| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pamela Salcedo-Tello, Karina Hern\\xc3\\xa1ndez-Ortega, Clorinda Aria. Susceptibility to GSK3\\xce\\xb2-induced tau phosphorylation differs between the young and aged hippocampus after Wnt signaling inhibition. Journal of Alzheimer's disease : JAD vol 39 issue 4 2014 24270208 |
susceptibility to gsk3\xce\xb2-induced tau phosphorylation differs between the young and aged hippocampus after wnt signaling inhibition. |
2014-10-30 |
2023-01-25 |
rat |
| Pamela Salcedo-Tello, Karina Hern\\xc3\\xa1ndez-Ortega, Clorinda Aria. Susceptibility to GSK3\\xce\\xb2-induced tau phosphorylation differs between the young and aged hippocampus after Wnt signaling inhibition. Journal of Alzheimer's disease : JAD vol 39 issue 4 2014 24270208 |
here, we report that the wnt antagonist dkk-1 selectively increases tau phosphorylation in the hippocampus of aged rats at ser199/202, ser396/404, and ser214 sites. |
2014-10-30 |
2023-01-25 |
rat |
| Zhong-Sen Qu, Liang Li, Xiao-Jiang Sun, Yu-Wu Zhao, Jin Zhang, Zhi Geng, Jian-Liang Fu, Qing-Guo Re. Glycogen synthase kinase-3 regulates production of amyloid-\\xce\\xb2 peptides and tau phosphorylation in diabetic rat brain. TheScientificWorldJournal vol 2014 issue 2014 24983010 |
and a \xce\xb2 40 and a \xce\xb2 42 were found overproduced and the microtubule-associated protein tau was hyperphosphorylated in the hippocampus. |
2014-10-28 |
2023-01-25 |
rat |
| Natalia A Stefanova, Oyuna S Kozhevnikova, Anton O Vitovtov, Kseniya Yi Maksimova, Sergey V Logvinov, Ekaterina A Rudnitskaya, Elena E Korbolina, Natalia A Muraleva, Nataliya G Kolosov. Senescence-accelerated OXYS rats: a model of age-related cognitive decline with relevance to abnormalities in Alzheimer disease. Cell cycle (Georgetown, Tex.) vol 13 issue 6 2014 24552807 |
we have shown that this deterioration happens against the background of overproduction of amyloid precursor protein (a\xce\xb2pp), accumulation of \xce\xb2-amyloid (a\xce\xb2), and hyperphosphorylation of the tau protein in the hippocampus and cortex. |
2014-10-22 |
2023-01-25 |
rat |
| Haijian Liu, Hao Wen. Up-regulation of Alzheimer's disease-associated proteins may cause enflurane anesthesia induced cognitive decline in aged rats. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology vol 35 issue 2 2014 23934553 |
in addition, we analyzed the expression level of \xce\xb2-amyloid and phosphorylation level of tau in the hippocampus by immunoblotting. |
2014-10-21 |
2023-01-25 |
rat |
| Haijian Liu, Hao Wen. Up-regulation of Alzheimer's disease-associated proteins may cause enflurane anesthesia induced cognitive decline in aged rats. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology vol 35 issue 2 2014 23934553 |
interestingly, the levels of \xce\xb2-amyloid and phosphorylated tau in the hippocampus increased significantly at early stage and then restored to pre-anesthetic levels. |
2014-10-21 |
2023-01-25 |
rat |
| Yan-Fang Xian, Qing-Qiu Mao, Justin C Y Wu, Zi-Ren Su, Jian-Nan Chen, Xiao-Ping Lai, Siu-Po Ip, Zhi-Xiu Li. Isorhynchophylline treatment improves the amyloid-\\xce\\xb2-induced cognitive impairment in rats via inhibition of neuronal apoptosis and tau protein hyperphosphorylation. Journal of Alzheimer's disease : JAD vol 39 issue 2 2014 24164737 |
in the present study, we aimed to investigate the effect of irn on cognitive function, neuronal apoptosis, and tau protein hyperphosphorylation in the hippocampus of the a\xce\xb225-35-treated rats and to elucidate its action mechanisms. |
2014-10-21 |
2023-01-25 |
rat |
| Yan-Fang Xian, Qing-Qiu Mao, Justin C Y Wu, Zi-Ren Su, Jian-Nan Chen, Xiao-Ping Lai, Siu-Po Ip, Zhi-Xiu Li. Isorhynchophylline treatment improves the amyloid-\\xce\\xb2-induced cognitive impairment in rats via inhibition of neuronal apoptosis and tau protein hyperphosphorylation. Journal of Alzheimer's disease : JAD vol 39 issue 2 2014 24164737 |
in addition, irn attenuated the a\xce\xb225-35-induced neuronal apoptosis in hippocampus by down-regulating the protein and mrna levels of the ratio of bcl-2/bax, cleaved caspase-3 and caspase-9, as well as suppressing the tau protein hyperphosphorylation at the ser396, ser404, and thr205 sites. |
2014-10-21 |
2023-01-25 |
rat |
| Tetsuro Tago, Shozo Furumoto, Nobuyuki Okamura, Ryuichi Harada, Yoichi Ishikawa, Hiroyuki Arai, Kazuhiko Yanai, Ren Iwata, Yukitsuka Kud. Synthesis and preliminary evaluation of 2-arylhydroxyquinoline derivatives for tau imaging. Journal of labelled compounds & radiopharmaceuticals vol 57 issue 1 2014 24448742 |
the binding affinities of compounds for tau were evaluated by fluorescent staining of the ad hippocampal section and a competitive binding assay using [(18) f]thk-523. |
2014-10-09 |
2023-01-25 |
Not clear |
| Xiao-Tian Huang, Zhong-Ming Qian, Xuan He, Qi Gong, Ka-Chun Wu, Li-Rong Jiang, Li-Na Lu, Zhou-Jing Zhu, Hai-Yan Zhang, Wing-Ho Yung, Ya K. Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treatment of Alzheimer's disease. Neurobiology of aging vol 35 issue 5 2014 24332448 |
hupa treatment reduced insoluble and soluble beta amyloid levels, ameliorated amyloid plaques formation, and hyperphosphorylated tau in the cortex and hippocampus of appswe/ps1de9 transgenic ad mice. |
2014-10-06 |
2023-01-25 |
mouse |
| Ilie-Cosmin Stancu, Laurence Ris, Bruno Vasconcelos, Claudia Marinangeli, L\\xc3\\xa9onie Goeminne, Vincent Laporte, Laetitia E Haylani, Julien Couturier, Olivier Schakman, Philippe Gailly, Nathalie Pierrot, Pascal Kienlen-Campard, Jean-No\\xc3\\xabl Octave, Ilse Dewachte. Tauopathy contributes to synaptic and cognitive deficits in a murine model for Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol 28 issue 6 2014 24604080 |
our data indicate for the first time that pathological a\xce\xb2 species (or app/ps1) induced changes in tau contribute to cognitive deficits correlating with synaptic deficits and hippocampal atrophy in an ad model. |
2014-10-06 |
2023-01-25 |
mouse |
| Mikio Shoj. [Alzheimer's disease: a type of cerebral amyloidosis]. Brain and nerve = Shinkei kenkyu no shinpo vol 66 issue 7 2014 24998828 |
diagnosis is defined by the presence of dementia, the exclusion of non-alzheimer type dementia, progressive atrophy of the hippocampus and temporoparietal cortex, decreased blood flow and glucose metabolism in the posterior cingulate gyrus and precuneus, decreased levels of a\xce\xb242, and increased levels of tau in the cerebrospinal fluid accompanied by positive amyloid proton emission tomography. |
2014-10-06 |
2023-01-25 |
Not clear |
| Julia Banzhaf-Strathmann, Eva Benito, Stephanie May, Thomas Arzberger, Sabina Tahirovic, Hans Kretzschmar, Andr\\xc3\\xa9 Fischer, Dieter Edbaue. MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease. The EMBO journal vol 33 issue 15 2014 25001178 |
injecting mir-125b into the hippocampus of mice impairs associative learning and is accompanied by downregulation of bcl-w, dusp6, and ppp1ca, resulting in increased tau phosphorylation in vivo. |
2014-09-30 |
2023-01-25 |
mouse |
| Gemma Manich, Jaume del Valle, Itsaso Cabez\\xc3\\xb3n, Antoni Camins, Merc\\xc3\\xa8 Pall\\xc3\\xa0s, Carme Pelegr\\xc3\\xad, Jordi Vilaplan. Presence of a neo-epitope and absence of amyloid beta and tau protein in degenerative hippocampal granules of aged mice. Age (Dordrecht, Netherlands) vol 36 issue 1 2014 23867972 |
presence of a neo-epitope and absence of amyloid beta and tau protein in degenerative hippocampal granules of aged mice. |
2014-09-29 |
2023-01-25 |
mouse |
| Bo-Ryoung Choi, Woo-Hyun Cho, Jiyoung Kim, Hyong Joo Lee, ChiHye Chung, Won Kyung Jeon, Jung-Soo Ha. Increased expression of the receptor for advanced glycation end products in neurons and astrocytes in a triple transgenic mouse model of Alzheimer's disease. Experimental & molecular medicine vol 46 issue 2014 24503708 |
in aged 3xtg-ad mice, expression of human tau was observed in the hippocampal area ca1 and co-localized with rage signals. |
2014-09-25 |
2023-01-25 |
mouse |
| Yi Shu, Hong Zhang, Tao Kang, Jun-jian Zhang, Ying Yang, Hui Liu, Lei Zhan. PI3K/Akt signal pathway involved in the cognitive impairment caused by chronic cerebral hypoperfusion in rats. PloS one vol 8 issue 12 2014 24339978 |
in previous studies we found that learning capacity and memory were gradually impaired with cch, which altered the expression of synaptophysin, microtubule associated protein-2, growth associated protein-43, brain-derived neurotrophic factor, nerve growth factor, n-methyl-d-aspartate receptor subunit 1, camp response element-binding protein and tau hyperphosphorylation in the hippocampus. |
2014-09-19 |
2023-01-25 |
rat |
| Changsheng Li, Sufang Liu, Ying Xing, Feng Ta. The role of hippocampal tau protein phosphorylation in isoflurane-induced cognitive dysfunction in transgenic APP695 mice. Anesthesia and analgesia vol 119 issue 2 2014 24977637 |
the role of hippocampal tau protein phosphorylation in isoflurane-induced cognitive dysfunction in transgenic app695 mice. |
2014-09-11 |
2023-01-25 |
mouse |
| Changsheng Li, Sufang Liu, Ying Xing, Feng Ta. The role of hippocampal tau protein phosphorylation in isoflurane-induced cognitive dysfunction in transgenic APP695 mice. Anesthesia and analgesia vol 119 issue 2 2014 24977637 |
in the present study, we tested our hypothesis that enhanced tau protein phosphorylation in hippocampus contributes to isoflurane-induced cognitive dysfunction in a mouse model of alzheimer disease. |
2014-09-11 |
2023-01-25 |
mouse |
| W H\\xc3\\xa4rtig, A Saul, J Kacza, J Grosche, S Goldhammer, D Michalski, O Wirth. Immunolesion-induced loss of cholinergic projection neurones promotes \\xce\\xb2-amyloidosis and tau hyperphosphorylation in the hippocampus of triple-transgenic mice. Neuropathology and applied neurobiology vol 40 issue 2 2014 23566195 |
immunolesion-induced loss of cholinergic projection neurones promotes \xce\xb2-amyloidosis and tau hyperphosphorylation in the hippocampus of triple-transgenic mice. |
2014-09-10 |
2023-01-25 |
mouse |
| W H\\xc3\\xa4rtig, A Saul, J Kacza, J Grosche, S Goldhammer, D Michalski, O Wirth. Immunolesion-induced loss of cholinergic projection neurones promotes \\xce\\xb2-amyloidosis and tau hyperphosphorylation in the hippocampus of triple-transgenic mice. Neuropathology and applied neurobiology vol 40 issue 2 2014 23566195 |
here, we introduce a more-complex animal model of ad by inducing cellular loss of cpn in an already existing transgenic background aiming to elucidate subsequent changes of hippocampal \xce\xb2-amyloid (a\xce\xb2) and tau pathology. |
2014-09-10 |
2023-01-25 |
mouse |