| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Charles Liu, Jon Russin, Christianne Heck, Keisuke Kawata, Radhika Adiga, William Yen, Jonathan Lambert, Benjamin Stear, Meng Law, Yvette Marquez, Peter Crino, David Millett, Dianne Langfor. Dysregulation of PINCH signaling in mesial temporal epilepsy. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 36. 2017-02-06. PMID:27838154. |
resected hippocampal tissue from 7 patients with mesial temporal lobe epilepsy (mtle) was assessed by western analyses to measure levels of pinch and hyperphosphorylated tau, as well as changes in phosphorylation levels of associated kinases akt and gsk3β in comparison to normal control tissue. |
2017-02-06 |
2023-08-13 |
human |
| O Picazo, J Espinosa-Raya, A Briones-Aranda, M Cerbó. Ovariectomy increases the age-induced hyperphosphorylation of Tau at hippocampal CA1. Cognitive processing. vol 17. issue 4. 2017-02-01. PMID:27271684. |
in this study, we explore the expression of tau hyperphosphorylation at hippocampus and the performance of rats in an autoshaping learning task at 5, 10 and 15 months after the ovaries removal. |
2017-02-01 |
2023-08-13 |
rat |
| O Picazo, J Espinosa-Raya, A Briones-Aranda, M Cerbó. Ovariectomy increases the age-induced hyperphosphorylation of Tau at hippocampal CA1. Cognitive processing. vol 17. issue 4. 2017-02-01. PMID:27271684. |
a progressive increase in hippocampal tau phosphorylation at ser-396 was observed in either intact or ovariectomized rats. |
2017-02-01 |
2023-08-13 |
rat |
| Bo-Wen Zheng, Li Yang, Xue-Ling Dai, Zhao-Feng Jiang, Han-Chang Huan. Roles of O-GlcNAcylation on amyloid-β precursor protein processing, tau phosphorylation, and hippocampal synapses dysfunction in Alzheimer's disease. Neurological research. vol 38. issue 2. 2017-01-13. PMID:27078700. |
roles of o-glcnacylation on amyloid-β precursor protein processing, tau phosphorylation, and hippocampal synapses dysfunction in alzheimer's disease. |
2017-01-13 |
2023-08-13 |
Not clear |
| Bo-Wen Zheng, Li Yang, Xue-Ling Dai, Zhao-Feng Jiang, Han-Chang Huan. Roles of O-GlcNAcylation on amyloid-β precursor protein processing, tau phosphorylation, and hippocampal synapses dysfunction in Alzheimer's disease. Neurological research. vol 38. issue 2. 2017-01-13. PMID:27078700. |
here, we review the roles of o-glcnacylation in app cleavage, tau phosphorylation and hippocampal synapses function. |
2017-01-13 |
2023-08-13 |
Not clear |
| Xue-Yan Li, Fang Wang, Gui-Hai Chen, Xue-Wei Li, Qi-Gang Yang, Lei Cao, Wen-Wen Ya. Inflammatory insult during pregnancy accelerates age-related behavioral and neurobiochemical changes in CD-1 mice. Age (Dordrecht, Netherlands). vol 38. issue 3. 2017-01-12. PMID:27194408. |
the neurobiochemical results indicated that gestational lps exposure also intensified age-related hippocampal changes, including increased amyloid-β42, phosphorylated tau, synaptotagmin-1 and gfap, and decreased syntaxin-1 and h4k8ac. |
2017-01-12 |
2023-08-13 |
mouse |
| Mario Merlini, Debora Wanner, Roger M Nitsc. Tau pathology-dependent remodelling of cerebral arteries precedes Alzheimer's disease-related microvascular cerebral amyloid angiopathy. Acta neuropathologica. vol 131. issue 5. 2017-01-06. PMID:26988843. |
therefore, we systematically quantified braak tau stage- and cerebral amyloid angiopathy (caa)-dependent alterations in the alpha-smooth muscle actin (α-sma), collagen, and elastin content of leptomeningeal arterioles, small arteries, and medium-sized arteries surrounding the gyrus frontalis medialis (gfm) and hippocampus (hipp), including the sulci, of 17 clinically and pathologically diagnosed ad subjects (braak stage iv-vi) and 28 non-demented control subjects (braak stage i-iv). |
2017-01-06 |
2023-08-13 |
human |
| Montasir Elahi, Zafrul Hasan, Yumiko Motoi, Shin-Ei Matsumoto, Koichi Ishiguro, Nobutaka Hattor. Region-Specific Vulnerability to Oxidative Stress, Neuroinflammation, and Tau Hyperphosphorylation in Experimental Diabetes Mellitus Mice. Journal of Alzheimer's disease : JAD. vol 51. issue 4. 2016-12-29. PMID:26923011. |
the hippocampus, midbrain, and cerebellum of aged (14 to 18 months old) non-transgenic (ntg) and transgenic mice overexpressing wild-type human tau (tg601 mice) were evaluated after a treatment with stz. |
2016-12-29 |
2023-08-13 |
mouse |
| Montasir Elahi, Zafrul Hasan, Yumiko Motoi, Shin-Ei Matsumoto, Koichi Ishiguro, Nobutaka Hattor. Region-Specific Vulnerability to Oxidative Stress, Neuroinflammation, and Tau Hyperphosphorylation in Experimental Diabetes Mellitus Mice. Journal of Alzheimer's disease : JAD. vol 51. issue 4. 2016-12-29. PMID:26923011. |
tau hyperphosphorylation was also enhanced in the hippocampus, but not in the midbrain or cerebellum. |
2016-12-29 |
2023-08-13 |
mouse |
| Teng Jiang, Ying-Dong Zhang, Jun-Shan Zhou, Xi-Chen Zhu, You-Yong Tian, Hong-Dong Zhao, Huan Lu, Qing Gao, Lan Tan, Jin-Tai Y. Angiotensin-(1-7) is Reduced and Inversely Correlates with Tau Hyperphosphorylation in Animal Models of Alzheimer's Disease. Molecular neurobiology. vol 53. issue 4. 2016-12-26. PMID:26044748. |
more importantly, an inverse correlation was found between ang-(1-7) level and tau hyperphosphorylation, a pathological hallmark of ad, in cerebral cortex and hippocampus of samp8 mice. |
2016-12-26 |
2023-08-13 |
mouse |
| Beatriz E García-Gómez, Francisco J Fernández-Gómez, Encarnación Muñoz-Delgado, Luc Buée, David Blum, Cecilio J Vida. MRNA Levels of ACh-Related Enzymes in the Hippocampus of THY-Tau22 Mouse: A Model of Human Tauopathy with No Signs of Motor Disturbance. Journal of molecular neuroscience : MN. vol 58. issue 4. 2016-12-26. PMID:26697857. |
the reports showing a hippocampal downregulation of choline acetyltransferase (chat) in samp8 mice, a model of aging, and an upregulation of acetylcholinesterase (ache) in tg-vlw mice, a model of ftdp17 tauopathy, may lead to think that the supply of ach to the hippocampus can be threatened as aging or tau pathology progress. |
2016-12-26 |
2023-08-13 |
mouse |
| Xiao-Ping Hong, Tao Chen, Ni-Na Yin, Yong-Ming Han, Fang Yuan, Yan-Jun Duan, Feng Shen, Yan-Hong Zhang, Ze-Bin Che. Puerarin Ameliorates D-Galactose Induced Enhanced Hippocampal Neurogenesis and Tau Hyperphosphorylation in Rat Brain. Journal of Alzheimer's disease : JAD. vol 51. issue 2. 2016-12-20. PMID:26890737. |
puerarin ameliorates d-galactose induced enhanced hippocampal neurogenesis and tau hyperphosphorylation in rat brain. |
2016-12-20 |
2023-08-13 |
rat |
| Xiao-Ping Hong, Tao Chen, Ni-Na Yin, Yong-Ming Han, Fang Yuan, Yan-Jun Duan, Feng Shen, Yan-Hong Zhang, Ze-Bin Che. Puerarin Ameliorates D-Galactose Induced Enhanced Hippocampal Neurogenesis and Tau Hyperphosphorylation in Rat Brain. Journal of Alzheimer's disease : JAD. vol 51. issue 2. 2016-12-20. PMID:26890737. |
enhanced neurogenesis has been reported in the hippocampus of patients with alzheimer's disease (ad), the most common neurodegenerative disorder characterized with amyloid-β (aβ) aggregation, tau hyperphosphorylation, and progressive neuronal loss. |
2016-12-20 |
2023-08-13 |
rat |
| Xiao-Ping Hong, Tao Chen, Ni-Na Yin, Yong-Ming Han, Fang Yuan, Yan-Jun Duan, Feng Shen, Yan-Hong Zhang, Ze-Bin Che. Puerarin Ameliorates D-Galactose Induced Enhanced Hippocampal Neurogenesis and Tau Hyperphosphorylation in Rat Brain. Journal of Alzheimer's disease : JAD. vol 51. issue 2. 2016-12-20. PMID:26890737. |
previously we reported that tau phosphorylation played an essential role in adult hippocampal neurogenesis, and activation of glycogen synthase kinase (gsk-3), a crucial tau kinase, could induce increased hippocampal neurogenesis. |
2016-12-20 |
2023-08-13 |
rat |
| Xiao-Ping Hong, Tao Chen, Ni-Na Yin, Yong-Ming Han, Fang Yuan, Yan-Jun Duan, Feng Shen, Yan-Hong Zhang, Ze-Bin Che. Puerarin Ameliorates D-Galactose Induced Enhanced Hippocampal Neurogenesis and Tau Hyperphosphorylation in Rat Brain. Journal of Alzheimer's disease : JAD. vol 51. issue 2. 2016-12-20. PMID:26890737. |
in the present study, we found that treatment of d-galactose rats with puerarin could significantly improve behavioral performance and ameliorate the enhanced neurogenesis and microtubule-associated protein tau hyperphosphorylation in the hippocampus of d-galactose rat brains. |
2016-12-20 |
2023-08-13 |
rat |
| Xiao-Ping Hong, Tao Chen, Ni-Na Yin, Yong-Ming Han, Fang Yuan, Yan-Jun Duan, Feng Shen, Yan-Hong Zhang, Ze-Bin Che. Puerarin Ameliorates D-Galactose Induced Enhanced Hippocampal Neurogenesis and Tau Hyperphosphorylation in Rat Brain. Journal of Alzheimer's disease : JAD. vol 51. issue 2. 2016-12-20. PMID:26890737. |
fgf-2/gsk-3 signaling pathway might be involved in the effects of puerarin on hippocampal neurogenesis and tau hyperphosphorylation. |
2016-12-20 |
2023-08-13 |
rat |
| Xiao-Ping Hong, Tao Chen, Ni-Na Yin, Yong-Ming Han, Fang Yuan, Yan-Jun Duan, Feng Shen, Yan-Hong Zhang, Ze-Bin Che. Puerarin Ameliorates D-Galactose Induced Enhanced Hippocampal Neurogenesis and Tau Hyperphosphorylation in Rat Brain. Journal of Alzheimer's disease : JAD. vol 51. issue 2. 2016-12-20. PMID:26890737. |
our finding provides primary in vivo evidence that puerarin can attenuate ad-like enhanced hippocampal neurogenesis and tau hyperphosphorylation. |
2016-12-20 |
2023-08-13 |
rat |
| F L'Episcopo, J Drouin-Ouellet, C Tirolo, A Pulvirenti, R Giugno, N Testa, S Caniglia, M F Serapide, G Cisbani, R A Barker, F Cicchetti, B Marchett. GSK-3β-induced Tau pathology drives hippocampal neuronal cell death in Huntington's disease: involvement of astrocyte-neuron interactions. Cell death & disease. vol 7. 2016-12-15. PMID:27124580. |
gsk-3β-induced tau pathology drives hippocampal neuronal cell death in huntington's disease: involvement of astrocyte-neuron interactions. |
2016-12-15 |
2023-08-13 |
mouse |
| F L'Episcopo, J Drouin-Ouellet, C Tirolo, A Pulvirenti, R Giugno, N Testa, S Caniglia, M F Serapide, G Cisbani, R A Barker, F Cicchetti, B Marchett. GSK-3β-induced Tau pathology drives hippocampal neuronal cell death in Huntington's disease: involvement of astrocyte-neuron interactions. Cell death & disease. vol 7. 2016-12-15. PMID:27124580. |
we identified a disease and stage-dependent upregulation of gsk-3β mrna and protein levels in the hd hippocampus, with the active isoform pgsk-3β-tyr(216) being strongly expressed in dentate gyrus (dg) neurons and astrocytes at a time when phosphorylation of tau at the at8 epitope was also present in these same neurons. |
2016-12-15 |
2023-08-13 |
mouse |
| Naiara Celarain, Javier Sánchez-Ruiz de Gordoa, María Victoria Zelaya, Miren Roldán, Rosa Larumbe, Laura Pulido, Carmen Echavarri, Maite Mendioro. TREM2 upregulation correlates with 5-hydroxymethycytosine enrichment in Alzheimer's disease hippocampus. Clinical epigenetics. vol 8. 2016-12-14. PMID:27051467. |
we measured trem2 mrna levels in the hippocampus in a cohort of neuropathologically confirmed controls and pure ad cases showing no other protein deposits than β-amyloid and phosphorylated tau. |
2016-12-14 |
2023-08-13 |
human |