All Relations between microtubule-associated protein tau and hippocampus

Publication Sentence Publish Date Extraction Date Species
Chunyan Zhu, Bing Xu, Xiaohong Sun, Qiwen Zhu, Yi Su. Targeting CCR3 to Reduce Amyloid-β Production, Tau Hyperphosphorylation, and Synaptic Loss in a Mouse Model of Alzheimer's Disease. Molecular neurobiology. vol 54. issue 10. 2018-07-27. PMID:27878757. in the present study, we showed that ccr3, the receptor for ccl11, was expressed by hippocampal neurons and treatment of primary hippocampal neuronal cultures (14 days in vitro) with ccl11 resulted in activation of cyclin-dependent kinase 5 and glycogen synthase kinase-3β, associated with elevated tau phosphorylation at multiple sites. 2018-07-27 2023-08-13 mouse
Huan Zhou, Ying Guo, Xing Li, Zheng-Yu Liuyang, Yang-Ping Shentu, Xiao-Peng Jing, Jia-Wei Liang, Xin-Wen Zhou, Xiao-Chuan Wang, Jian-Zhi Wang, Ji Zeng, Rong Li. Long-term Helicobacter pylori infection does not induce tauopathy and memory impairment in SD rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 37. issue 6. 2018-07-26. PMID:29270738. however, there was no significant change of tau phosphorylation at thr205 (pt205), thr231 (pt231), ser396 (ps396) and ser404 (ps404) sites in the hippocampus and cerebral cortex. 2018-07-26 2023-08-13 human
S L Angulo, R Orman, S A Neymotin, L Liu, L Buitrago, E Cepeda-Prado, D Stefanov, W W Lytton, M Stewart, S A Small, K E Duff, H Moren. Tau and amyloid-related pathologies in the entorhinal cortex have divergent effects in the hippocampal circuit. Neurobiology of disease. vol 108. 2018-07-23. PMID:28860088. tau and amyloid-related pathologies in the entorhinal cortex have divergent effects in the hippocampal circuit. 2018-07-23 2023-08-13 mouse
Miranda Tuwaig, Mélissa Savard, Benoît Jutras, Judes Poirier, D Louis Collins, Pedro Rosa-Neto, David Fontaine, John C S Breitne. Deficit in Central Auditory Processing as a Biomarker of Pre-Clinical Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 60. issue 4. 2018-07-23. PMID:28984583. adjusting for age, sex, education, pure-tone hearing, and apoeɛ4 status, we observed a persistent relationship between cap scores and csf tau levels, entorhinal and hippocampal cortex volumes, cortical thickness, and deficits in cognition (repeatable battery for assessment of neuropsychological status total score, and several of its index scales). 2018-07-23 2023-08-13 Not clear
Zhong-Hong Kong, Xin Chen, Hui-Po Hua, Liang Liang, Long-Juan Li. The Oral Pretreatment of Glycyrrhizin Prevents Surgery-Induced Cognitive Impairment in Aged Mice by Reducing Neuroinflammation and Alzheimer's-Related Pathology via HMGB1 Inhibition. Journal of molecular neuroscience : MN. vol 63. issue 3-4. 2018-07-20. PMID:29034441. additionally, the pretreatment of glycyrrhizin reduced the postoperative neuroinflammation (production of pro-inflammatory cytokines including il-1β, tnf-α, and il-6 as well as nf-κb nuclear expression) and alzheimer's-related pathology (tau phosphorylation at the site of at-8 and ser396 as well as aβ40 and 42 concentrations) in the hippocampus of the aged mice undergoing splenectomy surgery. 2018-07-20 2023-08-13 mouse
Diana Klakotskaia, Cansu Agca, Rachel A Richardson, Edward G Stopa, Todd R Schachtman, Yuksel Agc. Memory deficiency, cerebral amyloid angiopathy, and amyloid-β plaques in APP+PS1 double transgenic rat model of Alzheimer's disease. PloS one. vol 13. issue 4. 2018-07-16. PMID:29641600. immunohistochemistry using an antibody against amyloid-β (aβ) showed extensive and mostly diffuse aβ plaques in the hippocampus and dense plaques that contained tau in the cortex of the brains of the app+ps1 rats. 2018-07-16 2023-08-13 human
Kristian Steen Frederiksen, Le Gjerum, Gunhild Waldemar, Steen Gregers Hasselbalc. Effects of Physical Exercise on Alzheimer's Disease Biomarkers: A Systematic Review of Intervention Studies. Journal of Alzheimer's disease : JAD. vol 61. issue 1. 2018-07-13. PMID:29154278. we carried out a systematic review of intervention studies of physical exercise with hippocampal volume (on mri), amyloid-β, total tau, phosphorylated tau in cerebrospinal fluid (csf), 18f-fdg-pet or amyloid pet as outcome measures in healthy subjects, patients with subjective memory complaints, mild cognitive impairment, or ad. 2018-07-13 2023-08-13 human
Elizabeth M Lane, Timothy J Hohman, Angela L Jefferso. Insulin-like growth factor binding protein-2 interactions with Alzheimer's disease biomarkers. Brain imaging and behavior. vol 11. issue 6. 2018-07-09. PMID:27817134. ad neuroimaging initiative data were accessed (n = 354, 75 ± 7 years, 38 % female), including plasma igfbp-2, csf total tau, csf aβ-42, mri-quantified hippocampal volume, and neuropsychological performances. 2018-07-09 2023-08-13 Not clear
Yong Tang, Chonglin Yu, Jianming Wu, Haixia Chen, Yuan Zeng, Xiuling Wang, Le Yang, Qibing Mei, Shousong Cao, Dalian Qi. Lychee seed extract protects against neuronal injury and improves cognitive function in rats with type II diabetes mellitus with cognitive impairment. International journal of molecular medicine. vol 41. issue 1. 2018-07-09. PMID:29138799. the levels of glucose, insulin, aβ, ages, tau protein and acetylcholinesterase in the blood and/or hippocampus of rats were determined by blood‑glucose meter, radioimmunoassay, chemical chromatometry, enzyme‑linked immunosorbent assay (elisa) and immunohistochemical analysis, respectively. 2018-07-09 2023-08-13 rat
Yong Tang, Chonglin Yu, Jianming Wu, Haixia Chen, Yuan Zeng, Xiuling Wang, Le Yang, Qibing Mei, Shousong Cao, Dalian Qi. Lychee seed extract protects against neuronal injury and improves cognitive function in rats with type II diabetes mellitus with cognitive impairment. International journal of molecular medicine. vol 41. issue 1. 2018-07-09. PMID:29138799. the levels of glucose, insulin, aβ, ages and tau protein were significantly increased in the blood and/or hippocampus of t2dm rats, while lse remarkably decreased their levels compared to vehicle treatment (p<0.01). 2018-07-09 2023-08-13 rat
Yong Tang, Chonglin Yu, Jianming Wu, Haixia Chen, Yuan Zeng, Xiuling Wang, Le Yang, Qibing Mei, Shousong Cao, Dalian Qi. Lychee seed extract protects against neuronal injury and improves cognitive function in rats with type II diabetes mellitus with cognitive impairment. International journal of molecular medicine. vol 41. issue 1. 2018-07-09. PMID:29138799. the possible mechanisms may be associated with ir improvement and decreased formations of aβ, ages and tau protein in the hippocampus of t2dm rats. 2018-07-09 2023-08-13 rat
Ângela G Batista, Edilene S Soares, Monique C P Mendonça, Juliana K da Silva, Ana Paula Dionísio, Cesar R Sartori, Maria Alice da Cruz-Höfling, Mário R Maróstica Júnio. Jaboticaba berry peel intake prevents insulin-resistance-induced tau phosphorylation in mice. Molecular nutrition & food research. vol 61. issue 10. 2018-07-02. PMID:28544198. the hyperphosphorylation of microtubule-associated protein tau (tau) in the hippocampus can be caused by central and peripheral insulin resistance and these alterations are related to the development of tauopathies, such as alzheimer's disease. 2018-07-02 2023-08-13 mouse
Ângela G Batista, Edilene S Soares, Monique C P Mendonça, Juliana K da Silva, Ana Paula Dionísio, Cesar R Sartori, Maria Alice da Cruz-Höfling, Mário R Maróstica Júnio. Jaboticaba berry peel intake prevents insulin-resistance-induced tau phosphorylation in mice. Molecular nutrition & food research. vol 61. issue 10. 2018-07-02. PMID:28544198. in this study, we used a high-fat diet to induce obesity and insulin resistance in adult swiss mice and checked whether supplementation with myrciaria jaboticaba berry peel for 10 weeks could improve insulin sensitivity, learning/memory performance, and prevent tau phosphorylation in the hippocampus. 2018-07-02 2023-08-13 mouse
Ângela G Batista, Edilene S Soares, Monique C P Mendonça, Juliana K da Silva, Ana Paula Dionísio, Cesar R Sartori, Maria Alice da Cruz-Höfling, Mário R Maróstica Júnio. Jaboticaba berry peel intake prevents insulin-resistance-induced tau phosphorylation in mice. Molecular nutrition & food research. vol 61. issue 10. 2018-07-02. PMID:28544198. the treated group also showed lower tau phosphorylation in the hippocampus corroborating better learning/memory performance in the morris water maze test. 2018-07-02 2023-08-13 mouse
Dom-Gene Tu, Yao-Ling Chang, Chung-Hsi Chou, Yi-Ling Lin, Chia-Chun Chiang, Yuan-Yen Chang, Yi-Chen Che. Preventive effects of taurine against d-galactose-induced cognitive dysfunction and brain damage. Food & function. vol 9. issue 1. 2018-06-19. PMID:29068027. moreover, tau supplementation extended (p < 0.05) the searching period around the target quadrant in the probe test of the water maze, and neuronal degeneration and nucleus shrinkage in the hippocampus dentate gyrus area of d-galactose treated mice were observed to be attenuated. 2018-06-19 2023-08-13 mouse
Jing-Nian Ni, Jing Shi, Xue-Kai Zhang, Yi-Chang Yang, Xiao-Meng Liu, Ming-Qing Wei, Ting Li, Peng-Wen Wang, Jin-Zhou Tian, Yong-Yan Wan. Effect of GAPT extract on expression of tau protein and its phosphorylation related enzymes in hippocampal neurons of APPV717I transgenic mice. Chinese journal of integrative medicine. vol 23. issue 8. 2018-06-14. PMID:28634862. effect of gapt extract on expression of tau protein and its phosphorylation related enzymes in hippocampal neurons of appv717i transgenic mice. 2018-06-14 2023-08-13 mouse
Jing-Nian Ni, Jing Shi, Xue-Kai Zhang, Yi-Chang Yang, Xiao-Meng Liu, Ming-Qing Wei, Ting Li, Peng-Wen Wang, Jin-Zhou Tian, Yong-Yan Wan. Effect of GAPT extract on expression of tau protein and its phosphorylation related enzymes in hippocampal neurons of APPV717I transgenic mice. Chinese journal of integrative medicine. vol 23. issue 8. 2018-06-14. PMID:28634862. on expression of tau protein and its phosphorylation related enzyme in hippocampal neurons of appv717i transgenic mice. 2018-06-14 2023-08-13 mouse
Ning Xiao, Fu Zhang, Bofeng Zhu, Chao Liu, Zhoumeng Lin, Huijun Wang, Wei-Bing Xi. CDK5-mediated tau accumulation triggers methamphetamine-induced neuronal apoptosis via endoplasmic reticulum-associated degradation pathway. Toxicology letters. vol 292. 2018-06-12. PMID:29705343. we determined the expression of two phosphorylated tau proteins (serine 396 and threonine 231) in the human neuroblastoma sh-sy5y cells and in the hippocampus of sprague-dawley rats treated with vehicle or meth using western blotting, immunohistochemical staining and immunofluorescence staining. 2018-06-12 2023-08-13 human
Christoph Köhler, Vivien Fuhr, Maja Dineko. Distribution of spleen tyrosine kinase and tau phosphorylated at tyrosine 18 in a mouse model of tauopathy and in the human hippocampus. Brain research. vol 1677. 2018-06-11. PMID:28919467. distribution of spleen tyrosine kinase and tau phosphorylated at tyrosine 18 in a mouse model of tauopathy and in the human hippocampus. 2018-06-11 2023-08-13 mouse
Hao Wang, Xiaoxu Sun, Ning Zhang, Zhouye Ji, Zhanqiang Ma, Qiang Fu, Rong Qu, Shiping M. Ferulic acid attenuates diabetes-induced cognitive impairment in rats via regulation of PTP1B and insulin signaling pathway. Physiology & behavior. vol 182. 2018-06-11. PMID:28988132. meanwhile, ferulic acid could markedly ameliorate spatial memory of diabetic rats in morris water maze (mwm) and decrease ad-like pathologic changes (aβ deposition and tau phosphorylation) in the hippocampus, which might be correlated with the inhibition of inflammatory cytokines release and reduction of protein tyrosine phosphatase 1b (ptp1b) expression. 2018-06-11 2023-08-13 rat