| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuanyuan Liu, Mengying Wei, Kexin Yue, Mingxin Hu, Shizhe Li, Lihui Men, Zifeng Pi, Zhiqiang Liu, Zhongying Li. Study on Urine Metabolic Profile of Aβ25-35-Induced Alzheimer's Disease Using UHPLC-Q-TOF-MS. Neuroscience. vol 394. 2019-03-01. PMID:30316910. |
the results showed that compared with healthy control rats, ad rats suffered from cognitive dysfunction, hippocampus damage, aβ formation and tau phosphorylation at 8 weeks after surgery, suggesting that the aβ25-35-induced ad model was successfully established. |
2019-03-01 |
2023-08-13 |
rat |
| Yali Zhang, Jiahui Zhang, Enhao Wang, Wei Qian, Yan Fan, Ying Feng, Haimeng Yin, Yang Li, Yuning Wang, Tianli Yua. Microcystin-Leucine-Arginine Induces Tau Pathology Through Bα Degradation via Protein Phosphatase 2A Demethylation and Associated Glycogen Synthase Kinase-3β Phosphorylation. Toxicological sciences : an official journal of the Society of Toxicology. vol 162. issue 2. 2019-02-25. PMID:29228318. |
the results showed that mc-lr treatment significantly increased demethylation of pp2ac, with a concomitant increase in gsk-3β phosphorylation at ser9 resulting in elevated tau hyperphosphorylation at pp2a-favorable sites in sh-sy5y cells and rat hippocampus. |
2019-02-25 |
2023-08-13 |
rat |
| Chunxia Huang, John Man-Tak Chu, Yan Liu, Raymond Chuen-Chung Chang, Gordon Tin-Chun Won. Varenicline reduces DNA damage, tau mislocalization and post surgical cognitive impairment in aged mice. Neuropharmacology. vol 143. 2019-02-25. PMID:30273594. |
glia activation, aberrant tau phosphorylation (at8) and accumulation of phosphorylated h2ax in the hippocampus were detectable up to postoperative day 14, with neuronal apoptosis seen in the hippocampus. |
2019-02-25 |
2023-08-13 |
mouse |
| Gabriel Keine Kuga, Vitor Rosetto Muñoz, Rafael Calais Gaspar, Susana Castelo Branco Ramos Nakandakari, Adelino Sanchez Ramos da Silva, José Diego Botezelli, José Alexandre Curiacos de Almeida Leme, Ricardo José Gomes, Leandro Pereira de Moura, Dennys Esper Cintra, Eduardo Rochete Ropelle, José Rodrigo Paul. Impaired insulin signaling and spatial learning in middle-aged rats: The role of PTP1B. Experimental gerontology. vol 104. 2019-02-19. PMID:29421605. |
in this context, our study aims to investigate the age-related changes in ptp1b content, insulin signaling, β-amyloid content, and tau phosphorylation in the hippocampus of middle-aged rats. |
2019-02-19 |
2023-08-13 |
rat |
| Gabriel Keine Kuga, Vitor Rosetto Muñoz, Rafael Calais Gaspar, Susana Castelo Branco Ramos Nakandakari, Adelino Sanchez Ramos da Silva, José Diego Botezelli, José Alexandre Curiacos de Almeida Leme, Ricardo José Gomes, Leandro Pereira de Moura, Dennys Esper Cintra, Eduardo Rochete Ropelle, José Rodrigo Paul. Impaired insulin signaling and spatial learning in middle-aged rats: The role of PTP1B. Experimental gerontology. vol 104. 2019-02-19. PMID:29421605. |
also, the aging process increased tau phosphorylation and β-amyloid content in the hippocampus region. |
2019-02-19 |
2023-08-13 |
rat |
| Ercan Babür, Burak Tan, Sumeyra Delibaş, Marwa Yousef, Nurcan Dursun, Cem Süe. Depotentiation of Long-Term Potentiation Is Associated with Epitope-Specific Tau Hyper-/Hypophosphorylation in the Hippocampus of Adult Rats. Journal of molecular neuroscience : MN. vol 67. issue 2. 2019-02-19. PMID:30498986. |
depotentiation of long-term potentiation is associated with epitope-specific tau hyper-/hypophosphorylation in the hippocampus of adult rats. |
2019-02-19 |
2023-08-13 |
rat |
| Ercan Babür, Burak Tan, Sumeyra Delibaş, Marwa Yousef, Nurcan Dursun, Cem Süe. Depotentiation of Long-Term Potentiation Is Associated with Epitope-Specific Tau Hyper-/Hypophosphorylation in the Hippocampus of Adult Rats. Journal of molecular neuroscience : MN. vol 67. issue 2. 2019-02-19. PMID:30498986. |
western blot experiments indicated that tau protein was hyperphosphorylated at ser416 epitope but rather hypophosphorylated at thr231 epitope in the whole hippocampus upon depotentiation of ltp. |
2019-02-19 |
2023-08-13 |
rat |
| Ercan Babür, Burak Tan, Sumeyra Delibaş, Marwa Yousef, Nurcan Dursun, Cem Süe. Depotentiation of Long-Term Potentiation Is Associated with Epitope-Specific Tau Hyper-/Hypophosphorylation in the Hippocampus of Adult Rats. Journal of molecular neuroscience : MN. vol 67. issue 2. 2019-02-19. PMID:30498986. |
these findings indicate that some forms of long-term plastic changes might be related with epitope-specific tau phosphorylation and erk1/2 activation in the hippocampus. |
2019-02-19 |
2023-08-13 |
rat |
| Philip Regan, Daniel J Whitcomb, Kwangwook Ch. Physiological and Pathophysiological Implications of Synaptic Tau. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 23. issue 2. 2019-02-18. PMID:26908138. |
in particular, long-term depression, a form of synaptic weakening, is dependent on the presence of tau in hippocampal neurons. |
2019-02-18 |
2023-08-13 |
Not clear |
| Edna Maria Camelo Chaves, Jose Eduardo Ribeiro Honório-Júnior, Caren Nádia Soares Sousa, Valdécio Silveira Monteiro, Dayanne Terra Tenório Nonato, Leonardo Pimentel Dantas, Ana Silvia Suassuna Carneiro Lúcio, José Maria Barbosa-Filho, Manoel Cláudio Azevedo Patrocínio, Glauce Socorro Barros Viana, Silvânia Maria Mendes Vasconcelo. The anxiolytic-like effect of 6-styryl-2-pyrone in mice involves GABAergic mechanism of action. Metabolic brain disease. vol 33. issue 1. 2019-01-31. PMID:29086102. |
after behavioral tests, these animals were sacrificed and had their prefrontal cortex (pfc), hippocampus (hc) and striatum (st) dissected for assaying amino acids (aspartate- asp, glutamate- glu, glycine- gly, taurine- tau and gamma-aminobutyric acid- gaba). |
2019-01-31 |
2023-08-13 |
mouse |
| Suvi R K Hokkanen, Sally Hunter, Tuomo M Polvikoski, Hannah A D Keage, Thais Minett, Fiona E Matthews, Carol Brayn. Hippocampal sclerosis, hippocampal neuron loss patterns and TDP-43 in the aged population. Brain pathology (Zurich, Switzerland). vol 28. issue 4. 2019-01-23. PMID:28833898. |
we developed a semi-quantitative protocol, which captures various hippocampal neuron loss patterns, and compared their occurrence in the context of hs-aging, tdp-43, vascular and tau pathology in 672 brains (tdp-43 staining n = 642/672, 96%) donated for the population-based cambridge city over-75s cohort and the cognitive function and ageing study. |
2019-01-23 |
2023-08-13 |
Not clear |
| Kristen R Montgomery, A S C Louis Sam Titus, Lulu Wang, Santosh R D'Mell. Elevated MeCP2 in Mice Causes Neurodegeneration Involving Tau Dysregulation and Excitotoxicity: Implications for the Understanding and Treatment of MeCP2 Triplication Syndrome. Molecular neurobiology. vol 55. issue 12. 2019-01-18. PMID:29637441. |
mecp2-tg mice display elevated gfap and tau expression within the hippocampus and cortex followed by neuronal loss in these brain regions. |
2019-01-18 |
2023-08-13 |
mouse |
| Andrew Arner, Edward Rockenstein, Michael Mante, Jazmin Florio, Deborah Masliah, Bahar Salehi, Anthony Adame, Cassia Overk, Eliezer Masliah, Robert A Rissma. Increased Vulnerability of the Hippocampus in Transgenic Mice Overexpressing APP and Triple Repeat Tau. Journal of Alzheimer's disease : JAD. vol 61. issue 3. 2019-01-17. PMID:29332037. |
increased vulnerability of the hippocampus in transgenic mice overexpressing app and triple repeat tau. |
2019-01-17 |
2023-08-13 |
mouse |
| Andrew Arner, Edward Rockenstein, Michael Mante, Jazmin Florio, Deborah Masliah, Bahar Salehi, Anthony Adame, Cassia Overk, Eliezer Masliah, Robert A Rissma. Increased Vulnerability of the Hippocampus in Transgenic Mice Overexpressing APP and Triple Repeat Tau. Journal of Alzheimer's disease : JAD. vol 61. issue 3. 2019-01-17. PMID:29332037. |
we found that even in young animals we found that the presence of app/aβ increased the accumulation of 3r tau in the neocortex and hippocampus. |
2019-01-17 |
2023-08-13 |
mouse |
| Siddhartha Mondragón-Rodríguez, Anahí Salas-Gallardo, Perla González-Pereyra, Martín Macías, Benito Ordaz, Fernando Peña-Ortega, Azucena Aguilar-Vázquez, Erika Orta-Salazar, Sofía Díaz-Cintra, George Perry, Sylvain William. Phosphorylation of Tau protein correlates with changes in hippocampal theta oscillations and reduces hippocampal excitability in Alzheimer's model. The Journal of biological chemistry. vol 293. issue 22. 2019-01-16. PMID:29632073. |
phosphorylation of tau protein correlates with changes in hippocampal theta oscillations and reduces hippocampal excitability in alzheimer's model. |
2019-01-16 |
2023-08-13 |
mouse |
| Siddhartha Mondragón-Rodríguez, Anahí Salas-Gallardo, Perla González-Pereyra, Martín Macías, Benito Ordaz, Fernando Peña-Ortega, Azucena Aguilar-Vázquez, Erika Orta-Salazar, Sofía Díaz-Cintra, George Perry, Sylvain William. Phosphorylation of Tau protein correlates with changes in hippocampal theta oscillations and reduces hippocampal excitability in Alzheimer's model. The Journal of biological chemistry. vol 293. issue 22. 2019-01-16. PMID:29632073. |
mechanistically, we show that pyramidal neurons and some parvalbumin-positive interneurons in 1-month-old triple-transgenic ad mice accumulate hyperphosphorylated tau protein and that this accumulation correlates with changes in theta oscillations in hippocampal neurons. |
2019-01-16 |
2023-08-13 |
mouse |
| Yuetao Wen, Qingyuan Wu, Quanhong Shi, Yanfeng Xie, Wei Dan, YangMei Chen, Limin M. UCH-L1 inhibition aggravates mossy fiber sprouting in the pentylenetetrazole kindling model. Biochemical and biophysical research communications. vol 503. issue 4. 2019-01-14. PMID:29964011. |
our results suggest that uch-l1 may be associated with hippocampal msf followed the epileptogenesis through mediating phosphorylation of tau. |
2019-01-14 |
2023-08-13 |
rat |
| Xinghua Liu, Kuan Zeng, Mengzhu Li, Qun Wang, Rong Liu, Bin Zhang, Jian-Zhi Wang, Xiji Shu, Xiaochuan Wan. Expression of P301L-hTau in mouse MEC induces hippocampus-dependent memory deficit. Scientific reports. vol 7. issue 1. 2019-01-11. PMID:28634382. |
interestingly, expression of the mutant tau in mec induces endogenous tau hyperphosphorylation and accumulation in hippocampus and cortex, and inhibits neuronal activity with attenuated pp-dg synapse plasticity, leading to hippocampus-dependent memory deficit with intact olfactory function. |
2019-01-11 |
2023-08-13 |
mouse |
| Elena Lonati, Gessica Sala, Viviana Tresoldi, Silvia Coco, Domenico Salerno, Chiara Milani, Morris Losurdo, Francesca Farina, Laura Botto, Carlo Ferrarese, Paola Palestini, Alessandra Bulbarell. Ischemic Conditions Affect Rerouting of Tau Protein Levels: Evidences for Alteration in Tau Processing and Secretion in Hippocampal Neurons. Journal of molecular neuroscience : MN. vol 66. issue 4. 2019-01-10. PMID:30421280. |
ischemic conditions affect rerouting of tau protein levels: evidences for alteration in tau processing and secretion in hippocampal neurons. |
2019-01-10 |
2023-08-13 |
Not clear |
| Elena Lonati, Gessica Sala, Viviana Tresoldi, Silvia Coco, Domenico Salerno, Chiara Milani, Morris Losurdo, Francesca Farina, Laura Botto, Carlo Ferrarese, Paola Palestini, Alessandra Bulbarell. Ischemic Conditions Affect Rerouting of Tau Protein Levels: Evidences for Alteration in Tau Processing and Secretion in Hippocampal Neurons. Journal of molecular neuroscience : MN. vol 66. issue 4. 2019-01-10. PMID:30421280. |
thus, we investigated the effect of oxygen-glucose deprivation (ogd), an experimental condition mimicking cerebral ischemia, in search of alteration in tau processing and secretion in hippocampal neurons primary cultures. |
2019-01-10 |
2023-08-13 |
Not clear |