All Relations between microtubule-associated protein tau and hippocampus

Publication Sentence Publish Date Extraction Date Species
Shiran Salomon-Zimri, Ori Liraz, Daniel M Michaelso. Behavioral testing affects the phenotypic expression of APOE ε3 and APOE ε4 in targeted replacement mice and reduces the differences between them. Alzheimer's & dementia (Amsterdam, Netherlands). vol 1. issue 2. 2016-05-30. PMID:27239500. this was performed using young, naïve apoe ε4 and apoe ε3 mice in which the levels of distinct brain parameters are affected by the apoe genotype (e.g., elevated levels of amyloid beta [aβ] and hyperphosphorylated tau and reduced levels of vesicular glutamate transporter (vglut) in hippocampal neurons of apoe ε4 mice). 2016-05-30 2023-08-13 mouse
Daniel Carneiro Carrettiero, Fernando Enrique Santiago, Anna Carolina Parracho Motzko-Soares, Maria Camila Almeid. Temperature and toxic Tau in Alzheimer's disease: new insights. Temperature (Austin, Tex.). vol 2. issue 4. 2016-05-26. PMID:27227069. specifically, we argue that cold might preferentially affects central nervous system structures that are highly reliant upon plasticity, such as the hippocampus, and that the effect of cold on tau phosphorylation may constitute a pathology-initiating trigger leading to neurodegeneration. 2016-05-26 2023-08-13 human
Yao-Feng Zhu, Xian-Hui Li, Zhi-Peng Yuan, Chun-Yan Li, Rong-Bo Tian, Wei Jia, Zhu-Ping Xia. Allicin improves endoplasmic reticulum stress-related cognitive deficits via PERK/Nrf2 antioxidative signaling pathway. European journal of pharmacology. vol 762. 2016-05-24. PMID:26049013. tm increased tau phosphorylation, aβ42 deposit, and oxidative stress, and reduced antioxidative enzymes activity in the hippocampus. 2016-05-24 2023-08-13 rat
Annapaola Prestia, Anna Caroli, Sara K Wade, Wiesjie M van der Flier, Rik Ossenkoppele, Bart Van Berckel, Frederik Barkhof, Charlotte E Teunissen, Anders Wall, Stephen F Carter, Michael Schöll, Il Han Choo, Agneta Nordberg, Philip Scheltens, Giovanni B Frison. Prediction of AD dementia by biomarkers following the NIA-AA and IWG diagnostic criteria in MCI patients from three European memory clinics. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 11. issue 10. 2016-05-23. PMID:25646957. proposed diagnostic criteria (international working group and national institute on aging and alzheimer's association) for alzheimer's disease (ad) include markers of amyloidosis (abnormal cerebrospinal fluid [csf] amyloid beta [aβ]42) and neurodegeneration (hippocampal atrophy, temporo-parietal hypometabolism on [18f]-fluorodeoxyglucose-positron emission tomography (fdg-pet), and abnormal csf tau). 2016-05-23 2023-08-13 Not clear
Michiyo Iba, Jennifer D McBride, Jing L Guo, Bin Zhang, John Q Trojanowski, Virginia M-Y Le. Tau pathology spread in PS19 tau transgenic mice following locus coeruleus (LC) injections of synthetic tau fibrils is determined by the LC's afferent and efferent connections. Acta neuropathologica. vol 130. issue 3. 2016-05-17. PMID:26150341. we recently showed (iba et al., j neurosci 33:1024-1037, 2013) that inoculation of preformed synthetic tau fibrils (tau pffs) into the hippocampus of young transgenic (tg) mice (ps19) overexpressing human p301s mutant tau induced robust tau pathology in anatomically connected brain regions including the locus coeruleus (lc). 2016-05-17 2023-08-13 mouse
Michiyo Iba, Jennifer D McBride, Jing L Guo, Bin Zhang, John Q Trojanowski, Virginia M-Y Le. Tau pathology spread in PS19 tau transgenic mice following locus coeruleus (LC) injections of synthetic tau fibrils is determined by the LC's afferent and efferent connections. Acta neuropathologica. vol 130. issue 3. 2016-05-17. PMID:26150341. however, the spreading pattern of tau pathology observed in our lc-injected mice is different from that in ad brains since hippocampus and entorhinal cortex, which are affected in early stages of ad, were largely spared of tau inclusions in our model. 2016-05-17 2023-08-13 mouse
Jiachen Zhuo, Kaspar Keledjian, Su Xu, Adam Pampori, Volodymyr Gerzanich, J Marc Simard, Rao P Gullapall. Changes in Diffusion Kurtosis Imaging and Magnetic Resonance Spectroscopy in a Direct Cranial Blast Traumatic Brain Injury (dc-bTBI) Model. PloS one. vol 10. issue 8. 2016-05-17. PMID:26301778. concomitant increases in myo-inositol (ins) and taurine (tau) were also observed in the hippocampus, while early changes at 1 day in the glutamine (gln) were observed in the internal capsule, all indicating glial abnormality in these regions. 2016-05-17 2023-08-13 rat
Clair A Booth, Jonathan Witton, Jakub Nowacki, Krasimira Tsaneva-Atanasova, Matthew W Jones, Andrew D Randall, Jonathan T Brow. Altered Intrinsic Pyramidal Neuron Properties and Pathway-Specific Synaptic Dysfunction Underlie Aberrant Hippocampal Network Function in a Mouse Model of Tauopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 2. 2016-05-17. PMID:26758828. the formation and deposition of tau protein aggregates is proposed to contribute to cognitive impairments in dementia by disrupting neuronal function in brain regions, including the hippocampus. 2016-05-17 2023-08-13 mouse
Clair A Booth, Jonathan Witton, Jakub Nowacki, Krasimira Tsaneva-Atanasova, Matthew W Jones, Andrew D Randall, Jonathan T Brow. Altered Intrinsic Pyramidal Neuron Properties and Pathway-Specific Synaptic Dysfunction Underlie Aberrant Hippocampal Network Function in a Mouse Model of Tauopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 2. 2016-05-17. PMID:26758828. we used a battery of in vivo and in vitro electrophysiological recordings in the rtg4510 transgenic mouse model, which overexpresses a mutant form of human tau protein, to investigate the effects of tau pathology on hippocampal neuronal function in area ca1 of 7- to 8-month-old mice, an age point at which rtg4510 animals exhibit advanced tau pathology and progressive neurodegeneration. 2016-05-17 2023-08-13 mouse
Tahir Ali, Gwang Ho Yoon, Shahid Ali Shah, Hae Young Lee, Myeong Ok Ki. Osmotin attenuates amyloid beta-induced memory impairment, tau phosphorylation and neurodegeneration in the mouse hippocampus. Scientific reports. vol 5. 2016-05-16. PMID:26118757. osmotin attenuates amyloid beta-induced memory impairment, tau phosphorylation and neurodegeneration in the mouse hippocampus. 2016-05-16 2023-08-13 mouse
Tahir Ali, Myeong Ok Ki. Melatonin ameliorates amyloid beta-induced memory deficits, tau hyperphosphorylation and neurodegeneration via PI3/Akt/GSk3β pathway in the mouse hippocampus. Journal of pineal research. vol 59. issue 1. 2016-05-09. PMID:25858697. melatonin ameliorates amyloid beta-induced memory deficits, tau hyperphosphorylation and neurodegeneration via pi3/akt/gsk3β pathway in the mouse hippocampus. 2016-05-09 2023-08-13 mouse
Tahir Ali, Myeong Ok Ki. Melatonin ameliorates amyloid beta-induced memory deficits, tau hyperphosphorylation and neurodegeneration via PI3/Akt/GSk3β pathway in the mouse hippocampus. Journal of pineal research. vol 59. issue 1. 2016-05-09. PMID:25858697. aβ1-42-injection triggered memory impairment, synaptic disorder, hyperphosphorylation of tau protein, and neurodegeneration in the mice hippocampus. 2016-05-09 2023-08-13 mouse
Gang Liu, Chao Liu, Xue-Ning Zhan. Comparison of the neuropsychological mechanisms of 2,6-diisopropylphenol and N-methyl-D-aspartate receptor antagonist against electroconvulsive therapy-induced learning and memory impairment in depressed rats. Molecular medicine reports. vol 12. issue 3. 2016-05-03. PMID:25998151. tau protein hyperphosphorylation in the hippocampus was upregulated by ect, but was reduced by 2,6‑diisopropylphenol and the mk‑801 nmda receptor antagonist. 2016-05-03 2023-08-13 rat
Adriele Silva Alves de Oliveira, Fernando Enrique Santiago, Laiz Furlan Balioni, Merari de Fatima Ramires Ferrari, Maria Camila Almeida, Daniel Carneiro Carrettier. BAG2 expression dictates a functional intracellular switch between the p38-dependent effects of nicotine on tau phosphorylation levels via the α7 nicotinic receptor. Experimental neurology. vol 275 Pt 1. 2016-04-29. PMID:26496817. in sh-sy5y cell line and rat primary hippocampal cell culture low endogenous bag2 levels constitute an intracellular environment conducive to nicotine-induced accumulation of phosphorylated tau protein. 2016-04-29 2023-08-13 rat
Joannee Zumkehr, Carlos J Rodriguez-Ortiz, David Cheng, Zanett Kieu, Thin Wai, Charlesice Hawkins, Jason Kilian, Siok Lam Lim, Rodrigo Medeiros, Masashi Kitazaw. Ceftriaxone ameliorates tau pathology and cognitive decline via restoration of glial glutamate transporter in a mouse model of Alzheimer's disease. Neurobiology of aging. vol 36. issue 7. 2016-04-26. PMID:25964214. here, we find the temporal decrease in glt-1 levels in the hippocampus of the 3xtg-ad mouse model and that the pharmacological upregulation of glt-1 significantly ameliorates the age-dependent pathological tau accumulation, restores synaptic proteins, and rescues cognitive decline with minimal effects on aβ pathology. 2016-04-26 2023-08-13 mouse
Peng Liu, Jennifer B Paulson, Colleen L Forster, Samantha L Shapiro, Karen H Ashe, Kathleen R Zah. Characterization of a Novel Mouse Model of Alzheimer's Disease--Amyloid Pathology and Unique β-Amyloid Oligomer Profile. PloS one. vol 10. issue 5. 2016-04-25. PMID:25946042. histologically, we showed that (1) aβ plaques emerged in cerebral cortex and hippocampus as early as 8 and 10.5-12.5 months of age, respectively; (2) plaque deposition progressed in an age-dependent manner, occupying up to 19% of cortex at ~25 months of age; and (3) neuropathology--such as abnormal neuronal architecture, tau hyperphosphorylation and misfolding, and neuroinflammation--was observed in the vicinity of neuritic plaques. 2016-04-25 2023-08-13 mouse
Dave J Koss, Lianne Robinson, Anna Mietelska-Porowska, Anna Gasiorowska, Kristina Sepčić, Tom Turk, Marcel Jaspars, Grazyna Niewiadomska, Roderick H Scott, Bettina Platt, Gernot Riede. Polymeric alkylpyridinium salts permit intracellular delivery of human Tau in rat hippocampal neurons: requirement of Tau phosphorylation for functional deficits. Cellular and molecular life sciences : CMLS. vol 72. issue 23. 2016-04-25. PMID:26070304. polymeric alkylpyridinium salts permit intracellular delivery of human tau in rat hippocampal neurons: requirement of tau phosphorylation for functional deficits. 2016-04-25 2023-08-13 mouse
Dave J Koss, Lianne Robinson, Anna Mietelska-Porowska, Anna Gasiorowska, Kristina Sepčić, Tom Turk, Marcel Jaspars, Grazyna Niewiadomska, Roderick H Scott, Bettina Platt, Gernot Riede. Polymeric alkylpyridinium salts permit intracellular delivery of human Tau in rat hippocampal neurons: requirement of Tau phosphorylation for functional deficits. Cellular and molecular life sciences : CMLS. vol 72. issue 23. 2016-04-25. PMID:26070304. collectively, these data validate a novel model of locally infused recombinant htau protein as an inducer of tau pathology in the hippocampus of normal rats; future studies will provide insights into the pathological spread and maturation of tau pathology. 2016-04-25 2023-08-13 mouse
Huanhuan Han, Qingqing Qian, Yan Yu, Daiwei Zhao, Guangchun Su. Lamotrigine attenuates cerebral ischemia-induced cognitive impairment and decreases β-amyloid and phosphorylated tau in the hippocampus in rats. Neuroreport. vol 26. issue 12. 2016-04-20. PMID:26164461. lamotrigine attenuates cerebral ischemia-induced cognitive impairment and decreases β-amyloid and phosphorylated tau in the hippocampus in rats. 2016-04-20 2023-08-13 rat
Huanhuan Han, Qingqing Qian, Yan Yu, Daiwei Zhao, Guangchun Su. Lamotrigine attenuates cerebral ischemia-induced cognitive impairment and decreases β-amyloid and phosphorylated tau in the hippocampus in rats. Neuroreport. vol 26. issue 12. 2016-04-20. PMID:26164461. this study was carried out to examine the effects of ltg on cognitive dysfunction, β-amyloid1-42 accumulation, and tau protein hyperphosphorylation in the hippocampus of ischemic rats. 2016-04-20 2023-08-13 rat