Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Eleonora Gatta, Tony Lefebvre, Silvana Gaetani, Marc dos Santos, Jordan Marrocco, Anne-Marie Mir, Tommaso Cassano, Stefania Maccari, Ferdinando Nicoletti, Jérôme Mairess. Evidence for an imbalance between tau O-GlcNAcylation and phosphorylation in the hippocampus of a mouse model of Alzheimer's disease. Pharmacological research. vol 105. 2016-11-11. PMID:26816085. |
tau o-glcnacylation, assessed in tau immunoprecipitates, was substantially reduced in the hippocampus of 3xtg-ad mice, with no changes in the frontal cortex or in the cerebellum. |
2016-11-11 |
2023-08-13 |
mouse |
Sulana K Schroeder, Aurelie Joly-Amado, Marcia N Gordon, Dave Morga. Tau-Directed Immunotherapy: A Promising Strategy for Treating Alzheimer's Disease and Other Tauopathies. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 11. issue 1. 2016-11-09. PMID:26538351. |
pathological improvements as measured by gallyas staining for fully formed tangles and phosphorylated tau appeared 4 days after intracranial injection into the hippocampus. |
2016-11-09 |
2023-08-13 |
mouse |
YoungDoo Kim, Hyunwoo Choi, WonJae Lee, Hyejin Park, Tae-In Kam, Se-Hoon Hong, Jihoon Nah, Sunmin Jung, Bora Shin, Huikyong Lee, Tae-Yong Choi, Hyosun Choo, Kyung-Keun Kim, Se-Young Choi, Rakez Kayed, Yong-Keun Jun. Caspase-cleaved tau exhibits rapid memory impairment associated with tau oligomers in a transgenic mouse model. Neurobiology of disease. vol 87. 2016-10-20. PMID:26704708. |
injection with rapamycin significantly reduced the amounts of tau oligomers in the hippocampus, rescued spine density, and attenuated memory impairment in tauc3 mice. |
2016-10-20 |
2023-08-13 |
mouse |
T L Platt, T L Beckett, K Kohler, D M Niedowicz, M P Murph. Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease. Neuroscience. vol 315. 2016-10-19. PMID:26701291. |
the resulting phenotype included a striking increase in tau phosphorylation and the number of neurofibrillary tangles (nfts) found within the hippocampus. |
2016-10-19 |
2023-08-13 |
mouse |
Roya Behrouzi, Xiawei Liu, Dongyue Wu, Andrew C Robinson, Sayuri Tanaguchi-Watanabe, Sara Rollinson, Jing Shi, Jinzhou Tian, Hisham H M Hamdalla, John Ealing, Anna Richardson, Matthew Jones, Stuart Pickering-Brown, Yvonne S Davidson, Michael J Strong, Masato Hasegawa, Julie S Snowden, David M A Man. Pathological tau deposition in Motor Neurone Disease and frontotemporal lobar degeneration associated with TDP-43 proteinopathy. Acta neuropathologica communications. vol 4. 2016-10-14. PMID:27036121. |
paraffin sections of frontal, entorhinal, temporal and occipital cortex and hippocampus were immunostained for tau pathology using anti-tau antibodies, at8, pthr(175) and pthr(217), and for amyloid β protein (aβ) using 4g8 antibody. |
2016-10-14 |
2023-08-13 |
Not clear |
Roya Behrouzi, Xiawei Liu, Dongyue Wu, Andrew C Robinson, Sayuri Tanaguchi-Watanabe, Sara Rollinson, Jing Shi, Jinzhou Tian, Hisham H M Hamdalla, John Ealing, Anna Richardson, Matthew Jones, Stuart Pickering-Brown, Yvonne S Davidson, Michael J Strong, Masato Hasegawa, Julie S Snowden, David M A Man. Pathological tau deposition in Motor Neurone Disease and frontotemporal lobar degeneration associated with TDP-43 proteinopathy. Acta neuropathologica communications. vol 4. 2016-10-14. PMID:27036121. |
in most instances, this bore the histological characteristics of an alzheimer's disease process involving entorhinal cortex, hippocampus, temporal cortex, frontal cortex and occipital cortex in decreasing frequency, accompanied by a deposition of aβ up to thal phase 3, though 2 patients with mnd, and 1 with ftd did show tau pathology beyond braak stage iii. |
2016-10-14 |
2023-08-13 |
Not clear |
Siân Baker, Jürgen Göt. A local insult of okadaic acid in wild-type mice induces tau phosphorylation and protein aggregation in anatomically distinct brain regions. Acta neuropathologica communications. vol 4. 2016-10-14. PMID:27037086. |
oa injection induced tau phosphorylation that was observed not only at the injection site but also in anatomically distinct areas across both hemispheres, including the cortex and hippocampus 24 h post-injection. |
2016-10-14 |
2023-08-13 |
mouse |
Yan Yang, Delin Ma, Weijie Xu, Fuqiong Chen, Tingting Du, Wenzhu Yue, Shiying Shao, Gang Yua. Exendin-4 reduces tau hyperphosphorylation in type 2 diabetic rats via increasing brain insulin level. Molecular and cellular neurosciences. vol 70. 2016-10-13. PMID:26640240. |
we found that peripheral ex-4 injection in t2d rats reduced hyperphosphorylation of tau protein in rat hippocampus, probably via increasing hippocampal insulin which activated insulin signaling. |
2016-10-13 |
2023-08-13 |
rat |
Ke Li, Fang-Fang Liu, Chun-Xue He, He-Zhou Huang, Ao-Ji Xie, Fan Hu, Dan Liu, Jian-Zhi Wang, Ling-Qiang Zh. Olfactory Deprivation Hastens Alzheimer-Like Pathologies in a Human Tau-Overexpressed Mouse Model via Activation of cdk5. Molecular neurobiology. vol 53. issue 1. 2016-10-10. PMID:25465240. |
we found that tau phosphorylation in hippocampus was increased at thr-205, ser-214, thr-231, and ser-396 after obx. |
2016-10-10 |
2023-08-13 |
mouse |
Venkata Siva Sai Sujith Sajja, W Brad Hubbard, Christina S Hall, Farhad Ghoddoussi, Matthew P Galloway, Pamela J VandeVor. Enduring deficits in memory and neuronal pathology after blast-induced traumatic brain injury. Scientific reports. vol 5. 2016-09-26. PMID:26537106. |
at three months, tau was selectively elevated in the pfc and hipp whereas α-synuclein transiently increased in the hipp at one month after blast exposure. |
2016-09-26 |
2023-08-13 |
Not clear |
Mohcene Sadallah, Vivien Labat-Gest, Filippo Tempi. Propagation of Neuronal Damage to Embryonic Grafts Transplanted in the Hippocampus of Murine Models of Alzheimer's Disease. Rejuvenation research. vol 18. issue 6. 2016-09-26. PMID:26540615. |
to throw light on the mechanisms of propagation of neuronal damage to healthy tissue, wild-type (wt) hippocampal solid tissue chunks derived from green fluorescent protein (gfp)-positive embryos were grafted into the hippocampus of 6-month-old wt and 3xtg-ad mice, a triple-transgenic mouse model that exhibits both amyloid-beta (aβ) and tau protein pathology. |
2016-09-26 |
2023-08-13 |
mouse |
Liam Scott, Tamás Kiss, Thomas T Kawabe, Mihály Hajó. Neuronal network activity in the hippocampus of tau transgenic (Tg4510) mice. Neurobiology of aging. vol 37. 2016-09-26. PMID:26610388. |
neuronal network activity in the hippocampus of tau transgenic (tg4510) mice. |
2016-09-26 |
2023-08-13 |
mouse |
C Laurent, S Burnouf, B Ferry, V L Batalha, J E Coelho, Y Baqi, E Malik, E Mariciniak, S Parrot, A Van der Jeugd, E Faivre, V Flaten, C Ledent, R D'Hooge, N Sergeant, M Hamdane, S Humez, C E Müller, L V Lopes, L Buée, D Blu. A2A adenosine receptor deletion is protective in a mouse model of Tauopathy. Molecular psychiatry. vol 21. issue 1. 2016-09-16. PMID:25450226. |
in the present study, we removed the gene encoding a2ar from thy-tau22 mice and analysed the subsequent effects on both pathological (tau phosphorylation and aggregation, neuro-inflammation) and functional impairments (spatial learning and memory, hippocampal plasticity, neurotransmitter profile). |
2016-09-16 |
2023-08-13 |
mouse |
C Laurent, S Burnouf, B Ferry, V L Batalha, J E Coelho, Y Baqi, E Malik, E Mariciniak, S Parrot, A Van der Jeugd, E Faivre, V Flaten, C Ledent, R D'Hooge, N Sergeant, M Hamdane, S Humez, C E Müller, L V Lopes, L Buée, D Blu. A2A adenosine receptor deletion is protective in a mouse model of Tauopathy. Molecular psychiatry. vol 21. issue 1. 2016-09-16. PMID:25450226. |
we found that deleting a2ars protect from tau pathology-induced deficits in terms of spatial memory and hippocampal long-term depression. |
2016-09-16 |
2023-08-13 |
mouse |
C Laurent, S Burnouf, B Ferry, V L Batalha, J E Coelho, Y Baqi, E Malik, E Mariciniak, S Parrot, A Van der Jeugd, E Faivre, V Flaten, C Ledent, R D'Hooge, N Sergeant, M Hamdane, S Humez, C E Müller, L V Lopes, L Buée, D Blu. A2A adenosine receptor deletion is protective in a mouse model of Tauopathy. Molecular psychiatry. vol 21. issue 1. 2016-09-16. PMID:25450226. |
these effects were concomitant with a normalization of the hippocampal glutamate/gamma-amino butyric acid ratio, together with a global reduction in neuro-inflammatory markers and a decrease in tau hyperphosphorylation. |
2016-09-16 |
2023-08-13 |
mouse |
Jose Morales-Corraliza, Harrison Wong, Matthew J Mazzella, Shaoli Che, Sang Han Lee, Eva Petkova, Janice D Wagner, Scott E Hemby, Stephen D Ginsberg, Paul M Mathew. Brain-Wide Insulin Resistance, Tau Phosphorylation Changes, and Hippocampal Neprilysin and Amyloid-β Alterations in a Monkey Model of Type 1 Diabetes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 15. 2016-09-08. PMID:27076423. |
brain-wide insulin resistance, tau phosphorylation changes, and hippocampal neprilysin and amyloid-β alterations in a monkey model of type 1 diabetes. |
2016-09-08 |
2023-08-13 |
human |
Jose Morales-Corraliza, Harrison Wong, Matthew J Mazzella, Shaoli Che, Sang Han Lee, Eva Petkova, Janice D Wagner, Scott E Hemby, Stephen D Ginsberg, Paul M Mathew. Brain-Wide Insulin Resistance, Tau Phosphorylation Changes, and Hippocampal Neprilysin and Amyloid-β Alterations in a Monkey Model of Type 1 Diabetes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 15. 2016-09-08. PMID:27076423. |
thus, we document multiple biochemical changes in the insulin-controlled dm monkey brain that can link dm with the risk of developing ad, including dysregulation of the insulin-signaling pathway, changes in tau phosphorylation, and a decrease in nep expression in the hippocampus that is coupled with a localized increase in aβ. |
2016-09-08 |
2023-08-13 |
human |
Gaëlle Naert, Valentine Ferré, Johann Meunier, Emeline Keller, Susanna Malmström, Laurent Givalois, François Carreaux, Jean-Pierre Bazureau, Tangui Mauric. Leucettine L41, a DYRK1A-preferential DYRKs/CLKs inhibitor, prevents memory impairments and neurotoxicity induced by oligomeric Aβ25-35 peptide administration in mice. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 11. 2016-08-26. PMID:26381812. |
the oxidative stress, apoptotic markers, kinases involved in tau phosphorylation, and synaptic integrity were analyzed by western blot and elisa in the hippocampus. |
2016-08-26 |
2023-08-13 |
mouse |
Juan Jose Ramos-Rodriguez, Margarita Jimenez-Palomares, Maria Isabel Murillo-Carretero, Carmen Infante-Garcia, Esther Berrocoso, Fernando Hernandez-Pacho, Alfonso Maria Lechuga-Sancho, Irene Cozar-Castellano, Monica Garcia-Alloz. Central vascular disease and exacerbated pathology in a mixed model of type 2 diabetes and Alzheimer's disease. Psychoneuroendocrinology. vol 62. 2016-08-24. PMID:26254770. |
significant brain atrophy and tau pathology were detected in the cortex by 14 weeks, that spread to the hippocampus by 26 weeks of age. |
2016-08-24 |
2023-08-13 |
mouse |
Marie Violet, Alban Chauderlier, Lucie Delattre, Meryem Tardivel, Meliza Sendid Chouala, Audrey Sultan, Elodie Marciniak, Sandrine Humez, Lester Binder, Rakez Kayed, Bruno Lefebvre, Eliette Bonnefoy, Luc Buée, Marie-Christine Gala. Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo. Neurobiology of disease. vol 82. 2016-08-24. PMID:26385829. |
prefibrillar tau oligomers alter the nucleic acid protective function of tau in hippocampal neurons in vivo. |
2016-08-24 |
2023-08-13 |
mouse |