| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cyril Laurent, Guillaume Dorothée, Stéphane Hunot, Elodie Martin, Yann Monnet, Marie Duchamp, Yuan Dong, François-Pierre Légeron, Antoine Leboucher, Sylvie Burnouf, Emilie Faivre, Kévin Carvalho, Raphaëlle Caillierez, Nadège Zommer, Dominique Demeyer, Nathalie Jouy, Veronique Sazdovitch, Susanna Schraen-Maschke, Cécile Delarasse, Luc Buée, David Blu. Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy. Brain : a journal of neurology. vol 140. issue 1. 2017-06-05. PMID:27818384. |
to address this question, we took advantage of the thy-tau22 mouse model that progressively develops hippocampal tau pathology paralleling cognitive deficits and reappraised the interrelationship between tau pathology and brain immune responses. |
2017-06-05 |
2023-08-13 |
mouse |
| Cyril Laurent, Guillaume Dorothée, Stéphane Hunot, Elodie Martin, Yann Monnet, Marie Duchamp, Yuan Dong, François-Pierre Légeron, Antoine Leboucher, Sylvie Burnouf, Emilie Faivre, Kévin Carvalho, Raphaëlle Caillierez, Nadège Zommer, Dominique Demeyer, Nathalie Jouy, Veronique Sazdovitch, Susanna Schraen-Maschke, Cécile Delarasse, Luc Buée, David Blu. Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy. Brain : a journal of neurology. vol 140. issue 1. 2017-06-05. PMID:27818384. |
in addition to conventional astroglial and microglial responses, we identified a cd8-positive t cell infiltration in the hippocampus of tau transgenic mice associated with an early chemokine response, notably involving ccl3. |
2017-06-05 |
2023-08-13 |
mouse |
| Cyril Laurent, Guillaume Dorothée, Stéphane Hunot, Elodie Martin, Yann Monnet, Marie Duchamp, Yuan Dong, François-Pierre Légeron, Antoine Leboucher, Sylvie Burnouf, Emilie Faivre, Kévin Carvalho, Raphaëlle Caillierez, Nadège Zommer, Dominique Demeyer, Nathalie Jouy, Veronique Sazdovitch, Susanna Schraen-Maschke, Cécile Delarasse, Luc Buée, David Blu. Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy. Brain : a journal of neurology. vol 140. issue 1. 2017-06-05. PMID:27818384. |
such anti-cd3 treatment prevented hippocampal t cell infiltration in tau transgenic animals and reverted spatial memory deficits, in absence of tau pathology modulation. |
2017-06-05 |
2023-08-13 |
mouse |
| Lucas T Woods, Deepa Ajit, Jean M Camden, Laurie Erb, Gary A Weisma. Purinergic receptors as potential therapeutic targets in Alzheimer's disease. Neuropharmacology. vol 104. 2017-05-26. PMID:26519903. |
many of the pathological characteristics associated with ad are revealed post-mortem, including amyloid-β plaque deposition, neurofibrillary tangles containing hyperphosphorylated tau proteins and neuronal loss in the hippocampus and cortex. |
2017-05-26 |
2023-08-13 |
human |
| Richard Kvetnansky, Petr Novak, Peter Vargovic, Katarina Lejavova, Lubica Horvathova, Katarina Ondicova, George Manz, Peter Filipcik, Michal Novak, Boris Mrave. Exaggerated phosphorylation of brain tau protein in CRH KO mice exposed to repeated immobilization stress. Stress (Amsterdam, Netherlands). vol 19. issue 4. 2017-05-18. PMID:27484105. |
we assessed expression of phosphorylated tau (p-tau) at the phf-1 epitope and ne concentrations in the locus coeruleus (lc), a1/c1 and a2/c2 catecholaminergic cell groups, hippocampus, amygdala, nucleus basalis magnocellularis, and frontal cortex of unstressed, singly stressed or repeatedly stressed mice. |
2017-05-18 |
2023-08-13 |
mouse |
| Marta Nesteruk, Tomasz Nesteruk, Maria Styczyńska, Monika Mandecka, Anna Barczak, Maria Barcikowsk. Combined use of biochemical and volumetric biomarkers to assess the risk of conversion of mild cognitive impairment to Alzheimer's disease. Folia neuropathologica. vol 54. issue 4. 2017-05-09. PMID:28139818. |
the aim of our study was to evaluate the usefulness of several biomarkers in predicting the conversion of mild cognitive impairment (mci) to alzheimer's disease (ad): β-amyloid and tau proteins in cerebrospinal fluid and the volumetric evaluation of brain structures including the hippocampus in magnetic resonance imaging (mri). |
2017-05-09 |
2023-08-13 |
Not clear |
| Hong-Chun Li, Jie Xiao, Yi-Long Huang, Long-Jun Li, Hong Jiang, Li-Xuan Huang, Ting Yang, Ling Yang, Fan L. [Reduction in hypoxia-derived neuroinflammation and dysfunctional glutamate transporters by minocycline may restore hypoxia-injured cognition of neonatal rat]. Sheng li xue bao : [Acta physiologica Sinica]. vol 68. issue 2. 2017-04-28. PMID:27108901. |
inflammatory mediators (iba-1, il-1β, tnf-α and tgf-β1), glutamate transporters (eaat1 and eaat2), total tau and phosphorylated tau (phosphorylation sites: tyr18, thr205, thr231, ser396 and ser404) protein expressions in the hippocampus were detected by western blot 7 d after hypoxic exposure. |
2017-04-28 |
2023-08-13 |
rat |
| Hong-Chun Li, Jie Xiao, Yi-Long Huang, Long-Jun Li, Hong Jiang, Li-Xuan Huang, Ting Yang, Ling Yang, Fan L. [Reduction in hypoxia-derived neuroinflammation and dysfunctional glutamate transporters by minocycline may restore hypoxia-injured cognition of neonatal rat]. Sheng li xue bao : [Acta physiologica Sinica]. vol 68. issue 2. 2017-04-28. PMID:27108901. |
the protein expression levels of iba-1, il-1β, tnf-α, eaat2 and tau phosphorylated at t231 were increased, but the total tau expression was decreased in the hippocampus of the rats from hy group 7 d after hypoxia exposure. |
2017-04-28 |
2023-08-13 |
rat |
| Marta Fernández-Nogales, María Santos-Galindo, Jesús Merchán-Rubira, Jeroen J M Hoozemans, Alberto Rábano, Isidro Ferrer, Jesús Avila, Félix Hernández, José J Luca. Tau-positive nuclear indentations in P301S tauopathy mice. Brain pathology (Zurich, Switzerland). vol 27. issue 3. 2017-04-24. PMID:27338164. |
initial detection of rod-shaped tau immunostaining in nuclei of cortical and striatal neurons of hd brains and in hippocampal neurons of early braak stage ad led us to coin the term "tau nuclear rods (tnrs)." |
2017-04-24 |
2023-08-13 |
mouse |
| Gabor G Kovacs, Jasmin Rahimi, Thomas Ströbel, Mirjam I Lutz, Günther Regelsberger, Nathalie Streichenberger, Armand Perret-Liaudet, Romana Höftberger, Pawel P Liberski, Herbert Budka, Beata Sikorsk. Tau pathology in Creutzfeldt-Jakob disease revisited. Brain pathology (Zurich, Switzerland). vol 27. issue 3. 2017-04-24. PMID:27377321. |
to determine the spectrum of tau pathologies in cjd, we assessed phospho-tau (ptau) immunoreactivities in 75 sporadic cjd cases including an evaluation of the entorhinal cortex and six hippocampal subregions. |
2017-04-24 |
2023-08-13 |
human |
| Gabor G Kovacs, Jasmin Rahimi, Thomas Ströbel, Mirjam I Lutz, Günther Regelsberger, Nathalie Streichenberger, Armand Perret-Liaudet, Romana Höftberger, Pawel P Liberski, Herbert Budka, Beata Sikorsk. Tau pathology in Creutzfeldt-Jakob disease revisited. Brain pathology (Zurich, Switzerland). vol 27. issue 3. 2017-04-24. PMID:27377321. |
however, the pattern of hippocampal tau pathology often deviates from the stages of braak. |
2017-04-24 |
2023-08-13 |
human |
| Robert John Hatch, Yan Wei, Di Xia, Jürgen Göt. Hyperphosphorylated tau causes reduced hippocampal CA1 excitability by relocating the axon initial segment. Acta neuropathologica. vol 133. issue 5. 2017-04-20. PMID:28091722. |
a critical role for tau is supported by studies in transgenic mouse models that express the p301l tau mutation found in cases of familial frontotemporal dementia, with the accumulation of hyperphosphorylated tau in the hippocampus causing reductions in hippocampal long-term potentiation and impairments in spatial learning and memory. |
2017-04-20 |
2023-08-13 |
mouse |
| Robert John Hatch, Yan Wei, Di Xia, Jürgen Göt. Hyperphosphorylated tau causes reduced hippocampal CA1 excitability by relocating the axon initial segment. Acta neuropathologica. vol 133. issue 5. 2017-04-20. PMID:28091722. |
furthermore, using mutagenesis and primary hippocampal neuronal cultures, we reveal that this reduction in neuronal excitability results from the relocation of the axon initial segment (ais) down the axon in a tau phosphorylation-dependent manner. |
2017-04-20 |
2023-08-13 |
mouse |
| Keith A Josephs, Melissa E Murray, Nirubol Tosakulwong, Jennifer L Whitwell, David S Knopman, Mary M Machulda, Stephen D Weigand, Bradley F Boeve, Kejal Kantarci, Leonard Petrucelli, Val J Lowe, Clifford R Jack, Ronald C Petersen, Joseph E Parisi, Dennis W Dickso. Tau aggregation influences cognition and hippocampal atrophy in the absence of beta-amyloid: a clinico-imaging-pathological study of primary age-related tauopathy (PART). Acta neuropathologica. vol 133. issue 5. 2017-04-20. PMID:28160067. |
tau aggregation influences cognition and hippocampal atrophy in the absence of beta-amyloid: a clinico-imaging-pathological study of primary age-related tauopathy (part). |
2017-04-20 |
2023-08-13 |
Not clear |
| Zhao-Xu Zhang, Rui-Ping Zhao, De-Sheng Wang, Yan-Bing L. Fuzhisan Ameliorates the Memory Deficits in Aged SAMP8 Mice via Decreasing Aβ Production and Tau Hyperphosphorylation of the Hippocampus. Neurochemical research. vol 41. issue 11. 2017-04-05. PMID:27518086. |
fuzhisan ameliorates the memory deficits in aged samp8 mice via decreasing aβ production and tau hyperphosphorylation of the hippocampus. |
2017-04-05 |
2023-08-13 |
mouse |
| Xia-Chun Li, Yu Hu, Zhi-hao Wang, Yu Luo, Yao Zhang, Xiu-Ping Liu, Qiong Feng, Qun Wang, Keqiang Ye, Gong-Ping Liu, Jian-Zhi Wan. Human wild-type full-length tau accumulation disrupts mitochondrial dynamics and the functions via increasing mitofusins. Scientific reports. vol 6. 2017-03-07. PMID:27099072. |
here we report that overexpression of human wild-type full-length tau (termed htau) disrupted mitochondrial dynamics by enhancing fusion and induced their perinuclear accumulation in hek293 cells and rat primary hippocampal neurons. |
2017-03-07 |
2023-08-13 |
mouse |
| Xiaoping Du, Matthew B West, Weihua Cheng, Donald L Ewert, Wei Li, Debra Saunders, Rheal A Towner, Robert A Floyd, Richard D Kopk. Ameliorative Effects of Antioxidants on the Hippocampal Accumulation of Pathologic Tau in a Rat Model of Blast-Induced Traumatic Brain Injury. Oxidative medicine and cellular longevity. vol 2016. 2017-03-03. PMID:27034735. |
ameliorative effects of antioxidants on the hippocampal accumulation of pathologic tau in a rat model of blast-induced traumatic brain injury. |
2017-03-03 |
2023-08-13 |
rat |
| Xiaoping Du, Matthew B West, Weihua Cheng, Donald L Ewert, Wei Li, Debra Saunders, Rheal A Towner, Robert A Floyd, Richard D Kopk. Ameliorative Effects of Antioxidants on the Hippocampal Accumulation of Pathologic Tau in a Rat Model of Blast-Induced Traumatic Brain Injury. Oxidative medicine and cellular longevity. vol 2016. 2017-03-03. PMID:27034735. |
in the current study, we examined the localization patterns of normal tau and the potential blast-induced accumulation of neurotoxic variants of this microtubule-associated protein that are believed to potentiate the neurodegenerative effects associated with synaptic dysfunction in the hippocampus following three successive blast overpressure exposures in nontransgenic rats. |
2017-03-03 |
2023-08-13 |
rat |
| Xiaoping Du, Matthew B West, Weihua Cheng, Donald L Ewert, Wei Li, Debra Saunders, Rheal A Towner, Robert A Floyd, Richard D Kopk. Ameliorative Effects of Antioxidants on the Hippocampal Accumulation of Pathologic Tau in a Rat Model of Blast-Induced Traumatic Brain Injury. Oxidative medicine and cellular longevity. vol 2016. 2017-03-03. PMID:27034735. |
we observed a marked increase in the number of both hyperphosphorylated and oligomeric tau-positive hilar mossy cells and somatic accumulation of endogenous tau in oligodendrocytes in the hippocampus. |
2017-03-03 |
2023-08-13 |
rat |
| Yanjing Cao, Lizhen Liang, Jian Xu, Jiali Wu, Yongxing Yan, Ping Lin, Qiang Chen, Fengming Zheng, Qin Wang, Qian Ren, Zengmei Gou, Yifeng D. The effect of Scutellaria baicalensis stem-leaf flavonoids on spatial learning and memory in chronic cerebral ischemia-induced vascular dementia of rats. Acta biochimica et biophysica Sinica. vol 48. issue 5. 2017-02-27. PMID:27118553. |
sstf treatment inhibited the tau phosphorylation in both cortex and hippocampus in vad rats. |
2017-02-27 |
2023-08-13 |
rat |