| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sang-Won Min, Xu Chen, Tara E Tracy, Yaqiao Li, Yungui Zhou, Chao Wang, Kotaro Shirakawa, S Sakura Minami, Erwin Defensor, Sue Ann Mok, Peter Dongmin Sohn, Birgit Schilling, Xin Cong, Lisa Ellerby, Bradford W Gibson, Jeffrey Johnson, Nevan Krogan, Mehrdad Shamloo, Jason Gestwicki, Eliezer Masliah, Eric Verdin, Li Ga. Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits. Nature medicine vol 21 issue 10 2016 26390242 |
in the ps19 transgenic mouse model of ftd, administration of salsalate after disease onset inhibited p300 activity, lowered levels of total tau and tau acetylated at k174, rescued tau-induced memory deficits and prevented hippocampal atrophy. |
2016-01-19 |
2023-01-25 |
mouse |
| Alon Seifan, Karen S Marder, Jesse Mez, James M Noble, Etty P Cortes, Jean Paul Vonsattel, Lawrence S Honi. Hippocampal laminar distribution of tau relates to Alzheimer's disease and age of onset. Journal of Alzheimer's disease : JAD vol 43 issue 1 2016 25079799 |
hippocampal laminar distribution of tau relates to alzheimer's disease and age of onset. |
2016-01-15 |
2023-01-25 |
Not clear |
| Yunqing Ma, Dongke Wu, Wei Zhang, Jiankun Liu, Siping Chen, Binghong Hu. Investigation of PI3K/PKB/mTOR/S6K1 signaling pathway in relationship of type 2 diabetes and Alzheimer's disease. International journal of clinical and experimental medicine vol 8 issue 10 2016 26770471 |
based on the high-sugar high-fat diet, the single intraperitoneal injection of streptozotocin was performed to induce the t2dm rat model; the immunohistochemistry and rt-pcr technique were then performed to detect the expression levels of mtor, pi3k, pkb, s6k1 and phosphorylated tau protein in the hippocampal tissues of each group. |
2016-01-15 |
2023-01-25 |
Not clear |
| Yunqing Ma, Dongke Wu, Wei Zhang, Jiankun Liu, Siping Chen, Binghong Hu. Investigation of PI3K/PKB/mTOR/S6K1 signaling pathway in relationship of type 2 diabetes and Alzheimer's disease. International journal of clinical and experimental medicine vol 8 issue 10 2016 26770471 |
the related metabolic indicators of the t2dm group and the t2dm + ad group were significantly higher than the normal control group and the ad group (p<0.01); the morris water maze test of the ad group and the learning and memory of the t2dm + ad group were than significantly decreased than the t2dm group (p<0.01); the t2dm + ad group exhibited significantly increased expression levels of mtor, s6k1 and tau protein in the hippocampal tissues than the ad group and the t2dm group (p<0.05), and while the expression levels of pi3k and pkb were decreased (p<0.05). |
2016-01-15 |
2023-01-25 |
Not clear |
| Jochen Martin Decker, Lars Kr\\xc3\\xbcger, Astrid Sydow, Shanting Zhao, Michael Frotscher, Eckhard Mandelkow, Eva-Maria Mandelko. Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca(++) dysregulation. Acta neuropathologica communications vol 3 issue 2016 25853683 |
we used an inducible mouse model expressing the tau repeat domain with the pro-aggregant mutation \xce\x94k280 to analyze presynaptic tau pathology in the hippocampus. |
2016-01-13 |
2023-01-25 |
Not clear |
| Daniel J Whitcomb, Elek Moln\\xc3\\xa1. Is riluzole a new drug for Alzheimer's disease? Journal of neurochemistry vol 135 issue 2 2016 26451974 |
the authors employed a comprehensive analysis of possible restorative effects of the drug by examining glutamate levels in subregions of the hippocampus, expression of tau and its hyper-phosphorylated forms, and memory function using behavioral tests. |
2016-01-12 |
2023-01-25 |
Not clear |
| Charles Duyckaerts, Heiko Braak, Jean-Pierre Brion, Luc Bu\\xc3\\xa9e, Kelly Del Tredici, Michel Goedert, Glenda Halliday, Manuela Neumann, Maria Grazia Spillantini, Markus Tolnay, Toshiki Uchihar. PART is part of Alzheimer disease. Acta neuropathologica vol 129 issue 5 2016 25628035 |
it has been proposed that tau aggregation confined to entorhinal cortex and hippocampus, with no or only minimal a\xce\xb2 deposition, should be considered as a 'primary age-related tauopathy' (part) that is not integral to the continuum of sporadic alzheimer disease (ad). |
2016-01-11 |
2023-01-25 |
Not clear |
| Yun-Chieh Tasi, Ting-Yu Chin, Ying-Ju Chen, Chun-Chih Huang, Shou-Lun Lee, Tzong-Yuan W. Potential natural products for Alzheimer's disease: targeted search using the internal ribosome entry site of tau and amyloid-\\xce\\xb2 precursor protein. International journal of molecular sciences vol 16 issue 4 2016 25903151 |
western blot analysis of the tau protein in neuroblastoma (n2a) and rat hippocampal cells confirmed the halting of the expression of the tau proteins. |
2016-01-11 |
2023-01-25 |
rat |
| De-Lin Ma, Fu-Qiong Chen, Wei-Jie Xu, Wen-Zhu Yue, Gang Yuan, Yan Yan. Early intervention with glucagon-like peptide 1 analog liraglutide prevents tau hyperphosphorylation in diabetic db/db mice. Journal of neurochemistry vol 135 issue 2 2016 26183127 |
we found that db/db mice treated with saline exhibited an age-dependent decrease in csf insulin and an increase in hippocampal tau phosphorylation. |
2016-01-11 |
2023-01-25 |
mouse |
| Hei-Jen Huang, Shu-Ling Chen, Hsiu Mei Hsieh-L. Administration of NaHS Attenuates Footshock-Induced Pathologies and Emotional and Cognitive Dysfunction in Triple Transgenic Alzheimer's Mice. Frontiers in behavioral neuroscience vol 9 issue 2015 26635562 |
under footshock with sr stimulus, amyloid deposition, tau protein hyperphosphorylation, and microgliosis were highly increased in the stress-responsive brain structures, including the hippocampus and amygdala, of the ad mice. |
2015-12-04 |
2023-01-25 |
mouse |
| Eva Louwersheimer, Alfredo Ramirez, Carlos Cruchaga, Tim Becker, Johannes Kornhuber, Oliver Peters, Stefanie Heilmann, Jens Wiltfang, Frank Jessen, Pieter Jelle Visser, Philip Scheltens, Yolande A L Pijnenburg, Charlotte E Teunissen, Frederik Barkhof, John C van Swieten, Henne Holstege, Wiesje M Van der Flie. Influence of genetic variants in SORL1 gene on the manifestation of Alzheimer's disease. Neurobiology of aging vol 36 issue 3 2015 25659857 |
as endophenotype markers we used cognitive tests, cerebrospinal fluid (csf) biomarkers amyloid-beta, total tau (tau), tau phosphorylated at threonine 181, and hippocampal atrophy. |
2015-11-24 |
2023-01-25 |
Not clear |
| G G Kovacs, A J M Rozemuller, J C van Swieten, E Gelpi, K Majtenyi, S Al-Sarraj, C Troakes, I B\\xc3\\xb3di, A King, T Hortob\\xc3\\xa1gyi, M M Esiri, O Ansorge, G Giaccone, I Ferrer, T Arzberger, N Bogdanovic, T Nilsson, I Leisser, I Alafuzoff, J W Ironside, H Kretzschmar, H Budk. Neuropathology of the hippocampus in FTLD-Tau with Pick bodies: a study of the BrainNet Europe Consortium. Neuropathology and applied neurobiology vol 39 issue 2 2015 22471883 |
in view of confusion about the molecular pathology of pick's disease, we aimed to evaluate the spectrum of tau pathology and concomitant neurodegeneration-associated protein depositions in the characteristically affected hippocampus. |
2015-11-13 |
2023-01-25 |
Not clear |
| Junfeng Zhang, Hongying Tan, Wei Jiang, Zhiyi Zu. The choice of general anesthetics may not affect neuroinflammation and impairment of learning and memory after surgery in elderly rats. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology vol 10 issue 1 2015 25649847 |
surgery and anesthesia increased il-1\xce\xb2 and iba-1 but did not affect tau phosphorylated at s199/202 and s396 in the cerebral cortex and hippocampus. |
2015-11-12 |
2023-01-25 |
rat |
| Lei Zhao, Neng Gong, Meng Liu, Xiaoli Pan, Shaoming Sang, Xiaojing Sun, Zhe Yu, Qi Fang, Na Zhao, Guoqiang Fei, Lirong Jin, Chunjiu Zhong, Tianle X. Beneficial synergistic effects of microdose lithium with pyrroloquinoline quinone in an Alzheimer's disease mouse model. Neurobiology of aging vol 35 issue 12 2015 25018109 |
the results showed that li3pqq at a relative low dose (6 and 12\xc2\xa0mg/kg) exhibited more powerful effects in restoring the impairment of learning and memory, facilitating hippocampal long-term potentiation, and reducing cerebral amyloid deposition and phosphorylated tau level in app/ps1 transgenic mice than that of lithium chloride at both low and high dose (5 and 100\xc2\xa0mg/kg). |
2015-11-09 |
2023-01-25 |
Not clear |
| J R Perez-Polo, H C Rea, K M Johnson, M A Parsley, G C Unabia, G-Y Xu, D Prough, D S DeWitt, H Spratt, C E Hulsebosc. A rodent model of mild traumatic brain blast injury. Journal of neuroscience research vol 93 issue 4 2015 25410497 |
there were significant increases in phosphorylated tau (p-tau) levels, a putative precursor to the development of neuroencephalopathy, as early as 6 hr after mbbi in the cortex and the hippocampus but not in the thalamus or the amygdala. |
2015-10-30 |
2023-01-25 |
rat |
| Ivan Milenkovic, Tatjana Petrov, Gabor G Kovac. Patterns of hippocampal tau pathology differentiate neurodegenerative dementias. Dementia and geriatric cognitive disorders vol 38 issue 5-6 2015 25195847 |
patterns of hippocampal tau pathology differentiate neurodegenerative dementias. |
2015-10-26 |
2023-01-25 |
Not clear |
| Ivan Milenkovic, Tatjana Petrov, Gabor G Kovac. Patterns of hippocampal tau pathology differentiate neurodegenerative dementias. Dementia and geriatric cognitive disorders vol 38 issue 5-6 2015 25195847 |
deposits of phosphorylated tau protein and convergence of pathology in the hippocampus are the hallmarks of neurodegenerative tauopathies. |
2015-10-26 |
2023-01-25 |
Not clear |
| Tariq Ahmed, Ann Van der Jeugd, David Blum, Marie-Christine Galas, Rudi D'Hooge, Luc Buee, Detlef Balschu. Cognition and hippocampal synaptic plasticity in mice with a homozygous tau deletion. Neurobiology of aging vol 35 issue 11 2015 24913895 |
cognition and hippocampal synaptic plasticity in mice with a homozygous tau deletion. |
2015-10-19 |
2023-01-25 |
mouse |
| Shan Wang, Shan-lei Zhou, Fang-yuan Min, Jin-ju Ma, Xia-jie Shi, Erika Bereczki, Jing W. mTOR-mediated hyperphosphorylation of tau in the hippocampus is involved in cognitive deficits in streptozotocin-induced diabetic mice. Metabolic brain disease vol 29 issue 3 2015 24682776 |
mtor-mediated hyperphosphorylation of tau in the hippocampus is involved in cognitive deficits in streptozotocin-induced diabetic mice. |
2015-10-16 |
2023-01-25 |
mouse |
| Shan Wang, Shan-lei Zhou, Fang-yuan Min, Jin-ju Ma, Xia-jie Shi, Erika Bereczki, Jing W. mTOR-mediated hyperphosphorylation of tau in the hippocampus is involved in cognitive deficits in streptozotocin-induced diabetic mice. Metabolic brain disease vol 29 issue 3 2015 24682776 |
in the present study, we found that phosphorylated mtor at ser2448, phosphorylated p70s6k at thr421/ser424 and phosphorylated tau at ser396 were significantly increased in the hippocampus of streptozotocin (stz)-induced diabetic mice when compared with control mice. |
2015-10-16 |
2023-01-25 |
mouse |