| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ramona Belfiore, Alexis Rodin, Eric Ferreira, Ramon Velazquez, Caterina Branca, Antonella Caccamo, Salvatore Odd. Temporal and regional progression of Alzheimer's disease-like pathology in 3xTg-AD mice. Aging cell. vol 18. issue 1. 2020-03-30. PMID:30488653. |
phosphorylated tau at ser202/thr205 and ser422 was apparent in the hippocampus of 100% of 6-month-old mice, while only 50% of mice showed tau phosphorylation at thr212/ser214 at this age. |
2020-03-30 |
2023-08-13 |
mouse |
| Samuel Chiquita, Mário Ribeiro, João Castelhano, Francisco Oliveira, José Sereno, Marta Batista, Antero Abrunhosa, Ana C Rodrigues-Neves, Rafael Carecho, Filipa Baptista, Catarina Gomes, Paula I Moreira, António F Ambrósio, Miguel Castelo-Branc. A longitudinal multimodal in vivo molecular imaging study of the 3xTg-AD mouse model shows progressive early hippocampal and taurine loss. Human molecular genetics. vol 28. issue 13. 2020-03-30. PMID:30816415. |
molecular characterization evaluated hippocampal levels of amyloid β (aβ) and hyperphosphorylated tau. |
2020-03-30 |
2023-08-13 |
mouse |
| Samuel Chiquita, Mário Ribeiro, João Castelhano, Francisco Oliveira, José Sereno, Marta Batista, Antero Abrunhosa, Ana C Rodrigues-Neves, Rafael Carecho, Filipa Baptista, Catarina Gomes, Paula I Moreira, António F Ambrósio, Miguel Castelo-Branc. A longitudinal multimodal in vivo molecular imaging study of the 3xTg-AD mouse model shows progressive early hippocampal and taurine loss. Human molecular genetics. vol 28. issue 13. 2020-03-30. PMID:30816415. |
in summary, 3xtg-ad mice showed exploratory and recognition memory impairments, early hippocampal structural loss, increased aβ and hyperphosphorylated tau and decreased levels of taurine. |
2020-03-30 |
2023-08-13 |
mouse |
| Kyle R Christensen, Thomas G Beach, Geidy E Serrano, Nicholas M Kanaa. Pathogenic tau modifications occur in axons before the somatodendritic compartment in mossy fiber and Schaffer collateral pathways. Acta neuropathologica communications. vol 7. issue 1. 2020-03-30. PMID:30819250. |
the deposition of tau pathology in alzheimer's disease (ad) may occur first in axons of neurons and then progress back into the cell bodies to form neurofibrillary tangles, however, studies have not directly analyzed this relationship in relatively discrete circuits within the human hippocampus. |
2020-03-30 |
2023-08-13 |
human |
| Kyle R Christensen, Thomas G Beach, Geidy E Serrano, Nicholas M Kanaa. Pathogenic tau modifications occur in axons before the somatodendritic compartment in mossy fiber and Schaffer collateral pathways. Acta neuropathologica communications. vol 7. issue 1. 2020-03-30. PMID:30819250. |
here, we examined the localization of these tau pathologies in well-characterized post-mortem human tissue samples from the hippocampus of 44 cases ranging between non-demented and mild cognitively impaired to capture a time at which intrahippocampal pathways show a range in the extent of tau deposition. |
2020-03-30 |
2023-08-13 |
human |
| Chinnakkaruppan Adaikkan, Steven J Middleton, Asaf Marco, Ping-Chieh Pao, Hansruedi Mathys, David Nam-Woo Kim, Fan Gao, Jennie Z Young, Ho-Jun Suk, Edward S Boyden, Thomas J McHugh, Li-Huei Tsa. Gamma Entrainment Binds Higher-Order Brain Regions and Offers Neuroprotection. Neuron. vol 102. issue 5. 2020-03-23. PMID:31076275. |
here, we demonstrate that genus can entrain gamma oscillations in the visual cortex, hippocampus, and prefrontal cortex in tau p301s and ck-p25 mouse models of neurodegeneration. |
2020-03-23 |
2023-08-13 |
mouse |
| Passainte S Hassaan, Abeer E Dief, Teshreen M Zeitoun, Azza M Baraka, Robert M J Deacon, Amany Elshorbag. Cortical tau burden and behavioural dysfunctions in mice exposed to monosodium glutamate in early life. PloS one. vol 14. issue 8. 2020-03-09. PMID:31412065. |
accumulation of hyperphosphorylated tau protein was assessed in cortical and hippocampal neurons by immunohistochemistry, and in cerebral cortical homogenates. |
2020-03-09 |
2023-08-13 |
mouse |
| Passainte S Hassaan, Abeer E Dief, Teshreen M Zeitoun, Azza M Baraka, Robert M J Deacon, Amany Elshorbag. Cortical tau burden and behavioural dysfunctions in mice exposed to monosodium glutamate in early life. PloS one. vol 14. issue 8. 2020-03-09. PMID:31412065. |
intracellular hyperphosphorylated tau immunostaining was observed diffusely in the cortex and hippocampus, together with cortical atrophic neurons, extensive vacuolation and dysmorphic neuropil suggestive of spongiform neurodegeneration. |
2020-03-09 |
2023-08-13 |
mouse |
| Kathleen M McAvoy, Hameetha Rajamohamed Sait, Galina Marsh, Michael Peterson, Taylor L Reynolds, Jake Gagnon, Sarah Geisler, Prescott Leach, Chris Roberts, Ellen Cahir-McFarland, Richard M Ransohoff, Andrea Crott. Cell-autonomous and non-cell autonomous effects of neuronal BIN1 loss in vivo. PloS one. vol 14. issue 8. 2020-03-03. PMID:31408457. |
to address the relationship between reduction of bin1 and neuronal cell loss in the context of tau pathology, we knocked-down endogenous murine bin1 via stereotaxic injection of aav-bin1 shrna in the hippocampus of mice expressing tau p301s (ps19). |
2020-03-03 |
2023-08-13 |
mouse |
| E Orta-Salazar, A I Feria-Velasco, S Díaz-Cintr. Primary motor cortex alterations in Alzheimer disease: A study in the 3xTg-AD model. Neurologia (Barcelona, Spain). vol 34. issue 7. 2020-03-02. PMID:28433262. |
in humans and animal models, alzheimer disease (ad) is characterised by accumulation of amyloid-β peptide (aβ) and hyperphosphorylated tau protein, neuronal degeneration, and astrocytic gliosis, especially in vulnerable brain regions (hippocampus and cortex). |
2020-03-02 |
2023-08-13 |
mouse |
| Haibo Zhang, Ding Wang, Ping Gong, Aihua Lin, Yan Zhang, Richard D Ye, Yang Y. Formyl Peptide Receptor 2 Deficiency Improves Cognition and Attenuates Tau Hyperphosphorylation and Astrogliosis in a Mouse Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 67. issue 1. 2020-03-02. PMID:30475772. |
in the hippocampus and cortex of icv-stz mice, a marked increase was observed in tau phosphorylation at ser199, thr205, and ser396 compared with icv-saline control mice. |
2020-03-02 |
2023-08-13 |
mouse |
| Yi-Chun Chen, Ya-Jen Chiu, Chih-Hsin Lin, Wen-Chuin Hsu, Jia-Lu Wu, Chen-Hsiang Huang, Chia-Wei Lin, Ching-Fa Yao, Hei-Jen Huang, Yen-Shi Lo, Chiung-Mei Chen, Yih-Ru Wu, Kuo-Hsuan Chang, Guey-Jen Lee-Chen, Hsiu Mei Hsieh-L. Indole Compound NC009-1 Augments APOE and TRKA in Alzheimer's Disease Cell and Mouse Models for Neuroprotection and Cognitive Improvement. Journal of Alzheimer's disease : JAD. vol 67. issue 2. 2020-03-02. PMID:30689566. |
nc009-1 further rescued the downregulated apoe and trka and reduced aβ and tau levels in hippocampus and cortex, and ameliorated cognitive deficits in streptozocin-induced hyperglycemic 3×tg-ad mice. |
2020-03-02 |
2023-08-13 |
mouse |
| Pranesh Padmanabhan, Ramón Martínez-Mármol, Di Xia, Jürgen Götz, Frédéric A Meunie. Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines. eLife. vol 8. 2020-02-24. PMID:31237563. |
frontotemporal dementia mutant tau promotes aberrant fyn nanoclustering in hippocampal dendritic spines. |
2020-02-24 |
2023-08-13 |
mouse |
| Pranesh Padmanabhan, Ramón Martínez-Mármol, Di Xia, Jürgen Götz, Frédéric A Meunie. Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines. eLife. vol 8. 2020-02-24. PMID:31237563. |
as nanoclustering is essential for efficient signaling, we used single-molecule tracking to characterize the nanoscale distribution of fyn in mouse hippocampal neurons, and manipulated the expression of tau to test whether it controls fyn nanoscale organization. |
2020-02-24 |
2023-08-13 |
mouse |
| Sandra Aurora Niño, Adriana Morales-Martínez, Erika Chi-Ahumada, Leticia Carrizales, Roberto Salgado-Delgado, Francisca Pérez-Severiano, Sofía Díaz-Cintra, María E Jiménez-Capdeville, Sergio Zarazú. Arsenic Exposure Contributes to the Bioenergetic Damage in an Alzheimer's Disease Model. ACS chemical neuroscience. vol 10. issue 1. 2020-02-18. PMID:30141907. |
higher immunopositivity to amyloid isoforms and to phosphorylated tau was observed in frontal cortex and hippocampus of exposed animals. |
2020-02-18 |
2023-08-13 |
mouse |
| Chen-Zhuo Feng, Lin Cao, Dan Luo, Ling-Sha Ju, Jian-Jun Yang, Xin-Yi Xu, Yue-Ping Y. Dendrobium polysaccharides attenuate cognitive impairment in senescence-accelerated mouse prone 8 mice via modulation of microglial activation. Brain research. vol 1704. 2020-02-11. PMID:30253123. |
the accumulation of hippocampal aβ42 and phosphated tau proteins in samp8 mice was also reduced. |
2020-02-11 |
2023-08-13 |
mouse |
| Theresa M Harrison, Anne Maass, Jenna N Adams, Richard Du, Suzanne L Baker, William J Jagus. Tau deposition is associated with functional isolation of the hippocampus in aging. Nature communications. vol 10. issue 1. 2020-02-11. PMID:31653847. |
tau deposition is associated with functional isolation of the hippocampus in aging. |
2020-02-11 |
2023-08-13 |
Not clear |
| Theresa M Harrison, Anne Maass, Jenna N Adams, Richard Du, Suzanne L Baker, William J Jagus. Tau deposition is associated with functional isolation of the hippocampus in aging. Nature communications. vol 10. issue 1. 2020-02-11. PMID:31653847. |
we show that age and tau pathology are related to higher hippocampal reho. |
2020-02-11 |
2023-08-13 |
Not clear |
| Theresa M Harrison, Anne Maass, Jenna N Adams, Richard Du, Suzanne L Baker, William J Jagus. Tau deposition is associated with functional isolation of the hippocampus in aging. Nature communications. vol 10. issue 1. 2020-02-11. PMID:31653847. |
functional disconnection between the hippocampus and other components of the mtl memory system, particularly an anterior-temporal network specialized for object memory, is also associated with higher hippocampal reho and greater tau burden in anterior-temporal regions. |
2020-02-11 |
2023-08-13 |
Not clear |
| Theresa M Harrison, Anne Maass, Jenna N Adams, Richard Du, Suzanne L Baker, William J Jagus. Tau deposition is associated with functional isolation of the hippocampus in aging. Nature communications. vol 10. issue 1. 2020-02-11. PMID:31653847. |
these findings suggest that tau pathology plays a role in disconnecting the hippocampus from specific mtl memory systems leading to increased local coherence and memory decline. |
2020-02-11 |
2023-08-13 |
Not clear |