| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ivan Milenkovic, Tatjana Petrov, Gabor G Kovac. Patterns of hippocampal tau pathology differentiate neurodegenerative dementias. Dementia and geriatric cognitive disorders. vol 38. issue 5-6. 2015-10-26. PMID:25195847. |
deposits of phosphorylated tau protein and convergence of pathology in the hippocampus are the hallmarks of neurodegenerative tauopathies. |
2015-10-26 |
2023-08-13 |
Not clear |
| Tariq Ahmed, Ann Van der Jeugd, David Blum, Marie-Christine Galas, Rudi D'Hooge, Luc Buee, Detlef Balschu. Cognition and hippocampal synaptic plasticity in mice with a homozygous tau deletion. Neurobiology of aging. vol 35. issue 11. 2015-10-19. PMID:24913895. |
cognition and hippocampal synaptic plasticity in mice with a homozygous tau deletion. |
2015-10-19 |
2023-08-13 |
mouse |
| Shan Wang, Shan-lei Zhou, Fang-yuan Min, Jin-ju Ma, Xia-jie Shi, Erika Bereczki, Jing W. mTOR-mediated hyperphosphorylation of tau in the hippocampus is involved in cognitive deficits in streptozotocin-induced diabetic mice. Metabolic brain disease. vol 29. issue 3. 2015-10-16. PMID:24682776. |
mtor-mediated hyperphosphorylation of tau in the hippocampus is involved in cognitive deficits in streptozotocin-induced diabetic mice. |
2015-10-16 |
2023-08-12 |
mouse |
| Shan Wang, Shan-lei Zhou, Fang-yuan Min, Jin-ju Ma, Xia-jie Shi, Erika Bereczki, Jing W. mTOR-mediated hyperphosphorylation of tau in the hippocampus is involved in cognitive deficits in streptozotocin-induced diabetic mice. Metabolic brain disease. vol 29. issue 3. 2015-10-16. PMID:24682776. |
in the present study, we found that phosphorylated mtor at ser2448, phosphorylated p70s6k at thr421/ser424 and phosphorylated tau at ser396 were significantly increased in the hippocampus of streptozotocin (stz)-induced diabetic mice when compared with control mice. |
2015-10-16 |
2023-08-12 |
mouse |
| Shan Wang, Shan-lei Zhou, Fang-yuan Min, Jin-ju Ma, Xia-jie Shi, Erika Bereczki, Jing W. mTOR-mediated hyperphosphorylation of tau in the hippocampus is involved in cognitive deficits in streptozotocin-induced diabetic mice. Metabolic brain disease. vol 29. issue 3. 2015-10-16. PMID:24682776. |
rapamycin restored abnormal mtor/p70s6k signaling and attenuated the phosphorylation of tau protein in the hippocampus of diabetic mice. |
2015-10-16 |
2023-08-12 |
mouse |
| Shan Wang, Shan-lei Zhou, Fang-yuan Min, Jin-ju Ma, Xia-jie Shi, Erika Bereczki, Jing W. mTOR-mediated hyperphosphorylation of tau in the hippocampus is involved in cognitive deficits in streptozotocin-induced diabetic mice. Metabolic brain disease. vol 29. issue 3. 2015-10-16. PMID:24682776. |
these findings indicate that mtor/p70s6k signaling pathway is hyperactive in the hippocampus of stz-induced diabetic mice and inhibiting mtor signaling with rapamycin prevents the dm-related cognitive deficits partly through attenuating the hyperphosphorylation of tau protein. |
2015-10-16 |
2023-08-12 |
mouse |
| Sonja Buratovic, Bo Stenerlöw, Anders Fredriksson, Synnöve Sundell-Bergman, Henrik Viberg, Per Eriksso. Neonatal exposure to a moderate dose of ionizing radiation causes behavioural defects and altered levels of tau protein in mice. Neurotoxicology. vol 45. 2015-10-13. PMID:25265567. |
the neuroproteins camkii, gap-43, synaptophysin and total tau in male mouse cerebral cortex and hippocampus were analysed 24h post-irradiation and in adults at 6 months of age exposed to 0 or 500 mgy on pnd 10. |
2015-10-13 |
2023-08-13 |
mouse |
| Cheng-Shi Xu, An-Chun Liu, Juan Chen, Zhi-Yong Pan, Qi Wan, Zhi-Qiang Li, Ze-Fen Wan. Overactivation of NR2B-containing NMDA receptors through entorhinal-hippocampal connection initiates accumulation of hyperphosphorylated tau in rat hippocampus after transient middle cerebral artery occlusion. Journal of neurochemistry. vol 134. issue 3. 2015-10-09. PMID:25903928. |
overactivation of nr2b-containing nmda receptors through entorhinal-hippocampal connection initiates accumulation of hyperphosphorylated tau in rat hippocampus after transient middle cerebral artery occlusion. |
2015-10-09 |
2023-08-13 |
rat |
| Cheng-Shi Xu, An-Chun Liu, Juan Chen, Zhi-Yong Pan, Qi Wan, Zhi-Qiang Li, Ze-Fen Wan. Overactivation of NR2B-containing NMDA receptors through entorhinal-hippocampal connection initiates accumulation of hyperphosphorylated tau in rat hippocampus after transient middle cerebral artery occlusion. Journal of neurochemistry. vol 134. issue 3. 2015-10-09. PMID:25903928. |
increased tau phosphorylation has been identified in ischemic cortex, but little is known regarding the changes in the hippocampus. |
2015-10-09 |
2023-08-13 |
rat |
| Cheng-Shi Xu, An-Chun Liu, Juan Chen, Zhi-Yong Pan, Qi Wan, Zhi-Qiang Li, Ze-Fen Wan. Overactivation of NR2B-containing NMDA receptors through entorhinal-hippocampal connection initiates accumulation of hyperphosphorylated tau in rat hippocampus after transient middle cerebral artery occlusion. Journal of neurochemistry. vol 134. issue 3. 2015-10-09. PMID:25903928. |
we showed that unilateral transient mcao induced accumulation of hyperphosphorylated tau and concurrent dephosphorylation of glycogen synthase kinase-3β at ser 9 in the ipsilateral hippocampus. |
2015-10-09 |
2023-08-13 |
rat |
| Cheng-Shi Xu, An-Chun Liu, Juan Chen, Zhi-Yong Pan, Qi Wan, Zhi-Qiang Li, Ze-Fen Wan. Overactivation of NR2B-containing NMDA receptors through entorhinal-hippocampal connection initiates accumulation of hyperphosphorylated tau in rat hippocampus after transient middle cerebral artery occlusion. Journal of neurochemistry. vol 134. issue 3. 2015-10-09. PMID:25903928. |
inhibition of nmda receptor (nmdar) subunit nr2b, but not nr2a activity in the hippocampus attenuated the accumulation of hyperphosphorylated tau and spatial cognitive impairment in mcao rats. |
2015-10-09 |
2023-08-13 |
rat |
| Cheng-Shi Xu, An-Chun Liu, Juan Chen, Zhi-Yong Pan, Qi Wan, Zhi-Qiang Li, Ze-Fen Wan. Overactivation of NR2B-containing NMDA receptors through entorhinal-hippocampal connection initiates accumulation of hyperphosphorylated tau in rat hippocampus after transient middle cerebral artery occlusion. Journal of neurochemistry. vol 134. issue 3. 2015-10-09. PMID:25903928. |
together, our data suggest that overactivation of nr2b-containing nmdars through entorhinal-hippocampal connection plays an important role in the accumulation of hyperphosphorylated tau in the hippocampus following mcao. |
2015-10-09 |
2023-08-13 |
rat |
| Cheng-Shi Xu, An-Chun Liu, Juan Chen, Zhi-Yong Pan, Qi Wan, Zhi-Qiang Li, Ze-Fen Wan. Overactivation of NR2B-containing NMDA receptors through entorhinal-hippocampal connection initiates accumulation of hyperphosphorylated tau in rat hippocampus after transient middle cerebral artery occlusion. Journal of neurochemistry. vol 134. issue 3. 2015-10-09. PMID:25903928. |
we propose that excessive activation of nr2b-containing nmda receptors through entorhinal-hippocampal connection initiated the accumulation of hyperphosphorylated tau in the hippocampus, which subsequently induced cognitive deficit. |
2015-10-09 |
2023-08-13 |
rat |
| Di Xia, Chuanzhou Li, Jürgen Göt. Pseudophosphorylation of Tau at distinct epitopes or the presence of the P301L mutation targets the microtubule-associated protein Tau to dendritic spines. Biochimica et biophysica acta. vol 1852. issue 5. 2015-10-01. PMID:25558816. |
here we show in hippocampal neurons that endogenous tau enters the entire spine, albeit at low levels, whereas map2 only enters its neck or is restricted to the dendritic shaft. |
2015-10-01 |
2023-08-13 |
Not clear |
| F Clavaguera, J Hench, M Goedert, M Tolna. Invited review: Prion-like transmission and spreading of tau pathology. Neuropathology and applied neurobiology. vol 41. issue 1. 2015-09-15. PMID:25399729. |
in the most prevalent tauopathy, alzheimer's disease, tau pathology progresses in a stereotypical manner with the first lesions appearing in the locus coeruleus and the entorhinal cortex from where they appear to spread to the hippocampus and neocortex. |
2015-09-15 |
2023-08-13 |
Not clear |
| Weijie Xu, Yan Yang, Gang Yuan, Wenjun Zhu, Delin Ma, Shuhong H. Exendin-4, a glucagon-like peptide-1 receptor agonist, reduces Alzheimer disease-associated tau hyperphosphorylation in the hippocampus of rats with type 2 diabetes. Journal of investigative medicine : the official publication of the American Federation for Clinical Research. vol 63. issue 2. 2015-08-25. PMID:25479064. |
exendin-4, a glucagon-like peptide-1 receptor agonist, reduces alzheimer disease-associated tau hyperphosphorylation in the hippocampus of rats with type 2 diabetes. |
2015-08-25 |
2023-08-13 |
rat |
| Shannon N Campbell, Cheng Zhang, Louise Monte, Allyson D Roe, Kenner C Rice, Yvette Taché, Eliezer Masliah, Robert A Rissma. Increased tau phosphorylation and aggregation in the hippocampus of mice overexpressing corticotropin-releasing factor. Journal of Alzheimer's disease : JAD. vol 43. issue 3. 2015-08-21. PMID:25125464. |
increased tau phosphorylation and aggregation in the hippocampus of mice overexpressing corticotropin-releasing factor. |
2015-08-21 |
2023-08-13 |
mouse |
| Shannon N Campbell, Cheng Zhang, Louise Monte, Allyson D Roe, Kenner C Rice, Yvette Taché, Eliezer Masliah, Robert A Rissma. Increased tau phosphorylation and aggregation in the hippocampus of mice overexpressing corticotropin-releasing factor. Journal of Alzheimer's disease : JAD. vol 43. issue 3. 2015-08-21. PMID:25125464. |
although the links between stress and ad remain unsettled, data from our group and others have established that stress exposure in rodents may confer susceptibility to ad pathology by inducing hippocampal tau phosphorylation (tau-p). |
2015-08-21 |
2023-08-13 |
mouse |
| Ioannis Sotiropoulos, Joana Silva, Tetsuya Kimura, Ana Joao Rodrigues, Patricio Costa, Osborne F X Almeida, Nuno Sousa, Akihiko Takashim. Female hippocampus vulnerability to environmental stress, a precipitating factor in Tau aggregation pathology. Journal of Alzheimer's disease : JAD. vol 43. issue 3. 2015-08-21. PMID:25159665. |
female hippocampus vulnerability to environmental stress, a precipitating factor in tau aggregation pathology. |
2015-08-21 |
2023-08-13 |
mouse |
| Ioannis Sotiropoulos, Joana Silva, Tetsuya Kimura, Ana Joao Rodrigues, Patricio Costa, Osborne F X Almeida, Nuno Sousa, Akihiko Takashim. Female hippocampus vulnerability to environmental stress, a precipitating factor in Tau aggregation pathology. Journal of Alzheimer's disease : JAD. vol 43. issue 3. 2015-08-21. PMID:25159665. |
this study focused on how these various factors converge on the cellular mechanisms underlying tau aggregation in the hippocampus of chronically stressed male and female (middle-aged and old) mice expressing the most commonly found disease-associated tau mutation in humans, p301l-tau. |
2015-08-21 |
2023-08-13 |
mouse |