| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tetsuya Kimura, Daniel J Whitcomb, Jihoon Jo, Philip Regan, Thomas Piers, Seonghoo Heo, Christopher Brown, Tsutomu Hashikawa, Miyuki Murayama, Heon Seok, Ioannis Sotiropoulos, Eunjoon Kim, Graham L Collingridge, Akihiko Takashima, Kwangwook Ch. Microtubule-associated protein tau is essential for long-term depression in the hippocampus. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 369. issue 1633. 2014-08-11. PMID:24298146. |
to investigate a possible synaptic function of tau, we studied synaptic plasticity in the hippocampus and found a selective deficit in long-term depression (ltd) in tau knockout mice in vivo and in vitro, an effect that was replicated by rnai knockdown of tau in vitro. |
2014-08-11 |
2023-08-12 |
mouse |
| Isabel Carreras, Ann C McKee, Ji-Kyung Choi, Nurgul Aytan, Neil W Kowall, Bruce G Jenkins, Alpaslan Dedeogl. R-flurbiprofen improves tau, but not Aß pathology in a triple transgenic model of Alzheimer's disease. Brain research. vol 1541. 2014-07-28. PMID:24161403. |
to further understand the effects of nsaids in 3xtg-ad mice, we treated 3xtg-ad mice with r-flurbiprofen, an enantiomer of the nsaid flurbiprofen that maintains the gsm activity but has greatly reduced anti-inflammatory activity, and analyzed its effect on cognition, aß, tau, and the neurochemical profile of the hippocampus. |
2014-07-28 |
2023-08-12 |
mouse |
| Hamid Y Qureshi, Dong Han, Ryen MacDonald, Hemant K Paude. Overexpression of 14-3-3z promotes tau phosphorylation at Ser262 and accelerates proteosomal degradation of synaptophysin in rat primary hippocampal neurons. PloS one. vol 8. issue 12. 2014-07-28. PMID:24367683. |
overexpression of 14-3-3z promotes tau phosphorylation at ser262 and accelerates proteosomal degradation of synaptophysin in rat primary hippocampal neurons. |
2014-07-28 |
2023-08-12 |
rat |
| Hamid Y Qureshi, Dong Han, Ryen MacDonald, Hemant K Paude. Overexpression of 14-3-3z promotes tau phosphorylation at Ser262 and accelerates proteosomal degradation of synaptophysin in rat primary hippocampal neurons. PloS one. vol 8. issue 12. 2014-07-28. PMID:24367683. |
when overexpressed in rat hippocampal primary neurons, 14-3-3z causes an increase in ser(262) phosphorylation, a decrease in the amount of microtubule-bound tau, a reduction in the amount of polymerized microtubules, as well as microtubule instability. |
2014-07-28 |
2023-08-12 |
rat |
| Audrée De Montigny, Ismaël Elhiri, Julie Allyson, Michel Cyr, Guy Massicott. NMDA reduces Tau phosphorylation in rat hippocampal slices by targeting NR2A receptors, GSK3β, and PKC activities. Neural plasticity. vol 2013. 2014-07-22. PMID:24349798. |
nmda reduces tau phosphorylation in rat hippocampal slices by targeting nr2a receptors, gsk3β, and pkc activities. |
2014-07-22 |
2023-08-12 |
rat |
| Audrée De Montigny, Ismaël Elhiri, Julie Allyson, Michel Cyr, Guy Massicott. NMDA reduces Tau phosphorylation in rat hippocampal slices by targeting NR2A receptors, GSK3β, and PKC activities. Neural plasticity. vol 2013. 2014-07-22. PMID:24349798. |
in the present study, pharmacological inhibitors were deployed to investigate potential processes by which the n-methyl-d-aspartate (nmda) subtype of glutamate receptors modulates tau phosphorylation in rat hippocampal slices. |
2014-07-22 |
2023-08-12 |
rat |
| Audrée De Montigny, Ismaël Elhiri, Julie Allyson, Michel Cyr, Guy Massicott. NMDA reduces Tau phosphorylation in rat hippocampal slices by targeting NR2A receptors, GSK3β, and PKC activities. Neural plasticity. vol 2013. 2014-07-22. PMID:24349798. |
our results demonstrated that tau phosphorylation at ser199-202 residues was decreased in nmda-treated hippocampal slices, an effect that was not reproduced at ser262 and ser404 epitopes. |
2014-07-22 |
2023-08-12 |
rat |
| Ye-Nan Chi, Xu Zhang, Jie Cai, Feng-Yu Liu, Guo-Gang Xing, You Wa. Formaldehyde increases intracellular calcium concentration in primary cultured hippocampal neurons partly through NMDA receptors and T-type calcium channels. Neuroscience bulletin. vol 28. issue 6. 2014-07-21. PMID:23160928. |
formaldehyde induces mis-folding and aggregation of neuronal tau protein, hippocampal neuronal apoptosis, cognitive impairment and loss of memory functions, as well as excitation of peripheral nociceptive neurons in cancer pain models. |
2014-07-21 |
2023-08-12 |
Not clear |
| Yuanxin Deng, Yanwen Zhang, Shujie Jia, Junkang Liu, Yanxia Liu, Weiwei Xu, Lei Li. Effects of aluminum and extremely low frequency electromagnetic radiation on oxidative stress and memory in brain of mice. Biological trace element research. vol 156. issue 1-3. 2014-07-21. PMID:24158621. |
secondly are the pathologic abnormalities including neuronal cell loss and overexpression of phosphorylated tau protein in the hippocampus and cerebral cortex. |
2014-07-21 |
2023-08-12 |
mouse |
| Erika Calvo-Ochoa, Karina Hernández-Ortega, Patricia Ferrera, Sumiko Morimoto, Clorinda Aria. Short-term high-fat-and-fructose feeding produces insulin signaling alterations accompanied by neurite and synaptic reduction and astroglial activation in the rat hippocampus. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 34. issue 6. 2014-07-21. PMID:24667917. |
our results show that 7 days of hffd feeding induce obesity and insres, associated with the following alterations in the hippocampus: (1) a decreased insulin signaling; (2) a decreased hippocampal weight; (3) a reduction in dendritic arborization in ca1 and microtubule-associated protein 2 (map-2) levels; (4) a decreased dendritic spine number in ca1 and synaptophysin content, along with an increase in tau phosphorylation; and finally, (5) an increase in reactive astrocyte associated with microglial changes. |
2014-07-21 |
2023-08-12 |
rat |
| Qiu-Lan Ma, Xiaohong Zuo, Fusheng Yang, Oliver J Ubeda, Dana J Gant, Mher Alaverdyan, Nicolae C Kiosea, Sean Nazari, Ping Ping Chen, Fatiha Nothias, Piu Chan, Edmond Teng, Sally A Frautschy, Greg M Col. Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 21. 2014-07-11. PMID:24849348. |
we report that old (19-20 months; oko) but not middle-aged (8-9 months; mko) tau knock-out mice develop morris water maze (mwm) deficits and loss of hippocampal acetylated α-tubulin and excitatory synaptic proteins. |
2014-07-11 |
2023-08-13 |
mouse |
| Anat Boehm-Cagan, Daniel M Michaelso. Reversal of apoE4-driven brain pathology and behavioral deficits by bexarotene. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 21. 2014-07-11. PMID:24849361. |
furthermore, bexarotene reversed the apoe4-driven accumulation of aβ42 and hyperphosphorylated tau in hippocampal neurons, as well as the apoe4-induced reduction in the levels of the presynaptic marker vesicular glutamatergic transporter 1 (vglut1). |
2014-07-11 |
2023-08-13 |
mouse |
| Dustin Shilling, Marioly Müller, Hajime Takano, Don-On Daniel Mak, Ted Abel, Douglas A Coulter, J Kevin Fosket. Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 20. 2014-07-10. PMID:24828645. |
in 3xtg mice, reduced insp3r1 expression profoundly attenuated amyloid β accumulation and tau hyperphosphorylation and rescued hippocampal ltp and memory deficits. |
2014-07-10 |
2023-08-13 |
mouse |
| Yao Zhang, Rong-Hong Ma, Xia-Chun Li, Jia-Yu Zhang, Hai-Rong Shi, Wei Wei, Dan-Ju Luo, Qun Wang, Jian-Zhi Wang, Gong-Ping Li. Silencing [Formula: see text] Rescues Tau Pathologies and Memory Deficits through Rescuing PP2A and Inhibiting GSK-3β Signaling in Human Tau Transgenic Mice. Frontiers in aging neuroscience. vol 6. 2014-07-02. PMID:24987368. |
here, we found that silencing [formula: see text] by hippocampal infusion of [formula: see text] down-regulated [formula: see text] (~45%) with reduction of tau phosphorylation/accumulation, improvement of memory deficits, and dendritic plasticity in 12-month-old human tau transgenic mice. |
2014-07-02 |
2023-08-13 |
mouse |
| Marta Dobarro, Gorka Gerenu, María J Ramíre. Propranolol reduces cognitive deficits, amyloid and tau pathology in Alzheimer's transgenic mice. The international journal of neuropsychopharmacology. vol 16. issue 10. 2014-07-01. PMID:23768694. |
tau hyperphosphorylation shown by tg2576 mice was also decreased in the hippocampus of propranolol-treated mice, an effect probably related to an increase of gsk3β phosphorylation (inactive form) and a decreased jnk1 expression. |
2014-07-01 |
2023-08-12 |
mouse |
| Juha Lauré. Cellular prion protein as a therapeutic target in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 38. issue 2. 2014-06-27. PMID:23948943. |
the interaction of aβ oligomers with prpc in mice impairs hippocampal long-term potentiation, memory, and learning in a manner that involves fyn, tau, and glutamate receptors. |
2014-06-27 |
2023-08-12 |
mouse |
| Ryszard Pluta, Mirosław Jabłoński, Marzena Ułamek-Kozioł, Janusz Kocki, Judyta Brzozowska, Sławomir Januszewski, Wanda Furmaga-Jabłońska, Anna Bogucka-Kocka, Ryszard Maciejewski, Stanisław J Czuczwa. Sporadic Alzheimer's disease begins as episodes of brain ischemia and ischemically dysregulated Alzheimer's disease genes. Molecular neurobiology. vol 48. issue 3. 2014-06-18. PMID:23519520. |
nowadays, a handful of researchers share a newly emerged view that the ischemic episodes of brain best describe the pathogenic cascade, which eventually leads to neuronal loss, especially in hippocampus, with amyloid accumulation, tau protein pathology and irreversible dementia of alzheimer type. |
2014-06-18 |
2023-08-12 |
Not clear |
| Sylvia E Perez, Mary Ann Raghanti, Patrick R Hof, Lynn Kramer, Milos D Ikonomovic, Pascale N Lacor, Joseph M Erwin, Chet C Sherwood, Elliott J Mufso. Alzheimer's disease pathology in the neocortex and hippocampus of the western lowland gorilla (Gorilla gorilla gorilla). The Journal of comparative neurology. vol 521. issue 18. 2014-06-11. PMID:23881733. |
neurons stained for the tau marker alz50 were found in the neocortex and hippocampus of gorillas at all ages. |
2014-06-11 |
2023-08-12 |
Not clear |
| Marie Lise Frandemiche, Sandrine De Seranno, Travis Rush, Eve Borel, Auréliane Elie, Isabelle Arnal, Fabien Lanté, Alain Buisso. Activity-dependent tau protein translocation to excitatory synapse is disrupted by exposure to amyloid-beta oligomers. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 17. 2014-06-09. PMID:24760868. |
we observed similar tau translocation to the postsynaptic fraction in acute hippocampal slices subjected to long-term potentiation. |
2014-06-09 |
2023-08-13 |
human |
| Etsuko Oshima, Takeshi Ishihara, Osamu Yokota, Hanae Nakashima-Yasuda, Shigeto Nagao, Chikako Ikeda, Jun Naohara, Seishi Terada, Yosuke Uchitom. Accelerated tau aggregation, apoptosis and neurological dysfunction caused by chronic oral administration of aluminum in a mouse model of tauopathies. Brain pathology (Zurich, Switzerland). vol 23. issue 6. 2014-06-05. PMID:23574527. |
apoptosis was observed in the hippocampus in al-treated tau tg mice, but was virtually absent in the other experimental groups. |
2014-06-05 |
2023-08-12 |
mouse |