2023-08-13 |
human |
| Elise Gondard, Maria Luisa Soto-Montenegro, Amanda Cassol, Andres M Lozano, Clement Haman. Transcranial direct current stimulation does not improve memory deficits or alter pathological hallmarks in a rodent model of Alzheimer's disease. Journal of psychiatric research. vol 114. 2020-06-25. PMID:31054455. |
in addition, ad transgenics had an increased expression of tau, phosphorylated-tau and amyloid precursor protein in the hippocampus. |
2020-06-25 |
2023-08-13 |
mouse |
| Jing Guo, Cheng Xu, Shaozhou Ni, Shujuan Zhang, Qihang Li, Peng Zeng, Guilin Pi, Enjie Liu, Dong-Sheng Sun, Yanchao Liu, Zhouyi Wang, Haote Chen, Ying Yang, Jian-Zhi Wan. Elevation of pS262-Tau and Demethylated PP2A in Retina Occurs Earlier than in Hippocampus During Hyperhomocysteinemia. Journal of Alzheimer's disease : JAD. vol 68. issue 1. 2020-06-22. PMID:30775994. |
in retina and/or the hippocampus, significant loss of retinal ganglion cells and stenosis of retinal arteries with the ad-like tau and amyloid-β (aβ) pathologies and memory deficit were shown only in the 14-day hcy group. |
2020-06-22 |
2023-08-13 |
rat |
| Jing Guo, Cheng Xu, Shaozhou Ni, Shujuan Zhang, Qihang Li, Peng Zeng, Guilin Pi, Enjie Liu, Dong-Sheng Sun, Yanchao Liu, Zhouyi Wang, Haote Chen, Ying Yang, Jian-Zhi Wan. Elevation of pS262-Tau and Demethylated PP2A in Retina Occurs Earlier than in Hippocampus During Hyperhomocysteinemia. Journal of Alzheimer's disease : JAD. vol 68. issue 1. 2020-06-22. PMID:30775994. |
interestingly, accumulation of ser262 hyperphosphorylated tau (ps262-tau) but not aβ with decreased methylation of protein phosphatase-2a catalytic subunit (m-pp2ac) and increased de-methylated pp2ac (dm-pp2ac) was detected in retina of the 3-day hcy group, in which the retinal pathologies were preceded by those of the hippocampus. |
2020-06-22 |
2023-08-13 |
rat |
| Linlin Fan, Lingling Chen, Zhi Liang, Hongkun Bao, Dan Wang, Yilong Dong, Shangyong Zheng, Chunjie Xiao, Jing Du, Hongliang L. A Polysaccharide Extract from Maitake Culinary-Medicinal Mushroom, Grifola frondosa (Agaricomycetes) Ameliorates Learning and Memory Function in Aluminum Chloride-Induced Amnesia in Mice. International journal of medicinal mushrooms. vol 21. issue 11. 2020-06-10. PMID:32450016. |
furthermore, pgm treatment significantly enhanced the level of ampar and bdnf in the hippocampus, while suppressing the tau protein hyperphosphorylation at the ser396 site. |
2020-06-10 |
2023-08-13 |
mouse |
| Sen Li, Furong Xian, Xiao Guan, Kai Huang, Wenwen Yu, Dandan Li. Neural Protective Effects of Millet and Millet Polyphenols on High-Fat Diet-Induced Oxidative Stress in the Brain. Plant foods for human nutrition (Dordrecht, Netherlands). vol 75. issue 2. 2020-06-04. PMID:32078112. |
our results suggested that the intake of millet could alleviate oxidative stress in the hippocampus and downregulate the expression of the alzheimer's disease (ad)-related genes amyloid precursor protein (app), tau, and γ-secretase. |
2020-06-04 |
2023-08-13 |
rat |
| Katarina Ilic, Kristina Mlinac-Jerkovic, Natasa Jovanov-Milosevic, Goran Simic, Nikola Habek, Nenad Bogdanovic, Svjetlana Kalanj-Bogna. Hippocampal expression of cell-adhesion glycoprotein neuroplastin is altered in Alzheimer's disease. Journal of cellular and molecular medicine. vol 23. issue 2. 2020-05-21. PMID:30488668. |
here, we investigated the hippocampal expression of brain-specific neuroplastin isoform (np65), its relationship with amyloid and tau pathology in alzheimer's disease (ad), and potential involvement of neuroplastin in tissue response during the disease progression. |
2020-05-21 |
2023-08-13 |
human |