All Relations between microtubule-associated protein tau and hippocampus

Publication Sentence Publish Date Extraction Date Species
Yan-Juan Wang, Qing-Guo Ren, Wei-Gang Gong, Di Wu, Xiang Tang, Xiao-Li Li, Fang-Fang Wu, Feng Bai, Lin Xu, Zhi-Jun Zhan. Escitalopram attenuates β-amyloid-induced tau hyperphosphorylation in primary hippocampal neurons through the 5-HT1A receptor mediated Akt/GSK-3β pathway. Oncotarget. vol 7. issue 12. 2017-12-15. PMID:26950279. our results demonstrated that escitalopram attenuated aβ1-42-induced tau hyperphosphorylation in primary hippocampal neurons through the 5-ht1a receptor mediated akt/gsk-3β pathway. 2017-12-15 2023-08-13 rat
Aurélie Ledreux, Xiuzhe Wang, Marianne Schultzberg, Ann-Charlotte Granholm, Linnea R Freema. Detrimental effects of a high fat/high cholesterol diet on memory and hippocampal markers in aged rats. Behavioural brain research. vol 312. 2017-12-13. PMID:27343935. we investigated the effects of a high fat/high cholesterol (hfhc) diet on cognitive performance, neuroinflammation markers, and phosphorylated tau (p-tau) pathological markers in the hippocampus of young (4-month old) versus aged (14-month old) male rats. 2017-12-13 2023-08-13 rat
Aurélie Ledreux, Xiuzhe Wang, Marianne Schultzberg, Ann-Charlotte Granholm, Linnea R Freema. Detrimental effects of a high fat/high cholesterol diet on memory and hippocampal markers in aged rats. Behavioural brain research. vol 312. 2017-12-13. PMID:27343935. western blot analysis of the hippocampus showed higher levels of p-tau s202/t205 and t231 in aged hfhc rats, suggesting abnormal phosphorylation of tau protein following the hfhc diet exposure. 2017-12-13 2023-08-13 rat
Zi-Ai Zhao, Ya-Lei Ning, Ping Li, Nan Yang, Yan Peng, Ren-Ping Xiong, Yan Zhao, Dong Liu, Xu-Jia Zeng, Jiang-Fan Chen, Yuan-Guo Zho. Widespread hyperphosphorylated tau in the working memory circuit early after cortical impact injury of brain (Original study). Behavioural brain research. vol 323. 2017-12-13. PMID:28163095. given that tau hyperphosphorylation is an important cause of cognitive impairment in patients of alzheimer's disease, our present study detected the presence of hyperphosphorylated tau (p-tau), mainly at ser404, in multiple brain regions, including the ipsilateral parietal cortex, contralateral hippocampus and prefrontal cortex, immediately after the injury in a mouse tbi model; these changes lasted for at least 4w. 2017-12-13 2023-08-13 mouse
Kayla Raider, Delin Ma, Janna L Harris, Isabella Fuentes, Robert S Rogers, Joshua L Wheatley, Paige C Geiger, Hung-Wen Yeh, In-Young Choi, William M Brooks, John A Stanfor. A high fat diet alters metabolic and bioenergetic function in the brain: A magnetic resonance spectroscopy study. Neurochemistry international. vol 97. 2017-12-12. PMID:27125544. hippocampal pampk levels correlated significantly with tcr, aspartate (asp), phosphoethanolamine (pe), and taurine (tau), indicating beneficial effects of ampk activation on brain metabolic and energetic function, membrane turnover, and edema. 2017-12-12 2023-08-13 rat
Sofia Lopes, João Vaz-Silva, Vitor Pinto, Christina Dalla, Nikolaos Kokras, Benedikt Bedenk, Natalie Mack, Michael Czisch, Osborne F X Almeida, Nuno Sousa, Ioannis Sotiropoulo. Tau protein is essential for stress-induced brain pathology. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 26. 2017-12-12. PMID:27274066. here, we demonstrate that stress-driven hippocampal deficits in wild-type mice are accompanied by synaptic missorting of tau and enhanced fyn/glun2b-driven synaptic signaling. 2017-12-12 2023-08-13 mouse
Sofia Lopes, João Vaz-Silva, Vitor Pinto, Christina Dalla, Nikolaos Kokras, Benedikt Bedenk, Natalie Mack, Michael Czisch, Osborne F X Almeida, Nuno Sousa, Ioannis Sotiropoulo. Tau protein is essential for stress-induced brain pathology. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 26. 2017-12-12. PMID:27274066. in contrast, mice lacking tau [tau knockout (tau-ko) mice] do not exhibit stress-induced pathological behaviors and atrophy of hippocampal dendrites or deficits of hippocampal connectivity. 2017-12-12 2023-08-13 mouse
Elliott J Mufson, Milos D Ikonomovic, Scott E Counts, Sylvia E Perez, Michael Malek-Ahmadi, Stephen W Scheff, Stephen D Ginsber. Molecular and cellular pathophysiology of preclinical Alzheimer's disease. Behavioural brain research. vol 311. 2017-12-05. PMID:27185734. in this review, we illustrate relevant clinical pathological research in preclinical ad and throughout the progression of dementia in several areas including aβ and tau pathobiology, single population expression profiling of vulnerable hippocampal and basal forebrain neurons, neuroplasticity, neuroimaging, cerebrospinal fluid (csf) biomarker studies and their correlation with antemortem cognitive endpoints. 2017-12-05 2023-08-13 Not clear
Hyeongki Kim, Kyu-Sun Lee, Ae-Kyeong Kim, Miri Choi, Kwangman Choi, Mingu Kang, Seung-Wook Chi, Min-Sung Lee, Jeong-Soo Lee, So-Young Lee, Woo-Joo Song, Kweon Yu, Sungchan Ch. A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition. Disease models & mechanisms. vol 9. issue 8. 2017-12-04. PMID:27483355. moreover, oral administration of cx-4945 acutely suppressed tau hyperphosphorylation in the hippocampus of dyrk1a-overexpressing mice. 2017-12-04 2023-08-13 mouse
Emi Hayashi-Park, Bria N Ozment, Chelsea M Griffith, Haiying Zhang, Peter R Patrylo, Gregory M Ros. Experimentally induced diabetes worsens neuropathology, but not learning and memory, in middle aged 3xTg mice. Behavioural brain research. vol 322. issue Pt B. 2017-11-30. PMID:27173425. subsequently, the hippocampal region was examined using immunohistochemistry (6e10 antibody for amyloid) and immunoblotting (at8 antibody for phosphorylated tau). 2017-11-30 2023-08-13 mouse
Shinsuke Ishigaki, Yusuke Fujioka, Yohei Okada, Yuichi Riku, Tsuyoshi Udagawa, Daiyu Honda, Satoshi Yokoi, Kuniyuki Endo, Kensuke Ikenaka, Shinnosuke Takagi, Yohei Iguchi, Naruhiko Sahara, Akihiko Takashima, Hideyuki Okano, Mari Yoshida, Hitoshi Warita, Masashi Aoki, Hirohisa Watanabe, Haruo Okado, Masahisa Katsuno, Gen Sobu. Altered Tau Isoform Ratio Caused by Loss of FUS and SFPQ Function Leads to FTLD-like Phenotypes. Cell reports. vol 18. issue 5. 2017-11-28. PMID:28147269. hippocampus-specific fus- or sfpq-knockdown mice exhibit frontotemporal lobar degeneration (ftld)-like behaviors, reduced adult neurogenesis, accumulation of phosphorylated tau, and hippocampal atrophy with neuronal loss through an increased 4r-t/3r-t ratio. 2017-11-28 2023-08-13 mouse
Glenn R Yamakawa, Connor Lengkeek, Sabrina Salberg, Simon C Spanswick, Richelle Mychasiu. Behavioral and pathophysiological outcomes associated with caffeine consumption and repetitive mild traumatic brain injury (RmTBI) in adolescent rats. PloS one. vol 12. issue 11. 2017-11-28. PMID:29108016. finally, modifications to expression of 12 genes (adora2a, app, aqp4, bdnf, bmal1, clock, cry, gfap, orx1, orx2, per, tau), in the prefrontal cortex, hippocampus, and/or the hypothalamus were assessed. 2017-11-28 2023-08-13 rat
Xun-Hu Gu, Li-Jun Xu, Zhi-Qiang Liu, Bo Wei, Yuan-Jian Yang, Guo-Gang Xu, Xiao-Ping Yin, Wei Wan. The flavonoid baicalein rescues synaptic plasticity and memory deficits in a mouse model of Alzheimer's disease. Behavioural brain research. vol 311. 2017-11-27. PMID:27233830. changes in hippocampal 12/15 lipoxygenase (12/15lo) and glycogen synthase kinase 3β (gsk3β) activity, aβ production, tau phosphorylation, synaptic plasticity, and dendritic spine density were evaluated. 2017-11-27 2023-08-13 mouse
Helena Soler, Jonatan Dorca-Arévalo, Marta González, Sara Esmeralda Rubio, Jesús Ávila, Eduardo Soriano, Marta Pascua. The GABAergic septohippocampal connection is impaired in a mouse model of tauopathy. Neurobiology of aging. vol 49. 2017-11-16. PMID:27743524. we show that pyramidal neurons, mossy cells, and some parvalbumin (parv)-positive hippocampal interneurons in 2- and 8-month-old (mo) vlw mice accumulate phosphorylated forms of tau (p-tau). 2017-11-16 2023-08-13 mouse
Natalia A Stefanova, Natalia A Muraleva, Kseniya Yi Maksimova, Ekaterina A Rudnitskaya, Elena Kiseleva, Darya V Telegina, Nataliya G Kolosov. An antioxidant specifically targeting mitochondria delays progression of Alzheimer's disease-like pathology. Aging. vol 8. issue 11. 2017-11-16. PMID:27750209. via improvement of structural and functional state of mitochondria, treatment with skq1 alleviated the structural neurodegenerative alterations, prevented the neuronal loss and synaptic damage, increased the levels of synaptic proteins, enhanced neurotrophic supply, and decreased amyloid-β1-42 protein levels and tau hyperphosphorylation in the hippocampus of oxys rats, resulting in improvement of the learning ability and memory. 2017-11-16 2023-08-13 human
Ane-Victoria Idland, Roser Sala-Llonch, Tom Borza, Leiv Otto Watne, Torgeir Bruun Wyller, Anne Brækhus, Henrik Zetterberg, Kaj Blennow, Kristine Beate Walhovd, Anders Martin Fjel. CSF neurofilament light levels predict hippocampal atrophy in cognitively healthy older adults. Neurobiology of aging. vol 49. 2017-11-16. PMID:27794264. we tested whether csf nfl levels predict hippocampal atrophy rate in cognitively healthy older adults independently of the established csf alzheimer's disease (ad) biomarkers, β-amyloid 1-42, and phosphorylated tau (p-tau). 2017-11-16 2023-08-13 human
C Dioli, P Patrício, R Trindade, L G Pinto, J M Silva, M Morais, E Ferreiro, S Borges, A Mateus-Pinheiro, A J Rodrigues, N Sousa, J M Bessa, L Pinto, I Sotiropoulo. Tau-dependent suppression of adult neurogenesis in the stressed hippocampus. Molecular psychiatry. vol 22. issue 8. 2017-11-13. PMID:28555078. these data establish tau as a critical regulator of the cellular cascades underlying stress deficits on hippocampal neurogenesis in the adult brain. 2017-11-13 2023-08-13 mouse
Yipeng Wang, Varun Balaji, Senthilvelrajan Kaniyappan, Lars Krüger, Stephan Irsen, Katharina Tepper, RamReddy Chandupatla, Walter Maetzler, Anja Schneider, Eckhard Mandelkow, Eva-Maria Mandelko. The release and trans-synaptic transmission of Tau via exosomes. Molecular neurodegeneration. vol 12. issue 1. 2017-11-09. PMID:28086931. tau pathology in ad spreads in a hierarchical pattern, whereby it first appears in the entorhinal cortex, then spreads to the hippocampus and later to the surrounding areas. 2017-11-09 2023-08-13 Not clear
Deyan Kong, Qian Liu, Guangxu Xu, Zhenhua Huang, Ning Luo, Yuanheng Huang, Keshu Ca. Synergistic effect of tanshinone IIA and mesenchymal stem cells on preventing learning and memory deficits via anti-apoptosis, attenuating tau phosphorylation and enhancing the activity of central cholinergic system in vascular dementia. Neuroscience letters. vol 637. 2017-10-31. PMID:27845241. the combined administration of tsa and mscs demonstrated a synergistic effect on suppressing neuronal apoptosis in the hippocampus, attenuating tau phosphorylation and enhancing the activity of central cholinergic system. 2017-10-31 2023-08-13 rat
Sosuke Yagishita, Seiya Suzuki, Keisuke Yoshikawa, Keiko Iida, Ayako Hirata, Masahiko Suzuki, Akihiko Takashima, Kei Maruyama, Akira Hirasawa, Takeo Awaj. Treatment of intermittent hypoxia increases phosphorylated tau in the hippocampus via biological processes common to aging. Molecular brain. vol 10. issue 1. 2017-10-30. PMID:28057021. treatment of intermittent hypoxia increases phosphorylated tau in the hippocampus via biological processes common to aging. 2017-10-30 2023-08-13 mouse