| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rapha\\xc3\\xablle Caillierez, S\\xc3\\xa9verine B\\xc3\\xa9gard, Katia L\\xc3\\xa9colle, Vincent Deramecourt, Nad\\xc3\\xa8ge Zommer, Simon Dujardin, Anne Loyens, No\\xc3\\xablle Dufour, Gwenna\\xc3\\xablle Aur\\xc3\\xa9gan, Joris Winderickx, Philippe Hantraye, Nicole D\\xc3\\xa9glon, Luc Bu\\xc3\\xa9e, Morvane Coli. Lentiviral delivery of the human wild-type tau protein mediates a slow and progressive neurodegenerative tau pathology in the rat brain. Molecular therapy : the journal of the American Society of Gene Therapy vol 21 issue 7 2014 23609018 |
in the present study, we generated an original "sporadic tauopathy-like" model in the rat hippocampus, encoding six tau isoforms as found in humans, using lentiviral vectors (lvs) for the delivery of a human wt tau. |
2014-02-10 |
2023-01-25 |
rat |
| Deirdre Stolmeier, Ramasamy Thangavel, Poojya Anantharam, Mohammad M Khan, Duraisamy Kempuraj, Asgar Zahee. Glia maturation factor expression in hippocampus of human Alzheimer's disease. Neurochemical research vol 38 issue 8 2014 23640177 |
we further demonstrate that gmf immunoreactive glial cells were increased at the sites of tau containing nfts and aps of hippocampus in ad brains. |
2014-02-06 |
2023-01-25 |
human |
| Jose J Jarero-Basulto, Jose Luna-Mu\\xc3\\xb1oz, Raul Mena, Zdena Kristofikova, Daniela Ripova, George Perry, Lester I Binder, Francisco Garcia-Sierr. Proteolytic cleavage of polymeric tau protein by caspase-3: implications for Alzheimer disease. Journal of neuropathology and experimental neurology vol 72 issue 12 2014 24226268 |
in the hippocampus, we found distinct nonfibrillary aggregates of asp(421)-truncated tau. |
2014-01-13 |
2023-01-25 |
Not clear |
| Herv\\xc3\\xa9 Maurin, Claire Marie Seymour, Benoit Lechat, Peter Borghgraef, Herman Devijver, Tomasz Jaworski, Mathias V Schmidt, Sebastian Kuegler, Fred Van Leuve. Tauopathy differentially affects cell adhesion molecules in mouse brain: early down-regulation of nectin-3 in stratum lacunosum moleculare. PloS one vol 8 issue 5 2013 23704923 |
in particular was nectin-3 depleted from the specific region of the hippocampus, known as the stratum lacunosum and moleculare, in mice that express wild-type or mutant human protein tau, either chronically or sub-acutely. |
2013-12-30 |
2023-01-25 |
mouse |
| Robert Siman, Yin-Guo Lin, Gauri Malthankar-Phatak, Yina Don. A rapid gene delivery-based mouse model for early-stage Alzheimer disease-type tauopathy. Journal of neuropathology and experimental neurology vol 72 issue 11 2013 24128676 |
the perforant pathway projection from the entorhinal cortex (ec) to the hippocampal dentate gyrus is critically important for long-term memory and develops tau and amyloid pathologies and progressive degeneration starting in the early stages of alzheimer disease (ad). |
2013-12-17 |
2023-01-25 |
mouse |
| Dong Liu, Michael Pitta, Haiyang Jiang, Jong-Hwan Lee, Guofeng Zhang, Xinzhi Chen, Elisa M Kawamoto, Mark P Mattso. Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession. Neurobiology of aging vol 34 issue 6 2013 23273573 |
treatment of 3xtgad mice with nicotinamide for 8 months resulted in improved cognitive performance, and reduced a\xce\xb2 and hyperphosphorylated tau pathologies in hippocampus and cerebral cortex. |
2013-12-11 |
2023-01-25 |
mouse |
| Yoshihiro Kashiwaya, Christian Bergman, Jong-Hwan Lee, Ruiqian Wan, M Todd King, Mohamed R Mughal, Eitan Okun, Kieran Clarke, Mark P Mattson, Richard L Veec. A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease. Neurobiology of aging vol 34 issue 6 2013 23276384 |
ket-fed mice exhibited reduced levels of hyperphosphorylated tau deposition in the same regions of the hippocampus, amygdala, and cortex. |
2013-12-11 |
2023-01-25 |
mouse |
| S Flunkert, M Hierzer, T L\\xc3\\xb6ffler, R Rabl, J Neddens, S Duller, E L Schofield, M A Ward, M Posch, H Jungwirth, M Windisch, B Hutter-Paie. Elevated levels of soluble total and hyperphosphorylated tau result in early behavioral deficits and distinct changes in brain pathology in a new tau transgenic mouse model. Neuro-degenerative diseases vol 11 issue 4 2013 22797329 |
histological analyses showed a progressive increase in human tau protein in the amygdala over age, while hippocampal tau levels remained constant from 2 months onwards. |
2013-11-13 |
2023-01-25 |
mouse |
| Masahiro Maruyama, Hitoshi Shimada, Tetsuya Suhara, Hitoshi Shinotoh, Bin Ji, Jun Maeda, Ming-Rong Zhang, John Q Trojanowski, Virginia M-Y Lee, Maiko Ono, Kazuto Masamoto, Harumasa Takano, Naruhiko Sahara, Nobuhisa Iwata, Nobuyuki Okamura, Shozo Furumoto, Yukitsuka Kudo, Qing Chang, Takaomi C Saido, Akihiko Takashima, Jada Lewis, Ming-Kuei Jang, Ichio Aoki, Hiroshi Ito, Makoto Higuch. Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls. Neuron vol 79 issue 6 2013 24050400 |
a pyridinated pbb, [(11)c]pbb3, was next applied in a clinical pet study, and its robust signal in the ad hippocampus wherein tau pathology is enriched contrasted strikingly with that of a senile plaque radioligand, [(11)c]pittsburgh compound-b ([(11)c]pib). |
2013-11-13 |
2023-01-25 |
Not clear |
| Chu-Wan Lee, Yao-Hsiang Shih, Shih-Ying Wu, Tingting Yang, Chingju Lin, Yu-Min Ku. Hypoglycemia induces tau hyperphosphorylation. Current Alzheimer research vol 10 issue 3 2013 23036024 |
stz-icv treatment increased the levels of phosphorylated tau and activated gsk3\xce\xb2, but decreased the levels of activated akt in the hippocampus. |
2013-11-11 |
2023-01-25 |
rat |
| Lourdes Orejana, Luc\\xc3\\xada Barros-Mi\\xc3\\xb1ones, Norberto Aguirre, Elena Puert. Implication of JNK pathway on tau pathology and cognitive decline in a senescence-accelerated mouse model. Experimental gerontology vol 48 issue 6 2013 23501261 |
however, this same treatment of sildenafil, that had been shown to reverse the cognitive impairment and tau hyperphosphorylation in this animal model, also reversed the increased levels of activated jnk (p-jnk) found in the hippocampus of samp8 mice. |
2013-11-07 |
2023-01-25 |
mouse |
| Lourdes Orejana, Luc\\xc3\\xada Barros-Mi\\xc3\\xb1ones, Norberto Aguirre, Elena Puert. Implication of JNK pathway on tau pathology and cognitive decline in a senescence-accelerated mouse model. Experimental gerontology vol 48 issue 6 2013 23501261 |
when phosphorylated tau (at8 epitope) was analyzed a significant reduction was observed in the hippocampus of d-jnki-1 treated samp8 mice, providing a plausible explanation for the attenuation of cognitive decline shown by these animals. |
2013-11-07 |
2023-01-25 |
mouse |
| Nataliya G Kolosova, Anton O Vitovtov, Natalia A Muraleva, Andrey E Akulov, Natalia A Stefanova, Mikhail V Blagosklonn. Rapamycin suppresses brain aging in senescence-accelerated OXYS rats. Aging vol 5 issue 6 2013 23817674 |
rapamycin significantly decreased tau and inhibited its phosphorylation in the hippocampus of oxys and wistar rats. |
2013-11-07 |
2023-01-25 |
rat |
| Jon B Toledo, Steven E Arnold, Kevin Raible, Johannes Brettschneider, Sharon X Xie, Murray Grossman, Sarah E Monsell, Walter A Kukull, John Q Trojanowsk. Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer's Coordinating Centre. Brain : a journal of neurology vol 136 issue Pt 9 2013 23842566 |
presence of cerebrovascular disease, vascular pathology and vascular risk factors was studied in 5715 cases of the national alzheimer's coordinating centre database with a single neurodegenerative disease diagnosis (alzheimer's disease, frontotemporal lobar degeneration due to tau, and tar dna-binding protein 43 immunoreactive deposits, \xce\xb1-synucleinopathies, hippocampal sclerosis and prion disease) based on a neuropathological examination with or without cerebrovascular disease, defined neuropathologically. |
2013-11-07 |
2023-01-25 |
human |
| S\\xc3\\xb3nia C Correia, Renato X Santos, Maria S Santos, Gemma Casadesus, Joseph C Lamanna, George Perry, Mark A Smith, Paula I Moreir. Mitochondrial abnormalities in a streptozotocin-induced rat model of sporadic Alzheimer's disease. Current Alzheimer research vol 10 issue 4 2013 23061885 |
icvstz administration also resulted in a significant increase in hippocampal amyloid beta peptide 1-42 (a\xce\xb2(1-42)) levels as well as in cortical and hippocampal hyperphosphorylated tau protein levels. |
2013-11-05 |
2023-01-25 |
rat |
| Yun-Qing Ma, Dong-Ke Wu, Jian-Kun Li. mTOR and tau phosphorylated proteins in the hippocampal tissue of rats with type 2 diabetes and Alzheimer's disease. Molecular medicine reports vol 7 issue 2 2013 23165862 |
mtor and tau phosphorylated proteins in the hippocampal tissue of rats with type 2 diabetes and alzheimer's disease. |
2013-11-04 |
2023-01-25 |
rat |
| Yun-Qing Ma, Dong-Ke Wu, Jian-Kun Li. mTOR and tau phosphorylated proteins in the hippocampal tissue of rats with type 2 diabetes and Alzheimer's disease. Molecular medicine reports vol 7 issue 2 2013 23165862 |
mtor activity and tau protein hyperphosphorylation in the hippocampus were analyzed by immunohistochemical staining and rt-pcr. |
2013-11-04 |
2023-01-25 |
rat |
| Yun-Qing Ma, Dong-Ke Wu, Jian-Kun Li. mTOR and tau phosphorylated proteins in the hippocampal tissue of rats with type 2 diabetes and Alzheimer's disease. Molecular medicine reports vol 7 issue 2 2013 23165862 |
t2dm may excessively activate mtor in the hippocampal tissue by impairing insulin signaling, thereby increasing the extent of tau hyperphosphorylation and promoting the occurrence of ad. |
2013-11-04 |
2023-01-25 |
rat |
| Lies Clerx, Ineke A van Rossum, Leah Burns, Dirk L Knol, Philip Scheltens, Frans Verhey, Pauline Aalten, Pablo Lapuerta, Laura van de Pol, Ronald van Schijndel, Remko de Jong, Frederik Barkhof, Robin Wolz, Daniel Rueckert, Martina Bocchetta, Magdalini Tsolaki, Flavio Nobili, Lars-Olaf Wahlund, Lennart Minthon, Lutz Fr\\xc3\\xb6lich, Harald Hampel, Hilkka Soininen, Pieter Jelle Visse. Measurements of medial temporal lobe atrophy for prediction of Alzheimer's disease in subjects with mild cognitive impairment. Neurobiology of aging vol 34 issue 8 2013 23540941 |
hippocampal measurements correlated with csf total tau and phosphorylated tau, not with beta-amyloid 1-42. |
2013-11-04 |
2023-01-25 |
human |
| Florence Clavaguera, Isabelle Lavenir, Ben Falcon, Stephan Frank, Michel Goedert, Markus Tolna. \"Prion-like\" templated misfolding in tauopathies. Brain pathology (Zurich, Switzerland) vol 23 issue 3 2013 23587140 |
in alzheimer's disease, tau pathology develops in a stereotypical manner, with the first lesions appearing in the locus coeruleus and entorhinal cortex, from where they appear to spread to the hippocampus and neocortex. |
2013-10-28 |
2023-01-25 |
Not clear |