| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Juha Laur\\xc3\\xa9. Cellular prion protein as a therapeutic target in Alzheimer's disease. Journal of Alzheimer's disease : JAD vol 38 issue 2 2014 23948943 |
the interaction of a\xce\xb2 oligomers with prpc in mice impairs hippocampal long-term potentiation, memory, and learning in a manner that involves fyn, tau, and glutamate receptors. |
2014-06-27 |
2023-01-25 |
mouse |
| Ryszard Pluta, Miros\\xc5\\x82aw Jab\\xc5\\x82o\\xc5\\x84ski, Marzena U\\xc5\\x82amek-Kozio\\xc5\\x82, Janusz Kocki, Judyta Brzozowska, S\\xc5\\x82awomir Januszewski, Wanda Furmaga-Jab\\xc5\\x82o\\xc5\\x84ska, Anna Bogucka-Kocka, Ryszard Maciejewski, Stanis\\xc5\\x82aw J Czuczwa. Sporadic Alzheimer's disease begins as episodes of brain ischemia and ischemically dysregulated Alzheimer's disease genes. Molecular neurobiology vol 48 issue 3 2014 23519520 |
nowadays, a handful of researchers share a newly emerged view that the ischemic episodes of brain best describe the pathogenic cascade, which eventually leads to neuronal loss, especially in hippocampus, with amyloid accumulation, tau protein pathology and irreversible dementia of alzheimer type. |
2014-06-18 |
2023-01-25 |
Not clear |
| Sylvia E Perez, Mary Ann Raghanti, Patrick R Hof, Lynn Kramer, Milos D Ikonomovic, Pascale N Lacor, Joseph M Erwin, Chet C Sherwood, Elliott J Mufso. Alzheimer's disease pathology in the neocortex and hippocampus of the western lowland gorilla (Gorilla gorilla gorilla). The Journal of comparative neurology vol 521 issue 18 2014 23881733 |
neurons stained for the tau marker alz50 were found in the neocortex and hippocampus of gorillas at all ages. |
2014-06-11 |
2023-01-25 |
Not clear |
| Etsuko Oshima, Takeshi Ishihara, Osamu Yokota, Hanae Nakashima-Yasuda, Shigeto Nagao, Chikako Ikeda, Jun Naohara, Seishi Terada, Yosuke Uchitom. Accelerated tau aggregation, apoptosis and neurological dysfunction caused by chronic oral administration of aluminum in a mouse model of tauopathies. Brain pathology (Zurich, Switzerland) vol 23 issue 6 2014 23574527 |
apoptosis was observed in the hippocampus in al-treated tau tg mice, but was virtually absent in the other experimental groups. |
2014-06-05 |
2023-01-25 |
mouse |
| Vanessa A Guzman, Owen T Carmichael, Christopher Schwarz, Giuseppe Tosto, Molly E Zimmerman, Adam M Brickma. White matter hyperintensities and amyloid are independently associated with entorhinal cortex volume among individuals with mild cognitive impairment. Alzheimer's & dementia : the journal of the Alzheimer's Association vol 9 issue 5 Suppl 2014 23375566 |
current hypothetical models of alzheimer's disease (ad) pathogenesis emphasize the role of \xce\xb2-amyloid (a\xce\xb2), tau deposition, and neurodegenerative changes in the mesial temporal lobe, particularly the entorhinal cortex and hippocampus. |
2014-05-28 |
2023-01-25 |
Not clear |
| Ana M Garc\\xc3\\xada-Cabrero, Rosa Guerrero-L\\xc3\\xb3pez, Beatriz G Gir\\xc3\\xa1ldez, Mar\\xc3\\xada Llorens-Mart\\xc3\\xadn, Jes\\xc3\\xbas Avila, Jos\\xc3\\xa9 M Serratosa, Marina P S\\xc3\\xa1nche. Hyperexcitability and epileptic seizures in a model of frontotemporal dementia. Neurobiology of disease vol 58 issue 2014 23774255 |
astrocytosis and activated microglia are prominent in the hippocampus and other brain regions of young ftdp-17 mice where the human mutant tau transgene is expressed, before the appearance of hyperphosphorylated tau aggregates in these structures. |
2014-04-23 |
2023-01-25 |
mouse |
| Bertrand R Huber, James S Meabon, Tobin J Martin, Pierre D Mourad, Raymond Bennett, Brian C Kraemer, Ibolja Cernak, Eric C Petrie, Michael J Emery, Erik R Swenson, Cynthia Mayer, Edin Mehic, Elaine R Peskind, David G Coo. Blast exposure causes early and persistent aberrant phospho- and cleaved-tau expression in a murine model of mild blast-induced traumatic brain injury. Journal of Alzheimer's disease : JAD vol 37 issue 2 2014 23948882 |
in hippocampus, aberrant tau species persisted for at least 30 days post-exposure, while sod2 levels returned to sham control levels. |
2014-04-15 |
2023-01-25 |
mouse |
| Valentine Lahmy, Johann Meunier, Susanna Malmstr\\xc3\\xb6m, Gaelle Naert, Laurent Givalois, Seung Hyun Kim, Vanessa Villard, Alexandre Vamvakides, Tangui Mauric. Blockade of Tau hyperphosphorylation and A\\xce\\xb2\\xe2\\x82\\x81\\xe2\\x82\\x8b\\xe2\\x82\\x84\\xe2\\x82\\x82 generation by the aminotetrahydrofuran derivative ANAVEX2-73, a mixed muscarinic and \\xcf\\x83\\xe2\\x82\\x81 receptor agonist, in a nontransgenic mouse model of Alzheimer's disease. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology vol 38 issue 9 2014 23493042 |
we therefore first confirmed that a\xce\xb2\xe2\x82\x82\xe2\x82\x85\xe2\x82\x8b\xe2\x82\x83\xe2\x82\x85 injection induced hyperphosphorylation of tau protein, by showing that it rapidly decreased akt activity and activated glycogen synthase kinase-3\xce\xb2 (gsk-3\xce\xb2) in the mouse hippocampus. |
2014-04-04 |
2023-01-25 |
mouse |
| Joel A Saydoff, Ana Olariu, Jin Sheng, Zhongyi Hu, Qin Li, Rolando Garcia, Jiong Pei, Grace Y Sun, Reid von Borste. Uridine prodrug improves memory in Tg2576 and TAPP mice and reduces pathological factors associated with Alzheimer's disease in related models. Journal of Alzheimer's disease : JAD vol 36 issue 4 2014 23648515 |
tapp mouse hippocampal tau phosphorylation and lipid peroxidation were reduced by pn401 treatment. |
2014-03-24 |
2023-01-25 |
mouse |
| Narayan R Bhat, Lakshmi Thirumangalakud. Increased tau phosphorylation and impaired brain insulin/IGF signaling in mice fed a high fat/high cholesterol diet. Journal of Alzheimer's disease : JAD vol 36 issue 4 2014 23703152 |
immunoblot analysis of hippocampal tissue from c57bl/6 mice fed hfc for 2 months with anti-phospho-tau (i.e., phf1 and phospho-thr-231 tau) antibodies demonstrated the presence of hyperphosphorylated tau. |
2014-03-24 |
2023-01-25 |
mouse |
| Daniela Giuliani, Alessandra Ottani, Davide Zaffe, Maria Galantucci, Flavio Strinati, Renzo Lodi, Salvatore Guarin. Hydrogen sulfide slows down progression of experimental Alzheimer's disease by targeting multiple pathophysiological mechanisms. Neurobiology of learning and memory vol 104 issue 2014 23726868 |
hippocampus reduced activity of c-jun n-terminal kinases, extracellular signal-regulated kinases and p38, which have an established role not only in phosphorylation of tau protein but also in inflammation and apoptosis, was also found. |
2014-03-20 |
2023-01-25 |
rat |
| Hiroyuki Shimad. [The DIAN study]. Brain and nerve = Shinkei kenkyu no shinpo vol 65 issue 10 2014 24101429 |
subsequently, a chronological series of events took place: deposition of fibrillar a\xce\xb2 as measured by positron emission tomography with the use of pittsburgh compound b, increase in tau protein in the csf, hippocampal atrophy and hypometabolism of fdg-pet, and cognitive and clinical changes. |
2014-03-19 |
2023-01-25 |
human |
| Ralph Michael, Cees Otto, Aufried Lenferink, Ellen Gelpi, Gustavo A Montenegro, Jurja Rosandi\\xc4\\x87, Francisco Tresserra, Rafael I Barraquer, Gijs F J M Vrense. Absence of amyloid-beta in lenses of Alzheimer patients: a confocal Raman microspectroscopic study. Experimental eye research vol 119 issue 2014 24333259 |
this major difference in beta-sheet conformation between hippocampus and lens is supported by congo red and immunostaining of amyloid-beta and tau which were positive for plaques and tangles in the hippocampus but fully negative for the lens irrespective of the presence or absence of opacities. |
2014-03-18 |
2023-01-25 |
Not clear |
| Isabel Lastres-Becker, Nadia G Innamorato, Tomasz Jaworski, Alberto R\\xc3\\xa1bano, Sebastian K\\xc3\\xbcgler, Fred Van Leuven, Antonio Cuadrad. Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis. Brain : a journal of neurology vol 137 issue Pt 1 2014 24277722 |
here, we show that hippocampal ht22 cells expressing human tau(p301l) mutant protein produce fractalkine, which in microglia activates akt, inhibits glycogen synthase kinase-3\xce\xb2 and upregulates the transcription factor nrf2/nfe2l2 and its target genes including heme oxygenase 1. |
2014-03-11 |
2023-01-25 |
mouse |
| Isabel Lastres-Becker, Nadia G Innamorato, Tomasz Jaworski, Alberto R\\xc3\\xa1bano, Sebastian K\\xc3\\xbcgler, Fred Van Leuven, Antonio Cuadrad. Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis. Brain : a journal of neurology vol 137 issue Pt 1 2014 24277722 |
in a mouse model of tauopathy based on stereotaxic delivery in hippocampus of an adeno-associated viral vector for expression of tau(p301l), we confirmed that tau-injured neurons express fractalkine. |
2014-03-11 |
2023-01-25 |
mouse |
| Anika Saul, Frederik Sprenger, Thomas A Bayer, Oliver Wirth. Accelerated tau pathology with synaptic and neuronal loss in a novel triple transgenic mouse model of Alzheimer's disease. Neurobiology of aging vol 34 issue 11 2014 23747045 |
these data support the assumption of tau pathology being downstream of amyloid pathology, suggesting that both pathologies together trigger the severe neuron loss in the hippocampus in the 5xfad/ps19 mouse model. |
2014-03-05 |
2023-01-25 |
mouse |
| Andrea Prister\\xc3\\xa0, Daniele Saraulli, Stefano Farioli-Vecchioli, Georgios Strimpakos, Marco Costanzi, Maria Grazia di Certo, Sara Cannas, Maria Teresa Ciotti, Felice Tirone, Elisabetta Mattei, Vincenzo Cestari, Nadia Can. Impact of N-tau on adult hippocampal neurogenesis, anxiety, and memory. Neurobiology of aging vol 34 issue 11 2014 23769395 |
however, little is known about how tau pathology directly affects adult hippocampal neurogenesis, a unique form of structural plasticity implicated in hippocampus-dependent spatial learning and mood-related behavior. |
2014-03-05 |
2023-01-25 |
human |
| Andrea Prister\\xc3\\xa0, Daniele Saraulli, Stefano Farioli-Vecchioli, Georgios Strimpakos, Marco Costanzi, Maria Grazia di Certo, Sara Cannas, Maria Teresa Ciotti, Felice Tirone, Elisabetta Mattei, Vincenzo Cestari, Nadia Can. Impact of N-tau on adult hippocampal neurogenesis, anxiety, and memory. Neurobiology of aging vol 34 issue 11 2014 23769395 |
understanding how pathological tau species directly affect neurogenesis is important for developing potential therapeutic strategies to direct neurogenic instructive cues for hippocampal function repair. |
2014-03-05 |
2023-01-25 |
human |
| Jayasankar Kosaraju, Chaitanya Chakravarthi Gali, Rizwan Basha Khatwal, Anil Dubala, Santhivardhan Chinni, R M Damian Holsinger, V Subba Rao Madhunapantula, Satish Kumar Muthureddy Nataraj, Duraiswamy Basava. Saxagliptin: a dipeptidyl peptidase-4 inhibitor ameliorates streptozotocin induced Alzheimer's disease. Neuropharmacology vol 72 issue 2014 23603201 |
the effect of the dpp-4 inhibitor on hippocampal glp-1 levels, a\xce\xb2 burden, tau phosphorylation, inflammatory markers and memory retention were evaluated. |
2014-02-11 |
2023-01-25 |
Not clear |
| Jayasankar Kosaraju, Chaitanya Chakravarthi Gali, Rizwan Basha Khatwal, Anil Dubala, Santhivardhan Chinni, R M Damian Holsinger, V Subba Rao Madhunapantula, Satish Kumar Muthureddy Nataraj, Duraiswamy Basava. Saxagliptin: a dipeptidyl peptidase-4 inhibitor ameliorates streptozotocin induced Alzheimer's disease. Neuropharmacology vol 72 issue 2014 23603201 |
the results reveal an attenuation of a\xce\xb2, tau phosphorylation and inflammatory markers and an improvement in hippocampal glp-1 and memory retention following treatment. |
2014-02-11 |
2023-01-25 |
Not clear |