All Relations between microtubule-associated protein tau and hippocampus

Publication Sentence Publish Date Extraction Date Species
Ann Van der Jeugd, Katja Hochgräfe, Tariq Ahmed, Jochen M Decker, Astrid Sydow, Anne Hofmann, Dan Wu, Lars Messing, Detlef Balschun, Rudi D'Hooge, Eva-Maria Mandelko. Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau. Acta neuropathologica. vol 123. issue 6. 2012-09-24. PMID:22532069. we correlated hippocampal tau pathology with learning/memory performance and synaptic plasticity. 2012-09-24 2023-08-12 mouse
Xu-Ying Sun, Yu-Ping Wei, Yan Xiong, Xiao-Chuan Wang, Ao-Ji Xie, Xiu-Lian Wang, Yang Yang, Qun Wang, You-Ming Lu, Rong Liu, Jian-Zhi Wan. Synaptic released zinc promotes tau hyperphosphorylation by inhibition of protein phosphatase 2A (PP2A). The Journal of biological chemistry. vol 287. issue 14. 2012-09-20. PMID:22334661. to explore this possibility, we treated cultured hippocampal slices or primary neurons with glutamate or bic/4-ap to increase the synaptic activity with or without pretreatment of zinc chelators, and then detected the phosphorylation levels of tau. 2012-09-20 2023-08-12 Not clear
Xu-Ying Sun, Yu-Ping Wei, Yan Xiong, Xiao-Chuan Wang, Ao-Ji Xie, Xiu-Lian Wang, Yang Yang, Qun Wang, You-Ming Lu, Rong Liu, Jian-Zhi Wan. Synaptic released zinc promotes tau hyperphosphorylation by inhibition of protein phosphatase 2A (PP2A). The Journal of biological chemistry. vol 287. issue 14. 2012-09-20. PMID:22334661. the zinc release and translocation of excitatory synapses in the hippocampus were detected, and zinc-induced tau hyperphosphorylation was also observed in cultured brain slices incubated with exogenously supplemented zinc. 2012-09-20 2023-08-12 Not clear
Abdur Rahman, Khalid M Khan, Ghanim Al-Khaledi, Islam Khan, Tahany Al-Shemar. Over activation of hippocampal serine/threonine protein phosphatases PP1 and PP2A is involved in lead-induced deficits in learning and memory in young rats. Neurotoxicology. vol 33. issue 3. 2012-09-18. PMID:22387731. pb exposure increased the expression and activity of pp1 and decreased phosphorylation of tau at threonine-231 in hippocampus at both pnd21 and pnd30. 2012-09-18 2023-08-12 rat
Yuen-Shan Ho, Xifei Yang, Jeffery Chi-Fai Lau, Clara Hui-Ling Hung, Suthicha Wuwongse, Qishan Zhang, Jianzhi Wang, Larry Baum, Kwok-Fai So, Raymond Chuen-Chung Chan. Endoplasmic reticulum stress induces tau pathology and forms a vicious cycle: implication in Alzheimer's disease pathogenesis. Journal of Alzheimer's disease : JAD. vol 28. issue 4. 2012-09-17. PMID:22101233. in this study, we found that high levels of phosphorylated pkr-like er-resident kinase (p-perk) and phosphorylated eukaryotic initiation factor 2 alpha (p-eif2α) as markers for activation of upr in the hippocampus of aged p301l mutant tau transgenic mice. 2012-09-17 2023-08-12 mouse
Abderazzak Mouiha, Simon Duchesn. Toward a dynamic biomarker model in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 30. issue 1. 2012-09-10. PMID:22398375. we included 576 subjects (229 controls, 193 ad, and 154 mild cognitive impairment subjects who converted to ad) from the adni study, for whom baseline data on cerebrospinal fluid amyloid-β (aβ)42, phosphorylated tau (p-tau), and total-tau (t-tau), hippocampal volumes, and fdg-pet were available. 2012-09-10 2023-08-12 human
Aaron Clausen, Xiaobo Xu, Xiaoning Bi, Michel Baudr. Effects of the superoxide dismutase/catalase mimetic EUK-207 in a mouse model of Alzheimer's disease: protection against and interruption of progression of amyloid and tau pathology and cognitive decline. Journal of Alzheimer's disease : JAD. vol 30. issue 1. 2012-09-10. PMID:22406441. euk-207-treated 3xtg-ad mice did not display any deficit in fear conditioning and exhibited reduced aβ, tau, and phosphorylated tau accumulation in amygdala and hippocampus, as well as brain levels of aβ42, oxidized nucleic acids, and lipid peroxidation. 2012-09-10 2023-08-12 mouse
Aaron Clausen, Xiaobo Xu, Xiaoning Bi, Michel Baudr. Effects of the superoxide dismutase/catalase mimetic EUK-207 in a mouse model of Alzheimer's disease: protection against and interruption of progression of amyloid and tau pathology and cognitive decline. Journal of Alzheimer's disease : JAD. vol 30. issue 1. 2012-09-10. PMID:22406441. euk-207-treated 3xtg-ad mice did not display any deficit in fear conditioning and were protected against increases in brain levels of oxidized nucleic acids and lipid peroxidation; they also had reduced aβ, tau, and hyperphosphorylated tau accumulation in amygdala and hippocampus. 2012-09-10 2023-08-12 mouse
Jaya R P Prasanthi, Matthew Schrag, Bhanu Dasari, Gurdeep Marwarha, April Dickson, Wolff M Kirsch, Othman Ghrib. Deferiprone reduces amyloid-β and tau phosphorylation levels but not reactive oxygen species generation in hippocampus of rabbits fed a cholesterol-enriched diet. Journal of Alzheimer's disease : JAD. vol 30. issue 1. 2012-09-10. PMID:22406440. deferiprone reduces amyloid-β and tau phosphorylation levels but not reactive oxygen species generation in hippocampus of rabbits fed a cholesterol-enriched diet. 2012-09-10 2023-08-12 rabbit
Sylvie Burnouf, Karim Belarbi, Laetitia Troquier, Maxime Derisbourg, Dominique Demeyer, Antoine Leboucher, Cyril Laurent, Malika Hamdane, Luc Buee, David Blu. Hippocampal BDNF expression in a tau transgenic mouse model. Current Alzheimer research. vol 9. issue 4. 2012-09-07. PMID:22272617. hippocampal bdnf expression in a tau transgenic mouse model. 2012-09-07 2023-08-12 mouse
Sylvie Burnouf, Karim Belarbi, Laetitia Troquier, Maxime Derisbourg, Dominique Demeyer, Antoine Leboucher, Cyril Laurent, Malika Hamdane, Luc Buee, David Blu. Hippocampal BDNF expression in a tau transgenic mouse model. Current Alzheimer research. vol 9. issue 4. 2012-09-07. PMID:22272617. in the present study, we have evaluated this relationship using quantitative pcr, western blot and elisa in the thy-tau22 transgenic strain, known to display a progressive development of both hippocampal ad-like tau pathology and memory impairments. 2012-09-07 2023-08-12 mouse
Laetitia Troquier, Raphaelle Caillierez, Sylvie Burnouf, Francisco J Fernandez-Gomez, Marie-Eve Grosjean, Nadege Zommer, Nicolas Sergeant, Susanna Schraen-Maschke, David Blum, Luc Bue. Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach. Current Alzheimer research. vol 9. issue 4. 2012-09-07. PMID:22272619. starting from 3-6 months of age, thy-tau22 mice develop hippocampal neurofibrillary tangle-like inclusions and exhibit phosphorylation of tau on several ad-relevant tau epitopes. 2012-09-07 2023-08-12 mouse
Ben A Bahr, Meagan L Wisniewski, David Butle. Positive lysosomal modulation as a unique strategy to treat age-related protein accumulation diseases. Rejuvenation research. vol 15. issue 2. 2012-09-06. PMID:22533430. such positive modulators of the lysosomal system have been studied in the well-characterized hippocampal slice model of protein accumulation that exhibits the pathogenic cascade of tau aggregation, tubulin breakdown, microtubule destabilization, transport failure, and synaptic decline. 2012-09-06 2023-08-12 mouse
Yang Yu, Lan Zhang, Xiaojing Li, Xiaoqin Run, Zhihou Liang, Yi Li, Ying Liu, Moon H Lee, Inge Grundke-Iqbal, Khalid Iqbal, David J Vocadlo, Fei Liu, Cheng-Xin Gon. Differential effects of an O-GlcNAcase inhibitor on tau phosphorylation. PloS one. vol 7. issue 4. 2012-08-31. PMID:22536363. however, the elevation of tau phosphorylation at the sites above was not observed and gsk-3β was not activated in cultured adult hippocampal progenitor cells or in pc12 cells after thiamet-g treatment. 2012-08-31 2023-08-12 mouse
Jennifer Rodríguez-Vázquez, Ignacio Camacho-Arroyo, Javier Velázquez-Moctezum. Differential impact of REM sleep deprivation on cytoskeletal proteins of brain regions involved in sleep regulation. Neuropsychobiology. vol 65. issue 3. 2012-08-27. PMID:22456537. results showed an increase in tau content in the pons, preoptic area and hippocampus after 24 h of remsd, while in the frontal cortex a significant increase in tau content was observed after 72 h of remsd. 2012-08-27 2023-08-12 rat
Jennifer Rodríguez-Vázquez, Ignacio Camacho-Arroyo, Javier Velázquez-Moctezum. Differential impact of REM sleep deprivation on cytoskeletal proteins of brain regions involved in sleep regulation. Neuropsychobiology. vol 65. issue 3. 2012-08-27. PMID:22456537. a tau content decrease was observed in the hippocampus after 48 h of remsd. 2012-08-27 2023-08-12 rat
Jiejie Li, Jiao Deng, Wenli Sheng, Zhiyi Zu. Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice. Pharmacology, biochemistry, and behavior. vol 101. issue 4. 2012-08-23. PMID:22425595. activated/phosphorylated c-jun n-terminal kinase (jnk), a tau kinase, was increased in the db/db mouse hippocampus. 2012-08-23 2023-08-12 mouse
Lindsay C Reese, Giulio Taglialatel. A role for calcineurin in Alzheimer's disease. Current neuropharmacology. vol 9. issue 4. 2012-08-23. PMID:22654726. this bellwether symptom suggests involvement of the hippocampus -- a brain region responsible for memory formation -- and coincidentally an area heavily burdened by hyperphosphorylated tau and neuritic plaques of amyloid beta (aβ). 2012-08-23 2023-08-12 Not clear
Wei Wei, Ying-Hua Liu, Chang-E Zhang, Qun Wang, Zelan Wei, Darrell D Mousseau, Jian-Zhi Wang, Qing Tian, Gong-Ping Li. Folate/vitamin-B12 prevents chronic hyperhomocysteinemia-induced tau hyperphosphorylation and memory deficits in aged rats. Journal of Alzheimer's disease : JAD. vol 27. issue 3. 2012-08-20. PMID:21860088. we found that hyperhomocysteinemia induced tau hyperphosphorylation and accumulation in hippocampus and cortex. 2012-08-20 2023-08-12 rat
María Llorens-Martin, Cátia M Teixeira, Almudena Fuster-Matanzo, Jerónimo Jurado-Arjona, Víctor Borrell, Eduardo Soriano, Jesús Avila, Félix Hernánde. Tau isoform with three microtubule binding domains is a marker of new axons generated from the subgranular zone in the hippocampal dentate gyrus: implications for Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 29. issue 4. 2012-08-17. PMID:22337826. tau isoform with three microtubule binding domains is a marker of new axons generated from the subgranular zone in the hippocampal dentate gyrus: implications for alzheimer's disease. 2012-08-17 2023-08-12 mouse