| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karen L G Farizatto, Uzoma S Ikonne, Michael F Almeida, Merari F R Ferrari, Ben A Bah. Aβ42-mediated proteasome inhibition and associated tau pathology in hippocampus are governed by a lysosomal response involving cathepsin B: Evidence for protective crosstalk between protein clearance pathways. PloS one. vol 12. issue 8. 2017-10-09. PMID:28797057. |
oligomerized aβ42 (0.5-1.5 μm) reduced proteasome activity by 62% in hippocampal slice cultures over a 4-6-day period, corresponding with increased tau phosphorylation and reduced synaptophysin levels. |
2017-10-09 |
2023-08-13 |
Not clear |
| Na Jin, Huazhang Zhu, Xiao Liang, Wei Huang, Qingguo Xie, Peng Xiao, Jiazuan Ni, Qiong Li. Sodium selenate activated Wnt/β-catenin signaling and repressed amyloid-β formation in a triple transgenic mouse model of Alzheimer's disease. Experimental neurology. vol 297. 2017-10-05. PMID:28711506. |
increased aβ generation, tau hyperphosphorylation and neuronal apoptosis were found in the hippocampus of ad model mouse. |
2017-10-05 |
2023-08-13 |
mouse |
| Katherine Garcia Ravelli, Barbara Dos Anjos Rosário, Rosana Camarini, Marina Sorrentino Hernandes, Luiz Roberto Britt. Intracerebroventricular Streptozotocin as a Model of Alzheimer's Disease: Neurochemical and Behavioral Characterization in Mice. Neurotoxicity research. vol 31. issue 3. 2017-10-02. PMID:27913964. |
the main purpose of this study was to evaluate temporally the expression of ad-related proteins, such as amyloid-β (aβ), choline acetyltransferase (chat), synapsin, axonal neurofilaments, and phosphorylated tau in the hippocampus following intracerebroventricular (icv) administration of stz in adult mice. |
2017-10-02 |
2023-08-13 |
mouse |
| Tara Vanderweyde, Daniel J Apicco, Katherine Youmans-Kidder, Peter E A Ash, Casey Cook, Edroaldo Lummertz da Rocha, Karen Jansen-West, Alissa A Frame, Allison Citro, John D Leszyk, Pavel Ivanov, Jose F Abisambra, Martin Steffen, Hu Li, Leonard Petrucelli, Benjamin Wolozi. Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity. Cell reports. vol 15. issue 7. 2017-09-29. PMID:27160897. |
conversely, tia1 knockdown or knockout inhibits tau misfolding and associated toxicity in cultured hippocampal neurons, while overexpressing tia1 induces tau misfolding and stimulates neurodegeneration. |
2017-09-29 |
2023-08-13 |
mouse |
| Byeong Tak Jeon, Rok Won Heo, Eun Ae Jeong, Chin-Ok Yi, Jong Youl Lee, Kyung Eun Kim, Hwajin Kim, Gu Seob Ro. Effects of caloric restriction on O-GlcNAcylation, Ca(2+) signaling, and learning impairment in the hippocampus of ob/ob mice. Neurobiology of aging. vol 44. 2017-09-28. PMID:27318140. |
in addition, cr increased the levels of hippocampal o-linked-n-acetylglucosamine (o-glcnac) and glcnac transferase and decreased the expression of calcium/calmodulin-dependent protein kinase ii, lipocalin-2, and phosphorylated tau. |
2017-09-28 |
2023-08-13 |
mouse |
| Elodie Marciniak, Antoine Leboucher, Emilie Caron, Tariq Ahmed, Anne Tailleux, Julie Dumont, Tarik Issad, Ellen Gerhardt, Patrick Pagesy, Margaux Vileno, Clément Bournonville, Malika Hamdane, Kadiombo Bantubungi, Steve Lancel, Dominique Demeyer, Sabiha Eddarkaoui, Emmanuelle Vallez, Didier Vieau, Sandrine Humez, Emilie Faivre, Benjamin Grenier-Boley, Tiago F Outeiro, Bart Staels, Philippe Amouyel, Detlef Balschun, Luc Buee, David Blu. Tau deletion promotes brain insulin resistance. The Journal of experimental medicine. vol 214. issue 8. 2017-09-26. PMID:28652303. |
we found that tau deletion leads to an impaired hippocampal response to insulin, caused by altered irs-1 and pten (phosphatase and tensin homologue on chromosome 10) activities. |
2017-09-26 |
2023-08-13 |
mouse |
| Seung-Hoon Yang, Dongkeun Kenneth Lee, Jisu Shin, Sejin Lee, Seungyeop Baek, Jiyoon Kim, Hoyong Jung, Jung-Mi Hah, YoungSoo Ki. Nec-1 alleviates cognitive impairment with reduction of Aβ and tau abnormalities in APP/PS1 mice. EMBO molecular medicine. vol 9. issue 1. 2017-09-25. PMID:27861127. |
in the cortex and hippocampus of app/ps1 double-transgenic mice, nec-1 treatment reduced the levels of aβ oligomers, plaques and hyperphosphorylated tau without affecting production of aβ, while it altered the levels of apoptotic marker proteins. |
2017-09-25 |
2023-08-13 |
mouse |
| Jennifer L Furman, Jaime Vaquer-Alicea, Charles L White, Nigel J Cairns, Peter T Nelson, Marc I Diamon. Widespread tau seeding activity at early Braak stages. Acta neuropathologica. vol 133. issue 1. 2017-09-22. PMID:27878366. |
we measured tau seeding activity across four brain regions (hippocampus, frontal lobe, parietal lobe, and cerebellum) in 104 fresh-frozen human ad brain samples from all braak stages. |
2017-09-22 |
2023-08-13 |
mouse |
| Xike Qin, Yunling Wang, Hemant K Paude. Inhibition of Early Growth Response 1 in the Hippocampus Alleviates Neuropathology and Improves Cognition in an Alzheimer Model with Plaques and Tangles. The American journal of pathology. vol 187. issue 8. 2017-09-12. PMID:28641077. |
herein, we report that silencing of egr-1 in the hippocampus by shrna reduces tau phosphorylation, lowers amyloid-β (aβ) pathology, and improves cognition in the 3xtg-ad mouse model. |
2017-09-12 |
2023-08-13 |
mouse |
| Xike Qin, Yunling Wang, Hemant K Paude. Inhibition of Early Growth Response 1 in the Hippocampus Alleviates Neuropathology and Improves Cognition in an Alzheimer Model with Plaques and Tangles. The American journal of pathology. vol 187. issue 8. 2017-09-12. PMID:28641077. |
in hippocampal primary neurons, egr-1 binds to bace-1 and p35 promoters, enhances tau phosphorylation, activates cdk5 and bace-1, and accelerates amyloidogenic app processing. |
2017-09-12 |
2023-08-13 |
mouse |
| Jochen Martin Decker, Lars Krüger, Astrid Sydow, Frank Ja Dennissen, Zuzana Siskova, Eckhard Mandelkow, Eva-Maria Mandelko. The Tau/A152T mutation, a risk factor for frontotemporal-spectrum disorders, leads to NR2B receptor-mediated excitotoxicity. EMBO reports. vol 17. issue 4. 2017-09-07. PMID:26931569. |
we report on a novel transgenic mouse model expressing human full-length tau with the tau mutation a152t (htau(at)), a risk factor for ftd-spectrum disorders including psp and cbd brain neurons reveal pathological tau conformation, hyperphosphorylation, mis-sorting, aggregation, neuronal degeneration, and progressive loss, most prominently in area ca3 of the hippocampus. |
2017-09-07 |
2023-08-13 |
mouse |
| Sin-Woo Kang, Sung Jin Kim, Min-Sun Ki. Oxidative stress with tau hyperphosphorylation in memory impaired 1,2-diacetylbenzene-treated mice. Toxicology letters. vol 279. 2017-09-05. PMID:28734998. |
the authors examined the relevance of oxidative stress and tau hyperphosphorylation in the hippocampus. |
2017-09-05 |
2023-08-13 |
mouse |
| Sin-Woo Kang, Sung Jin Kim, Min-Sun Ki. Oxidative stress with tau hyperphosphorylation in memory impaired 1,2-diacetylbenzene-treated mice. Toxicology letters. vol 279. 2017-09-05. PMID:28734998. |
increased ros production, activated glycogen synthase kinase-3β (gsk-3β) and tau hyperphosphorylation were observed in hippocampal homogenates. |
2017-09-05 |
2023-08-13 |
mouse |
| Rosaliana Libro, Placido Bramanti, Emanuela Mazzo. Endogenous glucocorticoids: role in the etiopathogenesis of Alzheimer's disease. Neuro endocrinology letters. vol 38. issue 1. 2017-08-29. PMID:28456142. |
ad is the most common form of dementia, characterized by the pathological accumulation of two proteins: the amyloid beta (aβ) and the microtubule-associated protein tau in the neurons of the hippocampus and prefrontal cortex. |
2017-08-29 |
2023-08-13 |
Not clear |
| Xu-Ying Sun, Qing-Zhang Tuo, Zhen-Yu Liuyang, Ao-Ji Xie, Xiao-Long Feng, Xiong Yan, Mei Qiu, Shen Li, Xiu-Lian Wang, Fu-Yuan Cao, Xiao-Chuan Wang, Jian-Zhi Wang, Rong Li. Extrasynaptic NMDA receptor-induced tau overexpression mediates neuronal death through suppressing survival signaling ERK phosphorylation. Cell death & disease. vol 7. issue 11. 2017-08-28. PMID:27809304. |
activation of e-nmdars in wild-type mouse brains resulted in neuron loss in hippocampus, whereas tau deletion in neuronal cultures and in the mouse brains rescued the e-nmdars-induced neuronal death and degeneration. |
2017-08-28 |
2023-08-13 |
mouse |
| X-L Zhi, C-Y Li, M Xue, Y Hu, Y J. Changes in cognitive function due to combined propofol and remifentanil treatment are associated with phosphorylation of Tau in the hippocampus, abnormal total water and calcium contents of the brain, and elevated serum S100β levels. European review for medical and pharmacological sciences. vol 20. issue 10. 2017-08-23. PMID:27249618. |
changes in cognitive function due to combined propofol and remifentanil treatment are associated with phosphorylation of tau in the hippocampus, abnormal total water and calcium contents of the brain, and elevated serum s100β levels. |
2017-08-23 |
2023-08-13 |
Not clear |
| X-L Zhi, C-Y Li, M Xue, Y Hu, Y J. Changes in cognitive function due to combined propofol and remifentanil treatment are associated with phosphorylation of Tau in the hippocampus, abnormal total water and calcium contents of the brain, and elevated serum S100β levels. European review for medical and pharmacological sciences. vol 20. issue 10. 2017-08-23. PMID:27249618. |
we hypothesized that combined treatment with these drugs would exert its effect via increased phosphorylation of tau protein in the brain hippocampus. |
2017-08-23 |
2023-08-13 |
Not clear |
| Weijie Xu, Juanhong Liu, Delin Ma, Gang Yuan, Yan Lu, Yan Yan. Capsaicin reduces Alzheimer-associated tau changes in the hippocampus of type 2 diabetes rats. PloS one. vol 12. issue 2. 2017-08-17. PMID:28225806. |
capsaicin reduces alzheimer-associated tau changes in the hippocampus of type 2 diabetes rats. |
2017-08-17 |
2023-08-13 |
rat |
| Weijie Xu, Juanhong Liu, Delin Ma, Gang Yuan, Yan Lu, Yan Yan. Capsaicin reduces Alzheimer-associated tau changes in the hippocampus of type 2 diabetes rats. PloS one. vol 12. issue 2. 2017-08-17. PMID:28225806. |
the results revealed that the levels of phosphorylated tau protein at sites ser199, ser202 and ser396 in hippocampus of t2d+cap group were decreased significantly, but these phospho-sites in t2d+pf group didn't show such improvements compared with t2d group. |
2017-08-17 |
2023-08-13 |
rat |
| Weijie Xu, Juanhong Liu, Delin Ma, Gang Yuan, Yan Lu, Yan Yan. Capsaicin reduces Alzheimer-associated tau changes in the hippocampus of type 2 diabetes rats. PloS one. vol 12. issue 2. 2017-08-17. PMID:28225806. |
these results demonstrated that dietary capsaicin appears to prevent the hyperphosphorylation of ad-associated tau protein by increasing the activity of pi3k/akt and inhibiting gsk-3β in hippocampus of t2d rats, which supported that dietary capsaicin might have a potential use for the prevention of ad in t2d. |
2017-08-17 |
2023-08-13 |
rat |