| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hyeongki Kim, Kyu-Sun Lee, Ae-Kyeong Kim, Miri Choi, Kwangman Choi, Mingu Kang, Seung-Wook Chi, Min-Sung Lee, Jeong-Soo Lee, So-Young Lee, Woo-Joo Song, Kweon Yu, Sungchan Ch. A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition. Disease models & mechanisms vol 9 issue 8 2017 27483355 |
moreover, oral administration of cx-4945 acutely suppressed tau hyperphosphorylation in the hippocampus of dyrk1a-overexpressing mice. |
2017-12-04 |
2023-01-25 |
mouse |
| Emi Hayashi-Park, Bria N Ozment, Chelsea M Griffith, Haiying Zhang, Peter R Patrylo, Gregory M Ros. Experimentally induced diabetes worsens neuropathology, but not learning and memory, in middle aged 3xTg mice. Behavioural brain research vol 322 issue Pt B 2017 27173425 |
subsequently, the hippocampal region was examined using immunohistochemistry (6e10 antibody for amyloid) and immunoblotting (at8 antibody for phosphorylated tau). |
2017-11-30 |
2023-01-25 |
mouse |
| Shinsuke Ishigaki, Yusuke Fujioka, Yohei Okada, Yuichi Riku, Tsuyoshi Udagawa, Daiyu Honda, Satoshi Yokoi, Kuniyuki Endo, Kensuke Ikenaka, Shinnosuke Takagi, Yohei Iguchi, Naruhiko Sahara, Akihiko Takashima, Hideyuki Okano, Mari Yoshida, Hitoshi Warita, Masashi Aoki, Hirohisa Watanabe, Haruo Okado, Masahisa Katsuno, Gen Sobu. Altered Tau Isoform Ratio Caused by Loss of FUS and SFPQ Function Leads to FTLD-like Phenotypes. Cell reports vol 18 issue 5 2017 28147269 |
hippocampus-specific fus- or sfpq-knockdown mice exhibit frontotemporal lobar degeneration (ftld)-like behaviors, reduced adult neurogenesis, accumulation of phosphorylated tau, and hippocampal atrophy with neuronal loss through an increased 4r-t/3r-t ratio. |
2017-11-28 |
2023-01-26 |
mouse |
| Glenn R Yamakawa, Connor Lengkeek, Sabrina Salberg, Simon C Spanswick, Richelle Mychasiu. Behavioral and pathophysiological outcomes associated with caffeine consumption and repetitive mild traumatic brain injury (RmTBI) in adolescent rats. PloS one vol 12 issue 11 2017 29108016 |
finally, modifications to expression of 12 genes (adora2a, app, aqp4, bdnf, bmal1, clock, cry, gfap, orx1, orx2, per, tau), in the prefrontal cortex, hippocampus, and/or the hypothalamus were assessed. |
2017-11-28 |
2023-01-26 |
rat |
| Xun-Hu Gu, Li-Jun Xu, Zhi-Qiang Liu, Bo Wei, Yuan-Jian Yang, Guo-Gang Xu, Xiao-Ping Yin, Wei Wan. The flavonoid baicalein rescues synaptic plasticity and memory deficits in a mouse model of Alzheimer's disease. Behavioural brain research vol 311 issue 2017 27233830 |
changes in hippocampal 12/15 lipoxygenase (12/15lo) and glycogen synthase kinase 3\xce\xb2 (gsk3\xce\xb2) activity, a\xce\xb2 production, tau phosphorylation, synaptic plasticity, and dendritic spine density were evaluated. |
2017-11-27 |
2023-01-25 |
rat |
| Helena Soler, Jonatan Dorca-Ar\\xc3\\xa9valo, Marta Gonz\\xc3\\xa1lez, Sara Esmeralda Rubio, Jes\\xc3\\xbas \\xc3\\x81vila, Eduardo Soriano, Marta Pascua. The GABAergic septohippocampal connection is impaired in a mouse model of tauopathy. Neurobiology of aging vol 49 issue 2017 27743524 |
we show that pyramidal neurons, mossy cells, and some parvalbumin (parv)-positive hippocampal interneurons in 2- and 8-month-old (mo) vlw mice accumulate phosphorylated forms of tau (p-tau). |
2017-11-16 |
2023-01-26 |
mouse |
| Natalia A Stefanova, Natalia A Muraleva, Kseniya Yi Maksimova, Ekaterina A Rudnitskaya, Elena Kiseleva, Darya V Telegina, Nataliya G Kolosov. An antioxidant specifically targeting mitochondria delays progression of Alzheimer's disease-like pathology. Aging vol 8 issue 11 2017 27750209 |
via improvement of structural and functional state of mitochondria, treatment with skq1 alleviated the structural neurodegenerative alterations, prevented the neuronal loss and synaptic damage, increased the levels of synaptic proteins, enhanced neurotrophic supply, and decreased amyloid-\xce\xb21-42 protein levels and tau hyperphosphorylation in the hippocampus of oxys rats, resulting in improvement of the learning ability and memory. |
2017-11-16 |
2023-01-26 |
rat |
| Ane-Victoria Idland, Roser Sala-Llonch, Tom Borza, Leiv Otto Watne, Torgeir Bruun Wyller, Anne Br\\xc3\\xa6khus, Henrik Zetterberg, Kaj Blennow, Kristine Beate Walhovd, Anders Martin Fjel. CSF neurofilament light levels predict hippocampal atrophy in cognitively healthy older adults. Neurobiology of aging vol 49 issue 2017 27794264 |
we tested whether csf nfl levels predict hippocampal atrophy rate in cognitively healthy older adults independently of the established csf alzheimer's disease (ad) biomarkers, \xce\xb2-amyloid 1-42, and phosphorylated tau (p-tau). |
2017-11-16 |
2023-01-26 |
human |
| C Dioli, P Patr\\xc3\\xadcio, R Trindade, L G Pinto, J M Silva, M Morais, E Ferreiro, S Borges, A Mateus-Pinheiro, A J Rodrigues, N Sousa, J M Bessa, L Pinto, I Sotiropoulo. Tau-dependent suppression of adult neurogenesis in the stressed hippocampus. Molecular psychiatry vol 22 issue 8 2017 28555078 |
these data establish tau as a critical regulator of the cellular cascades underlying stress deficits on hippocampal neurogenesis in the adult brain. |
2017-11-13 |
2023-01-26 |
mouse |
| Yipeng Wang, Varun Balaji, Senthilvelrajan Kaniyappan, Lars Kr\\xc3\\xbcger, Stephan Irsen, Katharina Tepper, RamReddy Chandupatla, Walter Maetzler, Anja Schneider, Eckhard Mandelkow, Eva-Maria Mandelko. The release and trans-synaptic transmission of Tau via exosomes. Molecular neurodegeneration vol 12 issue 1 2017 28086931 |
tau pathology in ad spreads in a hierarchical pattern, whereby it first appears in the entorhinal cortex, then spreads to the hippocampus and later to the surrounding areas. |
2017-11-09 |
2023-01-26 |
Not clear |
| Deyan Kong, Qian Liu, Guangxu Xu, Zhenhua Huang, Ning Luo, Yuanheng Huang, Keshu Ca. Synergistic effect of tanshinone IIA and mesenchymal stem cells on preventing learning and memory deficits via anti-apoptosis, attenuating tau phosphorylation and enhancing the activity of central cholinergic system in vascular dementia. Neuroscience letters vol 637 issue 2017 27845241 |
the combined administration of tsa and mscs demonstrated a synergistic effect on suppressing neuronal apoptosis in the hippocampus, attenuating tau phosphorylation and enhancing the activity of central cholinergic system. |
2017-10-31 |
2023-01-26 |
rat |
| Sosuke Yagishita, Seiya Suzuki, Keisuke Yoshikawa, Keiko Iida, Ayako Hirata, Masahiko Suzuki, Akihiko Takashima, Kei Maruyama, Akira Hirasawa, Takeo Awaj. Treatment of intermittent hypoxia increases phosphorylated tau in the hippocampus via biological processes common to aging. Molecular brain vol 10 issue 1 2017 28057021 |
treatment of intermittent hypoxia increases phosphorylated tau in the hippocampus via biological processes common to aging. |
2017-10-30 |
2023-01-26 |
mouse |
| N\\xc3\\xbabia Broetto, Fernanda Hansen, Giovana Brolese, Cristiane Batassini, Franciane Lirio, Fabiana Galland, Jo\\xc3\\xa3o Paulo Almeida Dos Santos, M\\xc3\\xa1rcio Ferreira Dutra, Carlos-Alberto Gon\\xc3\\xa7alve. Intracerebroventricular administration of okadaic acid induces hippocampal glucose uptake dysfunction and tau phosphorylation. Brain research bulletin vol 124 issue 2017 27108544 |
intracerebroventricular administration of okadaic acid induces hippocampal glucose uptake dysfunction and tau phosphorylation. |
2017-10-26 |
2023-01-25 |
rat |
| N\\xc3\\xbabia Broetto, Fernanda Hansen, Giovana Brolese, Cristiane Batassini, Franciane Lirio, Fabiana Galland, Jo\\xc3\\xa3o Paulo Almeida Dos Santos, M\\xc3\\xa1rcio Ferreira Dutra, Carlos-Alberto Gon\\xc3\\xa7alve. Intracerebroventricular administration of okadaic acid induces hippocampal glucose uptake dysfunction and tau phosphorylation. Brain research bulletin vol 124 issue 2017 27108544 |
we herein investigated the effect of intracerebroventricular (icv) infusion of oka (100 and 200ng) on hippocampal tau phosphorylation at ser396, which is considered an important fibrillogenic tau protein site, and on glucose uptake, which is reduced early in ad. |
2017-10-26 |
2023-01-25 |
rat |
| N\\xc3\\xbabia Broetto, Fernanda Hansen, Giovana Brolese, Cristiane Batassini, Franciane Lirio, Fabiana Galland, Jo\\xc3\\xa3o Paulo Almeida Dos Santos, M\\xc3\\xa1rcio Ferreira Dutra, Carlos-Alberto Gon\\xc3\\xa7alve. Intracerebroventricular administration of okadaic acid induces hippocampal glucose uptake dysfunction and tau phosphorylation. Brain research bulletin vol 124 issue 2017 27108544 |
icv infusion of oka (at 200ng) induced a spatial cognitive deficit, hippocampal astrogliosis (based on gfap increment) and increase in tau phosphorylation at site 396 in this model. |
2017-10-26 |
2023-01-25 |
rat |
| Maud Gratuze, Emmanuel Plane. Regulation of brain insulin signaling: A new function for tau. The Journal of experimental medicine vol 214 issue 8 2017 28652305 |
they find that tau deletion impairs hippocampal response to insulin through irs-1 and pten dysregulation and suggest that, in alzheimer's disease, impairment of brain insulin signaling might occur via tau loss of function. |
2017-10-26 |
2023-01-26 |
Not clear |
| Masaki Takao, Nobuyoshi Hirose, Yasumichi Arai, Ban Mihara, Masaru Mimur. Neuropathology of supercentenarians - four autopsy case studies. Acta neuropathologica communications vol 4 issue 1 2017 27590044 |
in particular, we focused on the pathology of alzheimer's disease and lewy body disease, as well as the status of hippocampal sclerosis, tdp-43 pathology, aging-related tau astrogliopathy, and cerebrovascular diseases. |
2017-10-25 |
2023-01-25 |
human |
| Toshiki Uchihara, Kentaro Endo, Hiromi Kondo, Sachi Okabayashi, Nobuhiro Shimozawa, Yasuhiro Yasutomi, Eijiro Adachi, Nobuyuki Kimur. Tau pathology in aged cynomolgus monkeys is progressive supranuclear palsy/corticobasal degeneration- but not Alzheimer disease-like -Ultrastructural mapping of tau by EDX. Acta neuropathologica communications vol 4 issue 1 2017 27842611 |
we found, 1) extensive deposition of a\xce\xb2 in brains of cynomolgus monkeys over 25\xc2\xa0years of age, 2) selective deposition of 4-repeat tau as pretangles in neurons, and as coiled body-like structures in oligodendroglia-like cells and astrocytes, 3) preferential distribution of tau in the basal ganglia and neocortex rather than the hippocampus, and 4) age-associated increases in 30-34\xc2\xa0kda at8- and rd4-positive tau fragments in sarkosyl-insoluble fractions. |
2017-10-24 |
2023-01-26 |
human |
| Keith A Josephs, Dennis W Dickson, Nirubol Tosakulwong, Stephen D Weigand, Melissa E Murray, Leonard Petrucelli, Amanda M Liesinger, Matthew L Senjem, Anthony J Spychalla, David S Knopman, Joseph E Parisi, Ronald C Petersen, Clifford R Jack, Jennifer L Whitwel. Rates of hippocampal atrophy and presence of post-mortem TDP-43 in patients with Alzheimer's disease: a longitudinal retrospective study. The Lancet. Neurology vol 16 issue 11 2017 28919059 |
post-mortem studies have not identified an association between \xce\xb2-amyloid or tau and rates of hippocampal atrophy in patients with alzheimer's disease. |
2017-10-20 |
2023-01-26 |
Not clear |
| Zhao-Xu Zhang, Rui-Ping Zhao, De-Sheng Wang, An-Ning Wan. Fuzhisan ameliorates A\\xce\\xb2 production and tau phosphorylation in hippocampal of 11month old APP/PS1 transgenic mice: A Western blot study. Experimental gerontology vol 84 issue 2017 27612601 |
fuzhisan ameliorates a\xce\xb2 production and tau phosphorylation in hippocampal of 11month old app/ps1 transgenic mice: a western blot study. |
2017-10-12 |
2023-01-25 |
rat |