| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qiong Feng, Bo Cheng, Ru Yang, Feng-Yan Sun, Cui-Qing Zh. Dynamic changes of phosphorylated tau in mouse hippocampus after cold water stress. Neuroscience letters vol 388 issue 1 2005 16005567 |
to explore the possible long-tem effects of cws on tau phosphorylation, we employed the immunoblot and immunohistochemical methods to analyze the phosphorylation of tau in the hippocampus of mice subjected to cws. |
2005-10-28 |
2023-01-24 |
mouse |
| Qiong Feng, Bo Cheng, Ru Yang, Feng-Yan Sun, Cui-Qing Zh. Dynamic changes of phosphorylated tau in mouse hippocampus after cold water stress. Neuroscience letters vol 388 issue 1 2005 16005567 |
these findings demonstrate that cws leads to prominent changes of tau phosphorylation and p-tau localization in the hippocampus in a time dependent manner. |
2005-10-28 |
2023-01-24 |
mouse |
| S N Ramage, I C Anthony, F W Carnie, A Busuttil, R Robertson, J E Bel. Hyperphosphorylated tau and amyloid precursor protein deposition is increased in the brains of young drug abusers. Neuropathology and applied neurobiology vol 31 issue 4 2005 16008828 |
detailed immunohistochemical analysis of the hippocampus, brainstem and basal ganglia for hyperphosphorylated tau, beta-amyloid, beta-amyloid precursor protein (betaapp) and ubiquitin demonstrated an excess of at 8-positive neurofibrillary tangles (nft) in the drug abusers. |
2005-09-06 |
2023-01-24 |
human |
| Sigrun Roeber, Bjarne Krebs, Manuela Neumann, Otto Windl, Inga Zerr, Eva-Maria Grasbon-Frodl, Hans A Kretzschma. Creutzfeldt-Jakob disease in a patient with an R208H mutation of the prion protein gene (PRNP) and a 17-kDa prion protein fragment. Acta neuropathologica vol 109 issue 4 2005 15739100 |
neuropathological examination of the post mortem brain revealed tau pathology in the hippocampus and entorhinal cortex, as well as ballooned neurons in the cortex, hippocampus and subcortical gray matter. |
2005-09-01 |
2023-01-24 |
Not clear |
| Guo-Gang Xu, Yan-Qiu Deng, Shi-Jie Liu, Hong-Lian Li, Jian-Zhi Wan. Prolonged Alzheimer-like tau hyperphosphorylation induced by simultaneous inhibition of phosphoinositol-3 kinase and protein kinase C in N2a cells. Acta biochimica et biophysica Sinica vol 37 issue 5 2005 15880264 |
co-injection of wortmannin (inhibitor of phosphatidylinositol-3 kinase, pi3k) and gf109203x (inhibitor of protein kinase c, pkc) into the rat brain was found to induce spatial memory deficiency and enhance tau hyperphosphorylation in the hippocampus of rat brain. |
2005-08-23 |
2023-01-24 |
rat |
| Luisa Fasulo, Gabriele Ugolini, Antonino Cattane. Apoptotic effect of caspase-3 cleaved tau in hippocampal neurons and its potentiation by tau FTDP-mutation N279K. Journal of Alzheimer's disease : JAD vol 7 issue 1 2005 15750210 |
here we show the apoptotic properties of tau fragment tau151-421 in primary cultures of rat hippocampal neurons; such cellular model is of special interest considering the selective vulnerability of hippocampal neurones in ad. |
2005-08-02 |
2023-01-24 |
rat |
| Wang Xiao-Chuan, Hu Zheng-Hui, Fang Zheng-Yu, Feng Yue, Yang Yun-Huang, Wang Qun, Tang Xiao-Wei, Wu Yi-Gen, Wang Jian-Zh. Correlation of Alzheimer-like tau hyperphosphorylation and fMRI bold intensity. Current Alzheimer research vol 1 issue 2 2005 15975079 |
to explore the correlation between cerebral functional alterations revealed by functional magnetic resonance imaging (fmri) and alzheimer disease- (ad)-like tau hyperphosphorylation, we injected bilaterally 2 microl each of 20 mm isoproterenol (ip), a pka activator, or of saline as a vehicle control into the hippocampus of rats. |
2005-07-21 |
2023-01-24 |
rat |
| Wang Xiao-Chuan, Hu Zheng-Hui, Fang Zheng-Yu, Feng Yue, Yang Yun-Huang, Wang Qun, Tang Xiao-Wei, Wu Yi-Gen, Wang Jian-Zh. Correlation of Alzheimer-like tau hyperphosphorylation and fMRI bold intensity. Current Alzheimer research vol 1 issue 2 2005 15975079 |
immunohistochemical staining of hippocampus and cortex was carried out using phosphorylation-dependent tau antibodies. |
2005-07-21 |
2023-01-24 |
rat |
| Wang Xiao-Chuan, Hu Zheng-Hui, Fang Zheng-Yu, Feng Yue, Yang Yun-Huang, Wang Qun, Tang Xiao-Wei, Wu Yi-Gen, Wang Jian-Zh. Correlation of Alzheimer-like tau hyperphosphorylation and fMRI bold intensity. Current Alzheimer research vol 1 issue 2 2005 15975079 |
the results showed (1) that bold intensity in hippocampus and cortex of ip-injected rats was obviously lower than that of sham-operated group, indicating a decrease in cmro2 and cbf of the particular brain regions in ip-treated rats; (2) that tau was hyperphosphorylated at ser-262/ser-356 (12e8), ser-396/ser-404 (phf-1) sites in ca1 ca2 ca3 ca4 and dentate gyrus regions of hippocampal formation and cortex area in ip group, but not in sham rats; (3) that a negative correlation between tau hyperphosphorylation and bold intensity in hippocampus and cortex area of ip rats was observed. |
2005-07-21 |
2023-01-24 |
rat |
| Wang Xiao-Chuan, Hu Zheng-Hui, Fang Zheng-Yu, Feng Yue, Yang Yun-Huang, Wang Qun, Tang Xiao-Wei, Wu Yi-Gen, Wang Jian-Zh. Correlation of Alzheimer-like tau hyperphosphorylation and fMRI bold intensity. Current Alzheimer research vol 1 issue 2 2005 15975079 |
the data suggested that hippocampal and cortical tau hyperphosphorylation was intimately related to bold intensity of the same areas. |
2005-07-21 |
2023-01-24 |
rat |
| M D Martin-Rehrmann, H-S Hoe, E M Capuani, G W Rebec. Association of apolipoprotein J-positive beta-amyloid plaques with dystrophic neurites in Alzheimer's disease brain. Neurotoxicity research vol 7 issue 3 2005 15897157 |
apoj was found at the core of these deposits, and co-localized with the amyloid staining agent thioflavine-s. to test the direct effects of apoj on tau metabolism, we treated cells in culture with apoj-containing conditioned media, and we injected apoj-containing media into the rat hippocampus. |
2005-07-15 |
2023-01-24 |
rat |
| Shagufta Ahmad, Leslie J Fowler, Peter S Whitto. Effects of combined lamotrigine and valproate on basal and stimulated extracellular amino acids and monoamines in the hippocampus of freely moving rats. Naunyn-Schmiedeberg's archives of pharmacology vol 371 issue 1 2005 15660242 |
in order to investigate this we have studied the effects of combined treatment with ltg and vpa on basal and stimulated extracellular aspartate (asp), glutamate (glu), taurine (tau), gamma amino butyric acid (gaba), 5-hydroxytryptamine (5-ht) and dopamine (da) release in the hippocampus of freely moving rats using microdialysis. |
2005-07-11 |
2023-01-24 |
rat |
| Shagufta Ahmad, Leslie J Fowler, Peter S Whitto. Lamotrigine, carbamazepine and phenytoin differentially alter extracellular levels of 5-hydroxytryptamine, dopamine and amino acids. Epilepsy research vol 63 issue 2-3 2005 15777732 |
we have studied the effects of treatment with the anticonvulsants lamotrigine (ltg), phenytoin (phn) and carbamazepine (cbz) on basal and stimulated extracellular aspartate (asp), glutamate (glu), taurine (tau), gaba, 5-hydroxytryptamine (5-ht) and dopamine (da) in the hippocampus of freely moving rats using microdialysis. |
2005-06-24 |
2023-01-24 |
rat |
| Harald Hampel, Katharina B\\xc3\\xbcrger, Jens C Pruessner, Raymond Zinkowski, John DeBernardis, Daniel Kerkman, Gerda Leinsinger, Alan C Evans, Peter Davies, Hans-J\\xc3\\xbcrgen M\\xc3\\xb6ller, Stefan J Teipe. Correlation of cerebrospinal fluid levels of tau protein phosphorylated at threonine 231 with rates of hippocampal atrophy in Alzheimer disease. Archives of neurology vol 62 issue 5 2005 15883264 |
correlation of cerebrospinal fluid levels of tau protein phosphorylated at threonine 231 with rates of hippocampal atrophy in alzheimer disease. |
2005-06-17 |
2023-01-24 |
Not clear |
| Despina Yancopoulou, John H Xuereb, R Anthony Crowther, John R Hodges, Maria Grazia Spillantin. Tau and alpha-synuclein inclusions in a case of familial frontotemporal dementia and progressive aphasia. Journal of neuropathology and experimental neurology vol 64 issue 3 2005 15804056 |
the 2 patients' brains revealed abundant tau pathology in the hippocampus and basal ganglia, whereas tau and alpha-synuclein aggregates coexisted only in the nucleus basalis of meynert, the only region where alpha-synuclein was present. |
2005-05-09 |
2023-01-24 |
Not clear |
| Yi-Gang Che. Specific tau phosphorylation sites in hippocampus correlate with impairment of step-down inhibitory avoidance task in rats. Behavioural brain research vol 158 issue 2 2005 15698894 |
specific tau phosphorylation sites in hippocampus correlate with impairment of step-down inhibitory avoidance task in rats. |
2005-04-19 |
2023-01-24 |
rat |
| Yi-Gang Che. Specific tau phosphorylation sites in hippocampus correlate with impairment of step-down inhibitory avoidance task in rats. Behavioural brain research vol 158 issue 2 2005 15698894 |
it was found that among rats that developed the impairment in memory retention in step-down inhibitory avoidance task, tau protein in their hippocampus was hyperphosohorylated at thr231/ser235 (m4) sites of tau, and the significantly increased expression of pp-1 and the decreased one of pp-2b were also determined by western blot and/or immunohistochemistry. |
2005-04-19 |
2023-01-24 |
rat |
| Su Jeon Shin, Sung-Eun Lee, Jung Hyun Boo, Mihyang Kim, Young-Dae Yoon, Su-il Kim, Inhee Mook-Jun. Profiling proteins related to amyloid deposited brain of Tg2576 mice. Proteomics vol 4 issue 11 2005 15378736 |
alzheimer's disease (ad) is an age-related neurodegenerative disorder that is characterized by the extracellular deposition of beta-amyloid and intracellular hyperphosphorylation of tau in the cortex and hippocampus of the brain. |
2005-04-13 |
2023-01-24 |
mouse |
| Thor D Stein, Nicholas J Anders, Charles DeCarli, Sic L Chan, Mark P Mattson, Jeffrey A Johnso. Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 24 issue 35 2005 15342738 |
chronic infusion of an antibody against transthyretin into the hippocampus of mice overexpressing app with the swedish mutation (app(sw)) leads to increased abeta, tau phosphorylation, and neuronal loss and apoptosis within the ca1 neuronal field. |
2005-04-05 |
2023-01-24 |
mouse |
| Masaki Ikeda, Mikio Shoji, Toshitaka Kawarai, Takeshi Kawarabayashi, Etsuro Matsubara, Tetsuro Murakami, Atsushi Sasaki, Yasushi Tomidokoro, Yasushi Ikarashi, Hisashi Kuribara, Koichi Ishiguro, Masato Hasegawa, Shu-Hui Yen, M Azhar Chishti, Yasuo Harigaya, Koji Abe, Koichi Okamoto, Peter St George-Hyslop, David Westawa. Accumulation of filamentous tau in the cerebral cortex of human tau R406W transgenic mice. The American journal of pathology vol 166 issue 2 2005 15681835 |
the tgtaur406w 21807 line showed tau accumulation beginning in the hippocampus and amygdala at 6 months of age, which subsequently spread to the cortices and subcortical areas. |
2005-03-29 |
2023-01-24 |
mouse |