| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alberto Serrano-Pozo, Christopher M William, Isidro Ferrer, Emmanuelle Uro-Coste, Marie-Bernadette Delisle, Claude-Alain Maurage, Christoph Hock, Roger M Nitsch, Eliezer Masliah, John H Growdon, Matthew P Frosch, Bradley T Hyma. Beneficial effect of human anti-amyloid-beta active immunization on neurite morphology and tau pathology. Brain : a journal of neurology vol 133 issue Pt 5 2010 20360050 |
anti-amyloid-beta immunization might also ameliorate the hippocampal tau pathology through a decrease in tau phosphorylation. |
2010-05-17 |
2023-01-25 |
human |
| Naoto Oikawa, Nobuyuki Kimura, Katsuhiko Yanagisaw. Alzheimer-type tau pathology in advanced aged nonhuman primate brains harboring substantial amyloid deposition. Brain research vol 1315 issue 2010 20004650 |
to examine the accumulation of deposited abeta, phosphorylated tau accumulation, intracellular tau accumulation, and neurofibrillary tangle formation, the brains, mainly temporal cortex and hippocampus, of 34 cynomolgus monkeys aged 6 to 36 years were studied by biochemical and histochemical analyses. |
2010-05-06 |
2023-01-25 |
monkey |
| Naoto Oikawa, Nobuyuki Kimura, Katsuhiko Yanagisaw. Alzheimer-type tau pathology in advanced aged nonhuman primate brains harboring substantial amyloid deposition. Brain research vol 1315 issue 2010 20004650 |
histologically, intraneuronal and intraoligodendroglial tau accumulation was observed in temporal cortex and hippocampus of animals before the age of 20. |
2010-05-06 |
2023-01-25 |
monkey |
| Balu Chakravarthy, Chantal Gaudet, Michel M\\xc3\\xa9nard, Trevor Atkinson, Leslie Brown, Frank M Laferla, Ubaldo Armato, James Whitfiel. Amyloid-beta peptides stimulate the expression of the p75(NTR) neurotrophin receptor in SHSY5Y human neuroblastoma cells and AD transgenic mice. Journal of Alzheimer's disease : JAD vol 19 issue 3 2010 20157247 |
specifically, the level of the p75(ntr) receptor in the hippocampal membranes from 12-15 month old ad-triple transgenic mice (3xtg-ad) harboring ps1 (m146v), abetapp (swe), and tau (p301l) was nearly twice that in hippocampal membranes from age-matched wild-type mice. |
2010-05-05 |
2023-01-25 |
mouse |
| Chun Lai Nie, Yan Wei, Xinyong Chen, Yan Ying Liu, Wen Dui, Ying Liu, Martyn C Davies, Saul J B Tendler, Rong Giao H. Formaldehyde at low concentration induces protein tau into globular amyloid-like aggregates in vitro and in vivo. PloS one vol 2 issue 7 2010 17637844 |
our previous results show that neuronal tau aggregates in formaldehyde solution and that aggregated tau induces apoptosis of sh-sy5y and hippocampal cells. |
2010-04-23 |
2023-01-24 |
cattle |
| Karelle Leroy, Kunie Ando, C\\xc3\\xa9line H\\xc3\\xa9raud, Zehra Yilmaz, Mich\\xc3\\xa8le Authelet, Jean-Marie Boeynaems, Luc Bu\\xc3\\xa9e, Robert De Decker, Jean-Pierre Brio. Lithium treatment arrests the development of neurofibrillary tangles in mutant tau transgenic mice with advanced neurofibrillary pathology. Journal of Alzheimer's disease : JAD vol 19 issue 2 2010 20110614 |
nevertheless, this study indicates that even a relatively short-term per os treatment leading to high blood concentration of lithium is effective in arresting the formation of nfts in the hippocampus and the spinal cord of a tau transgenic model. |
2010-04-06 |
2023-01-25 |
mouse |
| Yang-Yang Yin, Hao Liu, Xiao-Bin Cong, Zhao Liu, Qun Wang, Jian-Zhi Wang, Ling-Qiang Zh. Acetyl-L-carnitine attenuates okadaic acid induced tau hyperphosphorylation and spatial memory impairment in rats. Journal of Alzheimer's disease : JAD vol 19 issue 2 2010 20110616 |
inhibition of pp2a through hippocampal injection of okadaic acid (oa) induces tau hyperphosphorylation and memory impairment of rats. |
2010-04-06 |
2023-01-25 |
rat |
| Tomasz Jaworski, Ilse Dewachter, Benoit Lechat, Sophie Croes, Annelies Termont, David Demedts, Peter Borghgraef, Herman Devijver, Robert K Filipkowski, Leszek Kaczmarek, Sebastian K\\xc3\\xbcgler, Fred Van Leuve. AAV-tau mediates pyramidal neurodegeneration by cell-cycle re-entry without neurofibrillary tangle formation in wild-type mice. PloS one vol 4 issue 10 2010 19794916 |
here, we approached the problem in non-transgenic models by intracerebral injection of adeno-associated viral vectors to express protein tau or amyloid precursor protein in the hippocampus in vivo. |
2010-03-12 |
2023-01-25 |
mouse |
| Masatake Fujimura, Fusako Usuki, Masumi Sawada, Akihiko Takashim. Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-N-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain. Neurotoxicology vol 30 issue 6 2010 19666049 |
methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-n-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain. |
2010-03-09 |
2023-01-25 |
mouse |
| Masatake Fujimura, Fusako Usuki, Masumi Sawada, Akihiko Takashim. Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-N-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain. Neurotoxicology vol 30 issue 6 2010 19666049 |
neither neuropathological changes nor tau hyperphosphorylation was detected in the hippocampus in this study although the mercury concentration here was twice that in the cerebral cortex. |
2010-03-09 |
2023-01-25 |
mouse |
| Masatake Fujimura, Fusako Usuki, Masumi Sawada, Akihiko Takashim. Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-N-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain. Neurotoxicology vol 30 issue 6 2010 19666049 |
these findings suggest that mehg exposure induces tau hyperphosphorylation at specific sites of tau mainly through the activation of jnk pathways, leading to neuropathological changes in the cerebral cortex selectively, but not in the hippocampus of mouse brain. |
2010-03-09 |
2023-01-25 |
mouse |
| L Lecanu, G Rammouz, A McCourty, E K Sidahmed, J Greeson, V Papadopoulo. Caprospinol reduces amyloid deposits and improves cognitive function in a rat model of Alzheimer's disease. Neuroscience vol 165 issue 2 2010 19850110 |
this recovery of cognitive function was accompanied by a reduction in hippocampal amyloid deposits, astrogliosis, neurodegeneration and tau protein phopshorylation. |
2010-02-24 |
2023-01-25 |
rat |
| Masaoki Takano, Mieko Otani, Akiko Sakai, Keiichi Kadoyama, Shogo Matsuyama, Akira Matsumoto, Mariko Takenokuchi, Miho Sumida, Taizo Taniguch. Use of a phosphosensor dye in proteomic analysis of human mutant tau transgenic mice. Neuroreport vol 20 issue 18 2010 19898260 |
to investigate how tau dysfunctions cause these features, we examined the expression and phosphorylation levels in sjlb mouse hippocampal proteins using a phosphosensor dye in two-dimensional poly acrylamide gel electrophoresis analysis and mass spectrometry. |
2010-02-01 |
2023-01-25 |
mouse |
| Bhumsoo Kim, Carey Backus, Sangsu Oh, John M Hayes, Eva L Feldma. Increased tau phosphorylation and cleavage in mouse models of type 1 and type 2 diabetes. Endocrinology vol 150 issue 12 2010 19819959 |
tau phosphorylation is increased in the cortex and hippocampus of db/db mice compared with db+ control mouse brain. |
2010-01-19 |
2023-01-25 |
mouse |
| Steffen Albrecht, Nenad Bogdanovic, Bernardino Ghetti, Bengt Winblad, Andr\\xc3\\xa9a C LeBlan. Caspase-6 activation in familial alzheimer disease brains carrying amyloid precursor protein or presenilin i or presenilin II mutations. Journal of neuropathology and experimental neurology vol 68 issue 12 2009 19915487 |
to determine whether casp-6 is also activated in familial ad, we performed an immunohistochemical analysis of active casp-6 and tau cleaved by casp-6 in temporal cortex and hippocampal tissue sections from cases of familial ad. |
2009-12-22 |
2023-01-25 |
Not clear |
| Robert A Rissma. Stress-induced tau phosphorylation: functional neuroplasticity or neuronal vulnerability? Journal of Alzheimer's disease : JAD vol 18 issue 2 2009 19584431 |
despite its association with disease, tau phosphorylation (tau-p) also plays an important role in neuroplasticity, such as dendritic/synaptic remodeling seen in the hippocampus in response to environmental challenges, such as stress. |
2009-12-17 |
2023-01-25 |
Not clear |
| Zheng Jing, John Caltagarone, Robert Bowse. Altered subcellular distribution of c-Abl in Alzheimer's disease. Journal of Alzheimer's disease : JAD vol 17 issue 2 2009 19363261 |
activated isoforms of c-abl were most abundant in ad hippocampus and co-localized with ad pathology, including granulovacuolar degeneration bodies, c-abl interacts with phosphorylated tau in ad brain and may contribute to the formation of tau pathology. |
2009-12-16 |
2023-01-25 |
human |
| Pu Chen, Aiguo Shen, Wei Zhao, Seong-Joon Baek, Hua Yuan, Jiming H. Raman signature from brain hippocampus could aid Alzheimer's disease diagnosis. Applied optics vol 48 issue 24 2009 19696863 |
the biochemical changes of brain hippocampus tissue including the deposit of beta-amyloid (abeta) protein, the increase of cholesterol, and hyperphosphorylated tau are observed through mrs when ad occurs. |
2009-11-04 |
2023-01-25 |
rat |
| Estelle Leclerc, Emmanuel Sturchler, Stefan W Vetter, Claus W Heizman. Crosstalk between calcium, amyloid beta and the receptor for advanced glycation endproducts in Alzheimer's disease. Reviews in the neurosciences vol 20 issue 2 2009 19774788 |
hallmarks of alzheimer's disease (ad) include the accumulation of amyloid beta peptide (abeta), hyperphosphorylation of tau protein, and increased inflammatory activity in the hippocampus and cerebral cortex. |
2009-10-20 |
2023-01-25 |
Not clear |
| N Schuff, N Woerner, L Boreta, T Kornfield, L M Shaw, J Q Trojanowski, P M Thompson, C R Jack, M W Weine. MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers. Brain : a journal of neurology vol 132 issue Pt 4 2009 19251758 |
6-12 months, with mri in the large multicentre setting of the alzheimer's disease neuroimaging initiative (adni); (ii) to determine the extent to which the polymorphism of the apolipoprotein e (apoe) gene modulates hippocampal change; and (iii) to determine if rates of hippocampal loss correlate with cerebrospinal fluid (csf) biomarkers of alzheimer's disease, such as the beta-amyloid (abeta(1-42)) and tau proteins (tau). |
2009-10-01 |
2023-01-25 |
Not clear |