| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katja Hochgr\\xc3\\xa4fe, Astrid Sydow, Eva-Maria Mandelko. Regulatable transgenic mouse models of Alzheimer disease: onset, reversibility and spreading of Tau pathology. The FEBS journal vol 280 issue 18 2013 23517246 |
while pro-aggregant full-length htau40/\xce\x94k280 leads to a 'pre-tangle' pathology, the repeat domain tau(rd)/\xce\x94k280 causes massive formation of neurofibrillary tangles and neuronal loss in the hippocampus. |
2013-10-25 |
2023-01-25 |
mouse |
| Akira Nakajima, Yuki Aoyama, Thuy-Ty Lan Nguyen, Eun-Joo Shin, Hyoung-Chun Kim, Shinnosuke Yamada, Tsuyoshi Nakai, Taku Nagai, Akihito Yokosuka, Yoshihiro Mimaki, Yasushi Ohizumi, Kiyofumi Yamad. Nobiletin, a citrus flavonoid, ameliorates cognitive impairment, oxidative burden, and hyperphosphorylation of tau in senescence-accelerated mouse. Behavioural brain research vol 250 issue 2013 23714077 |
furthermore, nobiletin reduced tau phosphorylation in the hippocampus of samp8 mice. |
2013-10-25 |
2023-01-25 |
mouse |
| P K Kamat, S Rai, S Swarnkar, R Shukla, S Ali, A K Najmi, C Nat. Okadaic acid-induced Tau phosphorylation in rat brain: role of NMDA receptor. Neuroscience vol 238 issue 2013 23415789 |
oka-induced memory-impaired rats showed increased mrna and protein expression of tau, ca(2+)/calmodulin-dependent protein kinase ii (camkii), calpain and gsk3\xce\xb2 in the hippocampus and cerebral cortex. |
2013-10-17 |
2023-01-25 |
rat |
| Maria J Casarejos, Juan Perucho, Ana Gomez, Maria P Mu\\xc3\\xb1oz, Marian Fernandez-Estevez, Onintza Sagredo, Javier Fernandez Ruiz, Manuel Guzman, Justo Garcia de Yebenes, Maria A Men. Natural cannabinoids improve dopamine neurotransmission and tau and amyloid pathology in a mouse model of tauopathy. Journal of Alzheimer's disease : JAD vol 35 issue 3 2013 23478312 |
with regard to tau and amyloid pathology, sativex\xc2\xae reduced the deposition of both in the hippocampus and cerebral cortex of pk-/-/tauvlw mice and increased autophagy. |
2013-10-17 |
2023-01-25 |
mouse |
| Sylvie Burnouf, Alberto Martire, Maxime Derisbourg, Cyril Laurent, Karim Belarbi, Antoine Leboucher, Francisco J Fernandez-Gomez, Laetitia Troquier, Sabiha Eddarkaoui, Marie-Eve Grosjean, Dominique Demeyer, Anne Muhr-Tailleux, Alain Buisson, Nicolas Sergeant, Malika Hamdane, Sandrine Humez, Patrizia Popoli, Luc Bu\\xc3\\xa9e, David Blu. NMDA receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a Tau transgenic model. Aging cell vol 12 issue 1 2013 23082852 |
nmda receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a tau transgenic model. |
2013-09-30 |
2023-01-25 |
mouse |
| Sylvie Burnouf, Alberto Martire, Maxime Derisbourg, Cyril Laurent, Karim Belarbi, Antoine Leboucher, Francisco J Fernandez-Gomez, Laetitia Troquier, Sabiha Eddarkaoui, Marie-Eve Grosjean, Dominique Demeyer, Anne Muhr-Tailleux, Alain Buisson, Nicolas Sergeant, Malika Hamdane, Sandrine Humez, Patrizia Popoli, Luc Bu\\xc3\\xa9e, David Blu. NMDA receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a Tau transgenic model. Aging cell vol 12 issue 1 2013 23082852 |
using thy-tau22 transgenic mice, we demonstrated that hippocampal tau pathology is associated with loss of synaptic enhancement normally induced by exogenous bdnf. |
2013-09-30 |
2023-01-25 |
mouse |
| Sylvie Burnouf, Alberto Martire, Maxime Derisbourg, Cyril Laurent, Karim Belarbi, Antoine Leboucher, Francisco J Fernandez-Gomez, Laetitia Troquier, Sabiha Eddarkaoui, Marie-Eve Grosjean, Dominique Demeyer, Anne Muhr-Tailleux, Alain Buisson, Nicolas Sergeant, Malika Hamdane, Sandrine Humez, Patrizia Popoli, Luc Bu\\xc3\\xa9e, David Blu. NMDA receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a Tau transgenic model. Aging cell vol 12 issue 1 2013 23082852 |
indeed, we observed a significant reduction of nmda-induced field excitatory postsynaptic potential depression in the hippocampus of tau mice together with a reduced phosphorylation of nr2b at the y1472, known to be critical for nmdar function. |
2013-09-30 |
2023-01-25 |
mouse |
| Ori Liraz, Anat Boehm-Cagan, Daniel M Michaelso. ApoE4 induces A\\xce\\xb242, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice. Molecular neurodegeneration vol 8 issue 2013 23684315 |
apoe4 induces a\xce\xb242, tau, and neuronal pathology in the hippocampus of young targeted replacement apoe4 mice. |
2013-09-20 |
2023-01-25 |
mouse |
| Makoto Hara, Katsuiku Hirokawa, Satoshi Kamei, Toshiki Uchihar. Isoform transition from four-repeat to three-repeat tau underlies dendrosomatic and regional progression of neurofibrillary pathology. Acta neuropathologica vol 125 issue 4 2013 23407988 |
regional progression of neurofibrillary tangles (nfts) around the hippocampus was traced on thick sections double immunofluorolabeled with rd3 and rd4 antibodies, specific for three- and four-repeat tau, respectively. |
2013-09-16 |
2023-01-25 |
Not clear |
| Edoardo Parrella, Tom Maxim, Francesca Maialetti, Lu Zhang, Junxiang Wan, Min Wei, Pinchas Cohen, Luigi Fontana, Valter D Long. Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model. Aging cell vol 12 issue 2 2013 23362919 |
whereas prcs did not affect the levels of \xce\xb2 amyloid (a\xce\xb2), they decreased tau phosphorylation in the hippocampus and alleviated the age-dependent impairment in cognitive performance. |
2013-08-27 |
2023-01-25 |
mouse |
| Hye Jeong Yang, Jin Taek Hwang, Dae Young Kwon, Min Jung Kim, Suna Kang, Na Rang Moon, Sunmin Par. Yuzu extract prevents cognitive decline and impaired glucose homeostasis in \\xce\\xb2-amyloid-infused rats. The Journal of nutrition vol 143 issue 7 2013 23719224 |
yuzu treatment prevented \xce\xb2-amyloid accumulation, increased tau phosphorylation, and attenuated hippocampal insulin signaling observed in ad-c rats. |
2013-08-26 |
2023-01-25 |
rat |
| Hongxia Shuai, Jinghui Zhang, Ji Zhang, Junhui Xie, Muxun Zhang, Ji Ma, Liming Zhang, Xiufeng Wan. Role of stereotaxically injected IgG from db/db mice in the phosphorylation of the microtubule-associated protein tau in hippocampus. Brain research vol 1486 issue 2013 23036273 |
role of stereotaxically injected igg from db/db mice in the phosphorylation of the microtubule-associated protein tau in hippocampus. |
2013-08-23 |
2023-01-25 |
mouse |
| Lars Messing, Jochen Martin Decker, Maria Joseph, Eckhard Mandelkow, Eva-Maria Mandelko. Cascade of tau toxicity in inducible hippocampal brain slices and prevention by aggregation inhibitors. Neurobiology of aging vol 34 issue 5 2013 23158765 |
cascade of tau toxicity in inducible hippocampal brain slices and prevention by aggregation inhibitors. |
2013-08-13 |
2023-01-25 |
mouse |
| Lars Messing, Jochen Martin Decker, Maria Joseph, Eckhard Mandelkow, Eva-Maria Mandelko. Cascade of tau toxicity in inducible hippocampal brain slices and prevention by aggregation inhibitors. Neurobiology of aging vol 34 issue 5 2013 23158765 |
to this end we established an in vitro model of tauopathy based on regulatable transgenic hippocampal organotypic slice cultures prepared from mice expressing proaggregant tau repeat domain with mutation \xce\x94k280 (tau(rd)\xce\x94k). |
2013-08-13 |
2023-01-25 |
mouse |
| Eduardo Rigon Zimmer, Eduardo Kalinine, Clarissa Branco Haas, Vitor Rocco Torrez, Diogo Onofre Souza, Alexandre Pastoris Muller, Luis Valmor Portel. Pretreatment with memantine prevents Alzheimer-like alterations induced by intrahippocampal okadaic acid administration in rats. Current Alzheimer research vol 9 issue 10 2013 22515493 |
additionally, we measured glutamate levels in the cerebrospinal fluid (csf) and the immunocontent of cdk5, p35, p25 and phosphorylated tau (ptauser199/202) in the hippocampus. |
2013-08-09 |
2023-01-25 |
rat |
| Min-Young Noh, Kwangwoo Chun, Byung Yong Kang, Heejaung Kim, Ji-Seon Park, Han-Chang Lee, Young-Ha Kim, Saekwang Ku, Seung Hyun Ki. Newly developed glycogen synthase kinase-3 (GSK-3) inhibitors protect neuronal cells death in amyloid-beta induced cell model and in a transgenic mouse model of Alzheimer's disease. Biochemical and biophysical research communications vol 435 issue 2 2013 23632329 |
in particular, 50 mg/kg c-7a treated mice significantly decreased the level of phosphorylated tau (ser396) in brain hippocampus. |
2013-08-06 |
2023-01-25 |
mouse |
| Chuang Guo, Pu Wang, Man-Li Zhong, Tao Wang, Xue-Shi Huang, Jia-Yi Li, Zhan-You Wan. Deferoxamine inhibits iron induced hippocampal tau phosphorylation in the Alzheimer transgenic mouse brain. Neurochemistry international vol 62 issue 2 2013 23262393 |
deferoxamine inhibits iron induced hippocampal tau phosphorylation in the alzheimer transgenic mouse brain. |
2013-07-22 |
2023-01-25 |
Not clear |
| Reisuke H Takahashi, Estibaliz Capetillo-Zarate, Michael T Lin, Teresa A Milner, Gunnar K Goura. Accumulation of intraneuronal \\xce\\xb2-amyloid 42 peptides is associated with early changes in microtubule-associated protein 2 in neurites and synapses. PloS one vol 8 issue 1 2013 23372648 |
we previously provided evidence for early co-localization of a\xce\xb242 peptides and hyperphosphorylated tau within postsynaptic terminals of ca1 dendrites in the hippocampus of ad transgenic mice. |
2013-07-22 |
2023-01-25 |
mouse |
| Cassia R Overk, Sylvia E Perez, Chunqi Ma, Matthew D Taves, Kiran K Soma, Elliott J Mufso. Sex steroid levels and AD-like pathology in 3xTgAD mice. Journal of neuroendocrinology vol 25 issue 2 2013 22889357 |
the age-related increase in hippocampal testosterone levels correlated positively with increases in the conformational tau isoform, alz50. |
2013-07-12 |
2023-01-25 |
mouse |
| Larry D Sparks, Richard J Kryscio, John C Hunsake. Early age-related progression of AD-like neuropathology in Down's syndrome. American journal of neurodegenerative disease vol 2 issue 2 2013 23844336 |
50 \xce\xbcm vibratome sections of formalin fixed hippocampal formations were immunohistochemically stained for amyloid-\xce\xb2 (6e10), app (22c11) and phosphorylated tau (at8) using standard methods. |
2013-07-11 |
2023-01-25 |
human |