| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hui-li Liu, Gang Zhao, He Zhang, Li-de Sh. Long-term treadmill exercise inhibits the progression of Alzheimer's disease-like neuropathology in the hippocampus of APP/PS1 transgenic mice. Behavioural brain research. vol 256. 2014-12-18. PMID:23968591. |
five months of treadmill exercise resulted in a robust reduction in β-amyloid (aβ) deposition and tau phosphorylation in the hippocampus of app/ps1 mice. |
2014-12-18 |
2023-08-12 |
mouse |
| Eric C Miller, Peter J Teravskis, Benjamin W Dummer, Xiaohui Zhao, Richard L Huganir, Dezhi Lia. Tau phosphorylation and tau mislocalization mediate soluble Aβ oligomer-induced AMPA glutamate receptor signaling deficits. The European journal of neuroscience. vol 39. issue 7. 2014-12-18. PMID:24713000. |
here, we show that tau mislocalizes to dendritic spines in cultured hippocampal neurons from appswe alzheimer's disease (ad)-transgenic mice and in cultured rat hippocampal neurons treated with soluble aβ oligomers. |
2014-12-18 |
2023-08-13 |
mouse |
| Ge Jin, Li-Hua Wang, Xue-Fei Ji, Tian-Yan Chi, Yue Qi, Qing Jiao, Qian Xu, Xiao-Yu Zhou, Rui Zhang, Li-Bo Zo. Xanthoceraside rescues learning and memory deficits through attenuating beta-amyloid deposition and tau hyperphosphorylation in APP mice. Neuroscience letters. vol 573. 2014-12-18. PMID:24810883. |
western blotting revealed that xanthoceraside decreased tau phosphorylation protein levels at ser396 and ser404 in the hippocampus; xanthoceraside also decreased app protein levels and gsk-3β phosphorylation. |
2014-12-18 |
2023-08-13 |
mouse |
| Shu Yang, Qihai Gong, Qin Wu, Fei Li, Yuanfu Lu, Jingshan Sh. Alkaloids enriched extract from Dendrobium nobile Lindl. attenuates tau protein hyperphosphorylation and apoptosis induced by lipopolysaccharide in rat brain. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 21. issue 5. 2014-12-15. PMID:24268296. |
the present study demonstrated that ednla attenuates lps-induced hyperphosphorylation of tau protein in rat's hippocampus and protects against lps-induced apoptosis in rat brain. |
2014-12-15 |
2023-08-12 |
rat |
| Tomohiro Onishi, Yoshio Matsumoto, Masahiko Hattori, Yuka Obayashi, Kimie Nakamura, Takashi Yano, Takashi Horiguchi, Hiroki Iwashit. Early-onset cognitive deficits and axonal transport dysfunction in P301S mutant tau transgenic mice. Neuroscience research. vol 80. 2014-12-04. PMID:24406748. |
tau phosphorylation in the hippocampus of tpr50 mice increased with age, particularly at s202/t205. |
2014-12-04 |
2023-08-12 |
mouse |
| Tomohiro Onishi, Yoshio Matsumoto, Masahiko Hattori, Yuka Obayashi, Kimie Nakamura, Takashi Yano, Takashi Horiguchi, Hiroki Iwashit. Early-onset cognitive deficits and axonal transport dysfunction in P301S mutant tau transgenic mice. Neuroscience research. vol 80. 2014-12-04. PMID:24406748. |
insolubilization and intracellular accumulation of tau were detected in the hippocampus by 9 months of age. |
2014-12-04 |
2023-08-12 |
mouse |
| Tomohiro Onishi, Yoshio Matsumoto, Masahiko Hattori, Yuka Obayashi, Kimie Nakamura, Takashi Yano, Takashi Horiguchi, Hiroki Iwashit. Early-onset cognitive deficits and axonal transport dysfunction in P301S mutant tau transgenic mice. Neuroscience research. vol 80. 2014-12-04. PMID:24406748. |
at this age or earlier, although no intracellular tau accumulation was observed in the hippocampus, abnormally increased microtubule (mt)-related proteins and mt hyperdynamics in the hippocampus, and impaired axonal transport in the septo-hippocampal pathway were already observed. |
2014-12-04 |
2023-08-12 |
mouse |
| Fangli Liu, Zhenfei Xue, Ning Li, Hui Huang, Yanyan Ying, Jin Li, Lin Wang, Wenjie L. Effects of lead exposure on the expression of amyloid β and phosphorylated tau proteins in the C57BL/6 mouse hippocampus at different life stages. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 28. issue 2. 2014-12-03. PMID:24582137. |
effects of lead exposure on the expression of amyloid β and phosphorylated tau proteins in the c57bl/6 mouse hippocampus at different life stages. |
2014-12-03 |
2023-08-12 |
mouse |
| Fangli Liu, Zhenfei Xue, Ning Li, Hui Huang, Yanyan Ying, Jin Li, Lin Wang, Wenjie L. Effects of lead exposure on the expression of amyloid β and phosphorylated tau proteins in the C57BL/6 mouse hippocampus at different life stages. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 28. issue 2. 2014-12-03. PMID:24582137. |
the objective of this study was to investigate the effects of lead exposure on spatial learning and memory capacity and the expression of amyloid β and phosphorylated tau proteins in the mouse hippocampus. |
2014-12-03 |
2023-08-12 |
mouse |
| Fangli Liu, Zhenfei Xue, Ning Li, Hui Huang, Yanyan Ying, Jin Li, Lin Wang, Wenjie L. Effects of lead exposure on the expression of amyloid β and phosphorylated tau proteins in the C57BL/6 mouse hippocampus at different life stages. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 28. issue 2. 2014-12-03. PMID:24582137. |
the protein expression of amyloid β and phosphorylated tau in the hippocampus was detected via western blot. |
2014-12-03 |
2023-08-12 |
mouse |
| Shunsuke Koga, Ayako Kojima, Satoshi Kuwabara, Yasumasa Yoshiyam. Immunohistochemical analysis of tau phosphorylation and astroglial activation with enhanced leptin receptor expression in diet-induced obesity mouse hippocampus. Neuroscience letters. vol 571. 2014-12-03. PMID:24785100. |
immunohistochemical analysis of tau phosphorylation and astroglial activation with enhanced leptin receptor expression in diet-induced obesity mouse hippocampus. |
2014-12-03 |
2023-08-13 |
mouse |
| Shunsuke Koga, Ayako Kojima, Satoshi Kuwabara, Yasumasa Yoshiyam. Immunohistochemical analysis of tau phosphorylation and astroglial activation with enhanced leptin receptor expression in diet-induced obesity mouse hippocampus. Neuroscience letters. vol 571. 2014-12-03. PMID:24785100. |
dio caused tau phosphorylation and astroglial activation in the hippocampus in wt mice. |
2014-12-03 |
2023-08-13 |
mouse |
| Shunsuke Koga, Ayako Kojima, Satoshi Kuwabara, Yasumasa Yoshiyam. Immunohistochemical analysis of tau phosphorylation and astroglial activation with enhanced leptin receptor expression in diet-induced obesity mouse hippocampus. Neuroscience letters. vol 571. 2014-12-03. PMID:24785100. |
although phosphorylated tau staining was only observed in the hippocampus, astrogliosis and microgliosis were present in both the amygdala and hippocampus. |
2014-12-03 |
2023-08-13 |
mouse |
| Shunsuke Koga, Ayako Kojima, Satoshi Kuwabara, Yasumasa Yoshiyam. Immunohistochemical analysis of tau phosphorylation and astroglial activation with enhanced leptin receptor expression in diet-induced obesity mouse hippocampus. Neuroscience letters. vol 571. 2014-12-03. PMID:24785100. |
our results demonstrate for the first time that dio causes tau phosphorylation and that astrocytic lepr might be involved in the pathological process in wt mouse hippocampus. |
2014-12-03 |
2023-08-13 |
mouse |
| Yun Zhang, Liyun Chen, Guangli Shen, Qian Zhao, Lijuan Shangguan, Maolin H. GRK5 dysfunction accelerates tau hyperphosphorylation in APP (swe) mice through impaired cholinergic activity. Neuroreport. vol 25. issue 7. 2014-11-28. PMID:24598771. |
grk dysfunction also promotes a deleterious cycle that further increases β-amyloid accumulation and exaggerates tau hyperphosphorylation in the hippocampus. |
2014-11-28 |
2023-08-12 |
mouse |
| Yun Zhang, Liyun Chen, Guangli Shen, Qian Zhao, Lijuan Shangguan, Maolin H. GRK5 dysfunction accelerates tau hyperphosphorylation in APP (swe) mice through impaired cholinergic activity. Neuroreport. vol 25. issue 7. 2014-11-28. PMID:24598771. |
moreover, treatment with methoctramine, a selective m2 antagonist, partially corrected the difference between wild-type control mice and grk5-dysfunctional app (swe) mice in hippocampal ach release, pkc and gsk3β activities, as well as tau hyperphosphorylation. |
2014-11-28 |
2023-08-12 |
mouse |
| Kristyn Bates, Robert Vink, Ralph Martins, Alan Harve. Aging, cortical injury and Alzheimer's disease-like pathology in the guinea pig brain. Neurobiology of aging. vol 35. issue 6. 2014-11-25. PMID:24360504. |
diffuse deposits of aβ were found in the hippocampal region of the oldest animals and alterations in amyloid precursor protein processing and tau immunoreactivity were observed with age. |
2014-11-25 |
2023-08-12 |
human |
| T L Briones, H Darwis. Decrease in age-related tau hyperphosphorylation and cognitive improvement following vitamin D supplementation are associated with modulation of brain energy metabolism and redox state. Neuroscience. vol 262. 2014-11-24. PMID:24412233. |
tau phosphorylation, markers of brain energy metabolism (adp/atp ratio and adenosine monophosphate-activated protein kinase) and redox state (levels of reactive oxygen species, activity of superoxide dismutase, and glutathione levels) as well as pp2a activity were measured in hippocampal tissues. |
2014-11-24 |
2023-08-12 |
rat |
| Lai-Ling Du, Jia-Zhao Xie, Xiang-Shu Cheng, Xiao-Hong Li, Fan-Li Kong, Xia Jiang, Zhi-Wei Ma, Jian-Zhi Wang, Chen Chen, Xin-Wen Zho. Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi. Age (Dordrecht, Netherlands). vol 36. issue 2. 2014-11-18. PMID:24142524. |
in conclusion, sirt1 protects hippocampus neurons from tau hyperphosphorylation and prevents cognitive impairment induced by icv-stz brain insulin resistance with decreased hippocampus erk1/2 activity. |
2014-11-18 |
2023-08-12 |
rat |
| Huda S Darusman, Jacub Pandelaki, Rahmad Mulyadi, Dondin Sajuthi, Indah A Putri, Otto H Kalliokoski, Josep Call, Klas S P Abelson, Steven J Schapiro, Albert Gjedde, Jann Ha. Poor memory performance in aged cynomolgus monkeys with hippocampal atrophy, depletion of amyloid beta 1-42 and accumulation of tau proteins in cerebrospinal fluid. In vivo (Athens, Greece). vol 28. issue 2. 2014-11-06. PMID:24632970. |
poor memory performance in aged cynomolgus monkeys with hippocampal atrophy, depletion of amyloid beta 1-42 and accumulation of tau proteins in cerebrospinal fluid. |
2014-11-06 |
2023-08-12 |
monkey |