| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zheng Jing, John Caltagarone, Robert Bowse. Altered subcellular distribution of c-Abl in Alzheimer's disease. Journal of Alzheimer's disease : JAD vol 17 issue 2 2009 19363261 |
activated isoforms of c-abl were most abundant in ad hippocampus and co-localized with ad pathology, including granulovacuolar degeneration bodies, c-abl interacts with phosphorylated tau in ad brain and may contribute to the formation of tau pathology. |
2009-12-16 |
2023-01-25 |
human |
| Pu Chen, Aiguo Shen, Wei Zhao, Seong-Joon Baek, Hua Yuan, Jiming H. Raman signature from brain hippocampus could aid Alzheimer's disease diagnosis. Applied optics vol 48 issue 24 2009 19696863 |
the biochemical changes of brain hippocampus tissue including the deposit of beta-amyloid (abeta) protein, the increase of cholesterol, and hyperphosphorylated tau are observed through mrs when ad occurs. |
2009-11-04 |
2023-01-25 |
rat |
| Estelle Leclerc, Emmanuel Sturchler, Stefan W Vetter, Claus W Heizman. Crosstalk between calcium, amyloid beta and the receptor for advanced glycation endproducts in Alzheimer's disease. Reviews in the neurosciences vol 20 issue 2 2009 19774788 |
hallmarks of alzheimer's disease (ad) include the accumulation of amyloid beta peptide (abeta), hyperphosphorylation of tau protein, and increased inflammatory activity in the hippocampus and cerebral cortex. |
2009-10-20 |
2023-01-25 |
Not clear |
| N Schuff, N Woerner, L Boreta, T Kornfield, L M Shaw, J Q Trojanowski, P M Thompson, C R Jack, M W Weine. MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers. Brain : a journal of neurology vol 132 issue Pt 4 2009 19251758 |
6-12 months, with mri in the large multicentre setting of the alzheimer's disease neuroimaging initiative (adni); (ii) to determine the extent to which the polymorphism of the apolipoprotein e (apoe) gene modulates hippocampal change; and (iii) to determine if rates of hippocampal loss correlate with cerebrospinal fluid (csf) biomarkers of alzheimer's disease, such as the beta-amyloid (abeta(1-42)) and tau proteins (tau). |
2009-10-01 |
2023-01-25 |
Not clear |
| N Schuff, N Woerner, L Boreta, T Kornfield, L M Shaw, J Q Trojanowski, P M Thompson, C R Jack, M W Weine. MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers. Brain : a journal of neurology vol 132 issue Pt 4 2009 19251758 |
moreover, increased rates of hippocampal loss were associated with presence of the apoe allele epsilon4 gene in alzheimer's disease and lower csf abeta(1-42) in mild cognitive impairment, irrespective of apoe genotype, whereas relations with tau were only trends. |
2009-10-01 |
2023-01-25 |
Not clear |
| Henrik Viber. Exposure to polybrominated diphenyl ethers 203 and 206 during the neonatal brain growth spurt affects proteins important for normal neurodevelopment in mice. Toxicological sciences : an official journal of the Society of Toxicology vol 109 issue 2 2009 19380496 |
furthermore, there were no significant changes in the levels of gap-43 and tau in the cerebral cortex or hippocampus after neonatal exposure to pbde 203 or 206. |
2009-09-03 |
2023-01-25 |
rat |
| Marta Barrachina, Isidre Ferre. DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain. Journal of neuropathology and experimental neurology vol 68 issue 8 2009 19606065 |
dna methylation was analyzed in selected regions of mapt, app, and psen1 in the frontal cortex and hippocampus of controls (n=26) and those with alzheimer disease at stages i to ii (n=17); alzheimer disease at stages iii to iv (n=15); alzheimer disease at stages v to vi (n=12); argyrophilic grain disease (n=10); frontotemporal lobar degeneration linked to tau mutations (n=6); frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions (n=4); frontotemporal lobar degeneration with motor neuron disease (n=3); pick disease (n=3); parkinson disease (n=8); dementia with lewy bodies, pure form (n=5); and dementia with lewy bodies, common form (n=15). |
2009-09-01 |
2023-01-25 |
human |
| Elaine Cristina Pereira, Daniel Luna Lucetti, Jos\\xc3\\xa9 Maria Barbosa-Filho, Eliane Magalh\\xc3\\xa3es de Brito, Vald\\xc3\\xa9cio Silvano Monteiro, Manoel Cl\\xc3\\xa1udio Azevedo Patroc\\xc3\\xadnio, Rebeca Ribeiro de Moura, Luzia Kalyne Almeida Moreira Leal, Danielle Silveira Macedo, Francisca Cl\\xc3\\xa9a Floren\\xc3\\xa7o de Sousa, Glauce Socorro de Barros Viana, Silv\\xc3\\xa2nia Maria Mendes Vasconcelo. Coumarin effects on amino acid levels in mice prefrontal cortex and hippocampus. Neuroscience letters vol 454 issue 2 2009 19429071 |
the present work evaluated the effect of coumarin administration on the levels of gamma-aminobutyric acid (gaba), glutamate (glu), glycine (gly) and taurine (tau) in the prefrontal cortex and hippocampus of mice. |
2009-08-17 |
2023-01-25 |
mouse |
| Elaine Cristina Pereira, Daniel Luna Lucetti, Jos\\xc3\\xa9 Maria Barbosa-Filho, Eliane Magalh\\xc3\\xa3es de Brito, Vald\\xc3\\xa9cio Silvano Monteiro, Manoel Cl\\xc3\\xa1udio Azevedo Patroc\\xc3\\xadnio, Rebeca Ribeiro de Moura, Luzia Kalyne Almeida Moreira Leal, Danielle Silveira Macedo, Francisca Cl\\xc3\\xa9a Floren\\xc3\\xa7o de Sousa, Glauce Socorro de Barros Viana, Silv\\xc3\\xa2nia Maria Mendes Vasconcelo. Coumarin effects on amino acid levels in mice prefrontal cortex and hippocampus. Neuroscience letters vol 454 issue 2 2009 19429071 |
in the hippocampus, only glutamate had its levels decreased after coumarin treatment, while diazepam increased the levels of gaba and tau and decreased the levels of glu in this brain region. |
2009-08-17 |
2023-01-25 |
mouse |
| Xi Kuang, Jun-Rong Du, Ya-Shu Chen, Jing Wang, Yan-Nan Wan. Protective effect of Z-ligustilide against amyloid beta-induced neurotoxicity is associated with decreased pro-inflammatory markers in rat brains. Pharmacology, biochemistry, and behavior vol 92 issue 4 2009 19324070 |
compared to the sham-operated rats, abeta(25-35) injection significantly prolonged the mean escape latency in vehicle-treated rats in the morris water maze test (p < 0.01) and increased both ad-related neuropathological signs (i.e., abeta, amyloid precursor protein, and phosphorylated tau immunoreactivity) and pro-inflammatory mediators (i.e., tnf-alpha and activated nf-kappab) in the prefrontal cortex and ca1 subregion of the hippocampus. |
2009-08-14 |
2023-01-25 |
rat |
| Henrik Viber. Neonatal ontogeny and neurotoxic effect of decabrominated diphenyl ether (PBDE 209) on levels of synaptophysin and tau. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience vol 27 issue 5 2009 19465108 |
the animals were euthanized 7 days after exposure to pbde 209 and levels of synaptophysin and tau were analyzed in the hippocampus and cerebral cortex. |
2009-08-12 |
2023-01-25 |
rat |
| Henrik Viber. Neonatal ontogeny and neurotoxic effect of decabrominated diphenyl ether (PBDE 209) on levels of synaptophysin and tau. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience vol 27 issue 5 2009 19465108 |
the analysis of protein levels showed no changes in tau in the hippocampus or cerebral cortex 7 days after exposure to pbde 209 on postnatal day 3. |
2009-08-12 |
2023-01-25 |
rat |
| C Reitz, L Honig, J P Vonsattel, M-X Tang, R Mayeu. Memory performance is related to amyloid and tau pathology in the hippocampus. Journal of neurology, neurosurgery, and psychiatry vol 80 issue 7 2009 19258354 |
memory performance is related to amyloid and tau pathology in the hippocampus. |
2009-07-29 |
2023-01-25 |
Not clear |
| Charles Duyckaerts, Beno\\xc3\\xaet Delatour, Marie-Claude Potie. Classification and basic pathology of Alzheimer disease. Acta neuropathologica vol 118 issue 1 2009 19381658 |
the progression of tau pathology is stepwise and stereotyped from the entorhinal cortex, through the hippocampus, to the isocortex. |
2009-07-29 |
2023-01-25 |
Not clear |
| Florence Clavaguera, Tristan Bolmont, R Anthony Crowther, Dorothee Abramowski, Stephan Frank, Alphonse Probst, Graham Fraser, Anna K Stalder, Martin Beibel, Matthias Staufenbiel, Mathias Jucker, Michel Goedert, Markus Tolna. Transmission and spreading of tauopathy in transgenic mouse brain. Nature cell biology vol 11 issue 7 2009 19503072 |
cognitive impairment becomes manifest when inclusions reach the hippocampus, with abundant neocortical tau inclusions and extracellular beta-amyloid deposits being the defining pathological hallmarks of alzheimer's disease. |
2009-07-20 |
2023-01-25 |
mouse |
| Evan Elliott, Offir Laufer, Irith Ginzbur. BAG-1M is up-regulated in hippocampus of Alzheimer's disease patients and associates with tau and APP proteins. Journal of neurochemistry vol 109 issue 4 2009 19317853 |
bag-1m is up-regulated in hippocampus of alzheimer's disease patients and associates with tau and app proteins. |
2009-07-16 |
2023-01-25 |
human |
| Evan Elliott, Offir Laufer, Irith Ginzbur. BAG-1M is up-regulated in hippocampus of Alzheimer's disease patients and associates with tau and APP proteins. Journal of neurochemistry vol 109 issue 4 2009 19317853 |
in addition, bag-1 binds to both tau and amyloid precursor protein physically, and is found highly expressed in the same neurons that contain intracellular tau or amyloid in hippocampal sections from ad patients. |
2009-07-16 |
2023-01-25 |
human |
| G Lace, G M Savva, G Forster, R de Silva, C Brayne, F E Matthews, J J Barclay, L Dakin, P G Ince, S B Wharto. Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study. Brain : a journal of neurology vol 132 issue Pt 5 2009 19321462 |
hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study. |
2009-06-24 |
2023-01-25 |
Not clear |
| G Lace, G M Savva, G Forster, R de Silva, C Brayne, F E Matthews, J J Barclay, L Dakin, P G Ince, S B Wharto. Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study. Brain : a journal of neurology vol 132 issue Pt 5 2009 19321462 |
we aimed to determine the extent and pattern of spread of tau pathology in the hippocampus, a susceptible region important in dementia and milder states of memory impairment, using hippocampal samples from the elderly population-based medical research council cognitive function and ageing study neuropathology cohort. |
2009-06-24 |
2023-01-25 |
Not clear |
| G Lace, G M Savva, G Forster, R de Silva, C Brayne, F E Matthews, J J Barclay, L Dakin, P G Ince, S B Wharto. Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study. Brain : a journal of neurology vol 132 issue Pt 5 2009 19321462 |
tau deposition was assessed in hippocampal anatomical sub-regions using the at8 antibody to phosphorylated tau and isoform-specific antibodies to 3 and 4-repeat tau (rd3 and rd4). |
2009-06-24 |
2023-01-25 |
Not clear |