| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dong Liu, Michael Pitta, Jong-Hwan Lee, Balmiki Ray, Debomoy K Lahiri, Katsutoshi Furukawa, Mohamed Mughal, Haiyang Jiang, Julissa Villarreal, Roy G Cutler, Nigel H Greig, Mark P Mattso. The KATP channel activator diazoxide ameliorates amyloid-\\xce\\xb2 and tau pathologies and improves memory in the 3xTgAD mouse model of Alzheimer's disease. Journal of Alzheimer's disease : JAD vol 22 issue 2 2011 20847430 |
3xtgad mice treated with diazoxide for 8 months exhibited improved performance in a learning and memory test, reduced levels of anxiety, decreased accumulation of a\xce\xb2 oligomers and hyperphosphorylated tau in the cortex and hippocampus, and increased cerebral blood flow. |
2011-03-09 |
2023-01-25 |
mouse |
| Xiao-Ping Hong, Cai-Xia Peng, Wei Wei, Qing Tian, Ying-Hua Liu, Xiu-Qing Yao, Yao Zhang, Fu-Yuan Cao, Qun Wang, Jian-Zhi Wan. Essential role of tau phosphorylation in adult hippocampal neurogenesis. Hippocampus vol 20 issue 12 2011 19816983 |
essential role of tau phosphorylation in adult hippocampal neurogenesis. |
2011-03-07 |
2023-01-25 |
rat |
| Xiao-Ping Hong, Cai-Xia Peng, Wei Wei, Qing Tian, Ying-Hua Liu, Xiu-Qing Yao, Yao Zhang, Fu-Yuan Cao, Qun Wang, Jian-Zhi Wan. Essential role of tau phosphorylation in adult hippocampal neurogenesis. Hippocampus vol 20 issue 12 2011 19816983 |
an increased hippocampal neurogenesis has been observed in alzheimer disease (ad), the most common neurodegenerative disorder characterized with accumulation of \xce\xb2-amyloid (a\xce\xb2) and hyperphosphorylated tau (p-tau). |
2011-03-07 |
2023-01-25 |
rat |
| Xiao-Ping Hong, Cai-Xia Peng, Wei Wei, Qing Tian, Ying-Hua Liu, Xiu-Qing Yao, Yao Zhang, Fu-Yuan Cao, Qun Wang, Jian-Zhi Wan. Essential role of tau phosphorylation in adult hippocampal neurogenesis. Hippocampus vol 20 issue 12 2011 19816983 |
a correlative increase of immature neuron markers and tau phosphorylation was induced in rat hippocampal dg by upregulating glycogen synthase kinase-3 (gsk-3), a crucial tau kinase, and the increased neurogenesis was due to an enhanced proliferation but not survival or differentiation of the newborn neurons. |
2011-03-07 |
2023-01-25 |
rat |
| Xiao-Ping Hong, Cai-Xia Peng, Wei Wei, Qing Tian, Ying-Hua Liu, Xiu-Qing Yao, Yao Zhang, Fu-Yuan Cao, Qun Wang, Jian-Zhi Wan. Essential role of tau phosphorylation in adult hippocampal neurogenesis. Hippocampus vol 20 issue 12 2011 19816983 |
the hippocampal neurogenesis was severely impaired in tau knockout mice and activation of gsk-3 in these mice did not rescue the deficits. |
2011-03-07 |
2023-01-25 |
rat |
| Xiao-Ping Hong, Cai-Xia Peng, Wei Wei, Qing Tian, Ying-Hua Liu, Xiu-Qing Yao, Yao Zhang, Fu-Yuan Cao, Qun Wang, Jian-Zhi Wan. Essential role of tau phosphorylation in adult hippocampal neurogenesis. Hippocampus vol 20 issue 12 2011 19816983 |
these results reveal an essential role of tau phosphorylation in adult hippocampal neurogenesis. |
2011-03-07 |
2023-01-25 |
rat |
| Odete A B da Cruz e Silva, Ana Gabriela Henriques, Sara Catarina Tim\\xc3\\xb3teo Santos Domingues, Edgar F da Cruz e Silv. Wnt signalling is a relevant pathway contributing to amyloid beta- peptide-mediated neuropathology in Alzheimer's disease. CNS & neurological disorders drug targets vol 9 issue 6 2011 20942790 |
individuals with alzheimer's disease (ad) exhibit extracellular senile plaques (sps) of aggregated a beta and intracellular neurofibrillary tangles that contain hyperphosphorylated tau protein (nfts), and also an extensive loss in basal forebrain cholinergic neurons that innervate the hippocampus and neocortex. |
2011-02-28 |
2023-01-25 |
Not clear |
| Azza Baraka, Samar ElGhotn. Study of the effect of inhibiting galanin in Alzheimer's disease induced in rats. European journal of pharmacology vol 641 issue 2-3 2011 20639139 |
i.c.v.-abeta also resulted in significant increase in hippocampal hyperphosphorylated tau protein as well as galanin. |
2011-01-31 |
2023-01-25 |
rat |
| Azza Baraka, Samar ElGhotn. Study of the effect of inhibiting galanin in Alzheimer's disease induced in rats. European journal of pharmacology vol 641 issue 2-3 2011 20639139 |
administration of studied antidiabetic drugs, glibenclamide and pioglitazone, resulted in significant improvement in spatial cognition and in learning and memory performance, as well as significant decrease in hippocampal hyperphosphorylated tau protein and hippocampal galanin. |
2011-01-31 |
2023-01-25 |
rat |
| Mirsada Cau\\xc5\\xa1evi\\xc4\\x87, Umbreen Farooq, Simon Lovestone, Richard Killic. \\xce\\xb2-Amyloid precursor protein and tau protein levels are differently regulated in human cerebellum compared to brain regions vulnerable to Alzheimer's type neurodegeneration. Neuroscience letters vol 485 issue 3 2011 20826196 |
unexpectedly, protein levels of glycogen synthase kinase 3 (gsk3), a major tau kinase, are at their lowest in hippocampus. |
2011-01-28 |
2023-01-25 |
human |
| Julie Blanchard, Lukas Wanka, Yunn-Chyn Tung, Mar\\xc3\\xada del Carmen C\\xc3\\xa1rdenas-Aguayo, Frank M LaFerla, Khalid Iqbal, Inge Grundke-Iqba. Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting A\\xce\\xb2 and tau pathologies in 3xTg-AD mice. Acta neuropathologica vol 120 issue 5 2011 20697724 |
although this treatment had no detectable effect on a\xce\xb2 and tau pathologies in 9-month animals, it enhanced neurogenesis in dentate gyrus, reduced ectopic birth in the granular cell layer, and increased neuronal plasticity in the hippocampus and cerebral cortex. |
2011-01-25 |
2023-01-25 |
mouse |
| Zhang Zhang, James W Simpkin. An okadaic acid-induced model of tauopathy and cognitive deficiency. Brain research vol 1359 issue 2011 20807517 |
these data suggest that the unilateral microinfusion of oa into the dorsal hippocampus causes cognitive deficiency, nfts-like pathological changes, and oxidative stress as seen in ad pathology via tau hyperphosphorylation caused by inhibition of protein phosphatases. |
2011-01-25 |
2023-01-25 |
rat |
| Seung-Yong Yoon, Jeong-Su Park, Jung-Eun Choi, Jin-Myung Choi, Woo-Je Lee, Seong-Who Kim, Dong-Hou Ki. Rosiglitazone reduces tau phosphorylation via JNK inhibition in the hippocampus of rats with type 2 diabetes and tau transfected SH-SY5Y cells. Neurobiology of disease vol 40 issue 2 2011 20655383 |
rosiglitazone reduces tau phosphorylation via jnk inhibition in the hippocampus of rats with type 2 diabetes and tau transfected sh-sy5y cells. |
2011-01-12 |
2023-01-25 |
rat |
| Seung-Yong Yoon, Jeong-Su Park, Jung-Eun Choi, Jin-Myung Choi, Woo-Je Lee, Seong-Who Kim, Dong-Hou Ki. Rosiglitazone reduces tau phosphorylation via JNK inhibition in the hippocampus of rats with type 2 diabetes and tau transfected SH-SY5Y cells. Neurobiology of disease vol 40 issue 2 2011 20655383 |
interestingly, rosiglitazone reduced tau phosphorylation only in the hippocampus of oletf type 2 diabetes rats, and not in that of stz-injected type 1 diabetes mice. |
2011-01-12 |
2023-01-25 |
rat |
| Seung-Yong Yoon, Jeong-Su Park, Jung-Eun Choi, Jin-Myung Choi, Woo-Je Lee, Seong-Who Kim, Dong-Hou Ki. Rosiglitazone reduces tau phosphorylation via JNK inhibition in the hippocampus of rats with type 2 diabetes and tau transfected SH-SY5Y cells. Neurobiology of disease vol 40 issue 2 2011 20655383 |
the activity of jnk was reduced in the hippocampus of rosiglitazone-treated oletf rats, correlating with a reduction in tau phosphorylation, however, which was not correlated with gsk3\xce\xb2 activity. |
2011-01-12 |
2023-01-25 |
rat |
| Jose F Abisambra, Laura J Blair, Shannon E Hill, Jeffrey R Jones, Clara Kraft, Justin Rogers, John Koren, Umesh K Jinwal, Lisa Lawson, Amelia G Johnson, Donna Wilcock, John C O'Leary, Karen Jansen-West, Martin Muschol, Todd E Golde, Edwin J Weeber, Jessica Banko, Chad A Dicke. Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 30 issue 46 2010 21084594 |
moreover, rapid decay in hippocampal long-term potentiation (ltp) intrinsic to this tau transgenic model was rescued by wild-type hsp27 overexpression but not by 3\xc3\x97s/d hsp27. |
2010-12-23 |
2023-01-25 |
Not clear |
| Stacey Fuller, Megan Steele, Gerald M\\xc3\\xbcnc. Activated astroglia during chronic inflammation in Alzheimer's disease--do they neglect their neurosupportive roles? Mutation research vol 690 issue 1-2 2010 19748514 |
alzheimer's disease (ad) is a neurodegenerative disorder, characterized histopathologically by the extracellular deposition of beta-amyloid peptide in senile plaques, as well as intracellular neurofibrillary tangles (nft) of hyperphosphorylated tau protein, extensive neuronal loss and synaptic changes in the hippocampus and cerebral cortex. |
2010-12-02 |
2023-01-25 |
Not clear |
| Ting Zhang, Bai-Shen Pan, Guang-Chun Sun, Xiao Sun, Feng-Yan Su. Diabetes synergistically exacerbates poststroke dementia and tau abnormality in brain. Neurochemistry international vol 56 issue 8 2010 20398714 |
moreover, we found that diabetes further increased at8, a marker of hyperphosphorylated tau, protein and immunopositive stained cells in the hippocampus of rats following mcao while reduced the level of phosphorylated glycogen synthase kinase 3-beta at serine-9 residues (p-ser9-gsk-3beta), indicating activation of gsk-3beta. |
2010-11-29 |
2023-01-25 |
rat |
| Gurdeep Marwarha, Bhanu Dasari, Jaya Prasanthi Rantham Prabhakara, Jared Schommer, Othman Ghrib. \\xce\\xb2-Amyloid regulates leptin expression and tau phosphorylation through the mTORC1 signaling pathway. Journal of neurochemistry vol 115 issue 2 2010 20670375 |
in this study, we show that incubation of organotypic slices from rabbit hippocampus with a\xce\xb2 down-regulates leptin expression, inhibits akt, activates gsk-3\xce\xb2, increases tau phosphorylation, and inactivates mtorc1. |
2010-11-22 |
2023-01-25 |
rabbit |
| Jes\\xc3\\xbas Avila, Elena G\\xc3\\xb3mez de Barreda, Tobias Engel, Jose J Lucas, F\\xc3\\xa9lix Hern\\xc3\\xa1nde. Tau phosphorylation in hippocampus results in toxic gain-of-function. Biochemical Society transactions vol 38 issue 4 2010 20658988 |
tau phosphorylation in hippocampus results in toxic gain-of-function. |
2010-11-12 |
2023-01-25 |
mouse |