All Relations between microtubule-associated protein tau and hippocampus

Publication Sentence Publish Date Extraction Date Species
Marie Violet, Lucie Delattre, Meryem Tardivel, Audrey Sultan, Alban Chauderlier, Raphaelle Caillierez, Smail Talahari, Fabrice Nesslany, Bruno Lefebvre, Eliette Bonnefoy, Luc Buée, Marie-Christine Gala. A major role for Tau in neuronal DNA and RNA protection in vivo under physiological and hyperthermic conditions. Frontiers in cellular neuroscience. vol 8. 2014-03-27. PMID:24672431. moreover, genomic dna and cytoplasmic and nuclear rna integrity were altered under hs in hippocampal neurons exhibiting tau deficiency, which suggests that tau also modulates rna metabolism. 2014-03-27 2023-08-12 mouse
Joel A Saydoff, Ana Olariu, Jin Sheng, Zhongyi Hu, Qin Li, Rolando Garcia, Jiong Pei, Grace Y Sun, Reid von Borste. Uridine prodrug improves memory in Tg2576 and TAPP mice and reduces pathological factors associated with Alzheimer's disease in related models. Journal of Alzheimer's disease : JAD. vol 36. issue 4. 2014-03-24. PMID:23648515. tapp mouse hippocampal tau phosphorylation and lipid peroxidation were reduced by pn401 treatment. 2014-03-24 2023-08-12 mouse
Narayan R Bhat, Lakshmi Thirumangalakud. Increased tau phosphorylation and impaired brain insulin/IGF signaling in mice fed a high fat/high cholesterol diet. Journal of Alzheimer's disease : JAD. vol 36. issue 4. 2014-03-24. PMID:23703152. immunoblot analysis of hippocampal tissue from c57bl/6 mice fed hfc for 2 months with anti-phospho-tau (i.e., phf1 and phospho-thr-231 tau) antibodies demonstrated the presence of hyperphosphorylated tau. 2014-03-24 2023-08-12 mouse
Daniela Giuliani, Alessandra Ottani, Davide Zaffe, Maria Galantucci, Flavio Strinati, Renzo Lodi, Salvatore Guarin. Hydrogen sulfide slows down progression of experimental Alzheimer's disease by targeting multiple pathophysiological mechanisms. Neurobiology of learning and memory. vol 104. 2014-03-20. PMID:23726868. hippocampus reduced activity of c-jun n-terminal kinases, extracellular signal-regulated kinases and p38, which have an established role not only in phosphorylation of tau protein but also in inflammation and apoptosis, was also found. 2014-03-20 2023-08-12 mouse
Hiroyuki Shimad. [The DIAN study]. Brain and nerve = Shinkei kenkyu no shinpo. vol 65. issue 10. 2014-03-19. PMID:24101429. subsequently, a chronological series of events took place: deposition of fibrillar aβ as measured by positron emission tomography with the use of pittsburgh compound b, increase in tau protein in the csf, hippocampal atrophy and hypometabolism of fdg-pet, and cognitive and clinical changes. 2014-03-19 2023-08-12 human
Ralph Michael, Cees Otto, Aufried Lenferink, Ellen Gelpi, Gustavo A Montenegro, Jurja Rosandić, Francisco Tresserra, Rafael I Barraquer, Gijs F J M Vrense. Absence of amyloid-beta in lenses of Alzheimer patients: a confocal Raman microspectroscopic study. Experimental eye research. vol 119. 2014-03-18. PMID:24333259. this major difference in beta-sheet conformation between hippocampus and lens is supported by congo red and immunostaining of amyloid-beta and tau which were positive for plaques and tangles in the hippocampus but fully negative for the lens irrespective of the presence or absence of opacities. 2014-03-18 2023-08-12 Not clear
Isabel Lastres-Becker, Nadia G Innamorato, Tomasz Jaworski, Alberto Rábano, Sebastian Kügler, Fred Van Leuven, Antonio Cuadrad. Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis. Brain : a journal of neurology. vol 137. issue Pt 1. 2014-03-11. PMID:24277722. here, we show that hippocampal ht22 cells expressing human tau(p301l) mutant protein produce fractalkine, which in microglia activates akt, inhibits glycogen synthase kinase-3β and upregulates the transcription factor nrf2/nfe2l2 and its target genes including heme oxygenase 1. 2014-03-11 2023-08-12 mouse
Isabel Lastres-Becker, Nadia G Innamorato, Tomasz Jaworski, Alberto Rábano, Sebastian Kügler, Fred Van Leuven, Antonio Cuadrad. Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis. Brain : a journal of neurology. vol 137. issue Pt 1. 2014-03-11. PMID:24277722. in a mouse model of tauopathy based on stereotaxic delivery in hippocampus of an adeno-associated viral vector for expression of tau(p301l), we confirmed that tau-injured neurons express fractalkine. 2014-03-11 2023-08-12 mouse
Anika Saul, Frederik Sprenger, Thomas A Bayer, Oliver Wirth. Accelerated tau pathology with synaptic and neuronal loss in a novel triple transgenic mouse model of Alzheimer's disease. Neurobiology of aging. vol 34. issue 11. 2014-03-05. PMID:23747045. these data support the assumption of tau pathology being downstream of amyloid pathology, suggesting that both pathologies together trigger the severe neuron loss in the hippocampus in the 5xfad/ps19 mouse model. 2014-03-05 2023-08-12 mouse
Andrea Pristerà, Daniele Saraulli, Stefano Farioli-Vecchioli, Georgios Strimpakos, Marco Costanzi, Maria Grazia di Certo, Sara Cannas, Maria Teresa Ciotti, Felice Tirone, Elisabetta Mattei, Vincenzo Cestari, Nadia Can. Impact of N-tau on adult hippocampal neurogenesis, anxiety, and memory. Neurobiology of aging. vol 34. issue 11. 2014-03-05. PMID:23769395. however, little is known about how tau pathology directly affects adult hippocampal neurogenesis, a unique form of structural plasticity implicated in hippocampus-dependent spatial learning and mood-related behavior. 2014-03-05 2023-08-12 mouse
Andrea Pristerà, Daniele Saraulli, Stefano Farioli-Vecchioli, Georgios Strimpakos, Marco Costanzi, Maria Grazia di Certo, Sara Cannas, Maria Teresa Ciotti, Felice Tirone, Elisabetta Mattei, Vincenzo Cestari, Nadia Can. Impact of N-tau on adult hippocampal neurogenesis, anxiety, and memory. Neurobiology of aging. vol 34. issue 11. 2014-03-05. PMID:23769395. understanding how pathological tau species directly affect neurogenesis is important for developing potential therapeutic strategies to direct neurogenic instructive cues for hippocampal function repair. 2014-03-05 2023-08-12 mouse
Jayasankar Kosaraju, Chaitanya Chakravarthi Gali, Rizwan Basha Khatwal, Anil Dubala, Santhivardhan Chinni, R M Damian Holsinger, V Subba Rao Madhunapantula, Satish Kumar Muthureddy Nataraj, Duraiswamy Basava. Saxagliptin: a dipeptidyl peptidase-4 inhibitor ameliorates streptozotocin induced Alzheimer's disease. Neuropharmacology. vol 72. 2014-02-11. PMID:23603201. the effect of the dpp-4 inhibitor on hippocampal glp-1 levels, aβ burden, tau phosphorylation, inflammatory markers and memory retention were evaluated. 2014-02-11 2023-08-12 rat
Jayasankar Kosaraju, Chaitanya Chakravarthi Gali, Rizwan Basha Khatwal, Anil Dubala, Santhivardhan Chinni, R M Damian Holsinger, V Subba Rao Madhunapantula, Satish Kumar Muthureddy Nataraj, Duraiswamy Basava. Saxagliptin: a dipeptidyl peptidase-4 inhibitor ameliorates streptozotocin induced Alzheimer's disease. Neuropharmacology. vol 72. 2014-02-11. PMID:23603201. the results reveal an attenuation of aβ, tau phosphorylation and inflammatory markers and an improvement in hippocampal glp-1 and memory retention following treatment. 2014-02-11 2023-08-12 rat
Raphaëlle Caillierez, Séverine Bégard, Katia Lécolle, Vincent Deramecourt, Nadège Zommer, Simon Dujardin, Anne Loyens, Noëlle Dufour, Gwennaëlle Aurégan, Joris Winderickx, Philippe Hantraye, Nicole Déglon, Luc Buée, Morvane Coli. Lentiviral delivery of the human wild-type tau protein mediates a slow and progressive neurodegenerative tau pathology in the rat brain. Molecular therapy : the journal of the American Society of Gene Therapy. vol 21. issue 7. 2014-02-10. PMID:23609018. in the present study, we generated an original "sporadic tauopathy-like" model in the rat hippocampus, encoding six tau isoforms as found in humans, using lentiviral vectors (lvs) for the delivery of a human wt tau. 2014-02-10 2023-08-12 mouse
Deirdre Stolmeier, Ramasamy Thangavel, Poojya Anantharam, Mohammad M Khan, Duraisamy Kempuraj, Asgar Zahee. Glia maturation factor expression in hippocampus of human Alzheimer's disease. Neurochemical research. vol 38. issue 8. 2014-02-06. PMID:23640177. we further demonstrate that gmf immunoreactive glial cells were increased at the sites of tau containing nfts and aps of hippocampus in ad brains. 2014-02-06 2023-08-12 human
Harald Lund, Richard F Cowburn, Elin Gustafsson, Kia Strömberg, Anne Svensson, Leif Dahllund, David Malinowsky, Dan Sunnemar. Tau-tubulin kinase 1 expression, phosphorylation and co-localization with phospho-Ser422 tau in the Alzheimer's disease brain. Brain pathology (Zurich, Switzerland). vol 23. issue 4. 2014-01-27. PMID:23088643. ttbk1 immunoreactivity appeared to vary with the level of phospho-tau staining, and was strong in the somatodendritic compartment of apparently healthy hippocampal neurons as well as in pre-tangle neurons where it co-localized with diffuse phospho-ser422 tau staining. 2014-01-27 2023-08-12 human
Shoko Morita, Seiji Miyat. Synaptic localization of growth-associated protein 43 in cultured hippocampal neurons during synaptogenesis. Cell biochemistry and function. vol 31. issue 5. 2014-01-21. PMID:23055398. double-labelling immunohistochemistry with an axonal marker tau revealed that the immunoreactivity of gap-43 was seen throughout axons of cultured hippocampal neurons but stronger at axonal puncta of developing neurons than axonal processes. 2014-01-21 2023-08-12 rat
M Oksman, L A Wisman, H Jiang, P Miettinen, D Kirik, H Tanil. Transduced wild-type but not P301S mutated human tau shows hyperphosphorylation in transgenic mice overexpressing A30P mutated human alpha-synuclein. Neuro-degenerative diseases. vol 12. issue 2. 2014-01-17. PMID:22948283. to study the relevance and functional implications of these findings in vivo, we transduced hippocampal neurons of wild-type or human a30p α-synuclein transgenic mice with wild-type or p301s mutated human tau using an adeno-associated virus vector. 2014-01-17 2023-08-12 mouse
Jose J Jarero-Basulto, Jose Luna-Muñoz, Raul Mena, Zdena Kristofikova, Daniela Ripova, George Perry, Lester I Binder, Francisco Garcia-Sierr. Proteolytic cleavage of polymeric tau protein by caspase-3: implications for Alzheimer disease. Journal of neuropathology and experimental neurology. vol 72. issue 12. 2014-01-13. PMID:24226268. in the hippocampus, we found distinct nonfibrillary aggregates of asp(421)-truncated tau. 2014-01-13 2023-08-12 Not clear
Hervé Maurin, Claire Marie Seymour, Benoit Lechat, Peter Borghgraef, Herman Devijver, Tomasz Jaworski, Mathias V Schmidt, Sebastian Kuegler, Fred Van Leuve. Tauopathy differentially affects cell adhesion molecules in mouse brain: early down-regulation of nectin-3 in stratum lacunosum moleculare. PloS one. vol 8. issue 5. 2013-12-30. PMID:23704923. in particular was nectin-3 depleted from the specific region of the hippocampus, known as the stratum lacunosum and moleculare, in mice that express wild-type or mutant human protein tau, either chronically or sub-acutely. 2013-12-30 2023-08-12 mouse