| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Teng Jiang, Ying-Dong Zhang, Jun-Shan Zhou, Xi-Chen Zhu, You-Yong Tian, Hong-Dong Zhao, Huan Lu, Qing Gao, Lan Tan, Jin-Tai Y. Angiotensin-(1-7) is Reduced and Inversely Correlates with Tau Hyperphosphorylation in Animal Models of Alzheimer's Disease. Molecular neurobiology vol 53 issue 4 2016 26044748 |
more importantly, an inverse correlation was found between ang-(1-7) level and tau hyperphosphorylation, a pathological hallmark of ad, in cerebral cortex and hippocampus of samp8 mice. |
2016-12-26 |
2023-01-25 |
mouse |
| Beatriz E Garc\\xc3\\xada-G\\xc3\\xb3mez, Francisco J Fern\\xc3\\xa1ndez-G\\xc3\\xb3mez, Encarnaci\\xc3\\xb3n Mu\\xc3\\xb1oz-Delgado, Luc Bu\\xc3\\xa9e, David Blum, Cecilio J Vida. MRNA Levels of ACh-Related Enzymes in the Hippocampus of THY-Tau22 Mouse: A Model of Human Tauopathy with No Signs of Motor Disturbance. Journal of molecular neuroscience : MN vol 58 issue 4 2016 26697857 |
the reports showing a hippocampal downregulation of choline acetyltransferase (chat) in samp8 mice, a model of aging, and an upregulation of acetylcholinesterase (ache) in tg-vlw mice, a model of ftdp17 tauopathy, may lead to think that the supply of ach to the hippocampus can be threatened as aging or tau pathology progress. |
2016-12-26 |
2023-01-25 |
mouse |
| Xiao-Ping Hong, Tao Chen, Ni-Na Yin, Yong-Ming Han, Fang Yuan, Yan-Jun Duan, Feng Shen, Yan-Hong Zhang, Ze-Bin Che. Puerarin Ameliorates D-Galactose Induced Enhanced Hippocampal Neurogenesis and Tau Hyperphosphorylation in Rat Brain. Journal of Alzheimer's disease : JAD vol 51 issue 2 2016 26890737 |
puerarin ameliorates d-galactose induced enhanced hippocampal neurogenesis and tau hyperphosphorylation in rat brain. |
2016-12-20 |
2023-01-25 |
rat |
| Xiao-Ping Hong, Tao Chen, Ni-Na Yin, Yong-Ming Han, Fang Yuan, Yan-Jun Duan, Feng Shen, Yan-Hong Zhang, Ze-Bin Che. Puerarin Ameliorates D-Galactose Induced Enhanced Hippocampal Neurogenesis and Tau Hyperphosphorylation in Rat Brain. Journal of Alzheimer's disease : JAD vol 51 issue 2 2016 26890737 |
enhanced neurogenesis has been reported in the hippocampus of patients with alzheimer's disease (ad), the most common neurodegenerative disorder characterized with amyloid-\xce\xb2 (a\xce\xb2) aggregation, tau hyperphosphorylation, and progressive neuronal loss. |
2016-12-20 |
2023-01-25 |
rat |
| Xiao-Ping Hong, Tao Chen, Ni-Na Yin, Yong-Ming Han, Fang Yuan, Yan-Jun Duan, Feng Shen, Yan-Hong Zhang, Ze-Bin Che. Puerarin Ameliorates D-Galactose Induced Enhanced Hippocampal Neurogenesis and Tau Hyperphosphorylation in Rat Brain. Journal of Alzheimer's disease : JAD vol 51 issue 2 2016 26890737 |
previously we reported that tau phosphorylation played an essential role in adult hippocampal neurogenesis, and activation of glycogen synthase kinase (gsk-3), a crucial tau kinase, could induce increased hippocampal neurogenesis. |
2016-12-20 |
2023-01-25 |
rat |
| Xiao-Ping Hong, Tao Chen, Ni-Na Yin, Yong-Ming Han, Fang Yuan, Yan-Jun Duan, Feng Shen, Yan-Hong Zhang, Ze-Bin Che. Puerarin Ameliorates D-Galactose Induced Enhanced Hippocampal Neurogenesis and Tau Hyperphosphorylation in Rat Brain. Journal of Alzheimer's disease : JAD vol 51 issue 2 2016 26890737 |
in the present study, we found that treatment of d-galactose rats with puerarin could significantly improve behavioral performance and ameliorate the enhanced neurogenesis and microtubule-associated protein tau hyperphosphorylation in the hippocampus of d-galactose rat brains. |
2016-12-20 |
2023-01-25 |
rat |
| Xiao-Ping Hong, Tao Chen, Ni-Na Yin, Yong-Ming Han, Fang Yuan, Yan-Jun Duan, Feng Shen, Yan-Hong Zhang, Ze-Bin Che. Puerarin Ameliorates D-Galactose Induced Enhanced Hippocampal Neurogenesis and Tau Hyperphosphorylation in Rat Brain. Journal of Alzheimer's disease : JAD vol 51 issue 2 2016 26890737 |
fgf-2/gsk-3 signaling pathway might be involved in the effects of puerarin on hippocampal neurogenesis and tau hyperphosphorylation. |
2016-12-20 |
2023-01-25 |
rat |
| Xiao-Ping Hong, Tao Chen, Ni-Na Yin, Yong-Ming Han, Fang Yuan, Yan-Jun Duan, Feng Shen, Yan-Hong Zhang, Ze-Bin Che. Puerarin Ameliorates D-Galactose Induced Enhanced Hippocampal Neurogenesis and Tau Hyperphosphorylation in Rat Brain. Journal of Alzheimer's disease : JAD vol 51 issue 2 2016 26890737 |
our finding provides primary in vivo evidence that puerarin can attenuate ad-like enhanced hippocampal neurogenesis and tau hyperphosphorylation. |
2016-12-20 |
2023-01-25 |
rat |
| F L'Episcopo, J Drouin-Ouellet, C Tirolo, A Pulvirenti, R Giugno, N Testa, S Caniglia, M F Serapide, G Cisbani, R A Barker, F Cicchetti, B Marchett. GSK-3\\xce\\xb2-induced Tau pathology drives hippocampal neuronal cell death in Huntington's disease: involvement of astrocyte-neuron interactions. Cell death & disease vol 7 issue 2016 27124580 |
we identified a disease and stage-dependent upregulation of gsk-3\xce\xb2 mrna and protein levels in the hd hippocampus, with the active isoform pgsk-3\xce\xb2-tyr(216) being strongly expressed in dentate gyrus (dg) neurons and astrocytes at a time when phosphorylation of tau at the at8 epitope was also present in these same neurons. |
2016-12-15 |
2023-01-25 |
mouse |
| Naiara Celarain, Javier S\\xc3\\xa1nchez-Ruiz de Gordoa, Mar\\xc3\\xada Victoria Zelaya, Miren Rold\\xc3\\xa1n, Rosa Larumbe, Laura Pulido, Carmen Echavarri, Maite Mendioro. TREM2 upregulation correlates with 5-hydroxymethycytosine enrichment in Alzheimer's disease hippocampus. Clinical epigenetics vol 8 issue 2016 27051467 |
we measured trem2 mrna levels in the hippocampus in a cohort of neuropathologically confirmed controls and pure ad cases showing no other protein deposits than \xce\xb2-amyloid and phosphorylated tau. |
2016-12-14 |
2023-01-25 |
human |
| Susanne P Pallo, John DiMaio, Alexis Cook, Bradley Nilsson, Gail V W Johnso. Mechanisms of tau and A\\xce\\xb2-induced excitotoxicity. Brain research vol 1634 issue 2016 26731336 |
in vivo studies showed that tau knockout (tau(-/-)) mice were significantly protected from seizures and hippocampal superoxide production induced with the glutamate analog, kainic acid (ka). |
2016-12-13 |
2023-01-25 |
rat |
| Liang Cheng, Shao-Hui Wang, Yun Huang, Xiao-Mei Lia. The hippocampus may be more susceptible to environmental noise than the auditory cortex. Hearing research vol 333 issue 2016 26773751 |
results showed significant peroxidation and tau hyperphosphorylation in the hippocampus with 1 week of noise exposure. |
2016-12-13 |
2023-01-25 |
mouse |
| Chunxia Huang, Olivia Tsz-Wa Ng, Yuen-Shan Ho, Michael Garnet Irwin, Raymond Chuen-Chung Chang, Gordon Tin-Chun Won. Effect of Continuous Propofol Infusion in Rat on Tau Phosphorylation with or without Temperature Control. Journal of Alzheimer's disease : JAD vol 51 issue 1 2016 26836157 |
propofol with hypothermia significantly increased phosphorylation of tau at at8, at180, thr205, and ser199 in cortex and hippocampus except ser396. |
2016-12-13 |
2023-01-25 |
rat |
| Na Qu, Xiang-Yu Zhou, Li Han, Lei Wang, Jia-Xin Xu, Teng Zhang, Jiang Chu, Qiao Chen, Jian-Zhi Wang, Qi Zhang, Qing Tia. Combination of PPT with LiCl Treatment Prevented Bilateral Ovariectomy-Induced Hippocampal-Dependent Cognition Deficit in Rats. Molecular neurobiology vol 53 issue 2 2016 25535091 |
after the combination treatment of these two drugs (ppt + licl), the improved learning and memory abilities of ovariectomized rats in morris water maze, increased dendritic spines in ca1 region, and decreased tau phosphorylation at ser-396 in hippocampus were observed. |
2016-11-14 |
2023-01-25 |
rat |
| Eleonora Gatta, Tony Lefebvre, Silvana Gaetani, Marc dos Santos, Jordan Marrocco, Anne-Marie Mir, Tommaso Cassano, Stefania Maccari, Ferdinando Nicoletti, J\\xc3\\xa9r\\xc3\\xb4me Mairess. Evidence for an imbalance between tau O-GlcNAcylation and phosphorylation in the hippocampus of a mouse model of Alzheimer's disease. Pharmacological research vol 105 issue 2016 26816085 |
evidence for an imbalance between tau o-glcnacylation and phosphorylation in the hippocampus of a mouse model of alzheimer's disease. |
2016-11-11 |
2023-01-25 |
mouse |
| Eleonora Gatta, Tony Lefebvre, Silvana Gaetani, Marc dos Santos, Jordan Marrocco, Anne-Marie Mir, Tommaso Cassano, Stefania Maccari, Ferdinando Nicoletti, J\\xc3\\xa9r\\xc3\\xb4me Mairess. Evidence for an imbalance between tau O-GlcNAcylation and phosphorylation in the hippocampus of a mouse model of Alzheimer's disease. Pharmacological research vol 105 issue 2016 26816085 |
in these mice, we showed that tau was hyperphosphorylated on both ser396 and thr205 in the hippocampus, and to a lower extent and exclusively on thr205 in the frontal cortex. |
2016-11-11 |
2023-01-25 |
mouse |
| Eleonora Gatta, Tony Lefebvre, Silvana Gaetani, Marc dos Santos, Jordan Marrocco, Anne-Marie Mir, Tommaso Cassano, Stefania Maccari, Ferdinando Nicoletti, J\\xc3\\xa9r\\xc3\\xb4me Mairess. Evidence for an imbalance between tau O-GlcNAcylation and phosphorylation in the hippocampus of a mouse model of Alzheimer's disease. Pharmacological research vol 105 issue 2016 26816085 |
tau o-glcnacylation, assessed in tau immunoprecipitates, was substantially reduced in the hippocampus of 3xtg-ad mice, with no changes in the frontal cortex or in the cerebellum. |
2016-11-11 |
2023-01-25 |
mouse |
| Sulana K Schroeder, Aurelie Joly-Amado, Marcia N Gordon, Dave Morga. Tau-Directed Immunotherapy: A Promising Strategy for Treating Alzheimer's Disease and Other Tauopathies. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology vol 11 issue 1 2016 26538351 |
pathological improvements as measured by gallyas staining for fully formed tangles and phosphorylated tau appeared 4 days after intracranial injection into the hippocampus. |
2016-11-09 |
2023-01-25 |
Not clear |
| YoungDoo Kim, Hyunwoo Choi, WonJae Lee, Hyejin Park, Tae-In Kam, Se-Hoon Hong, Jihoon Nah, Sunmin Jung, Bora Shin, Huikyong Lee, Tae-Yong Choi, Hyosun Choo, Kyung-Keun Kim, Se-Young Choi, Rakez Kayed, Yong-Keun Jun. Caspase-cleaved tau exhibits rapid memory impairment associated with tau oligomers in a transgenic mouse model. Neurobiology of disease vol 87 issue 2016 26704708 |
injection with rapamycin significantly reduced the amounts of tau oligomers in the hippocampus, rescued spine density, and attenuated memory impairment in tauc3 mice. |
2016-10-20 |
2023-01-25 |
mouse |
| T L Platt, T L Beckett, K Kohler, D M Niedowicz, M P Murph. Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease. Neuroscience vol 315 issue 2016 26701291 |
the resulting phenotype included a striking increase in tau phosphorylation and the number of neurofibrillary tangles (nfts) found within the hippocampus. |
2016-10-19 |
2023-01-25 |
mouse |