| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Koichi Okamoto, Masakuni Amari, Toshio Fukuda, Keiji Suzuki, Masamitsu Takatam. Comparison of AT8 immunoreactivity in the locus ceruleus and hippocampus of 154 brains from routine autopsies. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 37. issue 4. 2018-05-03. PMID:28168741. |
we compared semiquantitatively at8 immunoreactivity in the locus ceruleus (lc) and hippocampus of 154 brains from routine autopsies to investigate the initial sites of phosphorylated tau (phospho-tau) development. |
2018-05-03 |
2023-08-13 |
Not clear |
| Ichiro Akiguchi, Mercè Pallàs, Herbert Budka, Haruhiko Akiyama, Masaki Ueno, Jingxian Han, Hideo Yagi, Tomohumi Nishikawa, Yoichi Chiba, Hiroshi Sugiyama, Ryoya Takahashi, Keiko Unno, Keiichi Higuchi, Masanori Hosokaw. SAMP8 mice as a neuropathological model of accelerated brain aging and dementia: Toshio Takeda's legacy and future directions. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 37. issue 4. 2018-05-03. PMID:28261874. |
as for the hallmarks of alzheimer brains, tau morphology has not yet been confirmed regardless of the age-related increase in phosphorylated tau in samp8 mice brains, but early age-related aβ deposition in the hippocampus has recently been published. |
2018-05-03 |
2023-08-13 |
mouse |
| Yaling Yin, Yali Wang, Di Gao, Jinwang Ye, Xin Wang, Lin Fang, Dongqin Wu, Guilin Pi, Chengbiao Lu, Xin-Wen Zhou, Ying Yang, Jian-Zhi Wan. Accumulation of human full-length tau induces degradation of nicotinic acetylcholine receptor α4 via activating calpain-2. Scientific reports. vol 6. 2018-04-25. PMID:27277673. |
here, we found that overexpression of human wild-type full-length tau (termed htau) induced a significant reduction of α4 subunit of nicotinic acetylcholine receptors (nachrs) with an increased cleavage of the receptor producing a ~55kda fragment in primary hippocampal neurons and in the rat brains, meanwhile, the α4 nachr currents decreased. |
2018-04-25 |
2023-08-13 |
human |
| Jing Wu, Shan-Lei Zhou, Lin-Hua Pi, Xia-Jie Shi, Ling-Ran Ma, Zi Chen, Min-Li Qu, Xin Li, Sheng-Dan Nie, Duan-Fang Liao, Jin-Jing Pei, Shan Wan. High glucose induces formation of tau hyperphosphorylation via Cav-1-mTOR pathway: A potential molecular mechanism for diabetes-induced cognitive dysfunction. Oncotarget. vol 8. issue 25. 2018-04-25. PMID:28489581. |
we found: 1) that a chronic hgc directly decreases cav-1 expression, increases tau phosphorylation and activates mtor/s6k signalling in the brain neurons of diabetic rats, 2) that overexpression of cav-1 attenuates tau hyperphosphorylation induced by chronic hgc in primary hippocampal neurons, whereas down-regulation of cav-1 using cav-1 sirna dramatically worsens tau hyperphosphorylation via mtor/s6k signalling pathway, and 3) that the down-regulation of cav-1 induced by hgc is independent of mtor signalling. |
2018-04-25 |
2023-08-13 |
rat |
| Andrew Kneynsberg, Nicholas M Kanaa. Aging Does Not Affect Axon Initial Segment Structure and Somatic Localization of Tau Protein in Hippocampal Neurons of Fischer 344 Rats. eNeuro. vol 4. issue 4. 2018-04-25. PMID:28785724. |
aging does not affect axon initial segment structure and somatic localization of tau protein in hippocampal neurons of fischer 344 rats. |
2018-04-25 |
2023-08-13 |
rat |
| Andrew Kneynsberg, Nicholas M Kanaa. Aging Does Not Affect Axon Initial Segment Structure and Somatic Localization of Tau Protein in Hippocampal Neurons of Fischer 344 Rats. eNeuro. vol 4. issue 4. 2018-04-25. PMID:28785724. |
none of the outcome measurements assessed, including ais structure, ais protein levels, the distribution of tau in neurons of the hippocampus (hp), and total tau or phospho-tau protein levels were different in young, middle-, and old-age fischer 344 rats. |
2018-04-25 |
2023-08-13 |
rat |
| Yen Ying Lim, Jason Hassenstab, Carlos Cruchaga, Alison Goate, Anne M Fagan, Tammie L S Benzinger, Paul Maruff, Peter J Snyder, Colin L Masters, Ricardo Allegri, Jasmeer Chhatwal, Martin R Farlow, Neill R Graff-Radford, Christoph Laske, Johannes Levin, Eric McDade, John M Ringman, Martin Rossor, Stephen Salloway, Peter R Schofield, David M Holtzman, John C Morris, Randall J Batema. BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease. Brain : a journal of neurology. vol 139. issue Pt 10. 2018-04-10. PMID:27521573. |
bdnf val66met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant alzheimer's disease. |
2018-04-10 |
2023-08-13 |
Not clear |
| Yen Ying Lim, Jason Hassenstab, Carlos Cruchaga, Alison Goate, Anne M Fagan, Tammie L S Benzinger, Paul Maruff, Peter J Snyder, Colin L Masters, Ricardo Allegri, Jasmeer Chhatwal, Martin R Farlow, Neill R Graff-Radford, Christoph Laske, Johannes Levin, Eric McDade, John M Ringman, Martin Rossor, Stephen Salloway, Peter R Schofield, David M Holtzman, John C Morris, Randall J Batema. BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease. Brain : a journal of neurology. vol 139. issue Pt 10. 2018-04-10. PMID:27521573. |
we aimed to determine the effect of bdnf val66met on cognitive function, hippocampal function, tau and amyloid-β in preclinical autosomal dominant alzheimer's disease. |
2018-04-10 |
2023-08-13 |
Not clear |
| Carmen Infante-Garcia, Juan Jose Ramos-Rodriguez, Irene Delgado-Olmos, Carlos Gamero-Carrasco, Maria Teresa Fernandez-Ponce, Lourdes Casas, Casimiro Mantell, Monica Garcia-Alloz. Long-Term Mangiferin Extract Treatment Improves Central Pathology and Cognitive Deficits in APP/PS1 Mice. Molecular neurobiology. vol 54. issue 6. 2018-04-09. PMID:27443159. |
while mgf did not affect amyloid pathology, tau hyperphosphorylation was significantly reduced in the cortex and hippocampus. |
2018-04-09 |
2023-08-13 |
mouse |
| Xiaoping Du, Matthew B West, Qunfeng Cai, Weihua Cheng, Donald L Ewert, Wei Li, Robert A Floyd, Richard D Kopk. Antioxidants reduce neurodegeneration and accumulation of pathologic Tau proteins in the auditory system after blast exposure. Free radical biology & medicine. vol 108. 2018-04-09. PMID:28438658. |
our laboratory previously demonstrated that non-transgenic rats exposed to blast overpressures exhibited marked somatic accumulation of neurotoxic variants of the microtubule-associated protein, tau, in the hippocampus. |
2018-04-09 |
2023-08-13 |
rat |
| Alejandro Antón-Fernández, Jesús Merchán-Rubira, Jesús Avila, Félix Hernández, Javier DeFelipe, Alberto Muño. Phospho-Tau Accumulation and Structural Alterations of the Golgi Apparatus of Cortical Pyramidal Neurons in the P301S Tauopathy Mouse Model. Journal of Alzheimer's disease : JAD. vol 60. issue 2. 2018-04-09. PMID:28922155. |
here we use the p301s tauopathy mouse model to examine possible alterations of the ga in neurons that overexpress human tau (p301s mutated gene) in neocortical and hippocampal neurons, using double immunofluorescence techniques and confocal microscopy. |
2018-04-09 |
2023-08-13 |
mouse |
| Annachiara Cagnin, Sara Mariotto, Michele Fiorini, Marina Gaule, Nicola Bonetto, Matteo Tagliapietra, Emanuele Buratti, Gianluigi Zanusso, Sergio Ferrari, Salvatore Monac. Microglial and Neuronal TDP-43 Pathology in Anti-IgLON5-Related Tauopathy. Journal of Alzheimer's disease : JAD. vol 59. issue 1. 2018-04-06. PMID:28550263. |
postmortem brain examination disclosed neuronal tau pathology prevailing in the hippocampus, amygdala, and locus coeruleus, in addition to microglial/neuronal tdp-43 pathology, with overexpression of aberrantly phosphorylated forms and neurotoxic truncated fragments, in basal ganglia, nucleus basalis, thalamus, and midbrain. |
2018-04-06 |
2023-08-13 |
Not clear |
| Gang Wang, Yue Huang, Li-Ling Wang, Yong-Fang Zhang, Jing Xu, Yi Zhou, Guinevere F Lourenco, Bei Zhang, Ying Wang, Ru-Jing Ren, Glenda M Halliday, Sheng-Di Che. MicroRNA-146a suppresses ROCK1 allowing hyperphosphorylation of tau in Alzheimer's disease. Scientific reports. vol 6. 2018-04-02. PMID:27221467. |
intra-hippocampal delivery of a microrna-146a specific inhibitor (antagomir) into 5xfad mice showed enhanced hippocampal levels of rock1 protein and repressed tau hyperphosphorylation, partly restoring memory function in the 5xfad mice. |
2018-04-02 |
2023-08-13 |
mouse |
| Liliana Lozano, Jorge Guevara, Tony Lefebvre, Ivan Ramos-Martinez, Daniel Limón, Alfonso Díaz, Eduarda Cerón, Edgar Zenten. Effect of amyloid-Β (25-35) in hyperglycemic and hyperinsulinemic rats, effects on phosphorylation and O-GlcNAcylation of tau protein. Neuropeptides. vol 63. 2018-03-26. PMID:28427866. |
with this in mind, both o-glcnacylation and phosphorylation of tau protein were evaluated in the brain of rats with streptozotocin (stz)-induced hyperglycemia and hyperinsulinemia and treated with the aß25-35 peptide in the hippocampal region ca1. |
2018-03-26 |
2023-08-13 |
rat |
| Wanda M Snow, Ryan Dale, Zoe O'Brien-Moran, Richard Buist, Danial Peirson, Melanie Martin, Benedict C Albens. In Vivo Detection of Gray Matter Neuropathology in the 3xTg Mouse Model of Alzheimer's Disease with Diffusion Tensor Imaging. Journal of Alzheimer's disease : JAD. vol 58. issue 3. 2018-03-21. PMID:28505976. |
decreased fractional anisotropy (p < 0.01) and axial diffusivity (p < 0.05) were detected only in the hippocampus, in which both congophilic aβ plaques and hyperphosphorylated tau accumulation, consistent with neurofibrillary tangle formation, were detected. |
2018-03-21 |
2023-08-13 |
mouse |
| Jieun Kim, In-Young Choi, Karen E Duff, Phil Le. Progressive Pathological Changes in Neurochemical Profile of the Hippocampus and Early Changes in the Olfactory Bulbs of Tau Transgenic Mice (rTg4510). Neurochemical research. vol 42. issue 6. 2018-03-19. PMID:28523532. |
progressive pathological changes in neurochemical profile of the hippocampus and early changes in the olfactory bulbs of tau transgenic mice (rtg4510). |
2018-03-19 |
2023-08-13 |
mouse |
| Sergi Borrego-Écija, Oriol Grau-Rivera, Martí Colom-Cadena, José Luis Molinuevo, Eduard Tolosa, Raquel Sánchez-Valle, Ellen Gelp. Tauopathy with Hippocampal 4-Repeat Tau Immunoreactive Spherical Inclusions in a Patient with PSP. Brain pathology (Zurich, Switzerland). vol 28. issue 2. 2018-03-19. PMID:29516660. |
tauopathy with hippocampal 4-repeat tau immunoreactive spherical inclusions in a patient with psp. |
2018-03-19 |
2023-08-13 |
Not clear |
| Carmen Infante-Garcia, Juan Jose Ramos-Rodriguez, Yolanda Marin-Zambrana, Maria Teresa Fernandez-Ponce, Lourdes Casas, Casimiro Mantell, Monica Garcia-Alloz. Mango leaf extract improves central pathology and cognitive impairment in a type 2 diabetes mouse model. Brain pathology (Zurich, Switzerland). vol 27. issue 4. 2018-03-16. PMID:27537110. |
cortical and hippocampal atrophy was reduced in db/db mice and tau hyperphosphorylation was lower after mgf treatment, resulting in partial recovery of learning and memory disabilities. |
2018-03-16 |
2023-08-13 |
mouse |
| Xiang-Zhen Yuan, Sen Sun, Chen-Chen Tan, Jin-Tai Yu, Lan Ta. The Role of ADAM10 in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 58. issue 2. 2018-03-16. PMID:28409746. |
increasing evidence indicates that adam10 not only reduces the generation of aβ but may also affect the pathology of ad through potential mechanisms including reducing tau pathology, maintaining normal synaptic functions, and promoting hippocampal neurogenesis and the homeostasis of neuronal networks. |
2018-03-16 |
2023-08-13 |
Not clear |
| Anna E Blanken, Sona Hurtz, Chris Zarow, Kristina Biado, Hedieh Honarpisheh, Johanne Somme, Jenny Brook, Spencer Tung, Emily Kraft, Darrick Lo, Denise W Ng, Harry V Vinters, Liana G Apostolov. Associations between hippocampal morphometry and neuropathologic markers of Alzheimer's disease using 7 T MRI. NeuroImage. Clinical. vol 15. 2018-03-02. PMID:28491492. |
hippocampal slices were stained for amyloid beta (aβ), tau, and cresyl violet to evaluate neuronal counts. |
2018-03-02 |
2023-08-13 |
human |