| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Laurent, S Burnouf, B Ferry, V L Batalha, J E Coelho, Y Baqi, E Malik, E Mariciniak, S Parrot, A Van der Jeugd, E Faivre, V Flaten, C Ledent, R D'Hooge, N Sergeant, M Hamdane, S Humez, C E Müller, L V Lopes, L Buée, D Blu. A2A adenosine receptor deletion is protective in a mouse model of Tauopathy. Molecular psychiatry. vol 21. issue 1. 2016-09-16. PMID:25450226. |
these effects were concomitant with a normalization of the hippocampal glutamate/gamma-amino butyric acid ratio, together with a global reduction in neuro-inflammatory markers and a decrease in tau hyperphosphorylation. |
2016-09-16 |
2023-08-13 |
mouse |
| Jose Morales-Corraliza, Harrison Wong, Matthew J Mazzella, Shaoli Che, Sang Han Lee, Eva Petkova, Janice D Wagner, Scott E Hemby, Stephen D Ginsberg, Paul M Mathew. Brain-Wide Insulin Resistance, Tau Phosphorylation Changes, and Hippocampal Neprilysin and Amyloid-β Alterations in a Monkey Model of Type 1 Diabetes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 15. 2016-09-08. PMID:27076423. |
brain-wide insulin resistance, tau phosphorylation changes, and hippocampal neprilysin and amyloid-β alterations in a monkey model of type 1 diabetes. |
2016-09-08 |
2023-08-13 |
human |
| Jose Morales-Corraliza, Harrison Wong, Matthew J Mazzella, Shaoli Che, Sang Han Lee, Eva Petkova, Janice D Wagner, Scott E Hemby, Stephen D Ginsberg, Paul M Mathew. Brain-Wide Insulin Resistance, Tau Phosphorylation Changes, and Hippocampal Neprilysin and Amyloid-β Alterations in a Monkey Model of Type 1 Diabetes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 15. 2016-09-08. PMID:27076423. |
thus, we document multiple biochemical changes in the insulin-controlled dm monkey brain that can link dm with the risk of developing ad, including dysregulation of the insulin-signaling pathway, changes in tau phosphorylation, and a decrease in nep expression in the hippocampus that is coupled with a localized increase in aβ. |
2016-09-08 |
2023-08-13 |
human |
| Gaëlle Naert, Valentine Ferré, Johann Meunier, Emeline Keller, Susanna Malmström, Laurent Givalois, François Carreaux, Jean-Pierre Bazureau, Tangui Mauric. Leucettine L41, a DYRK1A-preferential DYRKs/CLKs inhibitor, prevents memory impairments and neurotoxicity induced by oligomeric Aβ25-35 peptide administration in mice. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 11. 2016-08-26. PMID:26381812. |
the oxidative stress, apoptotic markers, kinases involved in tau phosphorylation, and synaptic integrity were analyzed by western blot and elisa in the hippocampus. |
2016-08-26 |
2023-08-13 |
mouse |
| Juan Jose Ramos-Rodriguez, Margarita Jimenez-Palomares, Maria Isabel Murillo-Carretero, Carmen Infante-Garcia, Esther Berrocoso, Fernando Hernandez-Pacho, Alfonso Maria Lechuga-Sancho, Irene Cozar-Castellano, Monica Garcia-Alloz. Central vascular disease and exacerbated pathology in a mixed model of type 2 diabetes and Alzheimer's disease. Psychoneuroendocrinology. vol 62. 2016-08-24. PMID:26254770. |
significant brain atrophy and tau pathology were detected in the cortex by 14 weeks, that spread to the hippocampus by 26 weeks of age. |
2016-08-24 |
2023-08-13 |
mouse |
| Marie Violet, Alban Chauderlier, Lucie Delattre, Meryem Tardivel, Meliza Sendid Chouala, Audrey Sultan, Elodie Marciniak, Sandrine Humez, Lester Binder, Rakez Kayed, Bruno Lefebvre, Eliette Bonnefoy, Luc Buée, Marie-Christine Gala. Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo. Neurobiology of disease. vol 82. 2016-08-24. PMID:26385829. |
prefibrillar tau oligomers alter the nucleic acid protective function of tau in hippocampal neurons in vivo. |
2016-08-24 |
2023-08-13 |
mouse |
| Marie Violet, Alban Chauderlier, Lucie Delattre, Meryem Tardivel, Meliza Sendid Chouala, Audrey Sultan, Elodie Marciniak, Sandrine Humez, Lester Binder, Rakez Kayed, Bruno Lefebvre, Eliette Bonnefoy, Luc Buée, Marie-Christine Gala. Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo. Neurobiology of disease. vol 82. 2016-08-24. PMID:26385829. |
in a mouse model of tauopathy (thy-tau22), we demonstrate that hyperthermia selectively induces nucleic acid oxidative damage and nucleic acid strand breaks in the nucleus and cytoplasm of hippocampal neurons that display early tau phosphorylation but no tau fibrils. |
2016-08-24 |
2023-08-13 |
mouse |
| Danielle Steinmetz, Eugenia Ramos, Shannon N Campbell, Teresa Morales, Robert A Rissma. Reproductive Stage and Modulation of Stress-Induced Tau Phosphorylation in Female Rats. Journal of neuroendocrinology. vol 27. issue 11. 2016-08-18. PMID:26510116. |
although the specific mechanisms linking stress exposure and ad vulnerability have yet to be fully determined, our laboratory and others have shown that acute and repeated restraint stress in rodents leads to an increase in hippocampal tau phosphorylation (tau-p) and tau insolubility, a critical component of tau pathology in ad. |
2016-08-18 |
2023-08-13 |
rat |
| Danielle Steinmetz, Eugenia Ramos, Shannon N Campbell, Teresa Morales, Robert A Rissma. Reproductive Stage and Modulation of Stress-Induced Tau Phosphorylation in Female Rats. Journal of neuroendocrinology. vol 27. issue 11. 2016-08-18. PMID:26510116. |
this suggests a steep, yet transient stress-induced dephosphorylation of tau, influenced by gsk3, in the hippocampus of lactating rats. |
2016-08-18 |
2023-08-13 |
rat |
| Magdalena Gąssowska, Irena Baranowska-Bosiacka, Joanna Moczydłowska, Maciej Tarnowski, Anna Pilutin, Izabela Gutowska, Lidia Strużyńska, Dariusz Chlubek, Agata Adamczy. Perinatal exposure to lead (Pb) promotes Tau phosphorylation in the rat brain in a GSK-3β and CDK5 dependent manner: Relevance to neurological disorders. Toxicology. vol 347-349. 2016-08-18. PMID:27012722. |
28-day old pups were sacrificed and tau mrna and protein level as well as tau phosphorylation were analyzed in forebrain cortex (fc), cerebellum (c) and hippocampus (h). |
2016-08-18 |
2023-08-13 |
rat |
| Michelle H Le, April M Weissmiller, Louise Monte, Po Han Lin, Tia C Hexom, Orlangie Natera, Chengbiao Wu, Robert A Rissma. Functional Impact of Corticotropin-Releasing Factor Exposure on Tau Phosphorylation and Axon Transport. PloS one. vol 11. issue 1. 2016-08-11. PMID:26790099. |
stress exposure or increased levels of corticotropin-releasing factor (crf) induce hippocampal tau phosphorylation (tau-p) in rodent models, a process that is dependent on the type-1 crf receptor (crfr1). |
2016-08-11 |
2023-08-13 |
mouse |
| Suzanne Attiori Essis, Marie-Elaine Laurier-Laurin, Élise Pépin, Michel Cyr, Guy Massicott. GluN2B-containing NMDA receptors are upregulated in plasma membranes by the sphingosine-1-phosphate analog FTY720P. Brain research. vol 1624. 2016-08-10. PMID:26260438. |
these results suggest that activation of s1pr1 by fty720p enhances glun2b receptor phosphorylation in rat hippocampal slices, resulting in increased levels of glun1 and glun2b receptor subunits in neuronal membranes through a mechanism probably involving fyn and tau. |
2016-08-10 |
2023-08-13 |
rat |
| Naoto Watamura, Junya Toba, Aya Yoshii, Miyu Nikkuni, Toshio Ohshim. Colocalization of phosphorylated forms of WAVE1, CRMP2, and tau in Alzheimer's disease model mice: Involvement of Cdk5 phosphorylation and the effect of ATRA treatment. Journal of neuroscience research. vol 94. issue 1. 2016-08-05. PMID:26400044. |
first, we verified the colocalization of p-wave1 and p-crmp2 with aggregated hyperphosphorylated tau in the hippocampus at 23 months of age. |
2016-08-05 |
2023-08-13 |
mouse |
| Naoto Watamura, Junya Toba, Aya Yoshii, Miyu Nikkuni, Toshio Ohshim. Colocalization of phosphorylated forms of WAVE1, CRMP2, and tau in Alzheimer's disease model mice: Involvement of Cdk5 phosphorylation and the effect of ATRA treatment. Journal of neuroscience research. vol 94. issue 1. 2016-08-05. PMID:26400044. |
biochemical analysis revealed the inclusion of p-wave1, p-crmp2, and tau in the sarkosyl-insoluble fractions of hippocampal homogenates. |
2016-08-05 |
2023-08-13 |
mouse |
| Zhen Wu, Bin Yang, Chunxia Liu, Ge Liang, Maryellen F Eckenhoff, Weixia Liu, Stephen Pickup, Qingcheng Meng, Yuke Tian, Shitong Li, Huafeng We. Long-term dantrolene treatment reduced intraneuronal amyloid in aged Alzheimer triple transgenic mice. Alzheimer disease and associated disorders. vol 29. issue 3. 2016-08-02. PMID:25650693. |
the amyloid burden and tau neurofibrillary tangles in the hippocampus were determined using immunohistochemistry. |
2016-08-02 |
2023-08-13 |
mouse |
| Zhen Wu, Bin Yang, Chunxia Liu, Ge Liang, Maryellen F Eckenhoff, Weixia Liu, Stephen Pickup, Qingcheng Meng, Yuke Tian, Shitong Li, Huafeng We. Long-term dantrolene treatment reduced intraneuronal amyloid in aged Alzheimer triple transgenic mice. Alzheimer disease and associated disorders. vol 29. issue 3. 2016-08-02. PMID:25650693. |
we found that dantrolene significantly decreased the intraneuronal amyloid accumulation by as much as 76% compared with its corresponding vehicle control, together with a trend to reduce phosphorylated tau in the hippocampus. |
2016-08-02 |
2023-08-13 |
mouse |
| Xuling Li, Peng Lei, Qingzhang Tuo, Scott Ayton, Qiao-Xin Li, Steve Moon, Irene Volitakis, Rong Liu, Colin L Masters, David I Finkelstein, Ashley I Bus. Enduring Elevations of Hippocampal Amyloid Precursor Protein and Iron Are Features of β-Amyloid Toxicity and Are Mediated by Tau. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 12. issue 4. 2016-07-22. PMID:26260389. |
enduring elevations of hippocampal amyloid precursor protein and iron are features of β-amyloid toxicity and are mediated by tau. |
2016-07-22 |
2023-08-13 |
mouse |
| Xuling Li, Peng Lei, Qingzhang Tuo, Scott Ayton, Qiao-Xin Li, Steve Moon, Irene Volitakis, Rong Liu, Colin L Masters, David I Finkelstein, Ashley I Bus. Enduring Elevations of Hippocampal Amyloid Precursor Protein and Iron Are Features of β-Amyloid Toxicity and Are Mediated by Tau. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 12. issue 4. 2016-07-22. PMID:26260389. |
here, we utilized an alternative model of aβ toxicity by directly injecting aβ oligomers into the hippocampus of young and old wild-type and tau knockout mice. |
2016-07-22 |
2023-08-13 |
mouse |
| Xuling Li, Peng Lei, Qingzhang Tuo, Scott Ayton, Qiao-Xin Li, Steve Moon, Irene Volitakis, Rong Liu, Colin L Masters, David I Finkelstein, Ashley I Bus. Enduring Elevations of Hippocampal Amyloid Precursor Protein and Iron Are Features of β-Amyloid Toxicity and Are Mediated by Tau. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 12. issue 4. 2016-07-22. PMID:26260389. |
we found that ablation of tau protected against aβ-induced cognitive impairment, hippocampal neuron loss, and iron accumulation. |
2016-07-22 |
2023-08-13 |
mouse |
| Xiao-Fang Zhang, Yan-Feng Zhao, Shun-Wei Zhu, Wei-Jie Huang, Yan Luo, Qing-Ying Chen, Li-Jun Ge, Run-Sheng Li, Jian-Fei Wang, Mu Sun, Zhi-Cheng Xiao, Guo-Huang Fa. CXCL1 Triggers Caspase-3 Dependent Tau Cleavage in Long-Term Neuronal Cultures and in the Hippocampus of Aged Mice: Implications in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 48. issue 1. 2016-07-06. PMID:26401931. |
cxcl1 triggers caspase-3 dependent tau cleavage in long-term neuronal cultures and in the hippocampus of aged mice: implications in alzheimer's disease. |
2016-07-06 |
2023-08-13 |
mouse |