| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sylvia E Perez, Bin He, Muhammad Nadeem, Joanne Wuu, Stephen D Ginsberg, Milos D Ikonomovic, Elliott J Mufso. Hippocampal endosomal, lysosomal, and autophagic dysregulation in mild cognitive impairment: correlation with aβ and tau pathology. Journal of neuropathology and experimental neurology. vol 74. issue 4. 2015-06-15. PMID:25756588. |
endosomal-lysosomal and autophagic dysregulation occurs in the hippocampus in prodromal alzheimer disease (ad), but its relationship with β-amyloid (aβ) and tau pathology remains unclear. |
2015-06-15 |
2023-08-13 |
Not clear |
| Sylvia E Perez, Bin He, Muhammad Nadeem, Joanne Wuu, Stephen D Ginsberg, Milos D Ikonomovic, Elliott J Mufso. Hippocampal endosomal, lysosomal, and autophagic dysregulation in mild cognitive impairment: correlation with aβ and tau pathology. Journal of neuropathology and experimental neurology. vol 74. issue 4. 2015-06-15. PMID:25756588. |
these results indicate that alterations in hippocampal endosomal-lysosomal proteins in mci are independent of tau or aβ pathology. |
2015-06-15 |
2023-08-13 |
Not clear |
| Philip Regan, Thomas Piers, Jee-Hyun Yi, Dong-Hyun Kim, Seonghoo Huh, Se Jin Park, Jong Hoon Ryu, Daniel J Whitcomb, Kwangwook Ch. Tau phosphorylation at serine 396 residue is required for hippocampal LTD. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 12. 2015-06-15. PMID:25810511. |
tau phosphorylation at serine 396 residue is required for hippocampal ltd. tau is required for the induction of long-term depression (ltd) of synaptic transmission in the hippocampus. |
2015-06-15 |
2023-08-13 |
mouse |
| Qian Chen, Zhou Zhou, Lei Zhang, Shangcheng Xu, Chunhai Chen, Zhengping Y. The cellular distribution and Ser262 phosphorylation of tau protein are regulated by BDNF in vitro. PloS one. vol 9. issue 3. 2015-05-29. PMID:24618580. |
when primary e18 hippocampal neurons were treated with nocodazole, a blocker of microtubule polymerization, nascent neurites were lost and tau shifted to the soma. |
2015-05-29 |
2023-08-12 |
Not clear |
| Takeshi Kanno, Ayako Tsuchiya, Tomoyuki Nishizak. Hyperphosphorylation of Tau at Ser396 occurs in the much earlier stage than appearance of learning and memory disorders in 5XFAD mice. Behavioural brain research. vol 274. 2015-05-26. PMID:25172181. |
there was no significant difference in the tau phosphorylation at ser202/thr205 in the hippocampus between two groups, but ser396 phosphorylation for 5xfad mice was significantly higher than that for wild-type mice at ages ranging from 2 to 6 months. |
2015-05-26 |
2023-08-13 |
mouse |
| Chao Liu, Su Min, Ke Wei, Dong Liu, Jun Dong, Jie Luo, Xiao-Bin Li. [MK-801 or DNQX reduces electroconvulsive shock-induced impairment of learning-memory and hyperphosphorylation of Tau in rats]. Sheng li xue bao : [Acta physiologica Sinica]. vol 64. issue 4. 2015-05-16. PMID:22907299. |
the contents of tau protein which included tau5 (total tau protein), p-phf1(ser396/404), p-at8(ser199/202) and p-12e8(ser262) in the hippocampus of rats were detected by immunohistochemistry staining (sp) and western blot. |
2015-05-16 |
2023-08-12 |
rat |
| Chao Liu, Su Min, Ke Wei, Dong Liu, Jun Dong, Jie Luo, Xiao-Bin Li. [MK-801 or DNQX reduces electroconvulsive shock-induced impairment of learning-memory and hyperphosphorylation of Tau in rats]. Sheng li xue bao : [Acta physiologica Sinica]. vol 64. issue 4. 2015-05-16. PMID:22907299. |
ect and the glutamate ionic receptor blockers did not affect the total tau protein in the hippocampus of rats. |
2015-05-16 |
2023-08-12 |
rat |
| Chao Liu, Su Min, Ke Wei, Dong Liu, Jun Dong, Jie Luo, Xiao-Bin Li. [MK-801 or DNQX reduces electroconvulsive shock-induced impairment of learning-memory and hyperphosphorylation of Tau in rats]. Sheng li xue bao : [Acta physiologica Sinica]. vol 64. issue 4. 2015-05-16. PMID:22907299. |
ect up-regulated the hyperphosphorylation of tau protein in the hippocampus of depressed rats, while the glutamate ionic receptor blockers down-regulated it, and combination of the two factors presented a subtractive effect. |
2015-05-16 |
2023-08-12 |
rat |
| Chao Liu, Su Min, Ke Wei, Dong Liu, Jun Dong, Jie Luo, Xiao-Bin Li. [MK-801 or DNQX reduces electroconvulsive shock-induced impairment of learning-memory and hyperphosphorylation of Tau in rats]. Sheng li xue bao : [Acta physiologica Sinica]. vol 64. issue 4. 2015-05-16. PMID:22907299. |
our results indicate that ect up-regulates the content of glutamate in the hippocampus of depressed rats, which up-regulates the hyperphosphorylation of tau protein resulting in the impairment of learning and memory in depressed rats. |
2015-05-16 |
2023-08-12 |
rat |
| Jonathan E Cohen, Philip R Lee, R Douglas Field. Systematic identification of 3'-UTR regulatory elements in activity-dependent mRNA stability in hippocampal neurons. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 369. issue 1652. 2015-05-12. PMID:25135970. |
we further find that mir-485-5p controls ngf-induced neurite outgrowth in pc12 cells, tau expression and axonal development in hippocampal neurons. |
2015-05-12 |
2023-08-13 |
rat |
| Scott E Counts, Sylvia E Perez, Bin He, Elliott J Mufso. Intravenous immunoglobulin reduces tau pathology and preserves neuroplastic gene expression in the 3xTg mouse model of Alzheimer's disease. Current Alzheimer research. vol 11. issue 7. 2015-05-12. PMID:25156574. |
hence, ivig reduces hippocampal nft pathology in the 3xtg mouse through a mechanism that may involve preservation of neuronal plasticity and tau phosphorylation homeostasis. |
2015-05-12 |
2023-08-13 |
mouse |
| Marie-Elaine Laurier-Laurin, Audrée De Montigny, Suzanne Attiori Essis, Michel Cyr, Guy Massicott. Blockade of lysosomal acid ceramidase induces GluN2B-dependent Tau phosphorylation in rat hippocampal slices. Neural plasticity. vol 2014. 2015-05-11. PMID:25276436. |
blockade of lysosomal acid ceramidase induces glun2b-dependent tau phosphorylation in rat hippocampal slices. |
2015-05-11 |
2023-08-13 |
rat |
| Marie-Elaine Laurier-Laurin, Audrée De Montigny, Suzanne Attiori Essis, Michel Cyr, Guy Massicott. Blockade of lysosomal acid ceramidase induces GluN2B-dependent Tau phosphorylation in rat hippocampal slices. Neural plasticity. vol 2014. 2015-05-11. PMID:25276436. |
from a biochemical perspective, we observed that tau phosphorylation at the ser262 epitope was highly increased in hippocampal slices preincubated with the aci, an effect totally prevented by the global nmda receptor antagonist d/l(-)-2-amino-5-phosphonovaleric acid (ap-5), the calcium chelator 1,2-bis(o-aminophenoxy)ethane-n,n,n',n'-tetraacetic acid (bapta), and the glun2b (but not the glun2a) receptor antagonist ro25-6981. |
2015-05-11 |
2023-08-13 |
rat |
| Marie-Elaine Laurier-Laurin, Audrée De Montigny, Suzanne Attiori Essis, Michel Cyr, Guy Massicott. Blockade of lysosomal acid ceramidase induces GluN2B-dependent Tau phosphorylation in rat hippocampal slices. Neural plasticity. vol 2014. 2015-05-11. PMID:25276436. |
on the other hand, preincubation of hippocampal slices with the compound kn-62, an inhibitor known to interfere with calcium/calmodulin-dependent protein kinase ii (camkii), totally abolished the effect of aci on tau phosphorylation at ser262 epitopes. |
2015-05-11 |
2023-08-13 |
rat |
| Marie-Elaine Laurier-Laurin, Audrée De Montigny, Suzanne Attiori Essis, Michel Cyr, Guy Massicott. Blockade of lysosomal acid ceramidase induces GluN2B-dependent Tau phosphorylation in rat hippocampal slices. Neural plasticity. vol 2014. 2015-05-11. PMID:25276436. |
collectively, these results provide experimental evidence that ceramides play an important role in regulating tau phosphorylation in the hippocampus via a mechanism dependent on glun2b receptor subunits and camkii activation. |
2015-05-11 |
2023-08-13 |
rat |
| Dae-Young Kim, Sun-Young Jung, Tae-Woon Kim, Kwang-Sik Lee, Kijeong Ki. Treadmill exercise decreases incidence of Alzheimer's disease by suppressing glycogen synthase kinase-3β expression in streptozotocin-induced diabetic rats. Journal of exercise rehabilitation. vol 11. issue 2. 2015-05-11. PMID:25960981. |
in the present study, treadmill exercise suppressed hyperphosphorylation of tau in the hippocampus by decreased gsk-3β activity through pi3k/akt pathway activation in the diabetic rats. |
2015-05-11 |
2023-08-13 |
rat |
| Joëlle Rosseels, Jeff Van den Brande, Marie Violet, Dirk Jacobs, Pierre Grognet, Juan Lopez, Isabelle Huvent, Marina Caldara, Erwin Swinnen, Anthony Papegaey, Raphaëlle Caillierez, Valerie Buée-Scherrer, Sebastiaan Engelborghs, Guy Lippens, Morvane Colin, Luc Buée, Marie-Christine Galas, Eugeen Vanmechelen, Joris Winderick. Tau monoclonal antibody generation based on humanized yeast models: impact on Tau oligomerization and diagnostics. The Journal of biological chemistry. vol 290. issue 7. 2015-05-08. PMID:25540200. |
in hippocampal homogenates from thy-tau22 mice and cortex homogenates obtained from alzheimer patients, adx215 consistently stained specific low order tau oligomers in diseased brain, which in size correspond to tau dimers. |
2015-05-08 |
2023-08-13 |
mouse |
| Jingheng Cheng, Daoyun J. Rigid firing sequences undermine spatial memory codes in a neurodegenerative mouse model. eLife. vol 2. 2015-04-23. PMID:23805379. |
we propose that tau pathology and/or neurodegeneration renders hippocampal circuits overwhelmed by internal information and therefore prevents them from encoding spatial memories. |
2015-04-23 |
2023-08-12 |
mouse |
| Hong-Bin Luo, Yi-Yuan Xia, Xi-Ji Shu, Zan-Chao Liu, Ye Feng, Xing-Hua Liu, Guang Yu, Gang Yin, Yan-Si Xiong, Kuan Zeng, Jun Jiang, Keqiang Ye, Xiao-Chuan Wang, Jian-Zhi Wan. SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 46. 2015-04-23. PMID:25378699. |
furthermore, the enhanced sumo-immunoreactivity, costained with the hyperphosphorylated tau, is detected in cerebral cortex of the ad brains, and β-amyloid exposure of rat primary hippocampal neurons induces a dose-dependent sumoylation of the hyperphosphorylated tau. |
2015-04-23 |
2023-08-13 |
rat |
| Khushbu K Modi, Arundhati Jana, Supurna Ghosh, Richard Watson, Kalipada Paha. A physically-modified saline suppresses neuronal apoptosis, attenuates tau phosphorylation and protects memory in an animal model of Alzheimer's disease. PloS one. vol 9. issue 8. 2015-04-14. PMID:25089827. |
similarly, rns60 treatment suppressed neuronal apoptosis, attenuated tau phosphorylation, inhibited glial activation, and reduced the burden of aβ in the hippocampus and protected memory and learning in 5xfad transgenic mouse model of ad. |
2015-04-14 |
2023-08-13 |
mouse |