| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Martina L Mustroph, Michael A King, Ronald L Klein, Julio J Ramire. Adult-onset focal expression of mutated human tau in the hippocampus impairs spatial working memory of rats. Behavioural brain research vol 233 issue 1 2012 22561128 |
histological analysis of brains for expression of human tau revealed hyperphosphorylated human tau and nfts in the hippocampus in experimental animals only. |
2012-11-05 |
2023-01-25 |
rat |
| Aline A da Cunha, Ana Paula Horn, Juliana B Hoppe, Patr\\xc3\\xadcia B Grudzinski, Samanta O Loureiro, Andr\\xc3\\xa9a G K Ferreira, Maira J da Cunha, Felipe Schmitz, Christianne G Salbego, Angela T S Wys. Evidence that AKT and GSK-3\\xce\\xb2 pathway are involved in acute hyperhomocysteinemia. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience vol 30 issue 5 2012 22525229 |
in the present study we evaluated the effect of acute and chronic hyperhomocysteinemia on akt, nf-\xce\xbab/p65, gsk-3\xce\xb2, as well as tau protein in hippocampus of rats. |
2012-11-02 |
2023-01-25 |
rat |
| Aline A da Cunha, Ana Paula Horn, Juliana B Hoppe, Patr\\xc3\\xadcia B Grudzinski, Samanta O Loureiro, Andr\\xc3\\xa9a G K Ferreira, Maira J da Cunha, Felipe Schmitz, Christianne G Salbego, Angela T S Wys. Evidence that AKT and GSK-3\\xce\\xb2 pathway are involved in acute hyperhomocysteinemia. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience vol 30 issue 5 2012 22525229 |
our data showed that akt, nf-\xce\xbab/p65, gsk-3\xce\xb2 and tau protein are activated in hippocampus of rats subjected to acute hyperhomocysteinemia, suggesting that these signaling pathways may be, at least in part, important contributors to the neuroinflammation and/or brain dysfunction observed in some hyperhomocystinuric patients. |
2012-11-02 |
2023-01-25 |
rat |
| Sylvia E Perez, Muhammad Nadeem, Katherine R Sadleir, Joanna Matras, Christy M Kelley, Scott E Counts, Robert Vassar, Elliott J Mufso. Dimebon alters hippocampal amyloid pathology in 3xTg-AD mice. International journal of physiology, pathophysiology and pharmacology vol 4 issue 3 2012 23071869 |
in the present study, we evaluated the effects of dimebon upon \xce\xb2-amyloid (a\xce\xb2), tau and astrocytes in the hippocampus of triple transgenic (3xtg-ad) mice, which develop ad-like pathology in an age-dependent manner. |
2012-10-17 |
2023-01-25 |
mouse |
| Sylvia E Perez, Muhammad Nadeem, Katherine R Sadleir, Joanna Matras, Christy M Kelley, Scott E Counts, Robert Vassar, Elliott J Mufso. Dimebon alters hippocampal amyloid pathology in 3xTg-AD mice. International journal of physiology, pathophysiology and pharmacology vol 4 issue 3 2012 23071869 |
dimebon did not alter hippocampal tau levels. |
2012-10-17 |
2023-01-25 |
mouse |
| Peter Filipcik, Petr Novak, Boris Mravec, Katarina Ondicova, Gabriela Krajciova, Michal Novak, Richard Kvetnansk. Tau protein phosphorylation in diverse brain areas of normal and CRH deficient mice: up-regulation by stress. Cellular and molecular neurobiology vol 32 issue 5 2012 22222439 |
concerning tau modifications, detailed analysis of the mouse brain revealed that neurons in different brain regions including frontal cortex, temporal cortex, hippocampal c1 and ca3 regions, dentate gyrus as well as nucleus basalis meynert, and several brainstem nuclei such as locus coeruleus but also raphe nucleus and substantia nigra respond similarly to imo. |
2012-10-17 |
2023-01-25 |
mouse |
| Almudena Fuster-Matanzo, Mar\\xc3\\xada Llorens-Mart\\xc3\\xadn, Jer\\xc3\\xb3nimo Jurado-Arjona, Jes\\xc3\\xbas Avila, F\\xc3\\xa9lix Hern\\xc3\\xa1nde. Tau protein and adult hippocampal neurogenesis. Frontiers in neuroscience vol 6 issue 2012 22787440 |
tau protein and adult hippocampal neurogenesis. |
2012-10-02 |
2023-01-25 |
Not clear |
| Almudena Fuster-Matanzo, Mar\\xc3\\xada Llorens-Mart\\xc3\\xadn, Jer\\xc3\\xb3nimo Jurado-Arjona, Jes\\xc3\\xbas Avila, F\\xc3\\xa9lix Hern\\xc3\\xa1nde. Tau protein and adult hippocampal neurogenesis. Frontiers in neuroscience vol 6 issue 2012 22787440 |
here, we review recent findings suggesting that axonal outgrowth in subgranular zone during adult hippocampal neurogenesis requires a dynamic microtubule network and tau protein facilitates to maintain that dynamic cytoskeleton. |
2012-10-02 |
2023-01-25 |
Not clear |
| Tara L Spires-Jones, Leora M Fox, Anete Rozkalne, Rose Pitstick, George A Carlson, Aleksey G Kazantse. Inhibition of Sirtuin 2 with Sulfobenzoic Acid Derivative AK1 is Non-Toxic and Potentially Neuroprotective in a Mouse Model of Frontotemporal Dementia. Frontiers in pharmacology vol 3 issue 2012 22416232 |
the rtg4510 mouse model, which expresses a mutant form of the tau protein associated with ftd with parkinsonism-17, undergoes dramatic hippocampal and cortical neuronal loss making it an ideal model to study treatments for ftd-related neuronal loss. |
2012-10-02 |
2023-01-25 |
Not clear |
| Lourdes Orejana, Luc\\xc3\\xada Barros-Mi\\xc3\\xb1ones, Joaqu\\xc3\\xadn Jord\\xc3\\xa1n, Elena Puerta, Norberto Aguirr. Sildenafil ameliorates cognitive deficits and tau pathology in a senescence-accelerated mouse model. Neurobiology of aging vol 33 issue 3 2012 21546125 |
tau hyperphosphorylation (at8 but not phf-1 epitope) shown by samp8 mice at this age was also decreased in the hippocampus of sildenafil-treated mice, an effect probably related to a decrease in cyclin-dependent kinase 5 protein expression and activity (p25/p35 ratio). |
2012-09-28 |
2023-01-25 |
mouse |
| B S Hemanth Kumar, Sushanta Kumar Mishra, Poonam Rana, Sadhana Singh, Subash Khush. Neurodegenerative evidences during early onset of depression in CMS rats as detected by proton magnetic resonance spectroscopy at 7 T. Behavioural brain research vol 232 issue 1 2012 22449862 |
the results revealed a significant decrease of glutamate (glu), glutamine (gln), naa+naag, glx and gaba levels in both hippocampus and prefrontal cortex of cms animals and an elevated level of myo-ionisitol (mi) and taurine (tau) was observed only in hippocampus. |
2012-09-27 |
2023-01-25 |
rat |
| Ann Van der Jeugd, Katja Hochgr\\xc3\\xa4fe, Tariq Ahmed, Jochen M Decker, Astrid Sydow, Anne Hofmann, Dan Wu, Lars Messing, Detlef Balschun, Rudi D'Hooge, Eva-Maria Mandelko. Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau. Acta neuropathologica vol 123 issue 6 2012 22532069 |
we correlated hippocampal tau pathology with learning/memory performance and synaptic plasticity. |
2012-09-24 |
2023-01-25 |
mouse |
| Xu-Ying Sun, Yu-Ping Wei, Yan Xiong, Xiao-Chuan Wang, Ao-Ji Xie, Xiu-Lian Wang, Yang Yang, Qun Wang, You-Ming Lu, Rong Liu, Jian-Zhi Wan. Synaptic released zinc promotes tau hyperphosphorylation by inhibition of protein phosphatase 2A (PP2A). The Journal of biological chemistry vol 287 issue 14 2012 22334661 |
the zinc release and translocation of excitatory synapses in the hippocampus were detected, and zinc-induced tau hyperphosphorylation was also observed in cultured brain slices incubated with exogenously supplemented zinc. |
2012-09-20 |
2023-01-25 |
Not clear |
| Abdur Rahman, Khalid M Khan, Ghanim Al-Khaledi, Islam Khan, Tahany Al-Shemar. Over activation of hippocampal serine/threonine protein phosphatases PP1 and PP2A is involved in lead-induced deficits in learning and memory in young rats. Neurotoxicology vol 33 issue 3 2012 22387731 |
pb exposure increased the expression and activity of pp1 and decreased phosphorylation of tau at threonine-231 in hippocampus at both pnd21 and pnd30. |
2012-09-18 |
2023-01-25 |
rat |
| Yuen-Shan Ho, Xifei Yang, Jeffery Chi-Fai Lau, Clara Hui-Ling Hung, Suthicha Wuwongse, Qishan Zhang, Jianzhi Wang, Larry Baum, Kwok-Fai So, Raymond Chuen-Chung Chan. Endoplasmic reticulum stress induces tau pathology and forms a vicious cycle: implication in Alzheimer's disease pathogenesis. Journal of Alzheimer's disease : JAD vol 28 issue 4 2012 22101233 |
in this study, we found that high levels of phosphorylated pkr-like er-resident kinase (p-perk) and phosphorylated eukaryotic initiation factor 2 alpha (p-eif2\xce\xb1) as markers for activation of upr in the hippocampus of aged p301l mutant tau transgenic mice. |
2012-09-17 |
2023-01-25 |
rat |
| Abderazzak Mouiha, Simon Duchesn. Toward a dynamic biomarker model in Alzheimer's disease. Journal of Alzheimer's disease : JAD vol 30 issue 1 2012 22398375 |
we included 576 subjects (229 controls, 193 ad, and 154 mild cognitive impairment subjects who converted to ad) from the adni study, for whom baseline data on cerebrospinal fluid amyloid-\xce\xb2 (a\xce\xb2)42, phosphorylated tau (p-tau), and total-tau (t-tau), hippocampal volumes, and fdg-pet were available. |
2012-09-10 |
2023-01-25 |
human |
| Aaron Clausen, Xiaobo Xu, Xiaoning Bi, Michel Baudr. Effects of the superoxide dismutase/catalase mimetic EUK-207 in a mouse model of Alzheimer's disease: protection against and interruption of progression of amyloid and tau pathology and cognitive decline. Journal of Alzheimer's disease : JAD vol 30 issue 1 2012 22406441 |
euk-207-treated 3xtg-ad mice did not display any deficit in fear conditioning and exhibited reduced a\xce\xb2, tau, and phosphorylated tau accumulation in amygdala and hippocampus, as well as brain levels of a\xce\xb242, oxidized nucleic acids, and lipid peroxidation. |
2012-09-10 |
2023-01-25 |
mouse |
| Aaron Clausen, Xiaobo Xu, Xiaoning Bi, Michel Baudr. Effects of the superoxide dismutase/catalase mimetic EUK-207 in a mouse model of Alzheimer's disease: protection against and interruption of progression of amyloid and tau pathology and cognitive decline. Journal of Alzheimer's disease : JAD vol 30 issue 1 2012 22406441 |
euk-207-treated 3xtg-ad mice did not display any deficit in fear conditioning and were protected against increases in brain levels of oxidized nucleic acids and lipid peroxidation; they also had reduced a\xce\xb2, tau, and hyperphosphorylated tau accumulation in amygdala and hippocampus. |
2012-09-10 |
2023-01-25 |
mouse |
| Jaya R P Prasanthi, Matthew Schrag, Bhanu Dasari, Gurdeep Marwarha, April Dickson, Wolff M Kirsch, Othman Ghrib. Deferiprone reduces amyloid-\\xce\\xb2 and tau phosphorylation levels but not reactive oxygen species generation in hippocampus of rabbits fed a cholesterol-enriched diet. Journal of Alzheimer's disease : JAD vol 30 issue 1 2012 22406440 |
deferiprone reduces amyloid-\xce\xb2 and tau phosphorylation levels but not reactive oxygen species generation in hippocampus of rabbits fed a cholesterol-enriched diet. |
2012-09-10 |
2023-01-25 |
rabbit |
| Sylvie Burnouf, Karim Belarbi, Laetitia Troquier, Maxime Derisbourg, Dominique Demeyer, Antoine Leboucher, Cyril Laurent, Malika Hamdane, Luc Buee, David Blu. Hippocampal BDNF expression in a tau transgenic mouse model. Current Alzheimer research vol 9 issue 4 2012 22272617 |
hippocampal bdnf expression in a tau transgenic mouse model. |
2012-09-07 |
2023-01-25 |
Not clear |