| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yue Wang, Zhe Cheng, Wei Qin, Jianping Ji. Val97Leu mutant presenilin-1 induces tau hyperphosphorylation and spatial memory deficit in mice and the underlying mechanisms. Journal of neurochemistry vol 121 issue 1 2012 21929538 |
additionally, the hyperphosphorylated tau and tangle-like argentophilic structures were detected at ca3 and ca4, but not ca1, region of hippocampus, and we also found tangle-like structure and wizened degenerative neurons in frontal cortex. |
2012-05-03 |
2023-01-25 |
human |
| Diana A T Nijholt, Elise S van Haastert, Annemieke J M Rozemuller, Wiep Scheper, Jeroen J M Hoozeman. The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies. The Journal of pathology vol 226 issue 5 2012 22102449 |
the unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies. |
2012-04-27 |
2023-01-25 |
Not clear |
| Elisabete Ferreiro, Cl\\xc3\\xa1udia M F Pereir. Endoplasmic reticulum stress: a new playER in tauopathies. The Journal of pathology vol 226 issue 5 2012 22190226 |
the authors described that increased levels of upr activation markers are predominantly observed in neurons within the hippocampus, being correlated with early tau phosphorylation. |
2012-04-27 |
2023-01-25 |
Not clear |
| M Cecilia Ljungberg, Yousuf O Ali, Jie Zhu, Chia-Shan Wu, Kazuhiro Oka, R Grace Zhai, Hui-Chen L. CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy. Human molecular genetics vol 21 issue 2 2012 22027994 |
both the total amount of phospho-cre binding protein (creb) and the pcreb bound to nmnat2 cre sites in the cortex and the hippocampus of rtg4510 mice are significantly reduced, suggesting that nmnat2 is a direct target of creb under physiological conditions and that tau(p301l) overexpression down-regulates creb-mediated transcription. |
2012-04-26 |
2023-01-25 |
mouse |
| Alix de Calignon, Manuela Polydoro, Marc Su\\xc3\\xa1rez-Calvet, Christopher William, David H Adamowicz, Kathy J Kopeikina, Rose Pitstick, Naruhiko Sahara, Karen H Ashe, George A Carlson, Tara L Spires-Jones, Bradley T Hyma. Propagation of tau pathology in a model of early Alzheimer's disease. Neuron vol 73 issue 4 2012 22365544 |
tau pathology progresses from ec transgene-expressing neurons to neurons without detectable transgene expression, first to ec neighboring cells, followed by propagation to neurons downstream in the synaptic circuit such as the dentate gyrus, ca fields of the hippocampus, and cingulate cortex. |
2012-04-16 |
2023-01-25 |
mouse |
| Bettina Platt, Benjamin Drever, David Koss, Sandra Stoppelkamp, Amar Jyoti, Andrea Plano, Aneli Utan, Georgina Merrick, Duncan Ryan, Valeria Melis, Hong Wan, Marco Mingarelli, Emanuele Porcu, Louise Scrocchi, Andy Welch, Gernot Riede. Abnormal cognition, sleep, EEG and brain metabolism in a novel knock-in Alzheimer mouse, PLB1. PloS one vol 6 issue 11 2012 22096518 |
plb1(triple) mice presented with stable gene expression and age-related pathology of intra-neuronal amyloid and hyperphosphorylated tau in hippocampus and cortex from 6 months onwards. |
2012-04-10 |
2023-01-25 |
mouse |
| David J Irwin, Todd J Cohen, Murray Grossman, Steven E Arnold, Sharon X Xie, Virginia M-Y Lee, John Q Trojanowsk. Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies. Brain : a journal of neurology vol 135 issue Pt 3 2012 22366796 |
acetylated-tau pathology was compared with the sequential emergence of other tau modifications in the alzheimer's disease hippocampus using monoclonal antibodies to multiple well-characterized tau epitopes. |
2012-04-09 |
2023-01-25 |
Not clear |
| Yuu Yamazaki, Tomoyasu Matsubara, Tetsuya Takahashi, Takashi Kurashige, Eisuke Dohi, Masanori Hiji, Yoshito Nagano, Takemori Yamawaki, Masayasu Matsumot. Granulovacuolar degenerations appear in relation to hippocampal phosphorylated tau accumulation in various neurodegenerative disorders. PloS one vol 6 issue 11 2012 22073234 |
granulovacuolar degenerations appear in relation to hippocampal phosphorylated tau accumulation in various neurodegenerative disorders. |
2012-03-26 |
2023-01-25 |
Not clear |
| Robert D Dayton, David B Wang, Cooper D Cain, Lisa M Schrott, Julio J Ramirez, Michael A King, Ronald L Klei. Frontotemporal lobar degeneration-related proteins induce only subtle memory-related deficits when bilaterally overexpressed in the dorsal hippocampus. Experimental neurology vol 233 issue 2 2012 22177996 |
to model the hippocampal neurodegeneration and memory-related behavioral impairment that occurs in ftld and other tau and tdp-43 proteinopathy diseases, we used an adeno-associated virus serotype 9 (aav9) vector to induce bilateral expression of either microtubule-associated protein tau or transactive response dna binding protein 43 kda (tdp-43) in adult rat dorsal hippocampus. |
2012-03-26 |
2023-01-25 |
rat |
| Robert D Dayton, David B Wang, Cooper D Cain, Lisa M Schrott, Julio J Ramirez, Michael A King, Ronald L Klei. Frontotemporal lobar degeneration-related proteins induce only subtle memory-related deficits when bilaterally overexpressed in the dorsal hippocampus. Experimental neurology vol 233 issue 2 2012 22177996 |
the data demonstrate that tdp-43 produced mild behavioral impairment and hippocampal neurodegeneration in rats, whereas tau did not. |
2012-03-26 |
2023-01-25 |
rat |
| Robert D Dayton, David B Wang, Cooper D Cain, Lisa M Schrott, Julio J Ramirez, Michael A King, Ronald L Klei. Frontotemporal lobar degeneration-related proteins induce only subtle memory-related deficits when bilaterally overexpressed in the dorsal hippocampus. Experimental neurology vol 233 issue 2 2012 22177996 |
the models could be of value for studying mechanisms of ftld and other diseases with tau and tdp-43 pathology in the hippocampus including alzheimer's disease, with relevance to early stage mild impairment. |
2012-03-26 |
2023-01-25 |
rat |
| Ana Paula Costa, Ana Carolina Tramontina, Regina Biasibetti, Cristiane Batassini, Mark William Lopes, Krista Min\\xc3\\xa9ia Wartchow, Caren Bernardi, Lucas Silva Tortorelli, Rodrigo Bainy Leal, Carlos-Alberto Gon\\xc3\\xa7alve. Neuroglial alterations in rats submitted to the okadaic acid-induced model of dementia. Behavioural brain research vol 226 issue 2 2012 21982813 |
memory impairment induced by intra-hippocampal injection of oa has been reported, accompanied by remarkable neuropathological changes including hippocampal neurodegeneration, a paired helical filament-like phosphorylation of tau protein, and formation of \xce\xb2-amyloid containing plaque-like structures. |
2012-03-25 |
2023-01-25 |
rat |
| Jose L Cantero, Bernardo Moreno-Lopez, Federico Portillo, Alicia Rubio, Eva Hita-Ya\\xc3\\xb1ez, Jesus Avil. Role of tau protein on neocortical and hippocampal oscillatory patterns. Hippocampus vol 21 issue 8 2012 20607795 |
role of tau protein on neocortical and hippocampal oscillatory patterns. |
2012-03-16 |
2023-01-25 |
mouse |
| Jose L Cantero, Bernardo Moreno-Lopez, Federico Portillo, Alicia Rubio, Eva Hita-Ya\\xc3\\xb1ez, Jesus Avil. Role of tau protein on neocortical and hippocampal oscillatory patterns. Hippocampus vol 21 issue 8 2012 20607795 |
because of its elevated expression in neocortical regions and hippocampus, tau might play a role in sculpting collective neural responses underlying slow and fast brain oscillations and/or long-range synchronization patterns between hippocampus and neocortex. |
2012-03-16 |
2023-01-25 |
mouse |
| Jose L Cantero, Bernardo Moreno-Lopez, Federico Portillo, Alicia Rubio, Eva Hita-Ya\\xc3\\xb1ez, Jesus Avil. Role of tau protein on neocortical and hippocampal oscillatory patterns. Hippocampus vol 21 issue 8 2012 20607795 |
to test this hypothesis, local field potentials were recorded in tau-deficient (tau(-/-) ) and wild-type mice from different neocortical regions and from the hippocampus during spontaneous motor exploratory behavior. |
2012-03-16 |
2023-01-25 |
mouse |
| Jose L Cantero, Bernardo Moreno-Lopez, Federico Portillo, Alicia Rubio, Eva Hita-Ya\\xc3\\xb1ez, Jesus Avil. Role of tau protein on neocortical and hippocampal oscillatory patterns. Hippocampus vol 21 issue 8 2012 20607795 |
we found that tau(-/-) mice showed hippocampal theta slowing and reduced levels of gamma long-range synchronization involving the frontal cortex. |
2012-03-16 |
2023-01-25 |
mouse |
| Jose L Cantero, Bernardo Moreno-Lopez, Federico Portillo, Alicia Rubio, Eva Hita-Ya\\xc3\\xb1ez, Jesus Avil. Role of tau protein on neocortical and hippocampal oscillatory patterns. Hippocampus vol 21 issue 8 2012 20607795 |
also, the proper functioning of gap-junction channels might be compromised by the absence of tau in hippocampal networks. |
2012-03-16 |
2023-01-25 |
mouse |
| Mira Didic, Emmanuel J Barbeau, Olivier Felician, Eve Tramoni, Eric Guedj, Michel Poncet, Mathieu Ceccald. Which memory system is impaired first in Alzheimer's disease? Journal of Alzheimer's disease : JAD vol 27 issue 1 2012 21799246 |
however, during the "transentorhinal stage" of ad, neurofibrillary tangles (nft), related to tau protein pathology, develop in the anterior subhippocampal (perirhinal/entorhinal) cortex before the hippocampus. |
2012-02-27 |
2023-01-25 |
human |
| John L Robinson, Felix Geser, Maria M Corrada, Daniel J Berlau, Steven E Arnold, Virginia M-Y Lee, Claudia H Kawas, John Q Trojanowsk. Neocortical and hippocampal amyloid-\\xce\\xb2 and tau measures associate with dementia in the oldest-old. Brain : a journal of neurology vol 134 issue Pt 12 2012 22120149 |
neocortical and hippocampal amyloid-\xce\xb2 and tau measures associate with dementia in the oldest-old. |
2012-02-09 |
2023-01-25 |
human |
| John L Robinson, Felix Geser, Maria M Corrada, Daniel J Berlau, Steven E Arnold, Virginia M-Y Lee, Claudia H Kawas, John Q Trojanowsk. Neocortical and hippocampal amyloid-\\xce\\xb2 and tau measures associate with dementia in the oldest-old. Brain : a journal of neurology vol 134 issue Pt 12 2012 22120149 |
we used quantitative and/or semi-quantitative measures to assess the burden of amyloid-\xce\xb2, tau, tdp-43 and \xce\xb1-synuclein pathologies as well as hippocampal sclerosis. |
2012-02-09 |
2023-01-25 |
human |