| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joannee Zumkehr, Carlos J Rodriguez-Ortiz, David Cheng, Zanett Kieu, Thin Wai, Charlesice Hawkins, Jason Kilian, Siok Lam Lim, Rodrigo Medeiros, Masashi Kitazaw. Ceftriaxone ameliorates tau pathology and cognitive decline via restoration of glial glutamate transporter in a mouse model of Alzheimer's disease. Neurobiology of aging. vol 36. issue 7. 2016-04-26. PMID:25964214. |
here, we find the temporal decrease in glt-1 levels in the hippocampus of the 3xtg-ad mouse model and that the pharmacological upregulation of glt-1 significantly ameliorates the age-dependent pathological tau accumulation, restores synaptic proteins, and rescues cognitive decline with minimal effects on aβ pathology. |
2016-04-26 |
2023-08-13 |
mouse |
| Peng Liu, Jennifer B Paulson, Colleen L Forster, Samantha L Shapiro, Karen H Ashe, Kathleen R Zah. Characterization of a Novel Mouse Model of Alzheimer's Disease--Amyloid Pathology and Unique β-Amyloid Oligomer Profile. PloS one. vol 10. issue 5. 2016-04-25. PMID:25946042. |
histologically, we showed that (1) aβ plaques emerged in cerebral cortex and hippocampus as early as 8 and 10.5-12.5 months of age, respectively; (2) plaque deposition progressed in an age-dependent manner, occupying up to 19% of cortex at ~25 months of age; and (3) neuropathology--such as abnormal neuronal architecture, tau hyperphosphorylation and misfolding, and neuroinflammation--was observed in the vicinity of neuritic plaques. |
2016-04-25 |
2023-08-13 |
mouse |
| Dave J Koss, Lianne Robinson, Anna Mietelska-Porowska, Anna Gasiorowska, Kristina Sepčić, Tom Turk, Marcel Jaspars, Grazyna Niewiadomska, Roderick H Scott, Bettina Platt, Gernot Riede. Polymeric alkylpyridinium salts permit intracellular delivery of human Tau in rat hippocampal neurons: requirement of Tau phosphorylation for functional deficits. Cellular and molecular life sciences : CMLS. vol 72. issue 23. 2016-04-25. PMID:26070304. |
polymeric alkylpyridinium salts permit intracellular delivery of human tau in rat hippocampal neurons: requirement of tau phosphorylation for functional deficits. |
2016-04-25 |
2023-08-13 |
mouse |
| Dave J Koss, Lianne Robinson, Anna Mietelska-Porowska, Anna Gasiorowska, Kristina Sepčić, Tom Turk, Marcel Jaspars, Grazyna Niewiadomska, Roderick H Scott, Bettina Platt, Gernot Riede. Polymeric alkylpyridinium salts permit intracellular delivery of human Tau in rat hippocampal neurons: requirement of Tau phosphorylation for functional deficits. Cellular and molecular life sciences : CMLS. vol 72. issue 23. 2016-04-25. PMID:26070304. |
collectively, these data validate a novel model of locally infused recombinant htau protein as an inducer of tau pathology in the hippocampus of normal rats; future studies will provide insights into the pathological spread and maturation of tau pathology. |
2016-04-25 |
2023-08-13 |
mouse |
| Huanhuan Han, Qingqing Qian, Yan Yu, Daiwei Zhao, Guangchun Su. Lamotrigine attenuates cerebral ischemia-induced cognitive impairment and decreases β-amyloid and phosphorylated tau in the hippocampus in rats. Neuroreport. vol 26. issue 12. 2016-04-20. PMID:26164461. |
lamotrigine attenuates cerebral ischemia-induced cognitive impairment and decreases β-amyloid and phosphorylated tau in the hippocampus in rats. |
2016-04-20 |
2023-08-13 |
rat |
| Huanhuan Han, Qingqing Qian, Yan Yu, Daiwei Zhao, Guangchun Su. Lamotrigine attenuates cerebral ischemia-induced cognitive impairment and decreases β-amyloid and phosphorylated tau in the hippocampus in rats. Neuroreport. vol 26. issue 12. 2016-04-20. PMID:26164461. |
this study was carried out to examine the effects of ltg on cognitive dysfunction, β-amyloid1-42 accumulation, and tau protein hyperphosphorylation in the hippocampus of ischemic rats. |
2016-04-20 |
2023-08-13 |
rat |
| Huanhuan Han, Qingqing Qian, Yan Yu, Daiwei Zhao, Guangchun Su. Lamotrigine attenuates cerebral ischemia-induced cognitive impairment and decreases β-amyloid and phosphorylated tau in the hippocampus in rats. Neuroreport. vol 26. issue 12. 2016-04-20. PMID:26164461. |
moreover, ltg reduced β-amyloid1-42 and phosphorylated tau (at8) in the hippocampus after ischemia. |
2016-04-20 |
2023-08-13 |
rat |
| Huanhuan Han, Qingqing Qian, Yan Yu, Daiwei Zhao, Guangchun Su. Lamotrigine attenuates cerebral ischemia-induced cognitive impairment and decreases β-amyloid and phosphorylated tau in the hippocampus in rats. Neuroreport. vol 26. issue 12. 2016-04-20. PMID:26164461. |
these results suggested that the cognition-protective effects of ltg after cerebral ischemia might involve inhibition of toxic β-amyloid accumulation and tau hyperphosphorylation in the hippocampus. |
2016-04-20 |
2023-08-13 |
rat |
| Qin Ma, Ying-ying Ruan, Hui Xu, Xiao-meng Shi, Zhi-xiang Wang, Yan-li H. Safflower yellow reduces lipid peroxidation, neuropathology, tau phosphorylation and ameliorates amyloid β-induced impairment of learning and memory in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 76. 2016-04-12. PMID:26653563. |
pathological analysis also showed that sy treatment inhibited the morphological alteration of neurons and tau hyperphosphorylation induced by amyloid β (1-42)-injection in the cortex and hippocampus. |
2016-04-12 |
2023-08-13 |
rat |
| Sara Calafate, Arjan Buist, Katarzyna Miskiewicz, Vinoy Vijayan, Guy Daneels, Bart de Strooper, Joris de Wit, Patrik Verstreken, Diederik Moechar. Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation. Cell reports. vol 11. issue 8. 2016-04-05. PMID:25981034. |
using quantitative in vitro models, we demonstrate that, in parallel to non-synaptic mechanisms, synapses, but not merely the close distance between the cells, enhance the propagation of tau pathology between acceptor hippocampal neurons and tau donor cells. |
2016-04-05 |
2023-08-13 |
Not clear |
| Robert A Whittington, László Virág, Maud Gratuze, Franck R Petry, Anastasia Noël, Isabelle Poitras, Geoffrey Truchetti, François Marcouiller, Marie-Amélie Papon, Noura El Khoury, Kevin Wong, Alexis Bretteville, Françoise Morin, Emmanuel Plane. Dexmedetomidine increases tau phosphorylation under normothermic conditions in vivo and in vitro. Neurobiology of aging. vol 36. issue 8. 2016-03-17. PMID:26058840. |
when administered to nontransgenic mice, dex-induced tau hyperphosphorylation persisting up to 6 hours in the hippocampus for the at8 epitope. |
2016-03-17 |
2023-08-13 |
mouse |
| Edward Rockenstein, Cassia R Overk, Kiren Ubhi, Michael Mante, Christina Patrick, Anthony Adame, Alejandro Bisquert, Margarita Trejo-Morales, Brian Spencer, Eliezer Maslia. A novel triple repeat mutant tau transgenic model that mimics aspects of pick's disease and fronto-temporal tauopathies. PloS one. vol 10. issue 3. 2016-02-22. PMID:25803611. |
by immunocytochemistry, mice from line 13 displayed extensive accumulation of 3r tau in neuronal cells bodies in the pyramidal neurons of the neocortex, ca1-3 regions, and dentate gyrus of the hippocampus. |
2016-02-22 |
2023-08-13 |
mouse |
| V Corsetti, F Florenzano, A Atlante, A Bobba, M T Ciotti, F Natale, F Della Valle, A Borreca, A Manca, G Meli, C Ferraina, M Feligioni, S D'Aguanno, R Bussani, M Ammassari-Teule, V Nicolin, P Calissano, G Amador. NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease. Human molecular genetics. vol 24. issue 11. 2016-02-16. PMID:25687137. |
we reported that a 20-22 kda nh2-tau fragment mapping between 26 and 230 amino acids of the longest human tau isoform (aka nh2htau): (i) is detectable in cellular and animal ad models, as well in synaptic mitochondria and cerebrospinal fluids (csf) from human ad subjects; (ii) is neurotoxic in primary hippocampal neurons; (iii) compromises the mitochondrial biology both directly, by inhibiting the ant-1-dependent adp/atp exchange, and indirectly, by impairing their selective autophagic clearance (mitophagy). |
2016-02-16 |
2023-08-13 |
human |
| Jerry B Hunt, Kevin R Nash, Devon Placides, Peter Moran, Maj-Linda B Selenica, Firas Abuqalbeen, Kevin Ratnasamy, Nina Slouha, Santiago Rodriguez-Ospina, Miloni Savlia, Yashobha Ranaweera, Patrick Reid, Chad A Dickey, Rodrigo Uricia, Clement G Y Yang, Leslie A Sandusky, Marcia N Gordon, Dave Morgan, Daniel C Le. Sustained Arginase 1 Expression Modulates Pathological Tau Deposits in a Mouse Model of Tauopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 44. 2016-02-12. PMID:26538654. |
arg1 overexpression also mitigated hippocampal atrophy in tau transgenic mice. |
2016-02-12 |
2023-08-13 |
mouse |
| Ilie-Cosmin Stancu, Bruno Vasconcelos, Laurence Ris, Peng Wang, Agnès Villers, Eve Peeraer, Arjan Buist, Dick Terwel, Peter Baatsen, Tutu Oyelami, Nathalie Pierrot, Cindy Casteels, Guy Bormans, Pascal Kienlen-Campard, Jean-Nöel Octave, Diederik Moechars, Ilse Dewachte. Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice. Acta neuropathologica. vol 129. issue 6. 2016-02-10. PMID:25862635. |
electrophysiological analysis in organotypic hippocampal slices of tau transgenic mice demonstrated impaired synaptic transmission and impaired long-term potentiation following tau-seed induced tau-aggregation. |
2016-02-10 |
2023-08-13 |
mouse |
| Hai-juan Sui, Ling-ling Zhang, Zhou Liu, Ying Ji. Atorvastatin prevents Aβ oligomer-induced neurotoxicity in cultured rat hippocampal neurons by inhibiting Tau cleavage. Acta pharmacologica Sinica. vol 36. issue 5. 2016-02-10. PMID:25891085. |
atorvastatin prevents aβ oligomer-induced neurotoxicity in cultured rat hippocampal neurons by inhibiting tau cleavage. |
2016-02-10 |
2023-08-13 |
rat |
| Zhi-Hong Hu, Ling-Ling Fan, Yong-Mei H. [Effect of sodium nitrite on phosphorylation of cytoskeletal proteins and spatial learning and memory in rats]. Sheng li xue bao : [Acta physiologica Sinica]. vol 67. issue 5. 2016-02-10. PMID:26490065. |
phosphorylation level of tau and neurofilament, and the expression of protein phosphatase 2a (pp2a) catalytic subunit in the hippocampus were detected by immunohistochemistry and western blot. |
2016-02-10 |
2023-08-13 |
rat |
| Hirohide Asai, Seiko Ikezu, Satoshi Tsunoda, Maria Medalla, Jennifer Luebke, Tarik Haydar, Benjamin Wolozin, Oleg Butovsky, Sebastian Kügler, Tsuneya Ikez. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nature neuroscience. vol 18. issue 11. 2016-02-09. PMID:26436904. |
tau protein spreads from the entorhinal cortex to the hippocampal region early in the disease. |
2016-02-09 |
2023-08-13 |
mouse |
| Sethu Sankaranarayanan, Donna M Barten, Laurel Vana, Nino Devidze, Ling Yang, Gregory Cadelina, Nina Hoque, Lynn DeCarr, Stefanie Keenan, Alan Lin, Yang Cao, Bradley Snyder, Bin Zhang, Magdalena Nitla, Gregg Hirschfeld, Nestor Barrezueta, Craig Polson, Paul Wes, Vangipuram S Rangan, Angela Cacace, Charles F Albright, Jere Meredith, John Q Trojanowski, Virginia M-Y Lee, Kurt R Brunden, Michael Ahlijania. Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models. PloS one. vol 10. issue 5. 2016-02-04. PMID:25933020. |
in a second model, injection of preformed tau fibrils (pffs) comprised of recombinant tau protein encompassing the microtubule-repeat domains into the cortex and hippocampus of young p301s mutant tau over-expressing mice (ps19) led to robust tau pathology on the ipsilateral side with evidence of spread to distant sites, including the contralateral hippocampus and bilateral entorhinal cortex 4 weeks post-injection. |
2016-02-04 |
2023-08-13 |
mouse |
| Mar Matarin, Dervis A Salih, Marina Yasvoina, Damian M Cummings, Sebastian Guelfi, Wenfei Liu, Muzammil A Nahaboo Solim, Thomas G Moens, Rocio Moreno Paublete, Shabinah S Ali, Marina Perona, Roshni Desai, Kenneth J Smith, Judy Latcham, Michael Fulleylove, Jill C Richardson, John Hardy, Frances A Edward. A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology. Cell reports. vol 10. issue 4. 2016-01-28. PMID:25620700. |
the hippocampal network in tau mice was similar except that trem2 had hub status only in amyloid mice. |
2016-01-28 |
2023-08-13 |
mouse |