All Relations between microtubule-associated protein tau and hippocampus

Publication Sentence Publish Date Extraction Date Species
Lanxia Meng, Congcong Liu, Miao Liu, Jiehui Chen, Chaoyang Liu, Zhaohui Zhang, Guiqin Chen, Zhentao Zhan. The yeast protein Ure2p triggers Tau pathology in a mouse model of tauopathy. Cell reports. vol 42. issue 11. 2023-10-28. PMID:37897723. when injected into the hippocampus of tau p301s transgenic mice, the ure2p-seeded tau fibrils show enhanced seeding activity compared with pure tau fibrils. 2023-10-28 2023-11-08 mouse
Hisazumi Matsuki, Shintaro Mandai, Hiroki Shiwaku, Takaaki Koide, Naohiro Takahashi, Tomoki Yanagi, Shunsuke Inaba, Saaya Ida, Tamami Fujiki, Yutaro Mori, Fumiaki Ando, Takayasu Mori, Koichiro Susa, Soichiro Iimori, Eisei Sohara, Hidehiko Takahashi, Shinichi Uchid. Chronic kidney disease causes blood-brain barrier breakdown via urea-activated matrix metalloproteinase-2 and insolubility of tau protein. Aging. vol 15. 2023-10-27. PMID:37889501. sarkosyl-insoluble-proteomic analyses of the ckd mouse hippocampus revealed an accumulation of insoluble mapt (microtubule-associated protein tau) and rna-binding proteins such as small nuclear ribonucleoprotein u1 subunit 70 (snrnp70). 2023-10-27 2023-11-08 mouse
Ashok Iyaswamy, Abhimanyu Thakur, Xin-Jie Guan, Senthilkumar Krishnamoorthi, Tsz Yan Fung, Kejia Lu, Isha Gaurav, Zhijun Yang, Cheng-Fu Su, Kwok-Fai Lau, Kui Zhang, Roy Chun-Laam Ng, Qizhou Lian, King-Ho Cheung, Keqiang Ye, Huanhuan Joyce Chen, Min L. Fe65-engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathology of Alzheimer's disease. Signal transduction and targeted therapy. vol 8. issue 1. 2023-10-24. PMID:37867176. alzheimer's disease (ad) is a neurodegenerative disorder characterized by the predominant impairment of neurons in the hippocampus and the formation of amyloid plaques, hyperphosphorylated tau protein, and neurofibrillary tangles in the brain. 2023-10-24 2023-11-08 mouse
Kayo Yukawa, Satomi Yamamoto-Mcguire, Louis Cafaro, Christine Hong, Fredrik Kamme, Tsuneya Ikezu, Seiko Ikez. Antisense oligonucleotide-based targeting of Tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in PS19 tauopathy mice. Acta neuropathologica communications. vol 11. issue 1. 2023-10-20. PMID:37853497. antisense oligonucleotide-based targeting of tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in ps19 tauopathy mice. 2023-10-20 2023-11-08 mouse
Kayo Yukawa, Satomi Yamamoto-Mcguire, Louis Cafaro, Christine Hong, Fredrik Kamme, Tsuneya Ikezu, Seiko Ikez. Antisense oligonucleotide-based targeting of Tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in PS19 tauopathy mice. Acta neuropathologica communications. vol 11. issue 1. 2023-10-20. PMID:37853497. tau tubulin kinase-1 (ttbk1), a neuron-specific tau kinase, is highly expressed in the entorhinal cortex and hippocampal regions, where early tau pathology evolves in alzheimer's disease (ad). 2023-10-20 2023-11-08 mouse
Kurt A Jellinge. The Spectrum of Cognitive Dysfunction in Amyotrophic Lateral Sclerosis: An Update. International journal of molecular sciences. vol 24. issue 19. 2023-10-14. PMID:37834094. morphological substrates are frontotemporal and hippocampal atrophy with synaptic loss, associated with tdp-43 and other co-pathologies, including tau deposition. 2023-10-14 2023-10-15 Not clear
Aruna Sharma, Lianyuan Feng, Dafin F Muresanu, Z Ryan Tian, José Vicente Lafuente, Anca D Buzoianu, Ala Nozari, Lars Wiklund, Hari Shanker Sharm. Spinal cord injury induced exacerbation of Alzheimer's disease like pathophysiology is reduced by topical application of nanowired cerebrolysin with monoclonal antibodies to amyloid beta peptide, p-tau and tumor necrosis factor alpha. International review of neurobiology. vol 172. 2023-10-13. PMID:37833015. after 48 h of spinal cord injury elevation of amyloid beta peptide, phosphorylated tau (p-tau) and tumor necrosis factor-alpha (tnf-α) was seen in t9 and t12 segments of spinal cord in cerebral cortex, hippocampus and brain stem regions associated with microglial activation as seen by upregulation of iba1 and cd86. 2023-10-13 2023-10-15 Not clear
Kirsty Hamilton, Kate Morrow, Ermione Markantoni, Jenni Harve. Leptin prevents aberrant targeting of tau to hippocampal synapses via PI 3 kinase driven inhibition of GSK3β. Journal of neurochemistry. 2023-10-12. PMID:37822142. leptin prevents aberrant targeting of tau to hippocampal synapses via pi 3 kinase driven inhibition of gsk3β. 2023-10-12 2023-10-15 Not clear
Kirsty Hamilton, Kate Morrow, Ermione Markantoni, Jenni Harve. Leptin prevents aberrant targeting of tau to hippocampal synapses via PI 3 kinase driven inhibition of GSK3β. Journal of neurochemistry. 2023-10-12. PMID:37822142. amyloid-β (aβ) and hyper-phosphorylated tau are key hallmarks of alzheimer's disease (ad), with an accumulation of both proteins linked to hippocampal synaptic dysfunction. 2023-10-12 2023-10-15 Not clear
Timna Hitrec, Fabio Squarcio, Emiliana Piscitiello, Matteo Cerri, Davide Martelli, Alessandra Occhinegro, Ludovico Taddei, Domenico Tupone, Roberto Amici, Marco Lupp. Sleep deprivation soon after recovery from synthetic torpor enhances tau protein dephosphorylation in the rat brain. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. 2023-10-09. PMID:37812305. the effects of sd were studied by assessing: (i) deep brain temperature (tb); (ii) immunofluorescent staining for at8 (phosphorylated tau) and tau-1 (non-phosphorylated tau), assessed in 19 brain structures; (iii) different phosphorylated forms of tau and the main cellular factors involved in tau phospho-regulation, including pro- and anti-apoptotic markers, assessed through western blot in the parietal cortex and hippocampus; (iv) systemic factors which are involved in natural torpor; (v) microglia activation state, by considering morphometric variations. 2023-10-09 2023-10-15 rat
Hongli Li, Bo-Lin Xiang, Xiao Li, Cong Li, Yu Li, Ying Miao, Guo-Lan Ma, Yu-Hua Ma, Jia-Qi Chen, Qing-Yu Zhang, Long-Bao Lv, Ping Zheng, Rui Bi, Yong-Gang Ya. Cognitive Deficits and Alzheimer's Disease-Like Pathologies in the Aged Chinese Tree Shrew. Molecular neurobiology. 2023-10-09. PMID:37814108. moreover, the aged tree shrews exhibited several age-related phenotypes that are associated with ad, including increased levels of amyloid-β (aβ) accumulation and phosphorylated tau protein, synaptic and neuronal loss, and reactive gliosis in the cortex and the hippocampal tissues. 2023-10-09 2023-10-15 Not clear
María José Pérez, Rodrigo Ibarra-García-Padilla, Maoping Tang, George A Porter, Gail V W Johnson, Rodrigo A Quintanill. Caspase-3 cleaved tau impairs mitochondrial function through the opening of the mitochondrial permeability transition pore. Biochimica et biophysica acta. Molecular basis of disease. 2023-09-29. PMID:37774936. to investigate the mechanism behind mitochondrial dysfunction caused by this tau form, we used transient transfection and pharmacological approaches in immortalized cortical neurons and mouse primary hippocampal neurons. 2023-09-29 2023-10-07 mouse
María José Pérez, Rodrigo Ibarra-García-Padilla, Maoping Tang, George A Porter, Gail V W Johnson, Rodrigo A Quintanill. Caspase-3 cleaved tau impairs mitochondrial function through the opening of the mitochondrial permeability transition pore. Biochimica et biophysica acta. Molecular basis of disease. 2023-09-29. PMID:37774936. moreover, the impairment of mitochondrial length and bioenergetics induced by caspase-3-cleaved tau were prevented in hippocampal neurons obtained from cypd knock-out mice. 2023-09-29 2023-10-07 mouse
Giovanna Morello, Maria Guarnaccia, Valentina La Cognata, Valentina Latina, Pietro Calissano, Giuseppina Amadoro, Sebastiano Cavallar. Transcriptomic Analysis in the Hippocampus and Retina of Tg2576 AD Mice Reveals Defective Mitochondrial Oxidative Phosphorylation and Recovery by Tau 12A12mAb Treatment. Cells. vol 12. issue 18. 2023-09-28. PMID:37759477. transcriptomic analysis in the hippocampus and retina of tg2576 ad mice reveals defective mitochondrial oxidative phosphorylation and recovery by tau 12a12mab treatment. 2023-09-28 2023-10-07 mouse
Chiara Prinzi, Anna Kostenko, Gioacchino de Leo, Rosario Gulino, Giampiero Leanza, Antonella Caccam. Selective Noradrenaline Depletion in the Neocortex and Hippocampus Induces Working Memory Deficits and Regional Occurrence of Pathological Proteins. Biology. vol 12. issue 9. 2023-09-28. PMID:37759663. at about 12 weeks post-lesion, dose-dependent working memory deficits were detected in these animals, associated with a marked increase in cortical and hippocampal levels of tdp-43 phosphorylated at ser 409/410 and tau phosphorylated at thr 217. 2023-09-28 2023-10-07 rat
Aida Muntsant, Maria Del Mar Castillo-Ruiz, Lydia Giménez-Llor. Survival Bias, Non-Lineal Behavioral and Cortico-Limbic Neuropathological Signatures in 3xTg-AD Mice for Alzheimer's Disease from Premorbid to Advanced Stages and Compared to Normal Aging. International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37762098. the underlying temporal and spatial progression of aβ and tau pathologies pointed to a relevant cortico-limbic substrate roadmap: premorbid intracellular aβ immunoreactivity and pser202/pthr205 tau phosphorylation in the amygdala and ventral hippocampus, and the entorhinal cortex and ventral hippocampus as the areas most affected by aβ plaques. 2023-09-28 2023-10-07 mouse
Meixiang Huang, Carolyn Tallon, Xiaolei Zhu, Kaitlyn D J Huizar, Silvia Picciolini, Ajit G Thomas, Lukas Tenora, Wathsala Liyanage, Francesca Rodà, Alice Gualerzi, Rangaramanujam M Kannan, Marzia Bedoni, Rana Rais, Barbara S Slushe. Microglial-Targeted nSMase2 Inhibitor Fails to Reduce Tau Propagation in PS19 Mice. Pharmaceutics. vol 15. issue 9. 2023-09-28. PMID:37765332. the progression of alzheimer's disease (ad) correlates with the propagation of hyperphosphorylated tau (ptau) from the entorhinal cortex to the hippocampus and neocortex. 2023-09-28 2023-10-07 mouse
Mohammad Amin Rajizadeh, Amirhossein Moslemizadeh, Mahdieh Sadat Hosseini, Forouzan Rafiei, Zahra Soltani, Kayvan Khoramipou. Adiponectin receptor 1 could explain the sex differences in molecular basis of cognitive improvements induced by exercise training in type 2 diabetic rats. Scientific reports. vol 13. issue 1. 2023-09-27. PMID:37758935. leptin and adiponectin levels in serum were measured along with hippocampal expression of leptin and adiponectin receptors, amp-activated protein kinase (ampk), dephosphorylated glycogen synthase kinase-3 beta (dep-gsk3β), tau, and beta-amyloid (aβ). 2023-09-27 2023-10-07 rat
Mohammad Amin Rajizadeh, Amirhossein Moslemizadeh, Mahdieh Sadat Hosseini, Forouzan Rafiei, Zahra Soltani, Kayvan Khoramipou. Adiponectin receptor 1 could explain the sex differences in molecular basis of cognitive improvements induced by exercise training in type 2 diabetic rats. Scientific reports. vol 13. issue 1. 2023-09-27. PMID:37758935. however, after 8 weeks of hiit, hippocampal levels of apnr1 and ampk as well as quicki were lower and hippocampal levels of gsk, tau, and aβ were higher in females compared to male rats (p < 0.05). 2023-09-27 2023-10-07 rat
Genevieve L Stein-O'Brien, Ryan Palaganas, Ernest M Meyer, Javier Redding-Ochoa, Olga Pletnikova, Haidan Guo, William R Bell, Juan C Troncoso, Richard L Huganir, Meaghan Morri. Transcriptional Signatures of Hippocampal Tau Pathology in Primary Age-Related Tauopathy and Alzheimer's Disease. medRxiv : the preprint server for health sciences. 2023-09-25. PMID:37745408. transcriptional signatures of hippocampal tau pathology in primary age-related tauopathy and alzheimer's disease. 2023-09-25 2023-10-07 Not clear