| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ting Cui, Hong-Mei Qiu, Dan Huang, Qi-Xin Zhou, Xiao-Yan Fu, Hai-Yan Li, Xin-Hui Jian. Abnormal levels of seven amino neurotransmitters in depressed rat brain and determination by HPLC-FLD. Biomedical chromatography : BMC vol 31 issue 8 2017 28097679 |
the results showed that asp, gly, tau and gaba significantly decreased with increasing gln in the hippocampus of depressed rats, compared with that of the control group, among which obviously lower level of asp and higher level of gln in cortex were observed. |
2017-07-26 |
2023-01-26 |
rat |
| Ting Yang, Shaomin Li, Huixin Xu, Dominic M Walsh, Dennis J Selko. Large Soluble Oligomers of Amyloid \\xce\\xb2-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 37 issue 1 2017 28053038 |
soluble oligomers of amyloid \xce\xb2-protein (oa\xce\xb2) isolated from the brains of alzheimer's disease (ad) patients have been shown experimentally (in the absence of amyloid plaques) to impair hippocampal synaptic plasticity, decrease synapses, induce tau hyperphosphorylation and neuritic dystrophy, activate microglial inflammation, and impair memory in normal adult rodents. |
2017-07-24 |
2023-01-26 |
mouse |
| V Cubinkov\\xc3\\xa1, B Valachov\\xc3\\xa1, V Brezov\\xc3\\xa1kov\\xc3\\xa1, R Szab\\xc3\\xb3, I Zimov\\xc3\\xa1, Z Kosteck\\xc3\\xa1, S Jadha. Next generation tau models in Alzheimer's disease research - virus based gene delivery systems. Acta virologica vol 61 issue 1 2017 28105850 |
major advantage of aav as a delivery system is the site specific expression of tau, mostly in hippocampus and cortex, and thus elimination of unwanted ectopic transgene expression. |
2017-06-29 |
2023-01-26 |
Not clear |
| Michael F Almeida, Carolliny M Silva, Aline M D'Unhao, Merari F R Ferrar. Aged Lewis rats exposed to low and moderate doses of rotenone are a good model for studying the process of protein aggregation and its effects upon central nervous system cell physiology. Arquivos de neuro-psiquiatria vol 74 issue 9 2017 27706423 |
hyperphosphorylated tau, alpha-synuclein, amyloid-beta peptide and protein carbonylation (indicative of oxidative stress) were evaluated in the hippocampus, substantia nigra and locus coeruleus through immunohistochemistry or western blot. |
2017-06-28 |
2023-01-26 |
rat |
| Noem\\xc3\\xad Pallas-Bazarra, Jer\\xc3\\xb3nimo Jurado-Arjona, Marta Navarrete, Jose A Esteban, F\\xc3\\xa9lix Hern\\xc3\\xa1ndez, Jes\\xc3\\xbas \\xc3\\x81vila, Mar\\xc3\\xada Llorens-Mart\\xc3\\xad. Novel function of Tau in regulating the effects of external stimuli on adult hippocampal neurogenesis. The EMBO journal vol 35 issue 13 2017 27198172 |
novel function of tau in regulating the effects of external stimuli on adult hippocampal neurogenesis. |
2017-06-26 |
2023-01-25 |
mouse |
| Noem\\xc3\\xad Pallas-Bazarra, Jer\\xc3\\xb3nimo Jurado-Arjona, Marta Navarrete, Jose A Esteban, F\\xc3\\xa9lix Hern\\xc3\\xa1ndez, Jes\\xc3\\xbas \\xc3\\x81vila, Mar\\xc3\\xada Llorens-Mart\\xc3\\xad. Novel function of Tau in regulating the effects of external stimuli on adult hippocampal neurogenesis. The EMBO journal vol 35 issue 13 2017 27198172 |
here, we show that tau plays a novel in\xc2\xa0vivo role in the morphological and synaptic maturation of newborn hippocampal granule neurons under basal conditions. |
2017-06-26 |
2023-01-25 |
mouse |
| Noem\\xc3\\xad Pallas-Bazarra, Jer\\xc3\\xb3nimo Jurado-Arjona, Marta Navarrete, Jose A Esteban, F\\xc3\\xa9lix Hern\\xc3\\xa1ndez, Jes\\xc3\\xbas \\xc3\\x81vila, Mar\\xc3\\xada Llorens-Mart\\xc3\\xad. Novel function of Tau in regulating the effects of external stimuli on adult hippocampal neurogenesis. The EMBO journal vol 35 issue 13 2017 27198172 |
thus, our data demonstrate that tau(-/-) mice show impairments in the maturation of newborn granule neurons under basal conditions and that they are insensitive to the modulation of adult hippocampal neurogenesis exerted by both stimulatory and detrimental stimuli. |
2017-06-26 |
2023-01-25 |
mouse |
| Mohammad A Yousuf, Chunfeng Tan, Melissa I Torres-Altoro, Fang-Min Lu, Erik Plautz, Shanrong Zhang, Masaya Takahashi, Adan Hernandez, Steven G Kernie, Florian Plattner, James A Bib. Involvement of aberrant cyclin-dependent kinase 5/p25 activity in experimental traumatic brain injury. Journal of neurochemistry vol 138 issue 2 2017 26998748 |
here, we show that mice subjected to controlled cortical impact (cci), a well-established experimental tbi model, exhibit increased p25 levels and consistently elevated cdk5-dependent phosphorylation of microtubule-associated protein tau and retinoblastoma (rb) protein in hippocampal lysates. |
2017-06-23 |
2023-01-25 |
mouse |
| Tara E Tracy, Peter Dongmin Sohn, S Sakura Minami, Chao Wang, Sang-Won Min, Yaqiao Li, Yungui Zhou, David Le, Iris Lo, Ravikumar Ponnusamy, Xin Cong, Birgit Schilling, Lisa M Ellerby, Richard L Huganir, Li Ga. Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss. Neuron vol 90 issue 2 2017 27041503 |
transgenic mice expressing human tau with lysine-to-glutamine mutations to mimic k274 and k281 acetylation (taukq) exhibit ad-related memory deficits and impaired hippocampal long-term potentiation (ltp). |
2017-06-19 |
2023-01-25 |
human |
| Liviu-Gabriel Bodea, Harrison Tudor Evans, Ann Van der Jeugd, Lars M Ittner, Fabien Delerue, Jillian Kril, Glenda Halliday, John Hodges, Mathew C Kiernan, J\\xc3\\xbcrgen G\\xc3\\xb6t. Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model. Aging cell vol 16 issue 2 2017 28160413 |
unlike samp8 mice, pr5 mice are characterized by a robust tau pathology particularly in the amygdala and hippocampus. |
2017-06-19 |
2023-01-26 |
mouse |
| Liang Zhao, Yan Xiao, Xiao-Liang Wang, Jinjing Pei, Zhi-Zhong Gua. Original Research: Influence of okadaic acid on hyperphosphorylation of tau and nicotinic acetylcholine receptors in primary neurons. Experimental biology and medicine (Maywood, N.J.) vol 241 issue 16 2017 27190248 |
primary cultures of neurons isolated from the hippocampus of the brains of neonatal rats were exposed to okadaic acid or/and a\xce\xb21-42 tau phosphorylated at ser404 and ser202, and the protein expressions of \xce\xb17, \xce\xb14 and \xce\xb13 nachr subunits were quantified by western blotting, and their corresponding mrnas by real-time pcr. |
2017-06-06 |
2023-01-25 |
rat |
| Sarada Subramanian, Ganesh Savanur, Sowmya Madhavada. Passive immunization targeting the N-terminal region of phosphorylated tau (residues 68-71) improves spatial memory in okadaic acid induced tauopathy model rats. Biochemical and biophysical research communications vol 483 issue 1 2017 27998769 |
the cognitive impairment in patients with ad is closely associated with loss of synapses and the formation of neurofibrillary tangles (nft) containing hyperphosphorylated tau in the hippocampus. |
2017-06-06 |
2023-01-26 |
rat |
| Xiaoguang Li, Zhihao Wang, Lu Tan, Yali Wang, Chengbiao Lu, Rongxiang Chen, Shujuan Zhang, Yuan Gao, Yanchao Liu, Yaling Yin, Xinghua Liu, Enjie Liu, Ying Yang, Yu Hu, Zhipeng Xu, Fuqiang Xu, Jie Wang, Gong-Ping Liu, Jian-Zhi Wan. Correcting miR92a-vGAT-Mediated GABAergic Dysfunctions Rescues Human Tau-Induced Anxiety in Mice. Molecular therapy : the journal of the American Society of Gene Therapy vol 25 issue 1 2017 28129110 |
here, we found that overexpression of human wild-type, full-length tau (termed htau) in hippocampus significantly decreased the extracellular \xce\xb3-aminobutyric acid (gaba) level with inhibition of \xce\xb3 oscillation and the evoked inhibitory postsynaptic potential (eipsp). |
2017-06-06 |
2023-01-26 |
mouse |
| Xin You Tai, Matthias Koepp, John S Duncan, Nick Fox, Pamela Thompson, Sallie Baxendale, Joan Y W Liu, Cheryl Reeves, Zuzanna Michalak, Maria Tho. Hyperphosphorylated tau in patients with refractory epilepsy correlates with cognitive decline: a study of temporal lobe resections. Brain : a journal of neurology vol 139 issue Pt 9 2017 27497924 |
we also found unusual patterns of subpial tau deposition, sparing of the hippocampus and co-localization with mossy fibre sprouting, a feature of temporal lobe epilepsy. |
2017-06-05 |
2023-01-25 |
Not clear |
| Cyril Laurent, Guillaume Doroth\\xc3\\xa9e, St\\xc3\\xa9phane Hunot, Elodie Martin, Yann Monnet, Marie Duchamp, Yuan Dong, Fran\\xc3\\xa7ois-Pierre L\\xc3\\xa9geron, Antoine Leboucher, Sylvie Burnouf, Emilie Faivre, K\\xc3\\xa9vin Carvalho, Rapha\\xc3\\xablle Caillierez, Nad\\xc3\\xa8ge Zommer, Dominique Demeyer, Nathalie Jouy, Veronique Sazdovitch, Susanna Schraen-Maschke, C\\xc3\\xa9cile Delarasse, Luc Bu\\xc3\\xa9e, David Blu. Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy. Brain : a journal of neurology vol 140 issue 1 2017 27818384 |
to address this question, we took advantage of the thy-tau22 mouse model that progressively develops hippocampal tau pathology paralleling cognitive deficits and reappraised the interrelationship between tau pathology and brain immune responses. |
2017-06-05 |
2023-01-26 |
mouse |
| Cyril Laurent, Guillaume Doroth\\xc3\\xa9e, St\\xc3\\xa9phane Hunot, Elodie Martin, Yann Monnet, Marie Duchamp, Yuan Dong, Fran\\xc3\\xa7ois-Pierre L\\xc3\\xa9geron, Antoine Leboucher, Sylvie Burnouf, Emilie Faivre, K\\xc3\\xa9vin Carvalho, Rapha\\xc3\\xablle Caillierez, Nad\\xc3\\xa8ge Zommer, Dominique Demeyer, Nathalie Jouy, Veronique Sazdovitch, Susanna Schraen-Maschke, C\\xc3\\xa9cile Delarasse, Luc Bu\\xc3\\xa9e, David Blu. Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy. Brain : a journal of neurology vol 140 issue 1 2017 27818384 |
in addition to conventional astroglial and microglial responses, we identified a cd8-positive t cell infiltration in the hippocampus of tau transgenic mice associated with an early chemokine response, notably involving ccl3. |
2017-06-05 |
2023-01-26 |
mouse |
| Cyril Laurent, Guillaume Doroth\\xc3\\xa9e, St\\xc3\\xa9phane Hunot, Elodie Martin, Yann Monnet, Marie Duchamp, Yuan Dong, Fran\\xc3\\xa7ois-Pierre L\\xc3\\xa9geron, Antoine Leboucher, Sylvie Burnouf, Emilie Faivre, K\\xc3\\xa9vin Carvalho, Rapha\\xc3\\xablle Caillierez, Nad\\xc3\\xa8ge Zommer, Dominique Demeyer, Nathalie Jouy, Veronique Sazdovitch, Susanna Schraen-Maschke, C\\xc3\\xa9cile Delarasse, Luc Bu\\xc3\\xa9e, David Blu. Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy. Brain : a journal of neurology vol 140 issue 1 2017 27818384 |
such anti-cd3 treatment prevented hippocampal t cell infiltration in tau transgenic animals and reverted spatial memory deficits, in absence of tau pathology modulation. |
2017-06-05 |
2023-01-26 |
mouse |
| Lucas T Woods, Deepa Ajit, Jean M Camden, Laurie Erb, Gary A Weisma. Purinergic receptors as potential therapeutic targets in Alzheimer's disease. Neuropharmacology vol 104 issue 2017 26519903 |
many of the pathological characteristics associated with ad are revealed post-mortem, including amyloid-\xce\xb2 plaque deposition, neurofibrillary tangles containing hyperphosphorylated tau proteins and neuronal loss in the hippocampus and cortex. |
2017-05-26 |
2023-01-25 |
human |
| Richard Kvetnansky, Petr Novak, Peter Vargovic, Katarina Lejavova, Lubica Horvathova, Katarina Ondicova, George Manz, Peter Filipcik, Michal Novak, Boris Mrave. Exaggerated phosphorylation of brain tau protein in CRH KO mice exposed to repeated immobilization stress. Stress (Amsterdam, Netherlands) vol 19 issue 4 2017 27484105 |
we assessed expression of phosphorylated tau (p-tau) at the phf-1 epitope and ne concentrations in the locus coeruleus (lc), a1/c1 and a2/c2 catecholaminergic cell groups, hippocampus, amygdala, nucleus basalis magnocellularis, and frontal cortex of unstressed, singly stressed or repeatedly stressed mice. |
2017-05-18 |
2023-01-25 |
mouse |
| Marta Nesteruk, Tomasz Nesteruk, Maria Styczy\\xc5\\x84ska, Monika Mandecka, Anna Barczak, Maria Barcikowsk. Combined use of biochemical and volumetric biomarkers to assess the risk of conversion of mild cognitive impairment to Alzheimer's disease. Folia neuropathologica vol 54 issue 4 2017 28139818 |
the aim of our study was to evaluate the usefulness of several biomarkers in predicting the conversion of mild cognitive impairment (mci) to alzheimer's disease (ad): \xce\xb2-amyloid and tau proteins in cerebrospinal fluid and the volumetric evaluation of brain structures including the hippocampus in magnetic resonance imaging (mri). |
2017-05-09 |
2023-01-26 |
Not clear |