| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yue Wang, Jun-Xia Zhang, Xiao-Xia Du, Li Zhao, Qing Tian, Ling-Qiang Zhu, Shao-Hui Wang, Jian-Zhi Wan. Temporal correlation of the memory deficit with Alzheimer-like lesions induced by activation of glycogen synthase kinase-3. Journal of neurochemistry vol 106 issue 6 2008 18643871 |
we observed that the severe memory deficit occurred at 24 and 48 h, and simultaneously, gsk-3 activation, tau hyperphosphorylation at thr231, ser396, and ser404 and decline of ach in hippocampus were detected, and these changes were mostly recovered at 72 and 96 h after the injection of wt/gfx. |
2008-11-07 |
2023-01-25 |
rat |
| Yue Wang, Jun-Xia Zhang, Xiao-Xia Du, Li Zhao, Qing Tian, Ling-Qiang Zhu, Shao-Hui Wang, Jian-Zhi Wan. Temporal correlation of the memory deficit with Alzheimer-like lesions induced by activation of glycogen synthase kinase-3. Journal of neurochemistry vol 106 issue 6 2008 18643871 |
our data provide direct evidence demonstrating that activation of gsk-3 by wt/gfx may cause memory deficit through tau hyperphosphorylation and suppression of ach in hippocampus. |
2008-11-07 |
2023-01-25 |
rat |
| E B Shubenina, V S Kudrin, P M Klodt, A A Pokrovski\\xc4\\xad, T A Gudasheva, T A Voronina, R U Ostrovskai. [Interstrain differences in the content of excitatory and inhibitory amino acids in the brain of DBA/2J, Balb/c and C57BL/6 mice: characteristics of the effect of a dipeptide antipsychotic drug dilept]. Eksperimental'naia i klinicheskaia farmakologiia vol 71 issue 4 2008 18819433 |
we have performed a comparative study of the content of glutamate (glu), aspartate (asp), taurine (tau), glycine (gly) and gamma-amino-butyric acid (gaba) in the cortex, hippocampus, and striatum of the dba/2j, balb/c and c57bl/6 mice brain. |
2008-10-27 |
2023-01-25 |
mouse |
| E B Shubenina, V S Kudrin, P M Klodt, A A Pokrovski\\xc4\\xad, T A Gudasheva, T A Voronina, R U Ostrovskai. [Interstrain differences in the content of excitatory and inhibitory amino acids in the brain of DBA/2J, Balb/c and C57BL/6 mice: characteristics of the effect of a dipeptide antipsychotic drug dilept]. Eksperimental'naia i klinicheskaia farmakologiia vol 71 issue 4 2008 18819433 |
the levels of glu, tau and gaba in dba/2j hippocampus was lower than those in other experimental strains. |
2008-10-27 |
2023-01-25 |
mouse |
| Felix Geser, Matthew J Winton, Linda K Kwong, Yan Xu, Sharon X Xie, Lionel M Igaz, Ralph M Garruto, Daniel P Perl, Douglas Galasko, Virginia M-Y Lee, John Q Trojanowsk. Pathological TDP-43 in parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam. Acta neuropathologica vol 115 issue 1 2008 17713769 |
these results indicate that g-pdc and g-als are associated with pathological tdp-43 similar to ftld-u with/without mnd as well as als, and that neocortical or hippocampal tdp-43 pathology distinguishes controls from disease subjects better than tau pathology. |
2008-10-14 |
2023-01-24 |
human |
| Alicia Rubio, Mar P\\xc3\\xa9rez, Luis de Lecea, Jes\\xc3\\xbas Avil. Effect of cortistatin on tau phosphorylation at Ser262 site. Journal of neuroscience research vol 86 issue 11 2008 18438934 |
the development of intraneuronal lesions as a result of the progressive deposition of hyperphosphorylated tau at specific brain regions (such as hippocampus and cortex) plays a key role in the pathological process of alzheimer's disease. |
2008-09-30 |
2023-01-24 |
mouse |
| Bronwen Martin, Randall Brenneman, Kevin G Becker, Marjan Gucek, Robert N Cole, Stuart Maudsle. iTRAQ analysis of complex proteome alterations in 3xTgAD Alzheimer's mice: understanding the interface between physiology and disease. PloS one vol 3 issue 7 2008 18648646 |
the 3xtgad mice express mutant presenilin-1, amyloid precursor protein and tau, and exhibit ad-like amyloid and tau pathology in the hippocampus and cortex, and associated cognitive impairment. |
2008-09-24 |
2023-01-25 |
mouse |
| Marisol Espinoza, Rohan de Silva, Dennis W Dickson, Peter Davie. Differential incorporation of tau isoforms in Alzheimer's disease. Journal of Alzheimer's disease : JAD vol 14 issue 1 2008 18525123 |
immunohistochemical analysis of the hippocampus in 34 ad cases performed with these antibodies showed both 3r and 4r tau isoforms in tangles. |
2008-08-18 |
2023-01-24 |
human |
| Marisol Espinoza, Rohan de Silva, Dennis W Dickson, Peter Davie. Differential incorporation of tau isoforms in Alzheimer's disease. Journal of Alzheimer's disease : JAD vol 14 issue 1 2008 18525123 |
while biochemical studies showed that both isoforms were present in insoluble tau aggregates in ad hippocampus and cortex, not all tangles appear to be labeled with the 3r and 4r tau specific monoclonal antibodies. |
2008-08-18 |
2023-01-24 |
human |
| Sanna-Kaisa Herukka, Corina Pennanen, Hilkka Soininen, Tuula Pirttil\\xc3\\xa. CSF Abeta42, tau and phosphorylated tau correlate with medial temporal lobe atrophy. Journal of Alzheimer's disease : JAD vol 14 issue 1 2008 18525127 |
tau and phospho-tau correlated inversely with hippocampal volumes and left entorhinal cortex volume in the whole study group. |
2008-08-18 |
2023-01-24 |
human |
| Sanna-Kaisa Herukka, Corina Pennanen, Hilkka Soininen, Tuula Pirttil\\xc3\\xa. CSF Abeta42, tau and phosphorylated tau correlate with medial temporal lobe atrophy. Journal of Alzheimer's disease : JAD vol 14 issue 1 2008 18525127 |
in the stable group, tau correlated with hippocampal volumes. |
2008-08-18 |
2023-01-24 |
human |
| Ann C McKee, Isabel Carreras, Lokman Hossain, Hoon Ryu, William L Klein, Salvatore Oddo, Frank M LaFerla, Bruce G Jenkins, Neil W Kowall, Alpaslan Dedeogl. Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice. Brain research vol 1207 issue 2008 18374906 |
ibuprofen-treated transgenic mice showed a significant decrease in intraneuronal oligomeric abeta and hyperphosphorylated tau (at8) immunoreactivity in the hippocampus. |
2008-08-13 |
2023-01-24 |
mouse |
| Scott A Yuzwa, Matthew S Macauley, Julia E Heinonen, Xiaoyang Shan, Rebecca J Dennis, Yuan He, Garrett E Whitworth, Keith A Stubbs, Ernest J McEachern, Gideon J Davies, David J Vocadl. A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. Nature chemical biology vol 4 issue 8 2008 18587388 |
thiamet-g also efficiently reduced phosphorylation of tau at thr231, ser396 and ser422 in both rat cortex and hippocampus, which reveals the rapid and dynamic relationship between o-glcnac and phosphorylation of tau in vivo. |
2008-08-13 |
2023-01-25 |
rat |
| A G\\xc3\\xb3mez-Ramos, M D\\xc3\\xadaz-Hern\\xc3\\xa1ndez, A Rubio, M T Miras-Portugal, J Avil. Extracellular tau promotes intracellular calcium increase through M1 and M3 muscarinic receptors in neuronal cells. Molecular and cellular neurosciences vol 37 issue 4 2008 18272392 |
these results suggest that observed effect of tau protein on neuronal (neuroblastoma and primary cultures of hippocampal and cortical neurons) cells is through m1 and m3 muscarinic receptors. |
2008-08-04 |
2023-01-24 |
Not clear |
| Paloma Navarro, Rosa Guerrero, Eva Gallego, Jesus Avila, Rosario Luquin, Pedro J Garcia Ruiz, Marina P Sanche. Memory and exploratory impairment in mice that lack the Park-2 gene and that over-express the human FTDP-17 mutant Tau. Behavioural brain research vol 189 issue 2 2008 18346797 |
however, the presence of both mutations simultaneously causes a tau neuropathology, involving reactive astrocytosis, neuron loss in the cortex and hippocampus, and lesions in nigrostriatal and motor neurons. |
2008-07-09 |
2023-01-24 |
mouse |
| Qian Chen, Akira Nakajima, Se Hoon Choi, Xiaoli Xiong, Ya-Ping Tan. Loss of presenilin function causes Alzheimer's disease-like neurodegeneration in the mouse. Journal of neuroscience research vol 86 issue 7 2008 18189321 |
in the present article, we show that conditional knockout of ps1 from the adult stage in the forebrain of mice with the ps2 null mutation triggers robust ad-like neurodegeneration including brain shrinkage, cortical and hippocampal atrophy,ventricular enlargement, severe neuronal loss, gliosis, tau hyperphosphorylation, neurofillament tangle-like structures, and intracellular filaments. |
2008-07-08 |
2023-01-24 |
mouse |
| Y-J Zhang, Y-F Xu, X-H Liu, D Li, J Yin, Y-H Liu, X-Q Chen, J-Z Wan. Carboxyl terminus of heat-shock cognate 70-interacting protein degrades tau regardless its phosphorylation status without affecting the spatial memory of the rats. Journal of neural transmission (Vienna, Austria : 1996) vol 115 issue 3 2008 18301957 |
here, we demonstrated that hippocampal transfection of chip plasmid in rats could reach a time-dependent elevated expression of chip mrna and protein in 24 h. concomitantly, expression of exogenous chip could promote the degradation of the hyperphosphorylated tau induced by overactivation of glycogen synthase kinase-3 (gsk-3) or inhibition of protein phosphatase-2a (pp-2a) in the rat brains and n2a cells. |
2008-07-01 |
2023-01-24 |
rat |
| Rosa Guerrero, Paloma Navarro, Eva Gallego, Jesus Avila, Justo G de Yebenes, Marina P Sanche. Park2-null/tau transgenic mice reveal a functional relationship between parkin and tau. Journal of Alzheimer's disease : JAD vol 13 issue 2 2008 18376058 |
aggregates of phosphorylated tau in neurons and reactive gliosis are quite abundant in cortex and hippocampus of these mice. |
2008-06-10 |
2023-01-24 |
mouse |
| Rosa Guerrero, Paloma Navarro, Eva Gallego, Jesus Avila, Justo G de Yebenes, Marina P Sanche. Park2-null/tau transgenic mice reveal a functional relationship between parkin and tau. Journal of Alzheimer's disease : JAD vol 13 issue 2 2008 18376058 |
the levels of phosphorylated tau and hsp70 are increased in the double-mutant mice, while chip expression in hippocampus is lower when the park-2 gene is deleted. |
2008-06-10 |
2023-01-24 |
mouse |
| B Dudas, M Rose, U Cornelli, A Pavlovich, I Hani. Neuroprotective properties of glycosaminoglycans: potential treatment for neurodegenerative disorders. Neuro-degenerative diseases vol 5 issue 3-4 2008 18322390 |
moreover, neuroparin reduced tau 2 immunoreactivity in the rat hippocampus, stimulated by intra-amygdaloid injection of abeta(25-35). |
2008-05-15 |
2023-01-24 |
rat |