Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Maria J Casarejos, Juan Perucho, Ana Gomez, Maria P Muñoz, Marian Fernandez-Estevez, Onintza Sagredo, Javier Fernandez Ruiz, Manuel Guzman, Justo Garcia de Yebenes, Maria A Men. Natural cannabinoids improve dopamine neurotransmission and tau and amyloid pathology in a mouse model of tauopathy. Journal of Alzheimer's disease : JAD. vol 35. issue 3. 2013-10-17. PMID:23478312. |
with regard to tau and amyloid pathology, sativex® reduced the deposition of both in the hippocampus and cerebral cortex of pk-/-/tauvlw mice and increased autophagy. |
2013-10-17 |
2023-08-12 |
mouse |
Bradford C Dickerson, David A Wol. Biomarker-based prediction of progression in MCI: Comparison of AD signature and hippocampal volume with spinal fluid amyloid-β and tau. Frontiers in aging neuroscience. vol 5. 2013-10-16. PMID:24130528. |
biomarker-based prediction of progression in mci: comparison of ad signature and hippocampal volume with spinal fluid amyloid-β and tau. |
2013-10-16 |
2023-08-12 |
Not clear |
Sylvie Burnouf, Alberto Martire, Maxime Derisbourg, Cyril Laurent, Karim Belarbi, Antoine Leboucher, Francisco J Fernandez-Gomez, Laetitia Troquier, Sabiha Eddarkaoui, Marie-Eve Grosjean, Dominique Demeyer, Anne Muhr-Tailleux, Alain Buisson, Nicolas Sergeant, Malika Hamdane, Sandrine Humez, Patrizia Popoli, Luc Buée, David Blu. NMDA receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a Tau transgenic model. Aging cell. vol 12. issue 1. 2013-09-30. PMID:23082852. |
nmda receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a tau transgenic model. |
2013-09-30 |
2023-08-12 |
mouse |
Sylvie Burnouf, Alberto Martire, Maxime Derisbourg, Cyril Laurent, Karim Belarbi, Antoine Leboucher, Francisco J Fernandez-Gomez, Laetitia Troquier, Sabiha Eddarkaoui, Marie-Eve Grosjean, Dominique Demeyer, Anne Muhr-Tailleux, Alain Buisson, Nicolas Sergeant, Malika Hamdane, Sandrine Humez, Patrizia Popoli, Luc Buée, David Blu. NMDA receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a Tau transgenic model. Aging cell. vol 12. issue 1. 2013-09-30. PMID:23082852. |
using thy-tau22 transgenic mice, we demonstrated that hippocampal tau pathology is associated with loss of synaptic enhancement normally induced by exogenous bdnf. |
2013-09-30 |
2023-08-12 |
mouse |
Sylvie Burnouf, Alberto Martire, Maxime Derisbourg, Cyril Laurent, Karim Belarbi, Antoine Leboucher, Francisco J Fernandez-Gomez, Laetitia Troquier, Sabiha Eddarkaoui, Marie-Eve Grosjean, Dominique Demeyer, Anne Muhr-Tailleux, Alain Buisson, Nicolas Sergeant, Malika Hamdane, Sandrine Humez, Patrizia Popoli, Luc Buée, David Blu. NMDA receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a Tau transgenic model. Aging cell. vol 12. issue 1. 2013-09-30. PMID:23082852. |
indeed, we observed a significant reduction of nmda-induced field excitatory postsynaptic potential depression in the hippocampus of tau mice together with a reduced phosphorylation of nr2b at the y1472, known to be critical for nmdar function. |
2013-09-30 |
2023-08-12 |
mouse |
Ori Liraz, Anat Boehm-Cagan, Daniel M Michaelso. ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice. Molecular neurodegeneration. vol 8. 2013-09-20. PMID:23684315. |
apoe4 induces aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoe4 mice. |
2013-09-20 |
2023-08-12 |
mouse |
Makoto Hara, Katsuiku Hirokawa, Satoshi Kamei, Toshiki Uchihar. Isoform transition from four-repeat to three-repeat tau underlies dendrosomatic and regional progression of neurofibrillary pathology. Acta neuropathologica. vol 125. issue 4. 2013-09-16. PMID:23407988. |
regional progression of neurofibrillary tangles (nfts) around the hippocampus was traced on thick sections double immunofluorolabeled with rd3 and rd4 antibodies, specific for three- and four-repeat tau, respectively. |
2013-09-16 |
2023-08-12 |
Not clear |
Samantha Galluzzi, Cristina Geroldi, Giovanni Amicucci, Luisella Bocchio-Chiavetto, Matteo Bonetti, Cristian Bonvicini, Maria Cotelli, Roberta Ghidoni, Barbara Paghera, Orazio Zanetti, Giovanni B Frison. Supporting evidence for using biomarkers in the diagnosis of MCI due to AD. Journal of neurology. vol 260. issue 2. 2013-09-04. PMID:23070466. |
in this study, we enrolled 58 patients with mci, and for each of them ad biomarkers (csf abeta42 and tau, temporoparietal hypometabolism on 18f-fdg pet, and hippocampal volume) were collected. |
2013-09-04 |
2023-08-12 |
Not clear |
Edoardo Parrella, Tom Maxim, Francesca Maialetti, Lu Zhang, Junxiang Wan, Min Wei, Pinchas Cohen, Luigi Fontana, Valter D Long. Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model. Aging cell. vol 12. issue 2. 2013-08-27. PMID:23362919. |
whereas prcs did not affect the levels of β amyloid (aβ), they decreased tau phosphorylation in the hippocampus and alleviated the age-dependent impairment in cognitive performance. |
2013-08-27 |
2023-08-12 |
mouse |
Hye Jeong Yang, Jin Taek Hwang, Dae Young Kwon, Min Jung Kim, Suna Kang, Na Rang Moon, Sunmin Par. Yuzu extract prevents cognitive decline and impaired glucose homeostasis in β-amyloid-infused rats. The Journal of nutrition. vol 143. issue 7. 2013-08-26. PMID:23719224. |
yuzu treatment prevented β-amyloid accumulation, increased tau phosphorylation, and attenuated hippocampal insulin signaling observed in ad-c rats. |
2013-08-26 |
2023-08-12 |
rat |
Hongxia Shuai, Jinghui Zhang, Ji Zhang, Junhui Xie, Muxun Zhang, Ji Ma, Liming Zhang, Xiufeng Wan. Role of stereotaxically injected IgG from db/db mice in the phosphorylation of the microtubule-associated protein tau in hippocampus. Brain research. vol 1486. 2013-08-23. PMID:23036273. |
role of stereotaxically injected igg from db/db mice in the phosphorylation of the microtubule-associated protein tau in hippocampus. |
2013-08-23 |
2023-08-12 |
mouse |
Lars Messing, Jochen Martin Decker, Maria Joseph, Eckhard Mandelkow, Eva-Maria Mandelko. Cascade of tau toxicity in inducible hippocampal brain slices and prevention by aggregation inhibitors. Neurobiology of aging. vol 34. issue 5. 2013-08-13. PMID:23158765. |
cascade of tau toxicity in inducible hippocampal brain slices and prevention by aggregation inhibitors. |
2013-08-13 |
2023-08-12 |
mouse |
Lars Messing, Jochen Martin Decker, Maria Joseph, Eckhard Mandelkow, Eva-Maria Mandelko. Cascade of tau toxicity in inducible hippocampal brain slices and prevention by aggregation inhibitors. Neurobiology of aging. vol 34. issue 5. 2013-08-13. PMID:23158765. |
to this end we established an in vitro model of tauopathy based on regulatable transgenic hippocampal organotypic slice cultures prepared from mice expressing proaggregant tau repeat domain with mutation Δk280 (tau(rd)Δk). |
2013-08-13 |
2023-08-12 |
mouse |
Eduardo Rigon Zimmer, Eduardo Kalinine, Clarissa Branco Haas, Vitor Rocco Torrez, Diogo Onofre Souza, Alexandre Pastoris Muller, Luis Valmor Portel. Pretreatment with memantine prevents Alzheimer-like alterations induced by intrahippocampal okadaic acid administration in rats. Current Alzheimer research. vol 9. issue 10. 2013-08-09. PMID:22515493. |
additionally, we measured glutamate levels in the cerebrospinal fluid (csf) and the immunocontent of cdk5, p35, p25 and phosphorylated tau (ptauser199/202) in the hippocampus. |
2013-08-09 |
2023-08-12 |
rat |
Min-Young Noh, Kwangwoo Chun, Byung Yong Kang, Heejaung Kim, Ji-Seon Park, Han-Chang Lee, Young-Ha Kim, Saekwang Ku, Seung Hyun Ki. Newly developed glycogen synthase kinase-3 (GSK-3) inhibitors protect neuronal cells death in amyloid-beta induced cell model and in a transgenic mouse model of Alzheimer's disease. Biochemical and biophysical research communications. vol 435. issue 2. 2013-08-06. PMID:23632329. |
in particular, 50 mg/kg c-7a treated mice significantly decreased the level of phosphorylated tau (ser396) in brain hippocampus. |
2013-08-06 |
2023-08-12 |
mouse |
S Duke Han, Jonathan Gruhl, Laurel Beckett, Hiroko H Dodge, Nikki H Stricker, Sarah Farias, Dan Munga. Beta amyloid, tau, neuroimaging, and cognition: sequence modeling of biomarkers for Alzheimer's Disease. Brain imaging and behavior. vol 6. issue 4. 2013-08-02. PMID:22648764. |
we examined temporal relations among four classes of biomarkers: csf aβ, csf tau, neuroimaging variables (hippocampal volume, ventricular volume, fdg pet), and cognitive variables (memory and executive function). |
2013-08-02 |
2023-08-12 |
Not clear |
Chuang Guo, Pu Wang, Man-Li Zhong, Tao Wang, Xue-Shi Huang, Jia-Yi Li, Zhan-You Wan. Deferoxamine inhibits iron induced hippocampal tau phosphorylation in the Alzheimer transgenic mouse brain. Neurochemistry international. vol 62. issue 2. 2013-07-22. PMID:23262393. |
deferoxamine inhibits iron induced hippocampal tau phosphorylation in the alzheimer transgenic mouse brain. |
2013-07-22 |
2023-08-12 |
mouse |
Reisuke H Takahashi, Estibaliz Capetillo-Zarate, Michael T Lin, Teresa A Milner, Gunnar K Goura. Accumulation of intraneuronal β-amyloid 42 peptides is associated with early changes in microtubule-associated protein 2 in neurites and synapses. PloS one. vol 8. issue 1. 2013-07-22. PMID:23372648. |
we previously provided evidence for early co-localization of aβ42 peptides and hyperphosphorylated tau within postsynaptic terminals of ca1 dendrites in the hippocampus of ad transgenic mice. |
2013-07-22 |
2023-08-12 |
mouse |
Cassia R Overk, Sylvia E Perez, Chunqi Ma, Matthew D Taves, Kiran K Soma, Elliott J Mufso. Sex steroid levels and AD-like pathology in 3xTgAD mice. Journal of neuroendocrinology. vol 25. issue 2. 2013-07-12. PMID:22889357. |
the age-related increase in hippocampal testosterone levels correlated positively with increases in the conformational tau isoform, alz50. |
2013-07-12 |
2023-08-12 |
mouse |
Larry D Sparks, Richard J Kryscio, John C Hunsake. Early age-related progression of AD-like neuropathology in Down's syndrome. American journal of neurodegenerative disease. vol 2. issue 2. 2013-07-11. PMID:23844336. |
50 μm vibratome sections of formalin fixed hippocampal formations were immunohistochemically stained for amyloid-β (6e10), app (22c11) and phosphorylated tau (at8) using standard methods. |
2013-07-11 |
2023-08-12 |
human |