| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jesus Mendiola-Precoma, Karla Padilla, Alfredo Rodr\\xc3\\xadguez-Cruz, Laura C Berumen, Ricardo Miledi, Guadalupe Garc\\xc3\\xada-Alcoce. Theobromine-Induced Changes in A1 Purinergic Receptor Gene Expression and Distribution in a Rat Brain Alzheimer's Disease Model. Journal of Alzheimer's disease : JAD vol 55 issue 3 2018 27792010 |
dementia caused by alzheimer's disease (ad) is mainly characterized by accumulation in the brain of extra- and intraneuronal amyloid-\xce\xb2 (a\xce\xb2) and tau proteins, respectively, which selectively affect specific regions, particularly the neocortex and the hippocampus. |
2018-02-20 |
2023-01-26 |
rat |
| Kate\\xc5\\x99ina Storey, Silvie Johanidesov\\xc3\\xa1, Radoslav Mat\\xc4\\x9bj, Ji\\xc5\\x99\\xc3\\xad Keller, Zden\\xc4\\x9bk Rohan, Robert Rusin. FTLD-TDP and progressive supranuclear palsy in comorbidity-a report of two cases with different clinical presentations. Neurocase vol 23 issue 1 2018 27915581 |
neuropathological examination revealed neuronal and glial tau pathology together with ubiquitin, and phospho-tdp-43-immunoreactivities in the hippocampus, striatum, mesencephalon, and frontal and temporal cortices. |
2018-02-20 |
2023-01-26 |
Not clear |
| Hsiang Liao, Liang-Mao Chou, Yi-Wen Chien, Chi-Hao Wu, Jung-Su Chang, Ching-I Lin, Shyh-Hsiang Li. Grape powder consumption affects the expression of neurodegeneration-related brain proteins in rats chronically fed a high-fructose-high-fat diet. The Journal of nutritional biochemistry vol 43 issue 2018 28285155 |
western blotting was performed to measure the expression/phosphorylation levels of several cortical and hippocampal proteins, including amyloid precursor protein (app), tau, phosphatidylinositol-3-kinase (pi3k), extracellular signal-regulated kinase (erk), receptor for advanced glycation end products (rages), erythroid 2-related factor 2 (nrf2) and brain-derived neurotrophic factor (bdnf). |
2018-02-19 |
2023-01-26 |
rat |
| Suryanarayan Biswal, Deepti Sharma, Kushal Kumar, Tapas Chandra Nag, Kalpana Barhwal, Sunil Kumar Hota, Bhuvnesh Kuma. Global hypoxia induced impairment in learning and spatial memory is associated with precocious hippocampal aging. Neurobiology of learning and memory vol 133 issue 2018 27246251 |
a single episode of chronic hypobaric hypoxia exposure also resulted in the up-regulation of pro-aging protein, s100a9 and down regulation of tau, snap25, apoe and sod2 in the hippocampus similar to that in aged rats indicating hypoxia induced accelerated aging. |
2018-02-15 |
2023-01-25 |
rat |
| Lixia Yu, Yuan Chen, Weiguang Wang, Zhonghai Xiao, Yan Hon. Multi-Vitamin B Supplementation Reverses\\xc2\\xa0Hypoxia-Induced Tau Hyperphosphorylation and Improves Memory Function in Adult Mice. Journal of Alzheimer's disease : JAD vol 54 issue 1 2018 27497480 |
mice in the hh group exhibited significant spatial working and passive memory impairment, increased tau phosphorylation at thr181, ser262, ser202/thr205, and ser396 in the cortex and hippocampus, and elevated hcy levels compared with controls. |
2018-01-29 |
2023-01-25 |
mouse |
| Ana Laura Calderon-Garcidue\\xc3\\xb1as, Charles Duyckaert. Alzheimer disease. Handbook of clinical neurology vol 145 issue 2018 28987180 |
tau pathology affects in a stereotyped order some specific nuclei of the brainstem, the entorhinal area, the hippocampus, and the neocortex - first the associative areas and secondarily the primary cortices (braak stages). |
2018-01-29 |
2023-01-26 |
Not clear |
| Gabor G Kovac. Tauopathies. Handbook of clinical neurology vol 145 issue 2018 28987182 |
for cost-effective screening for tau pathologies in neuropathologic practice, examination of the hippocampus, amygdala, and basal ganglia is recommended. |
2018-01-29 |
2023-01-26 |
Not clear |
| Mary Ellen I Koran, Madison Wagener, Timothy J Hohma. Sex differences in the association between AD biomarkers and cognitive decline. Brain imaging and behavior vol 11 issue 1 2018 26843008 |
similarly, we observed an interaction between sex and total tau level on longitudinal hippocampal atrophy (p\xc2\xa0=\xc2\xa00.008), and longitudinal decline in executive function (p\xc2\xa0=\xc2\xa00.034). |
2018-01-25 |
2023-01-25 |
human |
| Mary Ellen I Koran, Madison Wagener, Timothy J Hohma. Sex differences in the association between AD biomarkers and cognitive decline. Brain imaging and behavior vol 11 issue 1 2018 26843008 |
women with a\xce\xb2-42 and total tau levels indicative of worse pathological changes showed more rapid hippocampal atrophy and cognitive decline. |
2018-01-25 |
2023-01-25 |
human |
| J D White, M J Eimerbrink, H B Hayes, A Hardy, E A Van Enkevort, J L Peterman, M J Chumley, G W Boeh. Hippocampal A\\xce\\xb2 expression, but not phosphorylated tau, predicts cognitive deficits following repeated peripheral poly I:C administration. Behavioural brain research vol 313 issue 2018 27449203 |
hippocampal a\xce\xb2 expression, but not phosphorylated tau, predicts cognitive deficits following repeated peripheral poly i:c administration. |
2018-01-25 |
2023-01-25 |
Not clear |
| J D White, M J Eimerbrink, H B Hayes, A Hardy, E A Van Enkevort, J L Peterman, M J Chumley, G W Boeh. Hippocampal A\\xce\\xb2 expression, but not phosphorylated tau, predicts cognitive deficits following repeated peripheral poly I:C administration. Behavioural brain research vol 313 issue 2018 27449203 |
immediately after testing, the hippocampus was collected to quantify a\xce\xb2 and phosphorylated tau accumulation. |
2018-01-25 |
2023-01-25 |
Not clear |
| Ying Liu, Lan Tan, Hui-Fu Wang, Yong Liu, Xiao-Ke Hao, Chen-Chen Tan, Teng Jiang, Bing Liu, Dao-Qiang Zhang, Jin-Tai Y. Multiple Effect of APOE Genotype on Clinical and Neuroimaging Biomarkers Across Alzheimer's Disease Spectrum. Molecular neurobiology vol 53 issue 7 2018 26298664 |
a total of 1718 participants from the adni cohort were selected, and we evaluated the impact of \xce\xb54 dose on cerebrospinal fluid (csf) levels' abeta1-42 (a\xce\xb21-42), tau, and phosphorylated-tau (p-tau); cortical amyloid deposition (florbetapir-pet-av45); brain atrophy (mri); brain metabolism (fdg-pet); hippocampal metabolism; and cognitive declines, through different cognitive subgroups. |
2018-01-16 |
2023-01-25 |
human |
| Ying Liu, Lan Tan, Hui-Fu Wang, Yong Liu, Xiao-Ke Hao, Chen-Chen Tan, Teng Jiang, Bing Liu, Dao-Qiang Zhang, Jin-Tai Y. Multiple Effect of APOE Genotype on Clinical and Neuroimaging Biomarkers Across Alzheimer's Disease Spectrum. Molecular neurobiology vol 53 issue 7 2018 26298664 |
we found that (1) \xce\xb54 was associated with decreased csf beta-amyloid (a\xce\xb21-42) and increased cerebral a\xce\xb2 deposition across the ad spectrum; (2) increased csf tau, p-tau and cerebral hypometabolism, hippocampal atrophy, and cognition decline were all associated with apoe \xce\xb54 in prodromal ad stage; (3) increased csf tau, p-tau and cerebral hypometabolism appear to begin earlier than hippocampal atrophy and cognitive decline. |
2018-01-16 |
2023-01-25 |
human |
| Sara Pinheiro, Joana Silva, Cristina Mota, Jo\\xc3\\xa3o Vaz-Silva, Ana Veloso, V\\xc3\\xadtor Pinto, Nuno Sousa, Jo\\xc3\\xa3o Cerqueira, Ioannis Sotiropoulo. Tau Mislocation in Glucocorticoid-Triggered Hippocampal Pathology. Molecular neurobiology vol 53 issue 7 2018 26328538 |
tau mislocation in glucocorticoid-triggered hippocampal pathology. |
2018-01-16 |
2023-01-25 |
rat |
| Sara Pinheiro, Joana Silva, Cristina Mota, Jo\\xc3\\xa3o Vaz-Silva, Ana Veloso, V\\xc3\\xadtor Pinto, Nuno Sousa, Jo\\xc3\\xa3o Cerqueira, Ioannis Sotiropoulo. Tau Mislocation in Glucocorticoid-Triggered Hippocampal Pathology. Molecular neurobiology vol 53 issue 7 2018 26328538 |
we demonstrate, both by biochemical and ultrastructural analysis, that gc administration led to cytosolic and dendritic tau accumulation in rat hippocampus, and triggered tau hyperphosphorylation in epitopes related to its malfunction (ser396/404) and cytoskeletal pathology (e.g., thr231 and ser262). |
2018-01-16 |
2023-01-25 |
rat |
| Lin-Tao Zhou, Shun-Hua Ye, Hai-Xuan Yang, Yong-Ting Zhou, Qi-Hua Zhao, Wei-Wen Sun, Mei-Mei Gao, Yong-Hong Yi, Yue-Sheng Lon. A novel role of fragile X mental retardation protein in pre-mRNA alternative splicing through RNA-binding protein 14. Neuroscience vol 349 issue 2018 28257890 |
we show that the relative skipping/inclusion ratio of the micro-exon l in the protrudin gene and exon 10 in the tau gene decreased in the hippocampus of fmr1 knockout (ko) mice. |
2018-01-16 |
2023-01-26 |
mouse |
| Dongsheng Zhou, Huaxia Liu, Chenli Li, Fangyan Wang, Yaosheng Shi, Lingjiang Liu, Xin Zhao, Aiming Liu, Junfang Zhang, Chuang Wang, Zhongming Che. Atorvastatin ameliorates cognitive impairment, A\\xce\\xb21-42 production and Tau hyperphosphorylation in APP/PS1 transgenic mice. Metabolic brain disease vol 31 issue 3 2018 26883430 |
moreover, atorvastatin significantly attenuated a\xce\xb21-42 accumulation and phosphorylation of tau (ser396) in the hippocampus and prefrontal cortex of tg app/ps1 mice. |
2018-01-12 |
2023-01-25 |
mouse |
| Tara E Tracy, Li Ga. Acetylated tau in Alzheimer's disease: An instigator of synaptic dysfunction underlying memory loss: Increased levels of acetylated tau blocks the postsynaptic signaling required for plasticity and promotes memory deficits associated with tauopathy. BioEssays : news and reviews in molecular, cellular and developmental biology vol 39 issue 4 2018 28083916 |
we propose that an increase in tau acetylated on these lysines blocks the expression of long-term potentiation at hippocampal synapses leading to impaired memory in ad. |
2018-01-12 |
2023-01-26 |
Not clear |
| Julia Gerson, Diana L Castillo-Carranza, Urmi Sengupta, Riddhi Bodani, Donald S Prough, Douglas S DeWitt, Bridget E Hawkins, Rakez Kaye. Tau Oligomers Derived from Traumatic Brain Injury Cause Cognitive Impairment and Accelerate Onset of Pathology in Htau Mice. Journal of neurotrauma vol 33 issue 22 2018 26729399 |
tau oligomer levels increased in the hippocampal injection sites and cerebellum, suggesting that tau oligomers may be responsible for seeding the spread of pathology post-tbi. |
2018-01-10 |
2023-01-25 |
rat |
| FangFang, Hongyan Li, Tingting Qin, Min Li, Shiping M. Thymol improves high-fat diet-induced cognitive deficits in mice via ameliorating brain insulin resistance and upregulating NRF2/HO-1 pathway. Metabolic brain disease vol 32 issue 2 2018 27761760 |
meanwhile, thymol improved the cognitive impairments in the morris water maze (mwm) test and decreased hfd-induced a\xce\xb2 deposition and tau hyperphosphorylation in the hippocampus, which may be correlated with the inhibition of hippocampal oxidative stress and inflammation. |
2018-01-05 |
2023-01-26 |
mouse |