All Relations between microtubule-associated protein tau and hippocampus

Publication Sentence Publish Date Extraction Date Species
Lucia Buccarello, Giuliano Grignaschi, Anna Maria Castaldo, Alessia Di Giancamillo, Cinzia Domeneghini, Roberto Cosimo Melcangi, Tiziana Borsell. Sex Impact on Tau-Aggregation and Postsynaptic Protein Levels in the P301L Mouse Model of Tauopathy. Journal of Alzheimer's disease : JAD. vol 56. issue 4. 2018-02-23. PMID:28157099. when compared to control mice (ctr), p301l transgenic mice (tg) presented a lower body weight, reduced survival rate, hyperphosphorylated tau, spine injury, and neuronal loss in both cerebral cortex and hippocampus at 15 months of age. 2018-02-23 2023-08-13 mouse
Hideomi Hamasaki, Hiroyuki Honda, Tsuyoshi Okamoto, Sachiko Koyama, Satoshi O Suzuki, Tomoyuki Ohara, Toshiharu Ninomiya, Yutaka Kiyohara, Toru Iwak. Recent Increases in Hippocampal Tau Pathology in the Aging Japanese Population: The Hisayama Study. Journal of Alzheimer's disease : JAD. vol 55. issue 2. 2018-02-22. PMID:27716666. recent increases in hippocampal tau pathology in the aging japanese population: the hisayama study. 2018-02-22 2023-08-13 Not clear
Marion T Turnbull, Elizabeth J Coulso. Cholinergic Basal Forebrain Lesion Decreases Neurotrophin Signaling without Affecting Tau Hyperphosphorylation in Genetically Susceptible Mice. Journal of Alzheimer's disease : JAD. vol 55. issue 3. 2018-02-20. PMID:27767994. our results reveal that the loss of bfcns in pre-symptomatic pr5 (p301l) tau transgenic mice results in a decrease in hippocampal brain-derived neurotrophic factor levels and reduced trkb receptor activation. 2018-02-20 2023-08-13 mouse
Marion T Turnbull, Elizabeth J Coulso. Cholinergic Basal Forebrain Lesion Decreases Neurotrophin Signaling without Affecting Tau Hyperphosphorylation in Genetically Susceptible Mice. Journal of Alzheimer's disease : JAD. vol 55. issue 3. 2018-02-20. PMID:27767994. however, there was no exacerbation of the levels of phosphorylated tau or its aggregation in the hippocampus of susceptible mice. 2018-02-20 2023-08-13 mouse
Marion T Turnbull, Elizabeth J Coulso. Cholinergic Basal Forebrain Lesion Decreases Neurotrophin Signaling without Affecting Tau Hyperphosphorylation in Genetically Susceptible Mice. Journal of Alzheimer's disease : JAD. vol 55. issue 3. 2018-02-20. PMID:27767994. this suggests that tau pathology is likely to be regulated independently of bfcn degeneration and the corresponding decrease in hippocampal neurotrophin levels, although these features may still contribute to disease etiology. 2018-02-20 2023-08-13 mouse
Jesus Mendiola-Precoma, Karla Padilla, Alfredo Rodríguez-Cruz, Laura C Berumen, Ricardo Miledi, Guadalupe García-Alcoce. Theobromine-Induced Changes in A1 Purinergic Receptor Gene Expression and Distribution in a Rat Brain Alzheimer's Disease Model. Journal of Alzheimer's disease : JAD. vol 55. issue 3. 2018-02-20. PMID:27792010. dementia caused by alzheimer's disease (ad) is mainly characterized by accumulation in the brain of extra- and intraneuronal amyloid-β (aβ) and tau proteins, respectively, which selectively affect specific regions, particularly the neocortex and the hippocampus. 2018-02-20 2023-08-13 rat
Kateřina Storey, Silvie Johanidesová, Radoslav Matěj, Jiří Keller, Zdeněk Rohan, Robert Rusin. FTLD-TDP and progressive supranuclear palsy in comorbidity-a report of two cases with different clinical presentations. Neurocase. vol 23. issue 1. 2018-02-20. PMID:27915581. neuropathological examination revealed neuronal and glial tau pathology together with ubiquitin, and phospho-tdp-43-immunoreactivities in the hippocampus, striatum, mesencephalon, and frontal and temporal cortices. 2018-02-20 2023-08-13 Not clear
Hsiang Liao, Liang-Mao Chou, Yi-Wen Chien, Chi-Hao Wu, Jung-Su Chang, Ching-I Lin, Shyh-Hsiang Li. Grape powder consumption affects the expression of neurodegeneration-related brain proteins in rats chronically fed a high-fructose-high-fat diet. The Journal of nutritional biochemistry. vol 43. 2018-02-19. PMID:28285155. western blotting was performed to measure the expression/phosphorylation levels of several cortical and hippocampal proteins, including amyloid precursor protein (app), tau, phosphatidylinositol-3-kinase (pi3k), extracellular signal-regulated kinase (erk), receptor for advanced glycation end products (rages), erythroid 2-related factor 2 (nrf2) and brain-derived neurotrophic factor (bdnf). 2018-02-19 2023-08-13 rat
Suryanarayan Biswal, Deepti Sharma, Kushal Kumar, Tapas Chandra Nag, Kalpana Barhwal, Sunil Kumar Hota, Bhuvnesh Kuma. Global hypoxia induced impairment in learning and spatial memory is associated with precocious hippocampal aging. Neurobiology of learning and memory. vol 133. 2018-02-15. PMID:27246251. a single episode of chronic hypobaric hypoxia exposure also resulted in the up-regulation of pro-aging protein, s100a9 and down regulation of tau, snap25, apoe and sod2 in the hippocampus similar to that in aged rats indicating hypoxia induced accelerated aging. 2018-02-15 2023-08-13 rat
Sarah L DeVos, Rebecca L Miller, Kathleen M Schoch, Brandon B Holmes, Carey S Kebodeaux, Amy J Wegener, Guo Chen, Tao Shen, Hien Tran, Brandon Nichols, Tom A Zanardi, Holly B Kordasiewicz, Eric E Swayze, C Frank Bennett, Marc I Diamond, Timothy M Mille. Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy. Science translational medicine. vol 9. issue 374. 2018-02-01. PMID:28123067. the resolution of tau pathology was accompanied by the prevention of hippocampal volume loss, neuronal death, and nesting deficits. 2018-02-01 2023-08-13 mouse
Lixia Yu, Yuan Chen, Weiguang Wang, Zhonghai Xiao, Yan Hon. Multi-Vitamin B Supplementation Reverses Hypoxia-Induced Tau Hyperphosphorylation and Improves Memory Function in Adult Mice. Journal of Alzheimer's disease : JAD. vol 54. issue 1. 2018-01-29. PMID:27497480. mice in the hh group exhibited significant spatial working and passive memory impairment, increased tau phosphorylation at thr181, ser262, ser202/thr205, and ser396 in the cortex and hippocampus, and elevated hcy levels compared with controls. 2018-01-29 2023-08-13 mouse
Ana Laura Calderon-Garcidueñas, Charles Duyckaert. Alzheimer disease. Handbook of clinical neurology. vol 145. 2018-01-29. PMID:28987180. tau pathology affects in a stereotyped order some specific nuclei of the brainstem, the entorhinal area, the hippocampus, and the neocortex - first the associative areas and secondarily the primary cortices (braak stages). 2018-01-29 2023-08-13 Not clear
Gabor G Kovac. Tauopathies. Handbook of clinical neurology. vol 145. 2018-01-29. PMID:28987182. for cost-effective screening for tau pathologies in neuropathologic practice, examination of the hippocampus, amygdala, and basal ganglia is recommended. 2018-01-29 2023-08-13 Not clear
Anat Boehm-Cagan, Roni Bar, Ori Liraz, John K Bielicki, Jan O Johansson, Daniel M Michaelso. ABCA1 Agonist Reverses the ApoE4-Driven Cognitive and Brain Pathologies. Journal of Alzheimer's disease : JAD. vol 54. issue 3. 2018-01-26. PMID:27567858. this was associated with a reversal of the apoe4-driven aβ42 accumulation and tau hyperphosphorylation in hippocampal neurons, as well as of the synaptic impairments and cognitive deficits. 2018-01-26 2023-08-13 mouse
Mary Ellen I Koran, Madison Wagener, Timothy J Hohma. Sex differences in the association between AD biomarkers and cognitive decline. Brain imaging and behavior. vol 11. issue 1. 2018-01-25. PMID:26843008. similarly, we observed an interaction between sex and total tau level on longitudinal hippocampal atrophy (p = 0.008), and longitudinal decline in executive function (p = 0.034). 2018-01-25 2023-08-13 human
Mary Ellen I Koran, Madison Wagener, Timothy J Hohma. Sex differences in the association between AD biomarkers and cognitive decline. Brain imaging and behavior. vol 11. issue 1. 2018-01-25. PMID:26843008. women with aβ-42 and total tau levels indicative of worse pathological changes showed more rapid hippocampal atrophy and cognitive decline. 2018-01-25 2023-08-13 human
J D White, M J Eimerbrink, H B Hayes, A Hardy, E A Van Enkevort, J L Peterman, M J Chumley, G W Boeh. Hippocampal Aβ expression, but not phosphorylated tau, predicts cognitive deficits following repeated peripheral poly I:C administration. Behavioural brain research. vol 313. 2018-01-25. PMID:27449203. hippocampal aβ expression, but not phosphorylated tau, predicts cognitive deficits following repeated peripheral poly i:c administration. 2018-01-25 2023-08-13 Not clear
J D White, M J Eimerbrink, H B Hayes, A Hardy, E A Van Enkevort, J L Peterman, M J Chumley, G W Boeh. Hippocampal Aβ expression, but not phosphorylated tau, predicts cognitive deficits following repeated peripheral poly I:C administration. Behavioural brain research. vol 313. 2018-01-25. PMID:27449203. immediately after testing, the hippocampus was collected to quantify aβ and phosphorylated tau accumulation. 2018-01-25 2023-08-13 Not clear
Ying Liu, Lan Tan, Hui-Fu Wang, Yong Liu, Xiao-Ke Hao, Chen-Chen Tan, Teng Jiang, Bing Liu, Dao-Qiang Zhang, Jin-Tai Y. Multiple Effect of APOE Genotype on Clinical and Neuroimaging Biomarkers Across Alzheimer's Disease Spectrum. Molecular neurobiology. vol 53. issue 7. 2018-01-16. PMID:26298664. a total of 1718 participants from the adni cohort were selected, and we evaluated the impact of ε4 dose on cerebrospinal fluid (csf) levels' abeta1-42 (aβ1-42), tau, and phosphorylated-tau (p-tau); cortical amyloid deposition (florbetapir-pet-av45); brain atrophy (mri); brain metabolism (fdg-pet); hippocampal metabolism; and cognitive declines, through different cognitive subgroups. 2018-01-16 2023-08-13 human
Ying Liu, Lan Tan, Hui-Fu Wang, Yong Liu, Xiao-Ke Hao, Chen-Chen Tan, Teng Jiang, Bing Liu, Dao-Qiang Zhang, Jin-Tai Y. Multiple Effect of APOE Genotype on Clinical and Neuroimaging Biomarkers Across Alzheimer's Disease Spectrum. Molecular neurobiology. vol 53. issue 7. 2018-01-16. PMID:26298664. we found that (1) ε4 was associated with decreased csf beta-amyloid (aβ1-42) and increased cerebral aβ deposition across the ad spectrum; (2) increased csf tau, p-tau and cerebral hypometabolism, hippocampal atrophy, and cognition decline were all associated with apoe ε4 in prodromal ad stage; (3) increased csf tau, p-tau and cerebral hypometabolism appear to begin earlier than hippocampal atrophy and cognitive decline. 2018-01-16 2023-08-13 human