| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Linn Hege Nilsen, Caroline Rae, Lars M Ittner, J\\xc3\\xbcrgen G\\xc3\\xb6tz, Ursula Sonnewal. Glutamate metabolism is impaired in transgenic mice with tau hyperphosphorylation. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism vol 33 issue 5 2013 23340677 |
overall, we revealed that astrocytes as well as glutamatergic and gabaergic neurons in the cortex of pr5 mice were in a hypermetabolic state, whereas in the hippocampus, where expression levels of mutant human tau are the highest, glutamate homeostasis was impaired. |
2013-06-28 |
2023-01-25 |
mouse |
| Lei Wang, Anne M Fagan, Aarti R Shah, Mirza Faisal Beg, John G Csernansky, John C Morris, David M Holtzma. Cerebrospinal fluid proteins predict longitudinal hippocampal degeneration in early-stage dementia of the Alzheimer type. Alzheimer disease and associated disorders vol 26 issue 4 2013 22156755 |
the present study was conducted to assess the relationship between csf a\xce\xb2 and tau protein levels and longitudinal measures of hippocampal structure in individuals with and without very mild dementia of the alzheimer type. |
2013-06-26 |
2023-01-25 |
Not clear |
| Bruno M Jedynak, Andrew Lang, Bo Liu, Elyse Katz, Yanwei Zhang, Bradley T Wyman, David Raunig, C Pierre Jedynak, Brian Caffo, Jerry L Princ. A computational neurodegenerative disease progression score: method and results with the Alzheimer's disease Neuroimaging Initiative cohort. NeuroImage vol 63 issue 3 2013 22885136 |
the group of biomarkers comprising the volume of the hippocampus and the protein concentration amyloid beta and tau were next in the timeline, and these were followed by three cognitive biomarkers. |
2013-06-25 |
2023-01-25 |
human |
| D\\xc3\\xa1vid Lendvai, Markus Morawski, L\\xc3\\xa1szl\\xc3\\xb3 N\\xc3\\xa9gyessy, Georgina G\\xc3\\xa1ti, Carsten J\\xc3\\xa4ger, G\\xc3\\xa1bor Baksa, Tibor Glasz, Johannes Attems, Heikki Tanila, Thomas Arendt, Tibor Harkany, Al\\xc3\\xa1n Alp\\xc3\\xa1. Neurochemical mapping of the human hippocampus reveals perisynaptic matrix around functional synapses in Alzheimer's disease. Acta neuropathologica vol 125 issue 2 2013 22961619 |
we demonstrate, by combining biochemical profiling and neuroanatomy in alzheimer's patients and transgenic (apde9) mice, the preserved turnover and distribution of axonal coats around functional synapses along dendrite segments containing hyperphosphorylated tau and in amyloid-\xce\xb2-laden hippocampal microdomains. |
2013-06-25 |
2023-01-25 |
mouse |
| Maria Luisa Rocco, Andrea Prister\\xc3\\xa0, Luana Pistillo, Luigi Aloe, Nadia Canu, Luigi Mann. Brain cholinergic markers and Tau phosphorylation are altered in experimental type 1 diabetes: normalization by electroacupuncture. Journal of Alzheimer's disease : JAD vol 33 issue 3 2013 23001708 |
here we assessed the variations of ngf and tau phosphorylation in the cortex and hippocampus, as well as the expression of choline acetyltransferase in the basal forebrain following diabetes induction and ea in adult rats. |
2013-06-25 |
2023-01-25 |
rat |
| Kevin F Bieniek, Melissa E Murray, Nicola J Rutherford, Monica Castanedes-Casey, Mariely DeJesus-Hernandez, Amanda M Liesinger, Matthew C Baker, Kevin B Boylan, Rosa Rademakers, Dennis W Dickso. Tau pathology in frontotemporal lobar degeneration with C9ORF72 hexanucleotide repeat expansion. Acta neuropathologica vol 125 issue 2 2013 23053135 |
increased tau pathology in ftld-c9orf72 was assessed with thioflavin-s fluorescent microscopy-based neurofibrillary tangle counts and with image analysis of tau burden in temporal cortex and hippocampus. |
2013-06-25 |
2023-01-25 |
Not clear |
| Bo Cui, Ming Quan Wu, Li Xing Zhu, Xiao Jun She, Qiang Ma, Hong Tao Li. Effect of chronic noise exposure on expression of N-methyl-D-aspartic acid receptor 2B and Tau phosphorylation in hippocampus of rats. Biomedical and environmental sciences : BES vol 26 issue 3 2013 23425798 |
effect of chronic noise exposure on expression of n-methyl-d-aspartic acid receptor 2b and tau phosphorylation in hippocampus of rats. |
2013-06-11 |
2023-01-25 |
rat |
| Bo Cui, Ming Quan Wu, Li Xing Zhu, Xiao Jun She, Qiang Ma, Hong Tao Li. Effect of chronic noise exposure on expression of N-methyl-D-aspartic acid receptor 2B and Tau phosphorylation in hippocampus of rats. Biomedical and environmental sciences : BES vol 26 issue 3 2013 23425798 |
to study the effect of chronic noise exposure on expression of n-methyl-d-aspartic acid receptor 2b (nr2b) and tau phosphorylation in hippocampus of rats. |
2013-06-11 |
2023-01-25 |
rat |
| Kiren Ubhi, Eliezer Maslia. Alzheimer's disease: recent advances and future perspectives. Journal of Alzheimer's disease : JAD vol 33 Suppl 1 issue 2013 22810100 |
neuropathologically, ad is characterized by the progressive loss of basal forebrain cholinergic neurons that innervate the hippocampus and cortex and the abnormal extracellular accumulation of amyloid-\xce\xb2 and intracellular tau protein. |
2013-06-06 |
2023-01-25 |
Not clear |
| Xiangdong Qu, Chengshi Xu, Hui Wang, Jie Xu, Weiran Liu, Yun Wang, Xingyuan Jia, Zhongcong Xie, Zhipeng Xu, Chao Ji, Anshi Wu, Yun Yu. Hippocampal glutamate level and glutamate aspartate transporter (GLAST) are up-regulated in senior rat associated with isoflurane-induced spatial learning/memory impairment. Neurochemical research vol 38 issue 1 2013 23070469 |
expression levels of glast, glt-1, nmdar1, nmdar2a/b, ampar and tau in hippocampus were assessed via quantitative western blotting. |
2013-05-29 |
2023-01-25 |
rat |
| Xiangdong Qu, Chengshi Xu, Hui Wang, Jie Xu, Weiran Liu, Yun Wang, Xingyuan Jia, Zhongcong Xie, Zhipeng Xu, Chao Ji, Anshi Wu, Yun Yu. Hippocampal glutamate level and glutamate aspartate transporter (GLAST) are up-regulated in senior rat associated with isoflurane-induced spatial learning/memory impairment. Neurochemical research vol 38 issue 1 2013 23070469 |
we found a continuous raised hippocampal glutamate and an up-regulation of glast rather than glt-1, nmdar1, nmdar2a/b, ampar or tau in hippocampus of aged rats associated with isoflurane-induced learning/memory impairment. |
2013-05-29 |
2023-01-25 |
rat |
| Leonardo C de Souza, Marie Chupin, Foudil Lamari, Claude Jardel, Delphine Leclercq, Olivier Colliot, St\\xc3\\xa9phane Leh\\xc3\\xa9ricy, Bruno Dubois, Marie Sarazi. CSF tau markers are correlated with hippocampal volume in Alzheimer's disease. Neurobiology of aging vol 33 issue 7 2013 21489655 |
in ad patients, antemortem mri hippocampal volumes (hvs) correlate with the density of neurofibrillary tangles (but not with senile plaques) at autopsy suggesting that hvs may better correlate with csf tau and hyperphosphorylated tau (p-tau) levels than csf amyloid beta protein (a\xce\xb2)(42) level. |
2013-05-27 |
2023-01-25 |
Not clear |
| James L Searcy, Jeremiah T Phelps, Tristano Pancani, Inga Kadish, Jelena Popovic, Katie L Anderson, Tina L Beckett, Michael P Murphy, Kuey-Chu Chen, Eric M Blalock, Philip W Landfield, Nada M Porter, Olivier Thibaul. Long-term pioglitazone treatment improves learning and attenuates pathological markers in a mouse model of Alzheimer's disease. Journal of Alzheimer's disease : JAD vol 30 issue 4 2013 22495349 |
after four months, pio-treated animals showed multiple beneficial effects, including improved learning on the active avoidance task, reduced serum cholesterol, decreased hippocampal amyloid-\xce\xb2 and tau deposits, and enhanced short- and long-term plasticity. |
2013-05-15 |
2023-01-25 |
Not clear |
| Carsten Merkwirth, Paola Martinelli, Anne Korwitz, Michela Morbin, Hella S Br\\xc3\\xb6nneke, Sabine D Jordan, Elena I Rugarli, Thomas Lange. Loss of prohibitin membrane scaffolds impairs mitochondrial architecture and leads to tau hyperphosphorylation and neurodegeneration. PLoS genetics vol 8 issue 11 2013 23144624 |
we observe early onset tau hyperphosphorylation and filament formation in the hippocampus, demonstrating a direct link between mitochondrial defects and tau pathology. |
2013-05-13 |
2023-01-25 |
mouse |
| Magdalena Wi\\xc4\\x99d\\xc5\\x82ocha, Bart\\xc5\\x82omiej Sta\\xc5\\x84czykiewicz, Marta Jakubik, Joanna Rymaszewsk. [Selected mice models based on APP, MAPT and presenilin gene mutations in research on the pathogenesis of Alzheimer's disease]. Postepy higieny i medycyny doswiadczalnej (Online) vol 66 issue 2013 22922141 |
their brain tissue, depending on the mutation, is characterized by histopathological changes, such as the presence of amyloid plaques, tau protein deposits and dystrophic neurites, gliosis, hippocampal atrophy and amyloid accumulation in vessels. |
2013-05-02 |
2023-01-25 |
mouse |
| Qiu-Lan Ma, Xiaohong Zuo, Fusheng Yang, Oliver J Ubeda, Dana J Gant, Mher Alaverdyan, Edmond Teng, Shuxin Hu, Ping-Ping Chen, Panchanan Maiti, Bruce Teter, Greg M Cole, Sally A Frautsch. Curcumin suppresses soluble tau dimers and corrects molecular chaperone, synaptic, and behavioral deficits in aged human tau transgenic mice. The Journal of biological chemistry vol 288 issue 6 2013 23264626 |
transgene-dependent elevations in soluble and insoluble phospho-tau monomer and soluble tau dimers accompanied deficits in behavior, hippocampal excitatory synaptic markers, and molecular chaperones (heat shock proteins (hsps)) involved in tau degradation and microtubule stability. |
2013-04-19 |
2023-01-25 |
mouse |
| Michiyo Iba, Jing L Guo, Jennifer D McBride, Bin Zhang, John Q Trojanowski, Virginia M-Y Le. Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 33 issue 3 2013 23325240 |
interestingly, injection of tau pffs into either hippocampus or striatum together with overlaying cortex gave rise to distinct pattern of spreading. |
2013-04-01 |
2023-01-25 |
mouse |
| Jerrah K Holth, Valerie C Bomben, J Graham Reed, Taeko Inoue, Linda Younkin, Steven G Younkin, Robia G Pautler, Juan Botas, Jeffrey L Noebel. Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 33 issue 4 2013 23345237 |
tau reduction decreased kcna1(-/-) video-eeg recorded seizure frequency and duration as well as normalized kcna1(-/-) hippocampal network hyperexcitability in vitro. |
2013-03-20 |
2023-01-25 |
mouse |
| Jerrah K Holth, Valerie C Bomben, J Graham Reed, Taeko Inoue, Linda Younkin, Steven G Younkin, Robia G Pautler, Juan Botas, Jeffrey L Noebel. Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 33 issue 4 2013 23345237 |
additionally, tau reduction increased kcna1(-/-) survival and prevented megencephaly and hippocampal hypertrophy, as determined by mri. |
2013-03-20 |
2023-01-25 |
mouse |
| Aliesha Gonz\\xc3\\xa1lez-Arenas, Ana Gabriela Pi\\xc3\\xb1a-Medina, Oscar Gonz\\xc3\\xa1lez-Flores, Porfirio G\\xc3\\xb3mora-Arrati, Graciela Elena Carrillo-Mart\\xc3\\xadnez, Marco Antonio Balandr\\xc3\\xa1n-Ru\\xc3\\xadz, Ignacio Camacho-Arroy. Expression pattern of Tau in the rat brain during pregnancy and the beginning of lactation. Brain research bulletin vol 89 issue 3-4 2013 22884690 |
in hippocampus tau content decreased on day 14 until day 21 compared with day 2 of gestation, however, in lactation day 2 the content of tau increased meanwhile phosphotau content progressively increased throughout pregnancy. |
2013-02-27 |
2023-01-25 |
rat |