| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yue-Ju Wang, Gui-Hai Chen, Xiang-You Hu, Ya-Ping Lu, Jiang-Ning Zhou, Rong-Yu Li. The expression of calcium/calmodulin-dependent protein kinase II-alpha in the hippocampus of patients with Alzheimer's disease and its links with AD-related pathology. Brain research vol 1031 issue 1 2005 15621017 |
since calcium/calmodulin-dependent protein kinase ii-alpha (camkii-alpha), one of the most abundant kinases in the brain, is involved in the phosphorylation of tau and amyloid precursor protein (app), we examined the expression of camkii-alpha and its relationships with the neuropathology in the hippocampus of ad patients using immunohistochemistry and double-labeling immunofluorescence methods. |
2005-03-18 |
2023-01-24 |
Not clear |
| V Echeverria, A Ducatenzeiler, E Dowd, J J\\xc3\\xa4nne, S M Grant, M Szyf, F Wandosell, J Avila, H Grimm, S B Dunnett, T Hartmann, L Alhonen, A C Cuell. Altered mitogen-activated protein kinase signaling, tau hyperphosphorylation and mild spatial learning dysfunction in transgenic rats expressing the beta-amyloid peptide intracellularly in hippocampal and cortical neurons. Neuroscience vol 129 issue 3 2005 15541880 |
altered mitogen-activated protein kinase signaling, tau hyperphosphorylation and mild spatial learning dysfunction in transgenic rats expressing the beta-amyloid peptide intracellularly in hippocampal and cortical neurons. |
2005-03-07 |
2023-01-24 |
rat |
| V Echeverria, A Ducatenzeiler, E Dowd, J J\\xc3\\xa4nne, S M Grant, M Szyf, F Wandosell, J Avila, H Grimm, S B Dunnett, T Hartmann, L Alhonen, A C Cuell. Altered mitogen-activated protein kinase signaling, tau hyperphosphorylation and mild spatial learning dysfunction in transgenic rats expressing the beta-amyloid peptide intracellularly in hippocampal and cortical neurons. Neuroscience vol 129 issue 3 2005 15541880 |
in these rats, the presence of intraneuronal abeta is sufficient to provoke up-regulation of the phosphorylated form of extracellular-regulated kinase (erk) 2 and its enzymatic activity in the hippocampus while no changes were observed in the activity or phosphorylation status of other putative tau kinases such as p38, glycogen synthase kinase 3, and cycline-dependent kinase 5. |
2005-03-07 |
2023-01-24 |
rat |
| Xiaomei Liao, Yingchun Zhang, Yipeng Wang, Jianzhi Wan. The effect of cdk-5 overexpression on tau phosphorylation and spatial memory of rat. Science in China. Series C, Life sciences vol 47 issue 3 2005 15524282 |
we demonstrated that 24 h after transfection into rat hippocampus, cdk-5 was overexpressed and induced a reduced staining with antibody tau-1 and an enhanced staining with antibodies 12e8 and phf-1, suggesting hyperphosphorylation of tau at ser199/202, ser262/356 and ser396/404 sites. |
2005-03-04 |
2023-01-24 |
rat |
| Satyabrata Kar, Stephen P M Slowikowski, David Westaway, Howard T J Moun. Interactions between beta-amyloid and central cholinergic neurons: implications for Alzheimer's disease. Journal of psychiatry & neuroscience : JPN vol 29 issue 6 2005 15644984 |
the brain of an individual with alzheimer's disease exhibits extracellular plaques of aggregated beta-amyloid protein (abeta), intracellular neurofibrillary tangles that contain hyperphosphorylated tau protein and a profound loss of basal forebrain cholinergic neurons that innervate the hippocampus and the neocortex. |
2005-02-23 |
2023-01-24 |
Not clear |
| Baolin Li, John Ryder, Yuan Su, Steven A Moore, Feng Liu, Patricia Solenberg, Kellie Brune, Niles Fox, Binhui Ni, Rugao Liu, Yan Zho. Overexpression of GSK3betaS9A resulted in tau hyperphosphorylation and morphology reminiscent of pretangle-like neurons in the brain of PDGSK3beta transgenic mice. Transgenic research vol 13 issue 4 2005 15517997 |
by analyzing the offspring from several transgenic mouse lines, including lines other than 3083 and 3107, it was found that overexpressed constitutively active human gsk3betas9a resulted in hyperphosphorylation of tau and morphology reminiscent of pretangle-like neurons in cortex and hippocampus. |
2005-02-22 |
2023-01-24 |
mouse |
| Li Sun, XiaoChuang Wang, Shengyuan Liu, Quan Wang, JianZhi Wang, Malika Bennecib, Cheng-Xin Gong, Amitabha Sengupta, Inge Grundke-Iqbal, Khalid Iqba. Bilateral injection of isoproterenol into hippocampus induces Alzheimer-like hyperphosphorylation of tau and spatial memory deficit in rat. FEBS letters vol 579 issue 1 2005 15620722 |
bilateral injection of isoproterenol into hippocampus induces alzheimer-like hyperphosphorylation of tau and spatial memory deficit in rat. |
2005-02-17 |
2023-01-24 |
rat |
| Li Sun, XiaoChuang Wang, Shengyuan Liu, Quan Wang, JianZhi Wang, Malika Bennecib, Cheng-Xin Gong, Amitabha Sengupta, Inge Grundke-Iqbal, Khalid Iqba. Bilateral injection of isoproterenol into hippocampus induces Alzheimer-like hyperphosphorylation of tau and spatial memory deficit in rat. FEBS letters vol 579 issue 1 2005 15620722 |
here, we show that injection of isoproterenol, an activator of camp-dependent kinase (pka), into rat hippocampus bilaterally results in the activation of pka, calcium/calmodulin-dependent kinase ii and cyclin-dependent kinase-5, inhibition of protein phosphatase-2a, hyperphosphorylation of tau at several alzheimer-like epitopes and a disturbance of spatial memory retention 48 h after the drug injection. |
2005-02-17 |
2023-01-24 |
rat |
| Shagufta Ahmad, Leslie J Fowler, Peter S Whitto. Effects of acute and chronic lamotrigine treatment on basal and stimulated extracellular amino acids in the hippocampus of freely moving rats. Brain research vol 1029 issue 1 2005 15533314 |
in the present study, we have investigated the effects of acute and chronic (up to 21 days) treatment with ltg on basal and either veratridine- or kcl-stimulated release of aspartate (asp), glu, taurine (tau) and gaba in the hippocampus of freely moving rats using microdialysis. |
2005-02-14 |
2023-01-24 |
rat |
| Dan-Ling Wang, Zhi-Qun Ling, Fu-Yuan Cao, Ling-Qiang Zhu, Jian-Zhi Wan. Melatonin attenuates isoproterenol-induced protein kinase A overactivation and tau hyperphosphorylation in rat brain. Journal of pineal research vol 37 issue 1 2005 15230863 |
in the present study, isoproterenol (iso) was injected bilaterally into hippocampus of rat brain; iso is a specific pka activator and it induces tau hyperphosphorylation. |
2005-02-10 |
2023-01-24 |
rat |
| Dan-Ling Wang, Zhi-Qun Ling, Fu-Yuan Cao, Ling-Qiang Zhu, Jian-Zhi Wan. Melatonin attenuates isoproterenol-induced protein kinase A overactivation and tau hyperphosphorylation in rat brain. Journal of pineal research vol 37 issue 1 2005 15230863 |
we found that hippocampal injection of iso (0.02 microm) induced pka overactivation and tau hyperphosphorylation at both paired helical filament (phf)-1 and tau-1 sites. |
2005-02-10 |
2023-01-24 |
rat |
| Markus Tolnay, Florence Clavaguer. Argyrophilic grain disease: a late-onset dementia with distinctive features among tauopathies. Neuropathology : official journal of the Japanese Society of Neuropathology vol 24 issue 4 2005 15641585 |
agd changes consist of the microtubule-associated protein tau in an abnormally and hyperphosphorylated state and are mainly found in limbic regions, for example, in the hippocampus, the entorhinal and transentorhinal cortices and the amygdala. |
2005-02-10 |
2023-01-24 |
Not clear |
| Octavio Mercado-G\\xc3\\xb3mez, Patricia Ferrera, Clorinda Aria. Histopathologic changes induced by the microtubule-stabilizing agent Taxol in the rat hippocampus in vivo. Journal of neuroscience research vol 78 issue 4 2005 15449327 |
we studied the effects of taxol on neuronal morphology and viability as well as changes in microtubule-associated proteins map2 and tau in rat hippocampus. |
2005-02-03 |
2023-01-24 |
rat |
| Octavio Mercado-G\\xc3\\xb3mez, Patricia Ferrera, Clorinda Aria. Histopathologic changes induced by the microtubule-stabilizing agent Taxol in the rat hippocampus in vivo. Journal of neuroscience research vol 78 issue 4 2005 15449327 |
interestingly paired helical filament (phf)-1 immunoreactivity, which is associated with a phosphorylated epitope of tau proteins, was induced in the damaged hippocampus. |
2005-02-03 |
2023-01-24 |
rat |
| D C Paviour, A J Lees, K A Josephs, T Ozawa, M Ganguly, C Strand, A Godbolt, R S Howard, T Revesz, J L Holto. Frontotemporal lobar degeneration with ubiquitin-only-immunoreactive neuronal changes: broadening the clinical picture to include progressive supranuclear palsy. Brain : a journal of neurology vol 127 issue Pt 11 2005 15459024 |
the ftld with ubiquitin-only-immunoreactive neuronal changes (ftld-u) subtype is pathologically characterized by ubiquitin-positive, tau and alpha-synuclein-negative neuronal cytoplasmic inclusions in the frontotemporal cortex and hippocampal dentate fascia. |
2005-01-18 |
2023-01-24 |
Not clear |
| Andrea Reyna-Neyra, Clorinda Arias, Patricia Ferrera, Sumiko Morimoto, Ignacio Camacho-Arroy. Changes in the content and distribution of microtubule associated protein 2 in the hippocampus of the rat during the estrous cycle. Journal of neurobiology vol 60 issue 4 2004 15307151 |
because this process implicates changes in neuronal cytoskeleton organization, we analyzed the content of microtubule associated protein 2 (map2) and tau in the hippocampus and the frontal cortex of the rat by western blot, as well as the hippocampal distribution of map2 during the estrous cycle by immunohistochemistry. |
2004-12-02 |
2023-01-24 |
rat |
| Andrea Reyna-Neyra, Clorinda Arias, Patricia Ferrera, Sumiko Morimoto, Ignacio Camacho-Arroy. Changes in the content and distribution of microtubule associated protein 2 in the hippocampus of the rat during the estrous cycle. Journal of neurobiology vol 60 issue 4 2004 15307151 |
in contrast, the content of tau did not vary during the estrous cycle in either the hippocampus or the frontal cortex. |
2004-12-02 |
2023-01-24 |
rat |
| Gytis Baranauska. Cell-type-specific splicing of KChIP4 mRNA correlates with slower kinetics of A-type current. The European journal of neuroscience vol 20 issue 2 2004 15233748 |
for example, in globus pallidus (gp) and basal forebrain (bf) neurons in rats, a-type current possesses a slowly inactivating (tau > 80 ms) component of inactivation that is absent in the currents obtained from striatal cholinergic interneurons (stri) and hippocampal area ca1 pyramidal neurons (hip). |
2004-09-30 |
2023-01-24 |
rat |
| Cristian A Zambrano, Jos\\xc3\\xa9 T Ega\\xc3\\xb1a, Marco T N\\xc3\\xba\\xc3\\xb1ez, Ricardo B Maccioni, Christian Gonz\\xc3\\xa1lez-Billaul. Oxidative stress promotes tau dephosphorylation in neuronal cells: the roles of cdk5 and PP1. Free radical biology & medicine vol 36 issue 11 2004 15135175 |
by using phospho-specific antibodies, we analyzed the changes in tau phosphorylation patterns after treatment of rat hippocampal and shsy5y human neuroblastoma cells with h2o2. |
2004-08-19 |
2023-01-24 |
rat |
| Gary W Arendash, Jada Lewis, Ralph E Leighty, Eileen McGowan, Jennifer R Cracchiolo, Mike Hutton, Marcos F Garci. Multi-metric behavioral comparison of APPsw and P301L models for Alzheimer's disease: linkage of poorer cognitive performance to tau pathology in forebrain. Brain research vol 1012 issue 1-2 2004 15158158 |
moreover, correlation analyses involving tau mice alone revealed linkage between poorer cognitive performance in all three water maze tasks and the number of neurofibrillary tangle (nft)-containing neurons in neocortex and hippocampus. |
2004-08-17 |
2023-01-24 |
mouse |