| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gabor G Kovacs, Linda K Kwong, Murray Grossman, David J Irwin, Edward B Lee, John L Robinson, Eunran Suh, Vivianna M Van Deerlin, Virginia M Lee, John Q Trojanowsk. Tauopathy with hippocampal 4-repeat tau immunoreactive spherical inclusions: a report of three cases. Brain pathology (Zurich, Switzerland) vol 28 issue 2 2018 28019685 |
common neuropathological features included neuronal loss in the hippocampus and dentate gyrus associated with spherical basophilic pick body-like inclusions showing 4r tau immunoreactivity, which was supported by the detection of predominantly 4r tau species by western blot examination. |
2018-08-30 |
2023-01-26 |
human |
| Gabor G Kovacs, Linda K Kwong, Murray Grossman, David J Irwin, Edward B Lee, John L Robinson, Eunran Suh, Vivianna M Van Deerlin, Virginia M Lee, John Q Trojanowsk. Tauopathy with hippocampal 4-repeat tau immunoreactive spherical inclusions: a report of three cases. Brain pathology (Zurich, Switzerland) vol 28 issue 2 2018 28019685 |
in addition, accumulation of tau immunoreactive argyrophilic astrocytes in the hippocampus and amygdala and oligodendroglial coiled bodies in the hippocampal white matter were observed. |
2018-08-30 |
2023-01-26 |
human |
| Gabor G Kovacs, Linda K Kwong, Murray Grossman, David J Irwin, Edward B Lee, John L Robinson, Eunran Suh, Vivianna M Van Deerlin, Virginia M Lee, John Q Trojanowsk. Tauopathy with hippocampal 4-repeat tau immunoreactive spherical inclusions: a report of three cases. Brain pathology (Zurich, Switzerland) vol 28 issue 2 2018 28019685 |
we suggest that this tauopathy variant with hippocampal 4r tau immunoreactive spherical inclusions might contribute to the cognitive deficits in the patients reported here. |
2018-08-30 |
2023-01-26 |
human |
| Anaclara Prada Jardim, Joan Liu, Jack Baber, Zuzanna Michalak, Cheryl Reeves, Matthew Ellis, Jan Novy, Jane de Tisi, Andrew McEvoy, Anna Miserocchi, Elza Marcia Targas Yacubian, Sanjay Sisodiya, Pamela Thompson, Maria Tho. Characterising subtypes of hippocampal sclerosis and reorganization: correlation with pre and postoperative memory deficit. Brain pathology (Zurich, Switzerland) vol 28 issue 2 2018 28380661 |
we also evaluated hippocampal regenerative activity (mcm2, nestin, olig2, calbindin), degeneration (at8/phosphorylated tau) and mossy-fiber pathway re-organization (znt3). |
2018-08-30 |
2023-01-26 |
Not clear |
| Tong Li, Kerstin E Braunstein, Juhong Zhang, Ashley Lau, Leslie Sibener, Christopher Deeble, Philip C Won. The neuritic plaque facilitates pathological conversion of tau in an Alzheimer's disease mouse model. Nature communications vol 7 issue 2018 27373369 |
we show that this tau fragment seeds the neuritic plaque-dependent pathological conversion of wild-type tau that spreads from the cortex and hippocampus to the brain stem. |
2018-08-27 |
2023-01-25 |
mouse |
| Miho Uematsu, Ayako Nakamura, Momoko Ebashi, Katsuiku Hirokawa, Ryosuke Takahashi, Toshiki Uchihar. Brainstem tau pathology in Alzheimer's disease is characterized by increase of three repeat tau and independent of amyloid\\xc2\\xa0\\xce\\xb2. Acta neuropathologica communications vol 6 issue 1 2018 29298724 |
in the hippocampus, the number of nfts, and the proportion of 3r tau progressively increases. |
2018-08-20 |
2023-01-26 |
Not clear |
| Qing-Hua Ma, Liu-Fang Jiang, Jian-Liang Mao, Wen-Xin Xu, Min Huan. Vildagliptin prevents cognitive deficits and neuronal apoptosis in a rat model of Alzheimer's disease. Molecular medicine reports vol 17 issue 3 2018 29257340 |
these results indicate that vildagliptin administration exerts a protective effect against cognitive deficits by reducing tau phosphorylation and increasing the expression of proteins associated with synaptic plasticity in the hippocampus. |
2018-08-15 |
2023-01-26 |
Not clear |
| Melike Yuksel, Kevser Biberoglu, Seda Onder, K Gonca Akbulut, Ozden Taca. Toluidine blue O modifies hippocampal amyloid pathology in a transgenic mouse model of Alzheimer's disease. Biochimie vol 146 issue 2018 29248542 |
similarly, tbo did not recover hyperphosphorylation of tau at residues thr181 and ser202/thr205 significantly in soluble and insoluble hippocampal fractions of 3xtg-ad mice. |
2018-08-13 |
2023-01-26 |
mouse |
| M Bol\\xc3\\xb3s, N Pallas-Bazarra, J Terreros-Roncal, J R Perea, J Jurado-Arjona, J \\xc3\\x81vila, M Llorens-Mart\\xc3\\xad. Soluble Tau has devastating effects on the structural plasticity of hippocampal granule neurons. Translational psychiatry vol 7 issue 12 2018 29217824 |
soluble tau has devastating effects on the structural plasticity of hippocampal granule neurons. |
2018-07-30 |
2023-01-26 |
mouse |
| M Bol\\xc3\\xb3s, N Pallas-Bazarra, J Terreros-Roncal, J R Perea, J Jurado-Arjona, J \\xc3\\x81vila, M Llorens-Mart\\xc3\\xad. Soluble Tau has devastating effects on the structural plasticity of hippocampal granule neurons. Translational psychiatry vol 7 issue 12 2018 29217824 |
here we evaluated the long-term impact of a single stereotaxic injection of human soluble tau on hippocampal granule neurons in mice. |
2018-07-30 |
2023-01-26 |
mouse |
| Satoshi Okuyama, Yoshimi Kotani, Kana Yamamoto, Atsushi Sawamoto, Kuniaki Sugawara, Masahiko Sudo, Yuu Ohkubo, Arisa Tamanaha, Mitsunari Nakajima, Yoshiko Furukaw. The peel of Citrus kawachiensis (kawachi bankan) ameliorates microglial activation, tau hyper-phosphorylation, and suppression of neurogenesis in the hippocampus of senescence-accelerated mice. Bioscience, biotechnology, and biochemistry vol 82 issue 5 2018 29424280 |
the peel of citrus kawachiensis (kawachi bankan) ameliorates microglial activation, tau hyper-phosphorylation, and suppression of neurogenesis in the hippocampus of senescence-accelerated mice. |
2018-07-30 |
2023-01-26 |
mouse |
| Satoshi Okuyama, Yoshimi Kotani, Kana Yamamoto, Atsushi Sawamoto, Kuniaki Sugawara, Masahiko Sudo, Yuu Ohkubo, Arisa Tamanaha, Mitsunari Nakajima, Yoshiko Furukaw. The peel of Citrus kawachiensis (kawachi bankan) ameliorates microglial activation, tau hyper-phosphorylation, and suppression of neurogenesis in the hippocampus of senescence-accelerated mice. Bioscience, biotechnology, and biochemistry vol 82 issue 5 2018 29424280 |
the c. kawachiensis treatment inhibited microglial activation in the hippocampus, the hyper-phosphorylation of tau at 231 of threonine in hippocampal neurons, and ameliorated the suppression of neurogenesis in the dentate gyrus of the hippocampus. |
2018-07-30 |
2023-01-26 |
mouse |
| Huan Zhou, Ying Guo, Xing Li, Zheng-Yu Liuyang, Yang-Ping Shentu, Xiao-Peng Jing, Jia-Wei Liang, Xin-Wen Zhou, Xiao-Chuan Wang, Jian-Zhi Wang, Ji Zeng, Rong Li. Long-term Helicobacter pylori infection does not induce tauopathy and memory impairment in SD rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban vol 37 issue 6 2018 29270738 |
however, there was no significant change of tau phosphorylation at thr205 (pt205), thr231 (pt231), ser396 (ps396) and ser404 (ps404) sites in the hippocampus and cerebral cortex. |
2018-07-26 |
2023-01-26 |
rat |
| S L Angulo, R Orman, S A Neymotin, L Liu, L Buitrago, E Cepeda-Prado, D Stefanov, W W Lytton, M Stewart, S A Small, K E Duff, H Moren. Tau and amyloid-related pathologies in the entorhinal cortex have divergent effects in the hippocampal circuit. Neurobiology of disease vol 108 issue 2018 28860088 |
tau and amyloid-related pathologies in the entorhinal cortex have divergent effects in the hippocampal circuit. |
2018-07-23 |
2023-01-26 |
mouse |
| Miranda Tuwaig, M\\xc3\\xa9lissa Savard, Beno\\xc3\\xaet Jutras, Judes Poirier, D Louis Collins, Pedro Rosa-Neto, David Fontaine, John C S Breitne. Deficit in Central Auditory Processing as a Biomarker of Pre-Clinical Alzheimer's Disease. Journal of Alzheimer's disease : JAD vol 60 issue 4 2018 28984583 |
adjusting for age, sex, education, pure-tone hearing, and apoe\xc9\x9b4 status, we observed a persistent relationship between cap scores and csf tau levels, entorhinal and hippocampal cortex volumes, cortical thickness, and deficits in cognition (repeatable battery for assessment of neuropsychological status total score, and several of its index scales). |
2018-07-23 |
2023-01-26 |
Not clear |
| Zhong-Hong Kong, Xin Chen, Hui-Po Hua, Liang Liang, Long-Juan Li. The Oral Pretreatment of Glycyrrhizin Prevents Surgery-Induced Cognitive Impairment in Aged Mice by Reducing Neuroinflammation and Alzheimer's-Related Pathology via HMGB1 Inhibition. Journal of molecular neuroscience : MN vol 63 issue 3-4 2018 29034441 |
additionally, the pretreatment of glycyrrhizin reduced the postoperative neuroinflammation (production of pro-inflammatory cytokines including il-1\xce\xb2, tnf-\xce\xb1, and il-6 as well as nf-\xce\xbab nuclear expression) and alzheimer's-related pathology (tau phosphorylation at the site of at-8 and ser396 as well as a\xce\xb240 and 42 concentrations) in the hippocampus of the aged mice undergoing splenectomy surgery. |
2018-07-20 |
2023-01-26 |
mouse |
| Diana Klakotskaia, Cansu Agca, Rachel A Richardson, Edward G Stopa, Todd R Schachtman, Yuksel Agc. Memory deficiency, cerebral amyloid angiopathy, and amyloid-\\xce\\xb2 plaques in APP+PS1 double transgenic rat model of Alzheimer's disease. PloS one vol 13 issue 4 2018 29641600 |
immunohistochemistry using an antibody against amyloid-\xce\xb2 (a\xce\xb2) showed extensive and mostly diffuse a\xce\xb2 plaques in the hippocampus and dense plaques that contained tau in the cortex of the brains of the app+ps1 rats. |
2018-07-16 |
2023-01-26 |
rat |
| Yong Tang, Chonglin Yu, Jianming Wu, Haixia Chen, Yuan Zeng, Xiuling Wang, Le Yang, Qibing Mei, Shousong Cao, Dalian Qi. Lychee seed extract protects against neuronal injury and improves cognitive function in rats with type II diabetes mellitus with cognitive impairment. International journal of molecular medicine vol 41 issue 1 2018 29138799 |
the levels of glucose, insulin, a\xce\xb2, ages, tau protein and acetylcholinesterase in the blood and/or hippocampus of rats were determined by blood\xe2\x80\x91glucose meter, radioimmunoassay, chemical chromatometry, enzyme\xe2\x80\x91linked immunosorbent assay\xc2\xa0(elisa) and immunohistochemical analysis, respectively. |
2018-07-09 |
2023-01-26 |
rat |
| Yong Tang, Chonglin Yu, Jianming Wu, Haixia Chen, Yuan Zeng, Xiuling Wang, Le Yang, Qibing Mei, Shousong Cao, Dalian Qi. Lychee seed extract protects against neuronal injury and improves cognitive function in rats with type II diabetes mellitus with cognitive impairment. International journal of molecular medicine vol 41 issue 1 2018 29138799 |
the levels of glucose, insulin, a\xce\xb2, ages and tau protein were significantly increased in the blood and/or hippocampus of t2dm rats, while lse remarkably decreased their levels compared to vehicle treatment (p<0.01). |
2018-07-09 |
2023-01-26 |
rat |
| Yong Tang, Chonglin Yu, Jianming Wu, Haixia Chen, Yuan Zeng, Xiuling Wang, Le Yang, Qibing Mei, Shousong Cao, Dalian Qi. Lychee seed extract protects against neuronal injury and improves cognitive function in rats with type II diabetes mellitus with cognitive impairment. International journal of molecular medicine vol 41 issue 1 2018 29138799 |
the possible mechanisms may be associated with ir improvement and decreased formations of a\xce\xb2, ages and tau protein in the hippocampus of t2dm rats. |
2018-07-09 |
2023-01-26 |
rat |