| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dom-Gene Tu, Yao-Ling Chang, Chung-Hsi Chou, Yi-Ling Lin, Chia-Chun Chiang, Yuan-Yen Chang, Yi-Chen Che. Preventive effects of taurine against d-galactose-induced cognitive dysfunction and brain damage. Food & function. vol 9. issue 1. 2018-06-19. PMID:29068027. |
moreover, tau supplementation extended (p < 0.05) the searching period around the target quadrant in the probe test of the water maze, and neuronal degeneration and nucleus shrinkage in the hippocampus dentate gyrus area of d-galactose treated mice were observed to be attenuated. |
2018-06-19 |
2023-08-13 |
mouse |
| Jing-Nian Ni, Jing Shi, Xue-Kai Zhang, Yi-Chang Yang, Xiao-Meng Liu, Ming-Qing Wei, Ting Li, Peng-Wen Wang, Jin-Zhou Tian, Yong-Yan Wan. Effect of GAPT extract on expression of tau protein and its phosphorylation related enzymes in hippocampal neurons of APPV717I transgenic mice. Chinese journal of integrative medicine. vol 23. issue 8. 2018-06-14. PMID:28634862. |
effect of gapt extract on expression of tau protein and its phosphorylation related enzymes in hippocampal neurons of appv717i transgenic mice. |
2018-06-14 |
2023-08-13 |
mouse |
| Jing-Nian Ni, Jing Shi, Xue-Kai Zhang, Yi-Chang Yang, Xiao-Meng Liu, Ming-Qing Wei, Ting Li, Peng-Wen Wang, Jin-Zhou Tian, Yong-Yan Wan. Effect of GAPT extract on expression of tau protein and its phosphorylation related enzymes in hippocampal neurons of APPV717I transgenic mice. Chinese journal of integrative medicine. vol 23. issue 8. 2018-06-14. PMID:28634862. |
on expression of tau protein and its phosphorylation related enzyme in hippocampal neurons of appv717i transgenic mice. |
2018-06-14 |
2023-08-13 |
mouse |
| Ning Xiao, Fu Zhang, Bofeng Zhu, Chao Liu, Zhoumeng Lin, Huijun Wang, Wei-Bing Xi. CDK5-mediated tau accumulation triggers methamphetamine-induced neuronal apoptosis via endoplasmic reticulum-associated degradation pathway. Toxicology letters. vol 292. 2018-06-12. PMID:29705343. |
we determined the expression of two phosphorylated tau proteins (serine 396 and threonine 231) in the human neuroblastoma sh-sy5y cells and in the hippocampus of sprague-dawley rats treated with vehicle or meth using western blotting, immunohistochemical staining and immunofluorescence staining. |
2018-06-12 |
2023-08-13 |
human |
| Christoph Köhler, Vivien Fuhr, Maja Dineko. Distribution of spleen tyrosine kinase and tau phosphorylated at tyrosine 18 in a mouse model of tauopathy and in the human hippocampus. Brain research. vol 1677. 2018-06-11. PMID:28919467. |
distribution of spleen tyrosine kinase and tau phosphorylated at tyrosine 18 in a mouse model of tauopathy and in the human hippocampus. |
2018-06-11 |
2023-08-13 |
mouse |
| Hao Wang, Xiaoxu Sun, Ning Zhang, Zhouye Ji, Zhanqiang Ma, Qiang Fu, Rong Qu, Shiping M. Ferulic acid attenuates diabetes-induced cognitive impairment in rats via regulation of PTP1B and insulin signaling pathway. Physiology & behavior. vol 182. 2018-06-11. PMID:28988132. |
meanwhile, ferulic acid could markedly ameliorate spatial memory of diabetic rats in morris water maze (mwm) and decrease ad-like pathologic changes (aβ deposition and tau phosphorylation) in the hippocampus, which might be correlated with the inhibition of inflammatory cytokines release and reduction of protein tyrosine phosphatase 1b (ptp1b) expression. |
2018-06-11 |
2023-08-13 |
rat |
| Florence Clavaguera, Markus Tolnay, Michel Goeder. The Prion-Like Behavior of Assembled Tau in Transgenic Mice. Cold Spring Harbor perspectives in medicine. vol 7. issue 10. 2018-06-07. PMID:27940600. |
the pattern of tau deposition in alzheimer's disease follows a stereotypical progression, with the first lesions appearing in the locus coeruleus and entorhinal cortex, from where they appear to spread to the hippocampus and neocortex. |
2018-06-07 |
2023-08-13 |
mouse |
| Betty M Tijms, Mara Ten Kate, Alida A Gouw, Andreas Borta, Sander Verfaillie, Charlotte E Teunissen, Philip Scheltens, Frederik Barkhof, Wiesje M van der Flie. Gray matter networks and clinical progression in subjects with predementia Alzheimer's disease. Neurobiology of aging. vol 61. 2018-06-04. PMID:29040871. |
results remained after correcting for tau, hippocampal volume, and mmse scores. |
2018-06-04 |
2023-08-13 |
human |
| Di Xia, Julia M Gutmann, Jürgen Göt. Mobility and subcellular localization of endogenous, gene-edited Tau differs from that of over-expressed human wild-type and P301L mutant Tau. Scientific reports. vol 6. 2018-05-25. PMID:27378256. |
to establish a framework for understanding this pathology, we used the genome-editing tool talen and generated tau-meos2 knock-in mice to determine the mobility and subcellular localization of endogenous tau in hippocampal cultures. |
2018-05-25 |
2023-08-13 |
mouse |
| Ladislav Baciak, Zdenka Gasparova, Tibor Liptaj, Ivo Jurane. In vivo magnetic resonance approach to trimethyltin induced neurodegeneration in rats. Brain research. vol 1673. 2018-05-22. PMID:28736106. |
hippocampal levels of n-acetylaspartate (naa), glutamate (glu), total creatine (tcr) and taurine (tau) significantly decreased, while the levels of myo-inositol (mins) and glutamine (gln) significantly increased in tmt treated rats compared to controls. |
2018-05-22 |
2023-08-13 |
mouse |
| b' Susana Garc\\xc3\\xada-Cerro, Noem\\xc3\\xad Rueda, Ver\\xc3\\xb3nica Vidal, Sara Lantigua, Carmen Mart\\xc3\\xadnez-Cu\\xc3\\xa. Normalizing the gene dosage of Dyrk1A in a mouse model of Down syndrome rescues several Alzheimer\'s disease phenotypes. Neurobiology of disease. vol 106. 2018-05-15. PMID:28647555.' |
normalizing the gene dosage of dyrk1a in the ts mouse rescued the density of senescent cells in the cingulate cortex, hippocampus and septum, prevented cholinergic neuron degeneration, and reduced app expression in the hippocampus, aβ load in the cortex and hippocampus, the expression of phosphorylated tau at the ser202 residue in the hippocampus and cerebellum and the levels of total tau in the cortex, hippocampus and cerebellum. |
2018-05-15 |
2023-08-13 |
mouse |
| Xiaolei Zhu, Sulei Wang, Linjie Yu, Jiali Jin, Xing Ye, Yi Liu, Yun X. HDAC3 negatively regulates spatial memory in a mouse model of Alzheimer's disease. Aging cell. vol 16. issue 5. 2018-05-15. PMID:28771976. |
lentivirus -mediated inhibition or overexpression of hdac3 was used in the hippocampus of app/ps1 mice to investigate the role of hdac3 in spatial memory, amyloid burden, dendritic spine density, glial activation and tau phosphorylation. |
2018-05-15 |
2023-08-13 |
mouse |
| Mu-Han Li, Jing Zhang, Run-Qing Zhao, Xian-Zhe Dong, Yuan Hu, Ting Chen, Jie Li, Li Liu, Ping Li. [Effect of six class of Kaixin San formulas on pharmacological and preliminary mechanism of Alzheimer's disease mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 7. 2018-05-15. PMID:28879742. |
in this study, six different kaixin san formulas were compared to investigate their effects on learning and memory decline, brain-derived neurotrophic factor (bdnf) in the hippocampus, tau protein, acetylcholinesterase (ache) and n-terminal pro-brain natriuretic peptide (nt-probnp). |
2018-05-15 |
2023-08-13 |
mouse |
| Mu-Han Li, Jing Zhang, Run-Qing Zhao, Xian-Zhe Dong, Yuan Hu, Ting Chen, Jie Li, Li Liu, Ping Li. [Effect of six class of Kaixin San formulas on pharmacological and preliminary mechanism of Alzheimer's disease mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 7. 2018-05-15. PMID:28879742. |
kunming mice were selected and established a mouse model of alzheimer's by intraperitoneal injection of d-galactose and sodium nitrite, continued intragastric 4 weeks, using the ability of learning and memory in morris water maze test to evaluate the animals in each group; the content of bdnf in the hippocampus of mice with western blotting detected; elisa method for the detection of each group of mice hippocampal tau protein,p-tau protein, aβ,ach,ache and serum nt-probnp levels. |
2018-05-15 |
2023-08-13 |
mouse |
| Mu-Han Li, Jing Zhang, Run-Qing Zhao, Xian-Zhe Dong, Yuan Hu, Ting Chen, Jie Li, Li Liu, Ping Li. [Effect of six class of Kaixin San formulas on pharmacological and preliminary mechanism of Alzheimer's disease mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 7. 2018-05-15. PMID:28879742. |
the results showed that, kaixin san of qianjin yaofang three dose recorded significantly improved learning and memory ability of mice; increased the content of bdnf and ach in the hippocampus; decreased the content of aβ, tau protein, p-tau protein in the hippocampus; high, middle dose significantly decreased the serum nt-probnp and ache in hippocampus, the effect is most significant. |
2018-05-15 |
2023-08-13 |
mouse |
| Mu-Han Li, Jing Zhang, Run-Qing Zhao, Xian-Zhe Dong, Yuan Hu, Ting Chen, Jie Li, Li Liu, Ping Li. [Effect of six class of Kaixin San formulas on pharmacological and preliminary mechanism of Alzheimer's disease mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 7. 2018-05-15. PMID:28879742. |
part dose of kaixin san of yixin fang, kaixin wan of yimen fang, dingzhi xiaowan of beji qianjin yaofang and dingzhi wan of guji luyan could improve the learning and memory ability evaluation indicators, significantly increased bdnf and ach in the hippocampus of ad model mice, reduced the aβ, tau protein, p-tau protein in hippocampus of ad model mice, decreased the nt-probnp and ache in serum of ad mice, the effect is more significant. |
2018-05-15 |
2023-08-13 |
mouse |
| Li-Na Lu, Zhong-Ming Qian, Ka-Chun Wu, Wing-Ho Yung, Ya K. Expression of Iron Transporters and Pathological Hallmarks of Parkinson's and Alzheimer's Diseases in the Brain of Young, Adult, and Aged Rats. Molecular neurobiology. vol 54. issue 7. 2018-05-10. PMID:27578012. |
we also found an age-dependent increase in hyperphosphorylated tau, total beta-amyloid, and neurotoxic oligomeric aggregates in the cortex and hippocampus as well as an increase in α-synuclein and a decrease in tyrosine hydroxylase positive neurons in the substantia nigra. |
2018-05-10 |
2023-08-13 |
rat |
| Tetsuya Kimura, Mamiko Suzuki, Takumi Akag. Age-dependent changes in synaptic plasticity enhance tau oligomerization in the mouse hippocampus. Acta neuropathologica communications. vol 5. issue 1. 2018-05-07. PMID:28874186. |
age-dependent changes in synaptic plasticity enhance tau oligomerization in the mouse hippocampus. |
2018-05-07 |
2023-08-13 |
mouse |
| Tetsuya Kimura, Mamiko Suzuki, Takumi Akag. Age-dependent changes in synaptic plasticity enhance tau oligomerization in the mouse hippocampus. Acta neuropathologica communications. vol 5. issue 1. 2018-05-07. PMID:28874186. |
analysis of the lc3 ratio, an indicator of autophagosome formation, showed that lfs increased cleaved lc3 (type ii) in the aged hippocampus relative to type i lc3, suggesting potentiation of the alp accompanied by ltd. pharmacological inhibition of autophagosome formation depressed lfs-induced oligomerization of tau. |
2018-05-07 |
2023-08-13 |
mouse |
| Jonas Elias Schweig, Hailan Yao, David Beaulieu-Abdelahad, Ghania Ait-Ghezala, Benoit Mouzon, Fiona Crawford, Michael Mullan, Daniel Pari. Alzheimer's disease pathological lesions activate the spleen tyrosine kinase. Acta neuropathologica communications. vol 5. issue 1. 2018-05-07. PMID:28877763. |
in tg tau p301s mice, a pure model of tauopathy, activated syk occurs in neurons that show an accumulation of misfolded and hyperphosphorylated tau in the cortex and hippocampus. |
2018-05-07 |
2023-08-13 |
mouse |