| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nicole Maphis, Guixiang Xu, Olga N Kokiko-Cochran, Shanya Jiang, Astrid Cardona, Richard M Ransohoff, Bruce T Lamb, Kiran Bhaska. Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain. Brain : a journal of neurology vol 138 issue Pt 6 2015 25833819 |
second, cd45(+) microglial activation correlates with the spatial memory deficit and spread of tau pathology in the anatomically connected regions of the hippocampus. |
2015-08-07 |
2023-01-25 |
mouse |
| V Melis, C Zabke, K Stamer, M Magbagbeolu, K Schwab, P Marschall, R W Veh, S Bachmann, S Deiana, P-H Moreau, K Davidson, K A Harrington, J E Rickard, D Horsley, R Garman, M Mazurkiewicz, G Niewiadomska, C M Wischik, C R Harrington, G Riedel, F Theurin. Different pathways of molecular pathophysiology underlie cognitive and motor tauopathy phenotypes in transgenic models for Alzheimer's disease and frontotemporal lobar degeneration. Cellular and molecular life sciences : CMLS vol 72 issue 11 2015 25523019 |
l66 has abundant tau pathology widely distributed throughout the brain, with particularly high counts of affected neurons in hippocampus and entorhinal cortex. |
2015-07-31 |
2023-01-25 |
human |
| Eve Peeraer, Astrid Bottelbergs, Kristof Van Kolen, Ilie-Cosmin Stancu, Bruno Vasconcelos, Michel Mahieu, Hilde Duytschaever, Luc Ver Donck, An Torremans, Ellen Sluydts, Nathalie Van Acker, John A Kemp, Marc Mercken, Kurt R Brunden, John Q Trojanowski, Ilse Dewachter, Virginia M Y Lee, Diederik Moechar. Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice. Neurobiology of disease vol 73 issue 2015 25220759 |
we show here that intracerebral injections of preformed synthetic tau fibrils into the hippocampus or frontal cortex of young tau transgenic mice expressing mutant human p301l tau induces tau hyperphosphorylation and aggregation around the site of injection, as well as a time-dependent propagation of tau pathology to interconnected brain areas distant from the injection site. |
2015-07-29 |
2023-01-25 |
human |
| Eve Peeraer, Astrid Bottelbergs, Kristof Van Kolen, Ilie-Cosmin Stancu, Bruno Vasconcelos, Michel Mahieu, Hilde Duytschaever, Luc Ver Donck, An Torremans, Ellen Sluydts, Nathalie Van Acker, John A Kemp, Marc Mercken, Kurt R Brunden, John Q Trojanowski, Ilse Dewachter, Virginia M Y Lee, Diederik Moechar. Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice. Neurobiology of disease vol 73 issue 2015 25220759 |
furthermore, we show that the tau pathology as a consequence of injection of tau preformed fibrils into the hippocampus induces selective loss of ca1 neurons. |
2015-07-29 |
2023-01-25 |
human |
| Lourdes Orejana, Luc\\xc3\\xada Barros-Mi\\xc3\\xb1ones, Joaquin Jordan, Angel Cedazo-Minguez, Rosa M Tordera, Norberto Aguirre, Elena Puert. Sildenafil Decreases BACE1 and Cathepsin B Levels and Reduces APP Amyloidogenic Processing in the SAMP8 Mouse. The journals of gerontology. Series A, Biological sciences and medical sciences vol 70 issue 6 2015 25063079 |
cognitive impairments and increased levels of hyperphosphorylated tau are found in the hippocampus of samp8 mice along with an increased \xce\xb2-secretase activity and amyloid-\xce\xb2 (a\xce\xb2) depositions that increase in number and extent with age. |
2015-07-20 |
2023-01-25 |
mouse |
| Chang-E Zhang, Xifei Yang, Lingyun Li, Xiaojing Sui, Qing Tian, Wei Wei, Jianzhi Wang, Gongping Li. Hypoxia-induced tau phosphorylation and memory deficit in rats. Neuro-degenerative diseases vol 14 issue 3 2015 24993525 |
in this study, we demonstrate that rats exposed to a hypoxic condition (10% oxygen concentration) for 1, 2, 4 and 8 weeks (6 h each day) displayed spatial memory impairment and increased tau phosphorylation at ser198/199/202, thr205, ser262, ser396 and ser404 in the hippocampus. |
2015-07-17 |
2023-01-25 |
rat |
| Fehmida Bibi, Muhammad Yasir, Sayed S Sohrab, Esam I Azhar, Mohammed H Al-Qahtani, Adel M Abuzenadah, Mohammad A Kamal, Muhammad I Nasee. Link between chronic bacterial inflammation and Alzheimer disease. CNS & neurological disorders drug targets vol 13 issue 7 2015 25230225 |
alzheimer's disease (ad) is a degenerative disease of brain that is associated with dementia, brain atrophy, accumulation of hyperphosphorylated tau protein and amyloid-beta peptide in hippocampus and cortex region of the brain. |
2015-07-13 |
2023-01-25 |
Not clear |
| Amina Chaalal, Roseline Poirier, David Blum, Brigitte Gillet, Pascale Le Blanc, Marie Basquin, Luc Bu\\xc3\\xa9e, Serge Laroche, Val\\xc3\\xa9rie Enderli. PTU-induced hypothyroidism in rats leads to several early neuropathological signs of Alzheimer's disease in the hippocampus and spatial memory impairments. Hippocampus vol 24 issue 11 2015 24978200 |
in the hippocampus, hypothyroidism resulted in tau hyperphosphorylation and increases in several proinflammatory cytokines. |
2015-07-07 |
2023-01-25 |
rat |
| Sylvia E Perez, Bin He, Muhammad Nadeem, Joanne Wuu, Stephen D Ginsberg, Milos D Ikonomovic, Elliott J Mufso. Hippocampal endosomal, lysosomal, and autophagic dysregulation in mild cognitive impairment: correlation with a\\xce\\xb2 and tau pathology. Journal of neuropathology and experimental neurology vol 74 issue 4 2015 25756588 |
hippocampal endosomal, lysosomal, and autophagic dysregulation in mild cognitive impairment: correlation with a\xce\xb2 and tau pathology. |
2015-06-15 |
2023-01-25 |
Not clear |
| Sylvia E Perez, Bin He, Muhammad Nadeem, Joanne Wuu, Stephen D Ginsberg, Milos D Ikonomovic, Elliott J Mufso. Hippocampal endosomal, lysosomal, and autophagic dysregulation in mild cognitive impairment: correlation with a\\xce\\xb2 and tau pathology. Journal of neuropathology and experimental neurology vol 74 issue 4 2015 25756588 |
endosomal-lysosomal and autophagic dysregulation occurs in the hippocampus in prodromal alzheimer disease (ad), but its relationship with \xce\xb2-amyloid (a\xce\xb2) and tau pathology remains unclear. |
2015-06-15 |
2023-01-25 |
Not clear |
| Sylvia E Perez, Bin He, Muhammad Nadeem, Joanne Wuu, Stephen D Ginsberg, Milos D Ikonomovic, Elliott J Mufso. Hippocampal endosomal, lysosomal, and autophagic dysregulation in mild cognitive impairment: correlation with a\\xce\\xb2 and tau pathology. Journal of neuropathology and experimental neurology vol 74 issue 4 2015 25756588 |
these results indicate that alterations in hippocampal endosomal-lysosomal proteins in mci are independent of tau or a\xce\xb2 pathology. |
2015-06-15 |
2023-01-25 |
Not clear |
| Philip Regan, Thomas Piers, Jee-Hyun Yi, Dong-Hyun Kim, Seonghoo Huh, Se Jin Park, Jong Hoon Ryu, Daniel J Whitcomb, Kwangwook Ch. Tau phosphorylation at serine 396 residue is required for hippocampal LTD. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 35 issue 12 2015 25810511 |
tau phosphorylation at serine 396 residue is required for hippocampal ltd. tau is required for the induction of long-term depression (ltd) of synaptic transmission in the hippocampus. |
2015-06-15 |
2023-01-25 |
mouse |
| Takeshi Kanno, Ayako Tsuchiya, Tomoyuki Nishizak. Hyperphosphorylation of Tau at Ser396 occurs in the much earlier stage than appearance of learning and memory disorders in 5XFAD mice. Behavioural brain research vol 274 issue 2015 25172181 |
there was no significant difference in the tau phosphorylation at ser202/thr205 in the hippocampus between two groups, but ser396 phosphorylation for 5xfad mice was significantly higher than that for wild-type mice at ages ranging from 2 to 6 months. |
2015-05-26 |
2023-01-25 |
mouse |
| Chao Liu, Su Min, Ke Wei, Dong Liu, Jun Dong, Jie Luo, Xiao-Bin Li. [MK-801 or DNQX reduces electroconvulsive shock-induced impairment of learning-memory and hyperphosphorylation of Tau in rats]. Sheng li xue bao : [Acta physiologica Sinica] vol 64 issue 4 2015 22907299 |
the contents of tau protein which included tau5 (total tau protein), p-phf1(ser396/404), p-at8(ser199/202) and p-12e8(ser262) in the hippocampus of rats were detected by immunohistochemistry staining (sp) and western blot. |
2015-05-16 |
2023-01-25 |
rat |
| Chao Liu, Su Min, Ke Wei, Dong Liu, Jun Dong, Jie Luo, Xiao-Bin Li. [MK-801 or DNQX reduces electroconvulsive shock-induced impairment of learning-memory and hyperphosphorylation of Tau in rats]. Sheng li xue bao : [Acta physiologica Sinica] vol 64 issue 4 2015 22907299 |
ect and the glutamate ionic receptor blockers did not affect the total tau protein in the hippocampus of rats. |
2015-05-16 |
2023-01-25 |
rat |
| Chao Liu, Su Min, Ke Wei, Dong Liu, Jun Dong, Jie Luo, Xiao-Bin Li. [MK-801 or DNQX reduces electroconvulsive shock-induced impairment of learning-memory and hyperphosphorylation of Tau in rats]. Sheng li xue bao : [Acta physiologica Sinica] vol 64 issue 4 2015 22907299 |
ect up-regulated the hyperphosphorylation of tau protein in the hippocampus of depressed rats, while the glutamate ionic receptor blockers down-regulated it, and combination of the two factors presented a subtractive effect. |
2015-05-16 |
2023-01-25 |
rat |
| Chao Liu, Su Min, Ke Wei, Dong Liu, Jun Dong, Jie Luo, Xiao-Bin Li. [MK-801 or DNQX reduces electroconvulsive shock-induced impairment of learning-memory and hyperphosphorylation of Tau in rats]. Sheng li xue bao : [Acta physiologica Sinica] vol 64 issue 4 2015 22907299 |
our results indicate that ect up-regulates the content of glutamate in the hippocampus of depressed rats, which up-regulates the hyperphosphorylation of tau protein resulting in the impairment of learning and memory in depressed rats. |
2015-05-16 |
2023-01-25 |
rat |
| Scott E Counts, Sylvia E Perez, Bin He, Elliott J Mufso. Intravenous immunoglobulin reduces tau pathology and preserves neuroplastic gene expression in the 3xTg mouse model of Alzheimer's disease. Current Alzheimer research vol 11 issue 7 2015 25156574 |
hence, ivig reduces hippocampal nft pathology in the 3xtg mouse through a mechanism that may involve preservation of neuronal plasticity and tau phosphorylation homeostasis. |
2015-05-12 |
2023-01-25 |
mouse |
| Marie-Elaine Laurier-Laurin, Audr\\xc3\\xa9e De Montigny, Suzanne Attiori Essis, Michel Cyr, Guy Massicott. Blockade of lysosomal acid ceramidase induces GluN2B-dependent Tau phosphorylation in rat hippocampal slices. Neural plasticity vol 2014 issue 2015 25276436 |
collectively, these results provide experimental evidence that ceramides play an important role in regulating tau phosphorylation in the hippocampus via a mechanism dependent on glun2b receptor subunits and camkii activation. |
2015-05-11 |
2023-01-25 |
rat |
| Dae-Young Kim, Sun-Young Jung, Tae-Woon Kim, Kwang-Sik Lee, Kijeong Ki. Treadmill exercise decreases incidence of Alzheimer's disease by suppressing glycogen synthase kinase-3\\xce\\xb2 expression in streptozotocin-induced diabetic rats. Journal of exercise rehabilitation vol 11 issue 2 2015 25960981 |
in the present study, treadmill exercise suppressed hyperphosphorylation of tau in the hippocampus by decreased gsk-3\xce\xb2 activity through pi3k/akt pathway activation in the diabetic rats. |
2015-05-11 |
2023-01-25 |
rat |