| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sylvie Burnouf, Karim Belarbi, Laetitia Troquier, Maxime Derisbourg, Dominique Demeyer, Antoine Leboucher, Cyril Laurent, Malika Hamdane, Luc Buee, David Blu. Hippocampal BDNF expression in a tau transgenic mouse model. Current Alzheimer research vol 9 issue 4 2012 22272617 |
in the present study, we have evaluated this relationship using quantitative pcr, western blot and elisa in the thy-tau22 transgenic strain, known to display a progressive development of both hippocampal ad-like tau pathology and memory impairments. |
2012-09-07 |
2023-01-25 |
Not clear |
| Laetitia Troquier, Raphaelle Caillierez, Sylvie Burnouf, Francisco J Fernandez-Gomez, Marie-Eve Grosjean, Nadege Zommer, Nicolas Sergeant, Susanna Schraen-Maschke, David Blum, Luc Bue. Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach. Current Alzheimer research vol 9 issue 4 2012 22272619 |
starting from 3-6 months of age, thy-tau22 mice develop hippocampal neurofibrillary tangle-like inclusions and exhibit phosphorylation of tau on several ad-relevant tau epitopes. |
2012-09-07 |
2023-01-25 |
mouse |
| Yang Yu, Lan Zhang, Xiaojing Li, Xiaoqin Run, Zhihou Liang, Yi Li, Ying Liu, Moon H Lee, Inge Grundke-Iqbal, Khalid Iqbal, David J Vocadlo, Fei Liu, Cheng-Xin Gon. Differential effects of an O-GlcNAcase inhibitor on tau phosphorylation. PloS one vol 7 issue 4 2012 22536363 |
however, the elevation of tau phosphorylation at the sites above was not observed and gsk-3\xce\xb2 was not activated in cultured adult hippocampal progenitor cells or in pc12 cells after thiamet-g treatment. |
2012-08-31 |
2023-01-25 |
mouse |
| Jennifer Rodr\\xc3\\xadguez-V\\xc3\\xa1zquez, Ignacio Camacho-Arroyo, Javier Vel\\xc3\\xa1zquez-Moctezum. Differential impact of REM sleep deprivation on cytoskeletal proteins of brain regions involved in sleep regulation. Neuropsychobiology vol 65 issue 3 2012 22456537 |
results showed an increase in tau content in the pons, preoptic area and hippocampus after 24 h of remsd, while in the frontal cortex a significant increase in tau content was observed after 72 h of remsd. |
2012-08-27 |
2023-01-25 |
rat |
| Jennifer Rodr\\xc3\\xadguez-V\\xc3\\xa1zquez, Ignacio Camacho-Arroyo, Javier Vel\\xc3\\xa1zquez-Moctezum. Differential impact of REM sleep deprivation on cytoskeletal proteins of brain regions involved in sleep regulation. Neuropsychobiology vol 65 issue 3 2012 22456537 |
a tau content decrease was observed in the hippocampus after 48 h of remsd. |
2012-08-27 |
2023-01-25 |
rat |
| Jiejie Li, Jiao Deng, Wenli Sheng, Zhiyi Zu. Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice. Pharmacology, biochemistry, and behavior vol 101 issue 4 2012 22425595 |
activated/phosphorylated c-jun n-terminal kinase (jnk), a tau kinase, was increased in the db/db mouse hippocampus. |
2012-08-23 |
2023-01-25 |
mouse |
| Lindsay C Reese, Giulio Taglialatel. A role for calcineurin in Alzheimer's disease. Current neuropharmacology vol 9 issue 4 2012 22654726 |
this bellwether symptom suggests involvement of the hippocampus -- a brain region responsible for memory formation -- and coincidentally an area heavily burdened by hyperphosphorylated tau and neuritic plaques of amyloid beta (a\xce\xb2). |
2012-08-23 |
2023-01-25 |
Not clear |
| Wei Wei, Ying-Hua Liu, Chang-E Zhang, Qun Wang, Zelan Wei, Darrell D Mousseau, Jian-Zhi Wang, Qing Tian, Gong-Ping Li. Folate/vitamin-B12 prevents chronic hyperhomocysteinemia-induced tau hyperphosphorylation and memory deficits in aged rats. Journal of Alzheimer's disease : JAD vol 27 issue 3 2012 21860088 |
we found that hyperhomocysteinemia induced tau hyperphosphorylation and accumulation in hippocampus and cortex. |
2012-08-20 |
2023-01-25 |
rat |
| Mar\\xc3\\xada Llorens-Martin, C\\xc3\\xa1tia M Teixeira, Almudena Fuster-Matanzo, Jer\\xc3\\xb3nimo Jurado-Arjona, V\\xc3\\xadctor Borrell, Eduardo Soriano, Jes\\xc3\\xbas Avila, F\\xc3\\xa9lix Hern\\xc3\\xa1nde. Tau isoform with three microtubule binding domains is a marker of new axons generated from the subgranular zone in the hippocampal dentate gyrus: implications for Alzheimer's disease. Journal of Alzheimer's disease : JAD vol 29 issue 4 2012 22337826 |
tau isoform with three microtubule binding domains is a marker of new axons generated from the subgranular zone in the hippocampal dentate gyrus: implications for alzheimer's disease. |
2012-08-17 |
2023-01-25 |
mouse |
| Jonathan Brouillette, Rapha\\xc3\\xablle Caillierez, Nad\\xc3\\xa8ge Zommer, Claire Alves-Pires, Iryna Benilova, David Blum, Bart De Strooper, Luc Bu\\xc3\\xa9. Neurotoxicity and memory deficits induced by soluble low-molecular-weight amyloid-\\xce\\xb21-42 oligomers are revealed in vivo by using a novel animal model. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 32 issue 23 2012 22674261 |
using a novel in vivo approach, we found that repeated hippocampal injections of small soluble a\xce\xb2(1-42) oligomers in awake, freely moving mice were able to induce marked neuronal loss, tau hyperphosphorylation, and deficits in hippocampus-dependent memory. |
2012-08-09 |
2023-01-25 |
mouse |
| P Korhonen, T van Groen, A Thornell, S Kyrylenko, M-L Soininen, J Ojala, E Peltomaa, H Tanila, A Salminen, E M Mandelkow, H Soinine. Characterization of a novel transgenic rat carrying human tau with mutation P301L. Neurobiology of aging vol 32 issue 12 2012 20097445 |
the htau-40/p301l rats expressed human tau mrna and protein in the limbic cortex and associated white matter, hippocampus and spinal cord. |
2012-08-08 |
2023-01-25 |
rat |
| Byeong Tak Jeon, Eun Ae Jeong, Hyun Joo Shin, Younghyurk Lee, Dong Hoon Lee, Hyun Joon Kim, Sang Soo Kang, Gyeong Jae Cho, Wan Sung Choi, Gu Seob Ro. Resveratrol attenuates obesity-associated peripheral and central inflammation and improves memory deficit in mice fed a high-fat diet. Diabetes vol 61 issue 6 2012 22362175 |
choline acetyltransferase was increased, and the phosphorylation of tau was decreased in the hippocampus of hfd-fed mice upon res treatment. |
2012-07-25 |
2023-01-25 |
mouse |
| Yasumasa Yoshiyama, Ayako Kojima, Kimiko Itoh, Tomoyuki Uchiyama, Kimihito Ara. Anticholinergics boost the pathological process of neurodegeneration with increased inflammation in a tauopathy mouse model. Neurobiology of disease vol 45 issue 1 2012 21889983 |
tau pathology, synaptic loss, and neurodegeneration in the hippocampal region, as well as tau insolubility and phosphorylation, were markedly increased in tp-treated mice and mildly increased in pp-treated mice. |
2012-07-23 |
2023-01-25 |
mouse |
| Johannes Brettschneider, David J Libon, Jon B Toledo, Sharon X Xie, Leo McCluskey, Lauren Elman, Felix Geser, Virginia M Y Lee, Murray Grossman, John Q Trojanowsk. Microglial activation and TDP-43 pathology correlate with executive dysfunction in amyotrophic lateral sclerosis. Acta neuropathologica vol 123 issue 3 2012 22210083 |
a lower mmse score correlated with tau pathology in hippocampus and smt gyrus, and with a\xce\xb2 pathology in limbic and most cortical regions. |
2012-07-23 |
2023-01-25 |
Not clear |
| K Belarbi, S Burnouf, F-J Fernandez-Gomez, J Desmerci\\xc3\\xa8res, L Troquier, J Brouillette, L Tsambou, M-E Grosjean, R Caillierez, D Demeyer, M Hamdane, K Schindowski, D Blum, L Bu\\xc3\\xa9. Loss of medial septum cholinergic neurons in THY-Tau22 mouse model: what links with tau pathology? Current Alzheimer research vol 8 issue 6 2012 21605043 |
the present study aimed to investigate the relationship between neurofibrillary degeneration and cholinergic defects in ad using thy-tau22 transgenic mouse model exhibiting a major hippocampal ad-like tau pathology and hyperphosphorylated tau species in the septohippocampal pathway. |
2012-07-19 |
2023-01-25 |
mouse |
| Robert A Rissman, Michael A Staup, Allyson Roe Lee, Nicholas J Justice, Kenner C Rice, Wylie Vale, Paul E Sawchenk. Corticotropin-releasing factor receptor-dependent effects of repeated stress on tau phosphorylation, solubility, and aggregation. Proceedings of the National Academy of Sciences of the United States of America vol 109 issue 16 2012 22451915 |
although the basis for such a link remains unclear, we previously reported differential involvement of corticotropin-releasing factor receptor (crfr) 1 and 2 in acute stress-induced tau phosphorylation (tau-p) and solubility in the hippocampus. |
2012-07-12 |
2023-01-25 |
mouse |
| Robert A Rissman, Michael A Staup, Allyson Roe Lee, Nicholas J Justice, Kenner C Rice, Wylie Vale, Paul E Sawchenk. Corticotropin-releasing factor receptor-dependent effects of repeated stress on tau phosphorylation, solubility, and aggregation. Proceedings of the National Academy of Sciences of the United States of America vol 109 issue 16 2012 22451915 |
using histochemical approaches in a transgenic crfr1 reporter mouse line, we found substantial overlap between hippocampal crfr1 expression and cells positive for phosphorylated tau after exposure to repeated stress. |
2012-07-12 |
2023-01-25 |
mouse |
| Yong-Kun Li, Xiao-Chun Chen, Yuan-Gui Zhu, Xiao-Song Peng, Yu-Qi Zeng, Jie Sheng, Tian-Wen Huan. [Ginsenoside Rb1 attenuates okadaic acid-induced Tau protein hyperphosphorylation in rat hippocampal neurons]. Sheng li xue bao : [Acta physiologica Sinica] vol 57 issue 2 2012 15830099 |
on the thirteen day of pretreatment, animals in rb1 pretreatment group as well as animals in oa group received a bolus injection of 0.483 microg of oa (1.5 microl of solution in dmso) at right dorsal aspect of hippocampus to induce tau hyperphosphrylation. |
2012-06-28 |
2023-01-24 |
rat |
| Tohru Matsuki, Mariam Zaka, Rita Guerreiro, Marcel P van der Brug, Jonathan A Cooper, Mark R Cookson, John A Hardy, Brian W Howel. Identification of Stk25 as a genetic modifier of Tau phosphorylation in Dab1-mutant mice. PloS one vol 7 issue 2 2012 22355340 |
tau is hyperphosphorylated in the hippocampus of dab1-null mice in a strain-dependent manner; however, it has not been clear if the tau phosphorylation phenotype is a secondary effect of the morbidity of these mutants. |
2012-06-18 |
2023-01-25 |
mouse |
| Sarah M Rothman, Nathan Herdener, Simonetta Camandola, Sarah J Texel, Mohamed R Mughal, Wei-Na Cong, Bronwen Martin, Mark P Mattso. 3xTgAD mice exhibit altered behavior and elevated A\\xce\\xb2 after chronic mild social stress. Neurobiology of aging vol 33 issue 4 2012 21855175 |
a triple-transgenic mouse model of ad (3xtgad mice) and nontransgenic control mice were used to test for an affect of chronic mild social stress on blood glucose, plasma glucocorticoids, plasma insulin, anxiety, and hippocampal amyloid \xce\xb2-particle (a\xce\xb2), phosphorylated tau (ptau), and brain-derived neurotrophic factor (bdnf) levels. |
2012-06-15 |
2023-01-25 |
mouse |