| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kunie Ando, Karelle Leroy, C\\xc3\\xa9line Heraud, Anna Kabova, Zehra Yilmaz, Mich\\xc3\\xa8le Authelet, Val\\xc3\\xa8rie Suain, Robert De Decker, Jean-Pierre Brio. Deletion of murine tau gene increases tau aggregation in a human mutant tau transgenic mouse model. Biochemical Society transactions vol 38 issue 4 2010 20658993 |
whereas tg30xtauko mice express fewer tau proteins compared with tg30tau, they exhibit augmented sarkosyl-insoluble tau in the brain and an increased number of gallyas-positive nfts in the hippocampus. |
2010-11-12 |
2023-01-25 |
mouse |
| Jie Yan, Xiao-Bo Sun, Hong-Quan Wang, Hong Zhao, Xiao-Yan Zhao, Yu-Xia Xu, Jing-Chun Guo, Cui-Qing Zh. Chronic restraint stress alters the expression and distribution of phosphorylated tau and MAP2 in cortex and hippocampus of rat brain. Brain research vol 1347 issue 2010 20513368 |
chronic restraint stress alters the expression and distribution of phosphorylated tau and map2 in cortex and hippocampus of rat brain. |
2010-11-02 |
2023-01-25 |
rat |
| Jie Yan, Xiao-Bo Sun, Hong-Quan Wang, Hong Zhao, Xiao-Yan Zhao, Yu-Xia Xu, Jing-Chun Guo, Cui-Qing Zh. Chronic restraint stress alters the expression and distribution of phosphorylated tau and MAP2 in cortex and hippocampus of rat brain. Brain research vol 1347 issue 2010 20513368 |
robust hyperphosphorylated tau immunolabeling was observed both in cortex and hippocampus of stressed animals and mainly located to perikaryal/dendritic elements. |
2010-11-02 |
2023-01-25 |
rat |
| C K\\xc3\\xb6hler, P Bista, J G\\xc3\\xb6tz, H Schr\\xc3\\xb6de. Analysis of the cholinergic pathology in the P301L tau transgenic pR5 model of tauopathy. Brain research vol 1347 issue 2010 20513372 |
to test the suitability of the pr5 model as a model of alzheimer's disease concerning the cholinergic innervation of the telencephalon, we determined the expression of the human tau transgene and the presence of neurofibrillary changes in the basal nucleus of meynert, the septal nuclei and the diagonal band of broca, sources of cholinergic innervation of the cerebral cortex and hippocampus. |
2010-11-02 |
2023-01-25 |
mouse |
| Niall M Corcoran, Daniel Martin, Birgit Hutter-Paier, Manfred Windisch, Thanh Nguyen, Lina Nheu, Lars E Sundstrom, Anthony J Costello, Christopher M Hoven. Sodium selenate specifically activates PP2A phosphatase, dephosphorylates tau and reverses memory deficits in an Alzheimer's disease model. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia vol 17 issue 8 2010 20537899 |
sodium selenate-treated transgenic tau441 mice had significantly lower levels of phospho- and total tau levels in the hippocampus and amygdala compared with controls and exhibited significantly improved spatial learning and memory on the morris water maze task. |
2010-10-19 |
2023-01-25 |
mouse |
| Kimiaki Hashiguchi, Takato Morioka, Nobuya Murakami, Satoshi O Suzuki, Akio Hiwatashi, Takashi Yoshiura, Tomio Sasak. Utility of 3-T FLAIR and 3D short tau inversion recovery MR imaging in the preoperative diagnosis of hippocampal sclerosis: direct comparison with 1.5-T FLAIR MR imaging. Epilepsia vol 51 issue 9 2010 20738382 |
utility of 3-t flair and 3d short tau inversion recovery mr imaging in the preoperative diagnosis of hippocampal sclerosis: direct comparison with 1.5-t flair mr imaging. |
2010-10-15 |
2023-01-25 |
Not clear |
| Kimiaki Hashiguchi, Takato Morioka, Nobuya Murakami, Satoshi O Suzuki, Akio Hiwatashi, Takashi Yoshiura, Tomio Sasak. Utility of 3-T FLAIR and 3D short tau inversion recovery MR imaging in the preoperative diagnosis of hippocampal sclerosis: direct comparison with 1.5-T FLAIR MR imaging. Epilepsia vol 51 issue 9 2010 20738382 |
to examine the utility of fluid-attenuated inversion recovery (flair) imaging and three-dimensional short tau inversion recovery (3dstir) imaging using a 3-tesla (3-t) magnetic resonance (mr) imager in the preoperative evaluation of hippocampal sclerosis (hs). |
2010-10-15 |
2023-01-25 |
Not clear |
| Osamu Yokota, Yvonne Davidson, Eileen H Bigio, Hideki Ishizu, Seishi Terada, Tetsuaki Arai, Masato Hasegawa, Haruhiko Akiyama, Stephen Sikkink, Stuart Pickering-Brown, David M A Man. Phosphorylated TDP-43 pathology and hippocampal sclerosis in progressive supranuclear palsy. Acta neuropathologica vol 120 issue 1 2010 20512649 |
tdp-43 and tau were frequently colocalized in the amygdala, but not in the hippocampal dentate gyrus. |
2010-10-14 |
2023-01-25 |
Not clear |
| Miao-Kun Sun, Daniel L Alko. Pharmacology of protein kinase C activators: cognition-enhancing and antidementic therapeutics. Pharmacology & therapeutics vol 127 issue 1 2010 20382181 |
pkc activators not only increase activity of pkc isozymes and thereby restore pkc signaling activity, including neurotrophic activity, synaptic/structural remodeling, and synaptogenesis in the hippocampus and related cortical areas, but also reduce the accumulation of neurotoxic amyloid and tau protein hyperphosphorylation in the brain. |
2010-10-07 |
2023-01-25 |
Not clear |
| Juan Deng, Cheng Shen, Yan-Jiang Wang, Meng Zhang, Jing Li, Zhi-Qiang Xu, Chang-Yue Gao, Chuan-Qing Fang, Hua-Dong Zho. Nicotine exacerbates tau phosphorylation and cognitive impairment induced by amyloid-beta 25-35 in rats. European journal of pharmacology vol 637 issue 1-3 2010 20363218 |
the present study investigated the effect of nicotine on tau phosphorylation and cognitive impairment induced by hippocampus injections of amyloid-beta (abeta) 25-35. |
2010-09-07 |
2023-01-25 |
rat |
| Juan Deng, Cheng Shen, Yan-Jiang Wang, Meng Zhang, Jing Li, Zhi-Qiang Xu, Chang-Yue Gao, Chuan-Qing Fang, Hua-Dong Zho. Nicotine exacerbates tau phosphorylation and cognitive impairment induced by amyloid-beta 25-35 in rats. European journal of pharmacology vol 637 issue 1-3 2010 20363218 |
the data show that nicotine (1mg/kg in base weight) treatment significantly exacerbates cognitive impairment and tau phosphorylation at ser-202 and thr-231 in the hippocampus compared with abeta25-35 injection groups in the abeta rat model of alzheimer's disease. |
2010-09-07 |
2023-01-25 |
rat |
| Giovanni B Frison. Alzheimer's disease neuroimaging initiative in Europe. Alzheimer's & dementia : the journal of the Alzheimer's Association vol 6 issue 3 2010 20451877 |
because the adni platform was first imported in europe, thanks to the pilot european adni, several adni-related initiatives have flourished, funded by the european commission's 7th framework programme, national governments, and the alzheimer's association aimed at: (i) collecting fresh data adni style (fp7 addneuromed, innovative medicine initiative pharma-cog/european adni, swedish adni, and italian adni); (ii) developing standard operational procedures for the collection of markers (international harmonization of csf abeta42 and tau, and european alzheimer's disease consortium-adni harmonization of hippocampal volumetry); and (iii) developing infrastructures for the treatment of adni data (fp7 neugrid and outgrid, and the french centre pour l'acquisition et le traitement de l'image). |
2010-08-11 |
2023-01-25 |
Not clear |
| N Li, Z L Yu, L Wang, Y T Zheng, J X Jia, Q Wang, M J Zhu, X L Liu, X Xia, W J L. Increased tau phosphorylation and beta amyloid in the hipocampus of mouse pups by early life lead exposure. Acta biologica Hungarica vol 61 issue 2 2010 20519167 |
the aim of this study was to investigate the effects of maternal lead exposure on the learning and memory ability and expression of tau protein phosphorylation (p-tau) and beta amyloid protein (abeta) in hippocampus of mice offspring. |
2010-08-10 |
2023-01-25 |
mouse |
| N Li, Z L Yu, L Wang, Y T Zheng, J X Jia, Q Wang, M J Zhu, X L Liu, X Xia, W J L. Increased tau phosphorylation and beta amyloid in the hipocampus of mouse pups by early life lead exposure. Acta biologica Hungarica vol 61 issue 2 2010 20519167 |
tau hyper-phosphorylation and abeta increase in the hippocampus of pups may contribute to the impairment of learning and memory associated with maternal pb exposure. |
2010-08-10 |
2023-01-25 |
mouse |
| Yuan-Shih Hu, Peng Xu, Gustavo Pigino, Scott T Brady, John Larson, Orly Lazaro. Complex environment experience rescues impaired neurogenesis, enhances synaptic plasticity, and attenuates neuropathology in familial Alzheimer's disease-linked APPswe/PS1DeltaE9 mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol 24 issue 6 2010 20086049 |
enhanced neurogenesis was accompanied by a significant reduction in levels of hyperphosphorylated tau and oligomeric abeta, the precursors of ad hallmarks, in the hippocampus and cortex of enriched mice. |
2010-07-21 |
2023-01-25 |
mouse |
| Luis Escribano, Ana-Mar\\xc3\\xada Sim\\xc3\\xb3n, Esther Gimeno, Mar Cuadrado-Tejedor, Rakel L\\xc3\\xb3pez de Maturana, Ana Garc\\xc3\\xada-Osta, Ana Ricobaraza, Alberto P\\xc3\\xa9rez-Mediavilla, Joaqu\\xc3\\xadn Del R\\xc3\\xado, Diana Frechill. Rosiglitazone rescues memory impairment in Alzheimer's transgenic mice: mechanisms involving a reduced amyloid and tau pathology. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology vol 35 issue 7 2010 20336061 |
in the hippocampus, neuropil threads containing phosphorylated tau, probably corresponding to dystrophic neurites, were also decreased by the drug. |
2010-07-09 |
2023-01-25 |
mouse |
| Ayodeji A Asuni, V Hugh Perry, Vincent O'Conno. Change in tau phosphorylation associated with neurodegeneration in the ME7 model of prion disease. Biochemical Society transactions vol 38 issue 2 2010 20298219 |
we have investigated the expression of hyperphosphorylated tau in the hippocampus of mice infected with the me7 prion agent. |
2010-06-11 |
2023-01-25 |
mouse |
| Fa-Fa Tian, Chang Zeng, Yun-Feng Ma, Ting-Hui Guo, Jin-Mei Chen, Ying Chen, Xiao-Feng Cai, Feng-Rong Li, Xin-Hua Wang, Wen-Jiao Huang, Yu-Zhong Wan. Potential roles of Cdk5/p35 and tau protein in hippocampal mossy fiber sprouting in the PTZ kindling model. Clinical laboratory vol 56 issue 3-4 2010 20476644 |
potential roles of cdk5/p35 and tau protein in hippocampal mossy fiber sprouting in the ptz kindling model. |
2010-06-03 |
2023-01-25 |
Not clear |
| Tohru Hasegawa, Nobuyuki Mikoda, Masashi Kitazawa, Frank M LaFerl. Treatment of Alzheimer's disease with anti-homocysteic acid antibody in 3xTg-AD male mice. PloS one vol 5 issue 1 2010 20098691 |
four-month-old prepathological 3xtg-ad mice exhibited higher levels of ha in the hippocampus than did age-matched nontransgenic mice, suggesting that ha accumulation may precede both abeta and tau pathologies. |
2010-05-20 |
2023-01-25 |
mouse |
| Silvia Josefina L\\xc3\\xb3pez-P\\xc3\\xa9rez, M\\xc3\\xb3nica Elisa Ure\\xc3\\xb1a-Guerrero, Alberto Morales-Villagr\\xc3\\xa1. Monosodium glutamate neonatal treatment as a seizure and excitotoxic model. Brain research vol 1317 issue 2010 20043888 |
glu levels and hippocampal total content of related amino acids (asp, glu, gln, gly, tau, ala and gaba) were estimated before, immediately and after each injection. |
2010-05-19 |
2023-01-25 |
rat |