| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Manuel Schweighauser, Holly J Garringer, Therése Klingstedt, K Peter R Nilsson, Masami Masuda-Suzukake, Jill R Murrell, Shannon L Risacher, Ruben Vidal, Sjors H W Scheres, Michel Goedert, Bernardino Ghetti, Kathy L Newel. Mutation ∆K281 in MAPT causes Pick's disease. Acta neuropathologica. 2023-06-23. PMID:37351604. |
at autopsy, numerous inclusions of hyperphosphorylated 3r tau were present in neurons and glial cells of neocortex and some subcortical regions, including hippocampus, caudate/putamen and globus pallidus. |
2023-06-23 |
2023-08-14 |
Not clear |
| Dianne Marquez Lopez, Connor J Maltby, Hannah Warming, Nullin Divecha, Mariana Vargas-Caballero, Mark J Coldwell, Katrin Deinhard. A luminescence-based reporter to study tau secretion reveals overlapping mechanisms for the release of healthy and pathological tau. Frontiers in neuroscience. vol 17. 2023-06-22. PMID:37342467. |
here, we established a sensitive bioluminescence-based assay to assess mechanisms underlying the secretion of pseudohyperphosphorylated and wild-type tau in cultured murine hippocampal neurons. |
2023-06-22 |
2023-08-14 |
Not clear |
| Anastasie Mate De Gerando, Lindsay A Welikovitch, Anita Khasnavis, Caitlin Commins, Calina Glynn, Joshua E Chun, Romain Perbet, Bradley T Hyma. Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau. Acta neuropathologica. 2023-06-21. PMID:37341831. |
sarkosyl-insoluble and hmw tau are nearly equivalent in potency in hek cell bioactivity assay for seeding aggregates, and their injection reveals similar local uptake into hippocampal neurons in ps19 tau transgenic mice. |
2023-06-21 |
2023-08-14 |
mouse |
| Stephanie A Schultz, Zahra Shirzadi, Aaron P Schultz, Lei Liu, Colleen D Fitzpatrick, Eric McDade, Nicolas R Barthelemy, Alan Renton, Bianca Esposito, Nelly Joseph-Mathurin, Carlos Cruchaga, Charles D Chen, Alison Goate, Ricardo Francisco Allegri, Tammie L S Benzinger, Sarah Berman, Helena C Chui, Anne M Fagan, Martin R Farlow, Nick C Fox, Brian A Gordon, Gregory S Day, Neill R Graff-Radford, Jason J Hassenstab, Bernard J Hanseeuw, Anna Hofmann, Clifford R Jack, Mathias Jucker, Celeste M Karch, Robert A Koeppe, Jae-Hong Lee, Allan I Levey, Johannes Levin, Ralph N Martins, Hiroshi Mori, John C Morris, James Noble, Richard J Perrin, Pedro Rosa-Neto, Stephen P Salloway, Raquel Sanchez-Valle, Peter R Schofield, Chengjie Xiong, Keith A Johnson, Randall J Bateman, Reisa A Sperling, Jasmeer P Chhatwa. Location of pathogenic variants in PSEN1 impacts progression of cognitive, clinical, and neurodegenerative measures in autosomal-dominant Alzheimer's disease. Aging cell. 2023-06-09. PMID:37291760. |
while both the cy and tm groups were found to have similarly elevated aβ compared to nc, tm carriers had greater cognitive impairment, smaller hippocampal volume, and elevated phosphorylated tau levels across the spectrum of pre-symptomatic and symptomatic phases of disease as compared to cy, using both cross-sectional and longitudinal data. |
2023-06-09 |
2023-08-14 |
Not clear |
| Anika Wuestefeld, Hannah Baumeister, Jenna N Adams, Robin de Flores, Carl Hodgetts, Negar Mazloum-Farzaghi, Rosanna K Olsen, Vyash Puliyadi, Tammy T Tran, Arnold Bakker, Kelsey L Canada, Marshall A Dalton, Ana M Daugherty, Renaud La Joie, Lei Wang, Madigan Bedard, Esther Buendia, Amanda Denning, David J Irwin, Ranjit Ittyerah, Edward B Lee, Sydney Lim, Maria Mercedes Iñiguez de Onzoño Martin, Monica Munoz Lopez, Theresa Schuck, Winifred Trotman, Alicia Vela, Paul Yushkevich, Katrin Amunts, Jean C Augustinack, Song-Lin Ding, Ricardo Insausti, Olga Kedo, David Berron, Laura E M Wiss. Comparison of histological delineations of medial temporal lobe cortices by four independent neuroanatomy laboratories. bioRxiv : the preprint server for biology. 2023-06-09. PMID:37292729. |
the medial temporal lobe (mtl) cortex, located adjacent to the hippocampus, is crucial for memory and prone to the accumulation of certain neuropathologies such as alzheimer's disease neurofibrillary tau tangles. |
2023-06-09 |
2023-08-14 |
human |
| Tatiana M Corey, Oscar Illanes, Matthew Lawrence, Sylvia E Perez, Shervin Liddie, John J Callana. Naturally occurring histological findings and Alzheimer's-like pathology in the brain of aging African green monkeys (Chlorocebus sabaeus). The Journal of comparative neurology. 2023-06-06. PMID:37279778. |
in 12 animals, 11 over the age of 10 years, phosphorylated tau cp13-immunoreactive neurons, neuropil, and oligodendrocyte-like cells were seen in the prefrontal, frontal, cingulate, orbital, temporal, and entorhinal cortices as well as the hippocampus; no neurofibrillary tangles were observed. |
2023-06-06 |
2023-08-14 |
monkey |
| Yunfang Su, Dahui Wang, Ningning Liu, Jiajia Yang, Ruiqin Sun, Zhenqiang Zhan. Clostridium butyricum improves cognitive dysfunction in ICV-STZ-induced Alzheimer's disease mice via suppressing TLR4 signaling pathway through the gut-brain axis. PloS one. vol 18. issue 6. 2023-06-02. PMID:37267300. |
the pharmacological effect of cb was assessed by behavior test, brain tissue h&e staining and tau protein phosphorylation levels of hippocampus tissues. |
2023-06-02 |
2023-08-14 |
mouse |
| Mengjuan Zhu, Bin Xiao, Tao Xue, Sifei Qin, Jiuyang Ding, Yue Wu, Qingqiu Tang, Mengfan Huang, Na Zhao, Yingshan Ye, Yuning Zhang, Boya Zhang, Juan Li, Fukun Guo, Yong Jiang, Lin Zhang, Lu Zhan. Cdc42GAP deficiency contributes to the Alzheimer's disease phenotype. Brain : a journal of neurology. 2023-05-31. PMID:37254741. |
in addition, overexpression of dominant-negative cdc42 in the primary hippocampal and cortical neurons of heterozygous cdc42gap mice reversed synaptic loss and tau hyperphosphorylation. |
2023-05-31 |
2023-08-14 |
mouse |
| Hannah Walgrave, Amber Penning, Giorgia Tosoni, Sarah Snoeck, Kristofer Davie, Emma Davis, Leen Wolfs, Annerieke Sierksma, Mayte Mars, Taofeng Bu, Nicola Thrupp, Lujia Zhou, Diederik Moechars, Renzo Mancuso, Mark Fiers, Andrew J M Howden, Bart De Strooper, Evgenia Salt. microRNA-132 regulates gene expression programs involved in microglial homeostasis. iScience. vol 26. issue 6. 2023-05-30. PMID:37250784. |
increasing mir-132 in ad mouse brain ameliorates amyloid and tau pathologies, and also restores adult hippocampal neurogenesis and memory deficits. |
2023-05-30 |
2023-08-14 |
mouse |
| Carlos G Ardanaz, Amaia Ezkurdia, Arantza Bejarano, Beatriz Echarte, Cristian Smerdou, Eva Martisova, Iván Martínez-Valbuena, María-Rosario Luquin, María J Ramírez, Maite Sola. JNK3 Overexpression in the Entorhinal Cortex Impacts on the Hippocampus and Induces Cognitive Deficiencies and Tau Misfolding. ACS chemical neuroscience. 2023-05-26. PMID:37236204. |
jnk3 overexpression in the entorhinal cortex impacts on the hippocampus and induces cognitive deficiencies and tau misfolding. |
2023-05-26 |
2023-08-14 |
human |
| Li Liang, Pengzheng Zhou, Chenfei Ye, Qi Yang, Ting M. Spatial-temporal patterns of brain disconnectome in Alzheimer's disease. Human brain mapping. 2023-05-25. PMID:37227021. |
our analysis suggests that brain wmh-related structural disconnectome contributes to ad evolution mainly through attacking connections between: (1) parahippocampal gyrus and superior frontal gyrus, orbital gyrus, and lateral occipital cortex; and (2) hippocampus and cingulate gyrus, which are also vulnerable to aβ and tau confirmed by other researches. |
2023-05-25 |
2023-08-14 |
human |
| Jafar Sadeghzadeh, Jaber Jafarzadeh, Pezhman Hadinezhad, Ahmad Nazari, Saeedeh Sohrabi, Vali Musazadeh, Ali Barzegar, Parviz Shahab. Profiling inflammatory mechanisms, hyperphosphorylated tau of hippocampal tissue and spatial memory following vitamin D3 treatment in the mice model of vascular dementia. International immunopharmacology. vol 120. 2023-05-23. PMID:37220695. |
profiling inflammatory mechanisms, hyperphosphorylated tau of hippocampal tissue and spatial memory following vitamin d3 treatment in the mice model of vascular dementia. |
2023-05-23 |
2023-08-14 |
mouse |
| Jafar Sadeghzadeh, Jaber Jafarzadeh, Pezhman Hadinezhad, Ahmad Nazari, Saeedeh Sohrabi, Vali Musazadeh, Ali Barzegar, Parviz Shahab. Profiling inflammatory mechanisms, hyperphosphorylated tau of hippocampal tissue and spatial memory following vitamin D3 treatment in the mice model of vascular dementia. International immunopharmacology. vol 120. 2023-05-23. PMID:37220695. |
the aim of this study was to investigate the effect of vitamin d3 (vitd3) on inflammatory mechanisms, hyperphosphorylated tau (p-tau) in the hippocampus, and cognitive impairment of the mouse model of vascular dementia (vad). |
2023-05-23 |
2023-08-14 |
mouse |
| Carola Tapia-Monsalves, Margrethe A Olesen, Francisca Villavicencio-Tejo, Rodrigo A Quintanill. Cyclosporine A (CsA) prevents synaptic impairment caused by truncated tau by caspase-3. Molecular and cellular neurosciences. 2023-05-14. PMID:37182572. |
we used mature hippocampal mice neurons to express a reporter protein (gfp, mcherry), coupled to full-length human tau protein (gfp-t4, mcherry-t4), and coupled to human tau protein cleaved at d421 by caspase-3 (gfp-t4c3, mcherry-t4c3) and synaptic elements were evaluated. |
2023-05-14 |
2023-08-14 |
mouse |
| Jianfeng Wu, Yi Su, Yanxi Chen, Wenhui Zhu, Eric M Reiman, Richard J Caselli, Kewei Chen, Paul M Thompson, Junwen Wang, Yalin Wan. A Surface-Based Federated Chow Test Model for Integrating APOE Status, Tau Deposition Measure, and Hippocampal Surface Morphometry. Journal of Alzheimer's disease : JAD. 2023-05-14. PMID:37182882. |
a surface-based federated chow test model for integrating apoe status, tau deposition measure, and hippocampal surface morphometry. |
2023-05-14 |
2023-08-14 |
Not clear |
| Jianfeng Wu, Yi Su, Yanxi Chen, Wenhui Zhu, Eric M Reiman, Richard J Caselli, Kewei Chen, Paul M Thompson, Junwen Wang, Yalin Wan. A Surface-Based Federated Chow Test Model for Integrating APOE Status, Tau Deposition Measure, and Hippocampal Surface Morphometry. Journal of Alzheimer's disease : JAD. 2023-05-14. PMID:37182882. |
tau neurofibrillary tangles are the primary driver of downstream neurodegeneration and subsequent cognitive impairment in ad, resulting in structural deformations such as hippocampal atrophy that can be observed in magnetic resonance imaging (mri) scans. |
2023-05-14 |
2023-08-14 |
Not clear |
| Qiyao Wang, Chenglong Xia, An Zhu, Yongjie Bao, Jiani Lu, Yuan Chen, Jiayi Xu, Binbin Wang, C Benjamin Naman, Liping Li, Qinwen Wang, Hao Liu, Hongze Liang, Wei Cu. Discrepancy of synaptic and microtubular protein phosphorylation in the hippocampus of APP/PS1 and MAPT×P301S transgenic mice at the early stage of Alzheimer's disease. Metabolic brain disease. 2023-05-09. PMID:37160613. |
thus in this study, a quantitative phosphoproteomics analysis was performed to evaluate global protein phosphorylation in the hippocampus of aβ overexpressing app/ps1 transgenic mice and tau overexpressing mapt×p301s transgenic mice, two in vivo ad model systems. |
2023-05-09 |
2023-08-14 |
mouse |
| Jessica Brown, Elena Camporesi, Juan Lantero-Rodriguez, Maria Olsson, Alice Wang, Blanca Medem, Henrik Zetterberg, Kaj Blennow, Thomas K Karikari, Mark Wall, Emily Hil. Tau in cerebrospinal fluid induces neuronal hyperexcitability and alters hippocampal theta oscillations. Acta neuropathologica communications. vol 11. issue 1. 2023-04-24. PMID:37095572. |
tau in cerebrospinal fluid induces neuronal hyperexcitability and alters hippocampal theta oscillations. |
2023-04-24 |
2023-08-14 |
mouse |
| Lydia Reinhardt, Fabrizio Musacchio, Maria Bichmann, Annika Behrendt, Ebru Ercan-Herbst, Juliane Stein, Isabelle Becher, Per Haberkant, Julia Mader, David C Schöndorf, Melanie Schmitt, Jürgen Korffmann, Peter Reinhardt, Christian Pohl, Mikhail Savitski, Corinna Klein, Laura Gasparini, Martin Fuhrmann, Dagmar E Ehrnhoefe. Dual truncation of tau by caspase-2 accelerates its CHIP-mediated degradation. Neurobiology of disease. 2023-04-22. PMID:37086756. |
caspase-2-generated tau fragments show increased aggregation potential in vitro, but do not accumulate in vivo after aav-mediated overexpression in mouse hippocampus. |
2023-04-22 |
2023-08-14 |
mouse |
| Christopher Daniel Morrone, Radha Raghuraman, S Abid Hussaini, Wai Haung Y. Proteostasis failure exacerbates neuronal circuit dysfunction and sleep impairments in Alzheimer's disease. Molecular neurodegeneration. vol 18. issue 1. 2023-04-21. PMID:37085942. |
canonical pathological hallmarks, β-amyloid, and tau, directly disrupt sleep, and neurodegeneration of locus coeruleus, hippocampal and hypothalamic neurons from tau proteinopathy causes disruption of the neuronal circuitry of sleep. |
2023-04-21 |
2023-08-14 |
Not clear |