| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Biswanath Dinda, Manikarna Dinda, Goutam Kulsi, Ankita Chakraborty, Subhajit Dind. Therapeutic potentials of plant iridoids in Alzheimer's and Parkinson's diseases: A review. European journal of medicinal chemistry. vol 169. 2019-05-28. PMID:30877973. |
ad is characterized by deposition of extracellular beta-amyloid (aβ) proteins and intracellular neurofibrillary tangles (nft), composed of hyperphosphorylated tau proteins in the neurons located particularly in hippocampus and cerebral cortex regions of brain, resulting the neuronal loss, while pd is characterized by deposition of intraneuronal aggregates of mostly composed of alpha-synuclein gene as lewy bodies (lb) in the striatal region, known as substantia nigra pars compacta (snpc) of brain, leading to the death of dopaminergic neurons. |
2019-05-28 |
2023-08-13 |
Not clear |
| Luana Heimfarth, Jeferson Delgado, Moara Rodrigues Mignori, Daniel Pens Gelain, José Cláudio Fonseca Moreira, Regina Pessoa-Pureu. Developmental neurotoxicity of the hippocampus following in utero exposure to methylmercury: impairment in cell signaling. Archives of toxicology. vol 92. issue 1. 2019-05-24. PMID:28821999. |
downregulated pi3k/akt/mtor pathway and activated/hypophosphorylated (ser9) gsk3β in mehg-treated pups could be upstream of hyperphosphorylated tau (ser396) destabilizing microtubules and contributing to neural dysfunction in the hippocampus of these rats. |
2019-05-24 |
2023-08-13 |
rat |
| Jacki M Rorabaugh, Termpanit Chalermpalanupap, Christian A Botz-Zapp, Vanessa M Fu, Natalie A Lembeck, Robert M Cohen, David Weinshenke. Chemogenetic locus coeruleus activation restores reversal learning in a rat model of Alzheimer's disease. Brain : a journal of neurology. vol 140. issue 11. 2019-05-23. PMID:29053824. |
in tgf344-ad rats, hyperphosphorylated tau was detected in the locus coeruleus prior to accrual in the medial entorhinal cortex or hippocampus, and tau pathology in the locus coeruleus was negatively correlated with noradrenergic innervation in the medial entorhinal cortex. |
2019-05-23 |
2023-08-13 |
human |
| Heidi I L Jacobs, Trey Hedden, Aaron P Schultz, Jorge Sepulcre, Rodrigo D Perea, Rebecca E Amariglio, Kathryn V Papp, Dorene M Rentz, Reisa A Sperling, Keith A Johnso. Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals. Nature neuroscience. vol 21. issue 3. 2019-05-15. PMID:29403032. |
to investigate these ideas in humans, we combined amyloid scans with longitudinal data on white matter connectivity, hippocampal volume, tau positron emission tomography and memory performance in 256 cognitively healthy older individuals. |
2019-05-15 |
2023-08-13 |
Not clear |
| Yasemin Bilgic, Enver Ahmet Demir, Nilufer Bilgic, Hatice Dogan, Okan Tutuk, Cemil Tume. Detrimental effects of chia (Salvia hispanica L.) seeds on learning and memory in aluminum chloride‑induced experimental Alzheimer's disease. Acta neurobiologiae experimentalis. vol 78. issue 4. 2019-05-07. PMID:30624431. |
hippocampal concentrations of amyloid-β42, amyloid precursor protein, and total tau protein were similarly increased in all disease‑induced animals (despite chia supplementation), as compared to the controls. |
2019-05-07 |
2023-08-13 |
rat |
| Mariarosa Anna Beatrice Melone, Clemente Dato, Simona Paladino, Cinzia Coppola, Claudia Trebini, Maria Teresa Giordana, Lorena Perron. Verapamil Inhibits Ser202/Thr205 Phosphorylation of Tau by Blocking TXNIP/ROS/p38 MAPK Pathway. Pharmaceutical research. vol 35. issue 2. 2019-04-29. PMID:29404777. |
since thioredoxin interacting protein (txnip), the inhibitor of the anti-oxidant system of thioredoxin, is up regulated in the hippocampus of ad patients, we investigated whether txnip plays a role in promoting tau phosphorylation and whether verapamil, an inhibitor of txnip expression, prevents txnip downstream effects. |
2019-04-29 |
2023-08-13 |
Not clear |
| Jing Guo, Shaozhou Ni, Qihang Li, Jian-Zhi Wang, Ying Yan. Folate/Vitamin B Alleviates Hyperhomocysteinemia-Induced Alzheimer-Like Pathologies in Rat Retina. Neuroscience bulletin. vol 35. issue 2. 2019-04-29. PMID:30264378. |
our previous study demonstrated that hhcy induces memory deficits with ad-like tau and amyloid-β (aβ) pathologies in the hippocampus, and supplementation with folate and vitamin b12 (fb) prevents the hhcy-induced ad-like pathologies in the hippocampus. |
2019-04-29 |
2023-08-13 |
rat |
| Tian Li, Juan-Juan Jiao, Christian Hölscher, Mei-Na Wu, Jun Zhang, Jia-Qing Tong, Xue-Fan Dong, Xue-Song Qu, Yue Cao, Hong-Yan Cai, Qiang Su, Jin-Shun Q. A novel GLP-1/GIP/Gcg triagonist reduces cognitive deficits and pathology in the 3xTg mouse model of Alzheimer's disease. Hippocampus. vol 28. issue 5. 2019-04-16. PMID:29473979. |
in addition, the triagonist significantly reduced hippocampal pathological damages, including amyloid-β (aβ) and phosphorylated tau aggregates, and upregulated the expression levels of |
2019-04-16 |
2023-08-13 |
mouse |
| Thalia Garvock-de Montbrun, Emre Fertan, Kurt Stover, Richard E Brow. Motor deficits in 16-month-old male and female 3xTg-AD mice. Behavioural brain research. vol 356. 2019-04-16. PMID:30208295. |
the 3xtg-ad mice develop extracellular aβ plaques and tau tangles in the hippocampus and motor cortex between 6 and 9 months of age. |
2019-04-16 |
2023-08-13 |
mouse |
| Xiaomei Wang, Dai Cheng, Weibo Jiang, Yuxia M. Mechanisms Underlying Aluminum Neurotoxicity Related to 14-3-3ζ Protein. Toxicological sciences : an official journal of the Society of Toxicology. vol 163. issue 1. 2019-04-15. PMID:29385627. |
by immune analysis with antibodies against tau, we found that tau accumulation mainly located in the neurons of cornu amonis 3 and dentate gyrus of the rat hippocampus. |
2019-04-15 |
2023-08-13 |
rat |
| Xiaomei Wang, Dai Cheng, Weibo Jiang, Yuxia M. Mechanisms Underlying Aluminum Neurotoxicity Related to 14-3-3ζ Protein. Toxicological sciences : an official journal of the Society of Toxicology. vol 163. issue 1. 2019-04-15. PMID:29385627. |
total free tau in hippocampus tissue and in neuronal cells increased 26.0% and 20.2%, respectively after al-exposure. |
2019-04-15 |
2023-08-13 |
rat |
| Xiaomei Wang, Dai Cheng, Weibo Jiang, Yuxia M. Mechanisms Underlying Aluminum Neurotoxicity Related to 14-3-3ζ Protein. Toxicological sciences : an official journal of the Society of Toxicology. vol 163. issue 1. 2019-04-15. PMID:29385627. |
by immunofluorescent staining, we found that the levels of tau and 14-3-3ζ co-location declined 15.9% or 12.1% in the hippocampus tissue or in neuronal cells after al exposure. |
2019-04-15 |
2023-08-13 |
rat |
| Vincent Maleysson, Guylène Page, Thierry Janet, Ronald L Klein, Obélia Haida, Anne Maurin, Serge Richard, Pascal Champeroux, Bernard Fauconnea. Relevance of electroencephalogram assessment in amyloid and tau pathology in rat. Behavioural brain research. vol 359. 2019-04-03. PMID:30367970. |
beta amyloid deposits and hyperphosphorylated tau are observed by immunohistofluorescence, only in the hippocampus. |
2019-04-03 |
2023-08-13 |
human |
| Amina Chaalal, Roseline Poirier, David Blum, Serge Laroche, Valérie Enderli. Thyroid Hormone Supplementation Restores Spatial Memory, Hippocampal Markers of Neuroinflammation, Plasticity-Related Signaling Molecules, and β-Amyloid Peptide Load in Hypothyroid Rats. Molecular neurobiology. vol 56. issue 1. 2019-04-01. PMID:29796989. |
we have previously reported that the antithyroid molecule propylthiouracil (ptu) given in the drinking water favors cerebral atrophy, brain neuroinflammation, aβ production, tau hyperphosphorylation, and altered plasticity-related cell-signaling pathways in the hippocampus in association with hippocampal-dependent spatial memory deficits. |
2019-04-01 |
2023-08-13 |
rat |
| Gozal Bahlakeh, Mehrdad Jahanshahi, Mohsen Saeid. Human chorionic gonadotropin decreases the phosphorylated tau protein level in streptozotocin-Alzheimeric male rats' hippocampus. Folia neuropathologica. vol 56. issue 2. 2019-03-28. PMID:30509034. |
human chorionic gonadotropin decreases the phosphorylated tau protein level in streptozotocin-alzheimeric male rats' hippocampus. |
2019-03-28 |
2023-08-13 |
mouse |
| Gozal Bahlakeh, Mehrdad Jahanshahi, Mohsen Saeid. Human chorionic gonadotropin decreases the phosphorylated tau protein level in streptozotocin-Alzheimeric male rats' hippocampus. Folia neuropathologica. vol 56. issue 2. 2019-03-28. PMID:30509034. |
the pharmacological suppression of luteinising hormone or human chorionic gonadotropin (hcg) can reduce aβ plaques in the brains of rats and mice, but the effects of hcg on the phosphorylated tau protein level in the hippocampus have not been studied. |
2019-03-28 |
2023-08-13 |
mouse |
| Gozal Bahlakeh, Mehrdad Jahanshahi, Mohsen Saeid. Human chorionic gonadotropin decreases the phosphorylated tau protein level in streptozotocin-Alzheimeric male rats' hippocampus. Folia neuropathologica. vol 56. issue 2. 2019-03-28. PMID:30509034. |
therefore, we investigated the effects of hcg on the phosphorylated tau protein level and its effect on hcg receptor-immunoreactive neuron density in the hippocampus of alzheimer's disease (ad) model rats (streptozotocin [stz] injected intracerebroventricularly). |
2019-03-28 |
2023-08-13 |
mouse |
| Li Jin, Li Lin, Guo-Yong Li, Sha Liu, Dan-Ju Luo, Qiong Feng, Dong-Sheng Sun, Wei Wang, Jian-Jun Liu, Qun Wang, Dan Ke, Xi-Fei Yang, Gong-Ping Li. Monosodium glutamate exposure during the neonatal period leads to cognitive deficits in adult Sprague-Dawley rats. Neuroscience letters. vol 682. 2019-03-11. PMID:29885453. |
we found that neonatal msg exposure induced hyperglycemia as well as alzheimer-like learning and memory deficits with decreased dendritic spine density and hippocampal synaptic-related protein expression and increased phosphorylated tau levels in ∼3-month-old sd rats. |
2019-03-11 |
2023-08-13 |
rat |
| Isabel Barón-Mendoza, Octavio García, Erika Calvo-Ochoa, Jorge Omar Rebollar-García, Daniel Garzón-Cortés, Reyes Haro, Aliesha González-Arena. Alterations in neuronal cytoskeletal and astrocytic proteins content in the brain of the autistic-like mouse strain C58/J. Neuroscience letters. vol 682. 2019-03-11. PMID:29885454. |
our results show that autistic-like mice present: 1) region-dependent altered expression and phosphorylation patterns of tau isoforms, associated with anomalous microtubule depolymerization; 2) reduced map2 a content in prefrontal cortex; 3) region-dependent changes in cofilin expression and phosphorylation, associated with abnormal actin filament depolymerizing dynamics; 4) diminished synaptopodin levels in the hippocampus; and 5) reduced content of the astrocyte-secreted protein tsp-1 in the prefrontal cortex and hippocampus. |
2019-03-11 |
2023-08-13 |
mouse |
| Cheril Tapia-Rojas, Nibaldo C Inestros. Wnt signaling loss accelerates the appearance of neuropathological hallmarks of Alzheimer's disease in J20-APP transgenic and wild-type mice. Journal of neurochemistry. vol 144. issue 4. 2019-03-08. PMID:29240990. |
wnt signaling inhibitors induced severe changes in the hippocampus, including alterations in wnt pathway components and loss of wnt signaling function, severe cognitive deficits, increased tau phosphorylation and aβ |
2019-03-08 |
2023-08-13 |
mouse |