| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Allal Boutajangout, Johanna Ingadottir, Peter Davies, Einar M Sigurdsso. Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain. Journal of neurochemistry vol 118 issue 4 2011 21644996 |
the treated mice performed better than controls on the traverse beam task (p < 0.03), and had 58% less tau pathology in the dentate gyrus of the hippocampus (p = 0.02). |
2011-09-16 |
2023-01-25 |
mouse |
| Johannes Attems, Arne Ittner, Kurt Jellinger, Roger M Nitsch, Magdalena Maj, Ludwig Wagner, J\\xc3\\xbcrgen G\\xc3\\xb6tz, Mathias Heikenwalde. Reduced secretagogin expression in the hippocampus of P301L tau transgenic mice. Journal of neural transmission (Vienna, Austria : 1996) vol 118 issue 5 2011 21442354 |
reduced secretagogin expression in the hippocampus of p301l tau transgenic mice. |
2011-09-08 |
2023-01-25 |
mouse |
| Johannes Attems, Arne Ittner, Kurt Jellinger, Roger M Nitsch, Magdalena Maj, Ludwig Wagner, J\\xc3\\xbcrgen G\\xc3\\xb6tz, Mathias Heikenwalde. Reduced secretagogin expression in the hippocampus of P301L tau transgenic mice. Journal of neural transmission (Vienna, Austria : 1996) vol 118 issue 5 2011 21442354 |
neuropathological features in alzheimer's disease (ad) include the presence of hyperphosphorylated forms of the microtubule-associated tau protein (tau) in hippocampal neurones. |
2011-09-08 |
2023-01-25 |
mouse |
| Johannes Attems, Arne Ittner, Kurt Jellinger, Roger M Nitsch, Magdalena Maj, Ludwig Wagner, J\\xc3\\xbcrgen G\\xc3\\xb6tz, Mathias Heikenwalde. Reduced secretagogin expression in the hippocampus of P301L tau transgenic mice. Journal of neural transmission (Vienna, Austria : 1996) vol 118 issue 5 2011 21442354 |
here, we investigated secretagogin expression in wild type (wt) mice as well as in hemizygous and homozygous p301l tau transgenic (tg) mice, which show pronounced and widespread tau pathology in hippocampal neurones. |
2011-09-08 |
2023-01-25 |
mouse |
| Johannes Attems, Arne Ittner, Kurt Jellinger, Roger M Nitsch, Magdalena Maj, Ludwig Wagner, J\\xc3\\xbcrgen G\\xc3\\xb6tz, Mathias Heikenwalde. Reduced secretagogin expression in the hippocampus of P301L tau transgenic mice. Journal of neural transmission (Vienna, Austria : 1996) vol 118 issue 5 2011 21442354 |
in wt mice hippocampal secretagogin-immunoreactive neurones were invariably detected, while immunoreactivity was much lower (p < 0.001) in tau tg mice. |
2011-09-08 |
2023-01-25 |
mouse |
| Johannes Attems, Arne Ittner, Kurt Jellinger, Roger M Nitsch, Magdalena Maj, Ludwig Wagner, J\\xc3\\xbcrgen G\\xc3\\xb6tz, Mathias Heikenwalde. Reduced secretagogin expression in the hippocampus of P301L tau transgenic mice. Journal of neural transmission (Vienna, Austria : 1996) vol 118 issue 5 2011 21442354 |
of note, hippocampal secretagogin immunoreactivity was absent in 62.5% of homozygous tau tg mice. |
2011-09-08 |
2023-01-25 |
mouse |
| Johannes Attems, Arne Ittner, Kurt Jellinger, Roger M Nitsch, Magdalena Maj, Ludwig Wagner, J\\xc3\\xbcrgen G\\xc3\\xb6tz, Mathias Heikenwalde. Reduced secretagogin expression in the hippocampus of P301L tau transgenic mice. Journal of neural transmission (Vienna, Austria : 1996) vol 118 issue 5 2011 21442354 |
our results suggest that increased levels of tau negatively influence secretagogin expression in the hippocampus of tau tg mice. |
2011-09-08 |
2023-01-25 |
mouse |
| Wen-Fei Tan, Xue-Zhao Cao, Jun-Ke Wang, Huang-Wei Lv, Bin-Yang Wu, Hong M. Protective effects of lithium treatment for spatial memory deficits induced by tau hyperphosphorylation in splenectomized rats. Clinical and experimental pharmacology & physiology vol 37 issue 10 2011 20659131 |
we used a splenectomized rat model with postoperative spatial learning and memory deficits to investigate the role of tau hyperphosphorylation and glycogen synthase kinase-3\xce\xb2 (gsk-3\xce\xb2) within the hippocampus. |
2011-09-02 |
2023-01-25 |
rat |
| Wen-Fei Tan, Xue-Zhao Cao, Jun-Ke Wang, Huang-Wei Lv, Bin-Yang Wu, Hong M. Protective effects of lithium treatment for spatial memory deficits induced by tau hyperphosphorylation in splenectomized rats. Clinical and experimental pharmacology & physiology vol 37 issue 10 2011 20659131 |
we measured site-specific phosphorylation of hippocampal tau (thr-205 and ser-396), gsk-3\xce\xb2 activity and expression of interleukin-1\xce\xb2 (il-1\xce\xb2), tumour necrosis factor-\xce\xb1 (tnf-\xce\xb1) mrna and protein as markers of inflammation. |
2011-09-02 |
2023-01-25 |
rat |
| Wen-Fei Tan, Xue-Zhao Cao, Jun-Ke Wang, Huang-Wei Lv, Bin-Yang Wu, Hong M. Protective effects of lithium treatment for spatial memory deficits induced by tau hyperphosphorylation in splenectomized rats. Clinical and experimental pharmacology & physiology vol 37 issue 10 2011 20659131 |
splenectomy was associated with learning and memory impairment 3 days later, as well as a rapid and massive hyperphosphorylation of hippocampal tau at thr-205 and ser-396, activated gsk-3\xce\xb2, and increased il-1\xce\xb2 and tnf-\xce\xb1 expression. |
2011-09-02 |
2023-01-25 |
rat |
| Ignacio Camacho-Arroyo, Aliesha Gonz\\xc3\\xa1lez-Arenas, Judith Espinosa-Raya, Ana Gabriela Pi\\xc3\\xb1a-Medina, Ofir Picaz. Short- and long-term treatment with estradiol or progesterone modifies the expression of GFAP, MAP2 and Tau in prefrontal cortex and hippocampus. Life sciences vol 89 issue 3-4 2011 21683086 |
short- and long-term treatment with estradiol or progesterone modifies the expression of gfap, map2 and tau in prefrontal cortex and hippocampus. |
2011-08-30 |
2023-01-25 |
Not clear |
| Ignacio Camacho-Arroyo, Aliesha Gonz\\xc3\\xa1lez-Arenas, Judith Espinosa-Raya, Ana Gabriela Pi\\xc3\\xb1a-Medina, Ofir Picaz. Short- and long-term treatment with estradiol or progesterone modifies the expression of GFAP, MAP2 and Tau in prefrontal cortex and hippocampus. Life sciences vol 89 issue 3-4 2011 21683086 |
we analyzed the effects of the short- and long-term administration of estradiol (e2) or progesterone (p4) after ovariectomy on the expression of map2, tau and gfap in prefrontal cortex and hippocampus. |
2011-08-30 |
2023-01-25 |
Not clear |
| D S Kern, K N Maclean, H Jiang, E Y Synder, J R Sladek, K B Bjugsta. Neural stem cells reduce hippocampal tau and reelin accumulation in aged Ts65Dn Down syndrome mice. Cell transplantation vol 20 issue 3 2011 20875225 |
neural stem cells reduce hippocampal tau and reelin accumulation in aged ts65dn down syndrome mice. |
2011-08-23 |
2023-01-25 |
mouse |
| Leora M Fox, Christopher M William, David H Adamowicz, Rose Pitstick, George A Carlson, Tara L Spires-Jones, Bradley T Hyma. Soluble tau species, not neurofibrillary aggregates, disrupt neural system integration in a tau transgenic model. Journal of neuropathology and experimental neurology vol 70 issue 7 2011 21666499 |
we interpret these data to indicate that soluble tau contributes to impairment of hippocampal function, although tangles do not preclude neurons from responding in a functional circuit. |
2011-08-22 |
2023-01-25 |
mouse |
| Lili C Kudo, Liubov Parfenova, Guijie Ren, Nancy Vi, Maria Hui, Zhongcai Ma, Kimbley Lau, Michelle Gray, Fawzia Bardag-Gorce, Martina Wiedau-Pazos, Koon-Sea Hui, Stanislav L Karste. Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in hPSA/TAU(P301L) double-transgenic mice. Human molecular genetics vol 20 issue 9 2011 21320871 |
double-transgenic animals for hpsa and tau(p301l) transgenes demonstrated a distinct trend for delayed paralysis and showed significantly improved motor neuron counts, no gliosis and markedly reduced levels of total and hyperphosphorylated tau in the spinal cord, brain stem, cortex, hippocampus and cerebellum of adult and aged animals when compared with tau(p301l) mice. |
2011-08-15 |
2023-01-25 |
mouse |
| Yifan Lu, Tong Li, Hamid Y Qureshi, Dong Han, Hemant K Paude. Early growth response 1 (Egr-1) regulates phosphorylation of microtubule-associated protein tau in mammalian brain. The Journal of biological chemistry vol 286 issue 23 2011 21489990 |
in this study, we found that lentivirus-mediated overexpression of egr-1 in rat brain hippocampus and primary neurons in culture activates proline-directed kinase cdk5, inactivates pp1, promotes tau phosphorylation at both proline-directed ser(396/404) and non-proline-directed ser(262) sites, and destabilizes microtubules. |
2011-08-05 |
2023-01-25 |
rat |
| Ioannis Sotiropoulos, Caterina Catania, Lucilia G Pinto, Rui Silva, G Elizabeth Pollerberg, Akihiko Takashima, Nuno Sousa, Osborne F X Almeid. Stress acts cumulatively to precipitate Alzheimer's disease-like tau pathology and cognitive deficits. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 31 issue 21 2011 21613497 |
results from healthy, wild-type, middle-aged rats show that chronic stress and gc induce abnormal hyperphosphorylation of tau in the hippocampus and prefrontal cortex (pfc), with contemporaneous impairments of hippocampus- and pfc-dependent behaviors. |
2011-08-04 |
2023-01-25 |
rat |
| Ann Van der Jeugd, Tariq Ahmed, Sylvie Burnouf, Karim Belarbi, Malika Hamdame, Marie-Eve Grosjean, Sandrine Humez, Detlef Balschun, David Blum, Luc Bu\\xc3\\xa9e, Rudi D'Hoog. Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission. Neurobiology of learning and memory vol 95 issue 3 2011 21167950 |
hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission. |
2011-08-03 |
2023-01-25 |
mouse |
| Ann Van der Jeugd, Tariq Ahmed, Sylvie Burnouf, Karim Belarbi, Malika Hamdame, Marie-Eve Grosjean, Sandrine Humez, Detlef Balschun, David Blum, Luc Bu\\xc3\\xa9e, Rudi D'Hoog. Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission. Neurobiology of learning and memory vol 95 issue 3 2011 21167950 |
we evaluated various forms of hippocampus-dependent learning and memory, and hippocampal synaptic plasticity in thy-tau22 transgenic mice, a murine tauopathy model that expresses double-mutated 4-repeat human tau, and shows neuropathological tau hyperphosphorylation and aggregation throughout the brain. |
2011-08-03 |
2023-01-25 |
mouse |
| Ann Van der Jeugd, Tariq Ahmed, Sylvie Burnouf, Karim Belarbi, Malika Hamdame, Marie-Eve Grosjean, Sandrine Humez, Detlef Balschun, David Blum, Luc Bu\\xc3\\xa9e, Rudi D'Hoog. Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission. Neurobiology of learning and memory vol 95 issue 3 2011 21167950 |
focussing on hippocampus, immunohistochemical studies in aged thy-tau22 mice revealed prominent hyper- and abnormal phosphorylation of tau in ca1 region, and an increase in glial fibrillary acidic protein (gfap) in hippocampus, but without signs of neuronal loss. |
2011-08-03 |
2023-01-25 |
mouse |