| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Willem Huijbers, Aaron P Schultz, Kathryn V Papp, Molly R LaPoint, Bernard Hanseeuw, Jasmeer P Chhatwal, Trey Hedden, Keith A Johnson, Reisa A Sperlin. Tau Accumulation in Clinically Normal Older Adults Is Associated with Hippocampal Hyperactivity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 3. 2019-10-16. PMID:30482786. |
together, the findings support a hypothetical model of the evolution of preclinical ad that place hippocampal hyperactivity concurrent with spread of tau pathology to neocortical regions before clinical impairment. |
2019-10-16 |
2023-08-13 |
human |
| Ramon Velazquez, Eric Ferreira, An Tran, Emily C Turner, Ramona Belfiore, Caterina Branca, Salvatore Odd. Acute tau knockdown in the hippocampus of adult mice causes learning and memory deficits. Aging cell. vol 17. issue 4. 2019-10-14. PMID:29749079. |
acute tau knockdown in the hippocampus of adult mice causes learning and memory deficits. |
2019-10-14 |
2023-08-13 |
mouse |
| Ramon Velazquez, Eric Ferreira, An Tran, Emily C Turner, Ramona Belfiore, Caterina Branca, Salvatore Odd. Acute tau knockdown in the hippocampus of adult mice causes learning and memory deficits. Aging cell. vol 17. issue 4. 2019-10-14. PMID:29749079. |
we found that acute knockdown of tau in the adult hippocampus significantly impaired motor coordination and spatial memory. |
2019-10-14 |
2023-08-13 |
mouse |
| Liang Cai, Kai Lu, Xin Chen, Jing-Yuan Huang, Bao-Ping Zhang, Han Zhan. Auricular vagus nerve stimulation protects against postoperative cognitive dysfunction by attenuating neuroinflammation and neurodegeneration in aged rats. Neuroscience letters. vol 703. 2019-10-11. PMID:30904576. |
concomitant with these beneficial effects, we found that treatment with avns attenuated postoperative neuroinflammation (i.e., the protein level of interleukin-1β and tumor necrosis factor-α, along with the nuclear protein expression of nf-κb) and alzheimer's-related pathology (tau phosphorylation at at-8 and ser396, as well as the levels of aβ40 and aβ42) in the hippocampus of the aged rats. |
2019-10-11 |
2023-08-13 |
rat |
| Salil Sharma, Ines Khadimallah, Adam Williamson Corya, Yousuf Omar Ali, Xi Rao, Yunlong Liu, Hui-Chen L. Presymptomatic change in microRNAs modulates Tau pathology. Scientific reports. vol 8. issue 1. 2019-10-09. PMID:29915328. |
to explore whether mir alterations in tauopathy contribute to pathological conditions, we first determined which hippocampal mirs are altered at the presymptomatic and symptomatic stages of tauopathy using rtg4510 mice (tau mice), a well-characterized tauopathy model. |
2019-10-09 |
2023-08-13 |
mouse |
| Tomas Ondrejcak, Igor Klyubin, Grant T Corbett, Graham Fraser, Wei Hong, Alexandra J Mably, Matthew Gardener, Jayne Hammersley, Michael S Perkinton, Andrew Billinton, Dominic M Walsh, Michael J Rowa. Cellular Prion Protein Mediates the Disruption of Hippocampal Synaptic Plasticity by Soluble Tau The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 50. 2019-10-09. PMID:30355631. |
cellular prion protein mediates the disruption of hippocampal synaptic plasticity by soluble tau intracellular neurofibrillary tangles (nfts) composed of tau protein are a neuropathological hallmark of several neurodegenerative diseases, the most common of which is alzheimer's disease (ad). |
2019-10-09 |
2023-08-13 |
rat |
| Tomas Ondrejcak, Igor Klyubin, Grant T Corbett, Graham Fraser, Wei Hong, Alexandra J Mably, Matthew Gardener, Jayne Hammersley, Michael S Perkinton, Andrew Billinton, Dominic M Walsh, Michael J Rowa. Cellular Prion Protein Mediates the Disruption of Hippocampal Synaptic Plasticity by Soluble Tau The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 50. 2019-10-09. PMID:30355631. |
here we investigated the effect of different tau species on synaptic plasticity in the male rat hippocampus |
2019-10-09 |
2023-08-13 |
rat |
| Lindsay A Welikovitch, Sonia Do Carmo, Zsófia Maglóczky, Péter Szocsics, János Lőke, Tamás Freund, A Claudio Cuell. Evidence of intraneuronal Aβ accumulation preceding tau pathology in the entorhinal cortex. Acta neuropathologica. vol 136. issue 6. 2019-10-09. PMID:30362029. |
using well-characterized monoclonal antibodies, we demonstrate that the age-dependent intraneuronal accumulation of soluble aβ is pervasive throughout the entorhinal cortex and hippocampus, and that this phase of the amyloid pathology becomes established within ad-vulnerable regions before the deposition of aβ plaques and the formation of tau neurofibrillary tangles. |
2019-10-09 |
2023-08-13 |
human |
| Kurt A Jellinge. Different patterns of hippocampal tau pathology in Alzheimer's disease and PART. Acta neuropathologica. vol 136. issue 5. 2019-10-08. PMID:30088091. |
different patterns of hippocampal tau pathology in alzheimer's disease and part. |
2019-10-08 |
2023-08-13 |
Not clear |
| Lisa Müller-Ehrenberg, Joost M Riphagen, Frans R J Verhey, Alexander T Sack, Heidi I L Jacob. Alzheimer's Disease Biomarkers Have Distinct Associations with Specific Hippocampal Subfield Volumes. Journal of Alzheimer's disease : JAD. vol 66. issue 2. 2019-10-08. PMID:30320590. |
these biomarker relationships with hippocampal subfield volumes seem to mirror the hippocampal-specific topography of aβ and tau reported in neuropathological staging models. |
2019-10-08 |
2023-08-13 |
human |
| Alexander J Moszczynski, Jason Gopaul, Patrick McCunn, Kathryn Volkening, Madeline Harvey, Robert Bartha, Susanne Schmid, Michael J Stron. Somatic Gene Transfer Using a Recombinant Adenoviral Vector (rAAV9) Encoding Pseudophosphorylated Human Thr175 Tau in Adult Rat Hippocampus Induces Tau Pathology. Journal of neuropathology and experimental neurology. vol 77. issue 8. 2019-10-03. PMID:29878234. |
somatic gene transfer using a recombinant adenoviral vector (raav9) encoding pseudophosphorylated human thr175 tau in adult rat hippocampus induces tau pathology. |
2019-10-03 |
2023-08-13 |
human |
| Alexander J Moszczynski, Jason Gopaul, Patrick McCunn, Kathryn Volkening, Madeline Harvey, Robert Bartha, Susanne Schmid, Michael J Stron. Somatic Gene Transfer Using a Recombinant Adenoviral Vector (rAAV9) Encoding Pseudophosphorylated Human Thr175 Tau in Adult Rat Hippocampus Induces Tau Pathology. Journal of neuropathology and experimental neurology. vol 77. issue 8. 2019-10-03. PMID:29878234. |
to determine whether pthr175 tau can induce tau pathology in vivo with an accompanying clinical phenotype, we used a recombinant adenoviral expression vector (raav9) to express a gfp-tagged thr175asp tau protein construct in adult female sprague-dawley rat hippocampus. |
2019-10-03 |
2023-08-13 |
human |
| João Vaz-Silva, Patrícia Gomes, Qi Jin, Mei Zhu, Viktoriya Zhuravleva, Sebastian Quintremil, Torcato Meira, Joana Silva, Chrysoula Dioli, Carina Soares-Cunha, Nikolaos P Daskalakis, Nuno Sousa, Ioannis Sotiropoulos, Clarissa L Waite. Endolysosomal degradation of Tau and its role in glucocorticoid-driven hippocampal malfunction. The EMBO journal. vol 37. issue 20. 2019-10-01. PMID:30166454. |
endolysosomal degradation of tau and its role in glucocorticoid-driven hippocampal malfunction. |
2019-10-01 |
2023-08-13 |
Not clear |
| João Vaz-Silva, Patrícia Gomes, Qi Jin, Mei Zhu, Viktoriya Zhuravleva, Sebastian Quintremil, Torcato Meira, Joana Silva, Chrysoula Dioli, Carina Soares-Cunha, Nikolaos P Daskalakis, Nuno Sousa, Ioannis Sotiropoulos, Clarissa L Waite. Endolysosomal degradation of Tau and its role in glucocorticoid-driven hippocampal malfunction. The EMBO journal. vol 37. issue 20. 2019-10-01. PMID:30166454. |
furthermore, we find that gc impair tau degradation by decreasing rab35 levels, and that aav-mediated expression of rab35 in the hippocampus rescues gc-induced tau accumulation and related neurostructural deficits. |
2019-10-01 |
2023-08-13 |
Not clear |
| Xuejin Cao, Hanrong Xu, Weixi Feng, Dongyuan Su, Ming Xia. Deletion of aquaporin-4 aggravates brain pathology after blocking of the meningeal lymphatic drainage. Brain research bulletin. vol 143. 2019-09-30. PMID:30347264. |
ldclns increased total and phosphorylated tau protein levels in the hippocampus of both genotype mice, but increased hippocampal amyloid beta 1-40 and 1-42 levels only in aqp4 null mice, with up-regulation of beta-site amyloid precursor protein-cleaving enzyme 1 and down-regulation of insulin degrading enzyme. |
2019-09-30 |
2023-08-13 |
mouse |
| Albert Lladó, Adrià Tort-Merino, Raquel Sánchez-Valle, Neus Falgàs, Mircea Balasa, Beatriz Bosch, Magda Castellví, Jaume Olives, Anna Antonell, Michael Hornberge. The hippocampal longitudinal axis-relevance for underlying tau and TDP-43 pathology. Neurobiology of aging. vol 70. 2019-09-27. PMID:29935415. |
the hippocampal longitudinal axis-relevance for underlying tau and tdp-43 pathology. |
2019-09-27 |
2023-08-13 |
human |
| Dong Liu, Hanbing Lu, Elliot Stein, Zhujuan Zhou, Yihong Yang, Mark P Mattso. Brain regional synchronous activity predicts tauopathy in 3×TgAD mice. Neurobiology of aging. vol 70. 2019-09-27. PMID:30015035. |
compared to age-matched wild-type mice, 6- to 8-month-old 3×tgad mice exhibited increased regional homogeneity in the hippocampus and parietal and temporal cortices, regions with tau pathology but not aβ pathology at this age. |
2019-09-27 |
2023-08-13 |
mouse |
| Dong Liu, Hanbing Lu, Elliot Stein, Zhujuan Zhou, Yihong Yang, Mark P Mattso. Brain regional synchronous activity predicts tauopathy in 3×TgAD mice. Neurobiology of aging. vol 70. 2019-09-27. PMID:30015035. |
by 18-24 months of age, 3×tgad mice exhibited extensive tau and aβ pathologies involving the hippocampus and multiple functionally related brain regions, with a spatial expansion of increased local synchronous activity to include those regions. |
2019-09-27 |
2023-08-13 |
mouse |
| Yanning Li, Runtao Ding, Xinghua Ren, Gehua Wen, Zhibin Dong, Hui Yao, Yaqing Tan, Hao Yu, Xiaolong Wang, Xiaoni Zhan, Jun Yao, Yan Lu, Guohua Zhang, Xu W. Long-term ketamine administration causes Tau protein phosphorylation and Tau protein-dependent AMPA receptor reduction in the hippocampus of mice. Toxicology letters. vol 315. 2019-09-23. PMID:31470060. |
long-term ketamine administration causes tau protein phosphorylation and tau protein-dependent ampa receptor reduction in the hippocampus of mice. |
2019-09-23 |
2023-08-13 |
mouse |
| Yanning Li, Runtao Ding, Xinghua Ren, Gehua Wen, Zhibin Dong, Hui Yao, Yaqing Tan, Hao Yu, Xiaolong Wang, Xiaoni Zhan, Jun Yao, Yan Lu, Guohua Zhang, Xu W. Long-term ketamine administration causes Tau protein phosphorylation and Tau protein-dependent AMPA receptor reduction in the hippocampus of mice. Toxicology letters. vol 315. 2019-09-23. PMID:31470060. |
in this study, we established a model of long-term (6 months) ketamine administration in wild-type (c57bl/6) and tau knockout mice to investigate the effects of different doses of ketamine administration on tau protein expression and phosphorylation in the mouse hippocampus. |
2019-09-23 |
2023-08-13 |
mouse |