| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Frédéric St-Cyr Giguère, Suzanne Attiori Essis, Laure Chagniel, Marc Germain, Michel Cyr, Guy Massicott. The sphingosine-1-phosphate receptor 1 agonist SEW2871 reduces Tau-Ser262 phosphorylation in rat hippocampal slices. Brain research. vol 1658. 2017-08-08. PMID:28104351. |
the present work compared the effects of more selective s1pr agonists on tau properties, using rat hippocampal slices as model system. |
2017-08-08 |
2023-08-13 |
rat |
| Maria Klingebiel, Maja Dinekov, Christoph Köhle. Analysis of ribosomal protein S6 baseline phosphorylation and effect of tau pathology in the murine brain and human hippocampus. Brain research. vol 1659. 2017-08-07. PMID:28119058. |
analysis of ribosomal protein s6 baseline phosphorylation and effect of tau pathology in the murine brain and human hippocampus. |
2017-08-07 |
2023-08-13 |
mouse |
| Eunhee Kim, Kazuko Sakata, Francesca-Fang Lia. Bidirectional interplay of HSF1 degradation and UPR activation promotes tau hyperphosphorylation. PLoS genetics. vol 13. issue 7. 2017-08-01. PMID:28678786. |
in addition, permanent hsf1 loss reversely causes chronic upr activation, leading to aberrant tau phosphorylation and aggregation in the hippocampus of aged hsf1 heterozygous knock-out mice. |
2017-08-01 |
2023-08-13 |
mouse |
| Wencheng Liu, Lingzhi Zhao, Brittany Blackman, Mayur Parmar, Man Ying Wong, Thomas Woo, Fangmin Yu, Maria J Chiuchiolo, Dolan Sondhi, Stephen M Kaminsky, Ronald G Crystal, Steven M Pau. Vectored Intracerebral Immunization with the Anti-Tau Monoclonal Antibody PHF1 Markedly Reduces Tau Pathology in Mutant Tau Transgenic Mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 49. 2017-07-28. PMID:27927959. |
in contrast to systemic passive immunization, we observed markedly reduced (≥80-90%) hippocampal insoluble pathological tau species and neurofibrillary tangles following a single dose of aav-vectored phf1 compared with mice treated with an aav-igg control vector. |
2017-07-28 |
2023-08-13 |
mouse |
| Ting Cui, Hong-Mei Qiu, Dan Huang, Qi-Xin Zhou, Xiao-Yan Fu, Hai-Yan Li, Xin-Hui Jian. Abnormal levels of seven amino neurotransmitters in depressed rat brain and determination by HPLC-FLD. Biomedical chromatography : BMC. vol 31. issue 8. 2017-07-26. PMID:28097679. |
the results showed that asp, gly, tau and gaba significantly decreased with increasing gln in the hippocampus of depressed rats, compared with that of the control group, among which obviously lower level of asp and higher level of gln in cortex were observed. |
2017-07-26 |
2023-08-13 |
rat |
| Ting Yang, Shaomin Li, Huixin Xu, Dominic M Walsh, Dennis J Selko. Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 1. 2017-07-24. PMID:28053038. |
soluble oligomers of amyloid β-protein (oaβ) isolated from the brains of alzheimer's disease (ad) patients have been shown experimentally (in the absence of amyloid plaques) to impair hippocampal synaptic plasticity, decrease synapses, induce tau hyperphosphorylation and neuritic dystrophy, activate microglial inflammation, and impair memory in normal adult rodents. |
2017-07-24 |
2023-08-13 |
mouse |
| L E Gardner, J D White, M J Eimerbrink, G W Boehm, M J Chumle. Imatinib methanesulfonate reduces hyperphosphorylation of tau following repeated peripheral exposure to lipopolysaccharide. Neuroscience. vol 331. 2017-07-11. PMID:27320209. |
our results may provide support for the hypothesis that enhanced expression of tau following lps administration is a protective measure by hippocampal neurons to compensate for the loss of the microtubule-stabilizing protein due to phosphorylation. |
2017-07-11 |
2023-08-13 |
mouse |
| V Cubinková, B Valachová, V Brezováková, R Szabó, I Zimová, Z Kostecká, S Jadha. Next generation tau models in Alzheimer's disease research - virus based gene delivery systems. Acta virologica. vol 61. issue 1. 2017-06-29. PMID:28105850. |
major advantage of aav as a delivery system is the site specific expression of tau, mostly in hippocampus and cortex, and thus elimination of unwanted ectopic transgene expression. |
2017-06-29 |
2023-08-13 |
Not clear |
| Michael F Almeida, Carolliny M Silva, Aline M D'Unhao, Merari F R Ferrar. Aged Lewis rats exposed to low and moderate doses of rotenone are a good model for studying the process of protein aggregation and its effects upon central nervous system cell physiology. Arquivos de neuro-psiquiatria. vol 74. issue 9. 2017-06-28. PMID:27706423. |
hyperphosphorylated tau, alpha-synuclein, amyloid-beta peptide and protein carbonylation (indicative of oxidative stress) were evaluated in the hippocampus, substantia nigra and locus coeruleus through immunohistochemistry or western blot. |
2017-06-28 |
2023-08-13 |
rat |
| Noemí Pallas-Bazarra, Jerónimo Jurado-Arjona, Marta Navarrete, Jose A Esteban, Félix Hernández, Jesús Ávila, María Llorens-Martí. Novel function of Tau in regulating the effects of external stimuli on adult hippocampal neurogenesis. The EMBO journal. vol 35. issue 13. 2017-06-26. PMID:27198172. |
novel function of tau in regulating the effects of external stimuli on adult hippocampal neurogenesis. |
2017-06-26 |
2023-08-13 |
mouse |
| Noemí Pallas-Bazarra, Jerónimo Jurado-Arjona, Marta Navarrete, Jose A Esteban, Félix Hernández, Jesús Ávila, María Llorens-Martí. Novel function of Tau in regulating the effects of external stimuli on adult hippocampal neurogenesis. The EMBO journal. vol 35. issue 13. 2017-06-26. PMID:27198172. |
here, we show that tau plays a novel in vivo role in the morphological and synaptic maturation of newborn hippocampal granule neurons under basal conditions. |
2017-06-26 |
2023-08-13 |
mouse |
| Noemí Pallas-Bazarra, Jerónimo Jurado-Arjona, Marta Navarrete, Jose A Esteban, Félix Hernández, Jesús Ávila, María Llorens-Martí. Novel function of Tau in regulating the effects of external stimuli on adult hippocampal neurogenesis. The EMBO journal. vol 35. issue 13. 2017-06-26. PMID:27198172. |
thus, our data demonstrate that tau(-/-) mice show impairments in the maturation of newborn granule neurons under basal conditions and that they are insensitive to the modulation of adult hippocampal neurogenesis exerted by both stimulatory and detrimental stimuli. |
2017-06-26 |
2023-08-13 |
mouse |
| Mohammad A Yousuf, Chunfeng Tan, Melissa I Torres-Altoro, Fang-Min Lu, Erik Plautz, Shanrong Zhang, Masaya Takahashi, Adan Hernandez, Steven G Kernie, Florian Plattner, James A Bib. Involvement of aberrant cyclin-dependent kinase 5/p25 activity in experimental traumatic brain injury. Journal of neurochemistry. vol 138. issue 2. 2017-06-23. PMID:26998748. |
here, we show that mice subjected to controlled cortical impact (cci), a well-established experimental tbi model, exhibit increased p25 levels and consistently elevated cdk5-dependent phosphorylation of microtubule-associated protein tau and retinoblastoma (rb) protein in hippocampal lysates. |
2017-06-23 |
2023-08-13 |
mouse |
| Tara E Tracy, Peter Dongmin Sohn, S Sakura Minami, Chao Wang, Sang-Won Min, Yaqiao Li, Yungui Zhou, David Le, Iris Lo, Ravikumar Ponnusamy, Xin Cong, Birgit Schilling, Lisa M Ellerby, Richard L Huganir, Li Ga. Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss. Neuron. vol 90. issue 2. 2017-06-19. PMID:27041503. |
transgenic mice expressing human tau with lysine-to-glutamine mutations to mimic k274 and k281 acetylation (taukq) exhibit ad-related memory deficits and impaired hippocampal long-term potentiation (ltp). |
2017-06-19 |
2023-08-13 |
mouse |
| Liviu-Gabriel Bodea, Harrison Tudor Evans, Ann Van der Jeugd, Lars M Ittner, Fabien Delerue, Jillian Kril, Glenda Halliday, John Hodges, Mathew C Kiernan, Jürgen Göt. Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model. Aging cell. vol 16. issue 2. 2017-06-19. PMID:28160413. |
unlike samp8 mice, pr5 mice are characterized by a robust tau pathology particularly in the amygdala and hippocampus. |
2017-06-19 |
2023-08-13 |
mouse |
| Liang Zhao, Yan Xiao, Xiao-Liang Wang, Jinjing Pei, Zhi-Zhong Gua. Original Research: Influence of okadaic acid on hyperphosphorylation of tau and nicotinic acetylcholine receptors in primary neurons. Experimental biology and medicine (Maywood, N.J.). vol 241. issue 16. 2017-06-06. PMID:27190248. |
primary cultures of neurons isolated from the hippocampus of the brains of neonatal rats were exposed to okadaic acid or/and aβ1-42 tau phosphorylated at ser404 and ser202, and the protein expressions of α7, α4 and α3 nachr subunits were quantified by western blotting, and their corresponding mrnas by real-time pcr. |
2017-06-06 |
2023-08-13 |
rat |
| Ze-Fen Wang, Zhi-Yong Pan, Cheng-Shi Xu, Zhi-Qiang L. Activation of G-protein coupled estrogen receptor 1 improves early-onset cognitive impairment via PI3K/Akt pathway in rats with traumatic brain injury. Biochemical and biophysical research communications. vol 482. issue 4. 2017-06-06. PMID:27908726. |
early-onset cognitive impairment following a single tbi was closely associated with acute hippocampal neuronal loss rather than tau pathology. |
2017-06-06 |
2023-08-13 |
human |
| Sarada Subramanian, Ganesh Savanur, Sowmya Madhavada. Passive immunization targeting the N-terminal region of phosphorylated tau (residues 68-71) improves spatial memory in okadaic acid induced tauopathy model rats. Biochemical and biophysical research communications. vol 483. issue 1. 2017-06-06. PMID:27998769. |
the cognitive impairment in patients with ad is closely associated with loss of synapses and the formation of neurofibrillary tangles (nft) containing hyperphosphorylated tau in the hippocampus. |
2017-06-06 |
2023-08-13 |
rat |
| Xiaoguang Li, Zhihao Wang, Lu Tan, Yali Wang, Chengbiao Lu, Rongxiang Chen, Shujuan Zhang, Yuan Gao, Yanchao Liu, Yaling Yin, Xinghua Liu, Enjie Liu, Ying Yang, Yu Hu, Zhipeng Xu, Fuqiang Xu, Jie Wang, Gong-Ping Liu, Jian-Zhi Wan. Correcting miR92a-vGAT-Mediated GABAergic Dysfunctions Rescues Human Tau-Induced Anxiety in Mice. Molecular therapy : the journal of the American Society of Gene Therapy. vol 25. issue 1. 2017-06-06. PMID:28129110. |
here, we found that overexpression of human wild-type, full-length tau (termed htau) in hippocampus significantly decreased the extracellular γ-aminobutyric acid (gaba) level with inhibition of γ oscillation and the evoked inhibitory postsynaptic potential (eipsp). |
2017-06-06 |
2023-08-13 |
mouse |
| Xin You Tai, Matthias Koepp, John S Duncan, Nick Fox, Pamela Thompson, Sallie Baxendale, Joan Y W Liu, Cheryl Reeves, Zuzanna Michalak, Maria Tho. Hyperphosphorylated tau in patients with refractory epilepsy correlates with cognitive decline: a study of temporal lobe resections. Brain : a journal of neurology. vol 139. issue Pt 9. 2017-06-05. PMID:27497924. |
we also found unusual patterns of subpial tau deposition, sparing of the hippocampus and co-localization with mossy fibre sprouting, a feature of temporal lobe epilepsy. |
2017-06-05 |
2023-08-13 |
Not clear |