| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bin Zhang, Makoto Higuchi, Yasumasa Yoshiyama, Takeshi Ishihara, Mark S Forman, Dan Martinez, Sonali Joyce, John Q Trojanowski, Virginia M-Y Le. Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 24 issue 19 2004 15140937 |
rw but not hwt tau tg mice developed an age-dependent accumulation of insoluble filamentous tau aggregates in neuronal perikarya of the cerebral cortex, hippocampus, cerebellum, and spinal cord. |
2004-08-13 |
2023-01-24 |
mouse |
| P Cardona-Gomez, M Perez, J Avila, L M Garcia-Segura, F Wandosel. Estradiol inhibits GSK3 and regulates interaction of estrogen receptors, GSK3, and beta-catenin in the hippocampus. Molecular and cellular neurosciences vol 25 issue 3 2004 15033165 |
the present data show that estradiol, in vivo, induces a transient activation of gsk3 in the adult female rat hippocampus, followed by a more sustained inhibition, as inferred from phosphorylation levels of tau. |
2004-05-26 |
2023-01-24 |
rat |
| F F Cruz-S\\xc3\\xa1nchez, N Durany, J Thome, P Riederer, D Zamb\\xc3\\xb3. Correlation between Apolipoprotein-E polymorphism and Alzheimer's disease pathology. Journal of Alzheimer's disease : JAD vol 2 issue 3-4 2004 12214086 |
representative cerebral regions (cortex, gyrus cinguli, putamen, hippocampus, white matter) from 28 ad cases, 7 svdd and 38 non-neurological controls were studied using classical histological techniques and immunohistochemistry for tau protein and amyloid-beta. |
2004-05-05 |
2023-01-24 |
Not clear |
| Salvatore Oddo, Antonella Caccamo, Masashi Kitazawa, Bertrand P Tseng, Frank M LaFerl. Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease. Neurobiology of aging vol 24 issue 8 2004 14643377 |
we find that abeta deposits initiate in the cortex and progress to the hippocampus with aging, whereas tau pathology is first apparent in the hippocampus and then progresses to the cortex. |
2004-03-11 |
2023-01-24 |
mouse |
| Ronald L Klein, Wen-Lang Lin, Dennis W Dickson, Jada Lewis, Michael Hutton, Karen Duff, Edwin M Meyer, Michael A Kin. Rapid neurofibrillary tangle formation after localized gene transfer of mutated tau. The American journal of pathology vol 164 issue 1 2004 14695347 |
tau gene transfer to the hippocampal region of amyloid-depositing transgenic mice produced pretangles and threads, as well as intensely tau-immunoreactive neurites in amyloid plaques. |
2004-02-27 |
2023-01-24 |
rat |
| Hillel Grossma. Does diabetes protect or provoke Alzheimer's disease? Insights into the pathobiology and future treatment of Alzheimer's disease. CNS spectrums vol 8 issue 11 2004 14702004 |
insulin dysregulation may contribute to ad pathology through several mechanisms including decreased cortical glucose utilization particularly in the hippocampus and entorhinal cortex; increased oxidative stress through the formation of advanced glycation end-products; increased tau phosphorylation and neurofibrillary tangle formation; increased b-amyloid aggregation through inhibition of insulin-degrading enzyme. |
2004-02-23 |
2023-01-24 |
Not clear |
| Othman Ghribi, Patcharin Prammonjago, Mary M Herman, Natalie K Spaulding, John Savor. Abeta(1-42)-induced JNK and ERK activation in rabbit hippocampus is differentially regulated by lithium but is not involved in the phosphorylation of tau. Brain research. Molecular brain research vol 119 issue 2 2004 14625087 |
abeta(1-42)-induced jnk and erk activation in rabbit hippocampus is differentially regulated by lithium but is not involved in the phosphorylation of tau. |
2004-02-20 |
2023-01-24 |
rabbit |
| Alexei R Koudinov, Natalia V Koudinov. Cholesterol, synaptic function and Alzheimer's disease. Pharmacopsychiatry vol 36 Suppl 2 issue 2003 14574623 |
from additional immunofluorescent analysis of the slices, we could demonstrate that the cholesterol imbalance also caused neurodegeneration of hippocampal neural cell processes and the appearance of tau protein pathology in the mossy fibers. |
2003-12-10 |
2023-01-24 |
rat |
| Kun Zou, Daesung Kim, Atsuko Kakio, Kyunghee Byun, Jian-Sheng Gong, Jaewoo Kim, Myeungju Kim, Naoya Sawamura, Sei-ichi Nishimoto, Katsumi Matsuzaki, Bonghee Lee, Katsuhiko Yanagisawa, Makoto Michikaw. Amyloid beta-protein (Abeta)1-40 protects neurons from damage induced by Abeta1-42 in culture and in rat brain. Journal of neurochemistry vol 87 issue 3 2003 14535944 |
abeta1-42 injection into the rat entorhinal cortex (ec) caused the hyperphosphorylation of tau on both sides of ec and hippocampus and increased the number of glial fibrillary acidic protein (gfap)-positive astrocytes in the ipsilateral ec, which were prevented by the concurrent injection of abeta1-40. |
2003-11-24 |
2023-01-24 |
rat |
| Hoau-Yan Wang, Weiwei Li, Nancy J Benedetti, Daniel H S Le. Alpha 7 nicotinic acetylcholine receptors mediate beta-amyloid peptide-induced tau protein phosphorylation. The Journal of biological chemistry vol 278 issue 34 2003 12801934 |
we show that a beta 42 elicited rapid and reversible tau protein phosphorylation on three proline-directed sites (ser-202, thr-181, and thr-231) in systems enriched in alpha 7 nicotinic acetylcholine receptors (alpha 7nachr) including serum-deprived human sk-n-mc neuroblastoma cells and hippocampal synaptosomes. |
2003-10-29 |
2023-01-24 |
human |
| Faith M Harris, Walter J Brecht, Qin Xu, Ina Tesseur, Lisa Kekonius, Tony Wyss-Coray, Jo Dee Fish, Eliezer Masliah, Paul C Hopkins, Kimberly Scearce-Levie, Karl H Weisgraber, Lennart Mucke, Robert W Mahley, Yadong Huan. Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America vol 100 issue 19 2003 12939405 |
the cortex and hippocampus of these mice displayed ad-like neurodegenerative alterations, including abnormally phosphorylated tau (p-tau) and gallyas silver-positive neurons that contained cytosolic straight filaments with diameters of 15-20 nm, resembling preneurofibrillary tangles. |
2003-10-29 |
2023-01-24 |
mouse |
| M A Kurt, D C Davies, M Kidd, K Duff, D R Howlet. Hyperphosphorylated tau and paired helical filament-like structures in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes. Neurobiology of disease vol 14 issue 1 2003 13678670 |
lm immunocytochemistry revealed cerebral abeta deposits to be present from 8 weeks of age, whereas hyperphosphorylated tau was not detected until 24 weeks of age, when it appeared as punctate deposits in close association with the abeta deposits in the cortex and hippocampus. |
2003-10-29 |
2023-01-24 |
mouse |
| E Head, I T Lott, P R Hof, C Bouras, J H Su, R Kim, R Haier, C W Cotma. Parallel compensatory and pathological events associated with tau pathology in middle aged individuals with Down syndrome. Journal of neuropathology and experimental neurology vol 62 issue 9 2003 14533781 |
immunohistochemistry and confocal microscopy studies in the hippocampus from 15 individuals ranging in age from 5 months to 67 years compared markers of normal and abnormal tau accumulation (phosphorylated tau [at8, mc-1], tau-1, n-terminal tau) with the extent and location of neuronal growth marker immunoreactivity (bdnf, gap-43, map-2). |
2003-10-28 |
2023-01-24 |
Not clear |
| Thomas Arendt, Jens Stieler, Arjen M Strijkstra, Roelof A Hut, Jan R\\xc3\\xbcdiger, Eddy A Van der Zee, Tibor Harkany, Max Holzer, Wolfgang H\\xc3\\xa4rti. Reversible paired helical filament-like phosphorylation of tau is an adaptive process associated with neuronal plasticity in hibernating animals. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 23 issue 18 2003 12904458 |
distribution of phf-like tau followed a consistent pattern, being most intense in the entorhinal cortex, hippocampus, and isocortical areas. |
2003-09-09 |
2023-01-24 |
Not clear |
| Markus Schubert, Derek P Brazil, Deborah J Burks, Jake A Kushner, Jing Ye, Carrie L Flint, Janet Farhang-Fallah, Pieter Dikkes, Xavier M Warot, Carlos Rio, Gabriel Corfas, Morris F Whit. Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 23 issue 18 2003 12904469 |
second, neurofibrillary tangles containing phosphorylated tau accumulated in the hippocampus of old irs2 knock-out mice, suggesting that irs2 signaling is neuroprotective. |
2003-09-09 |
2023-01-24 |
mouse |
| A Gonz\\xc3\\xa1lez-Quevedo, F Obreg\\xc3\\xb3n, M Urbina, T Rouss\\xc3\\xb3, L Lim. Effects of taurine deficiency and chronic methanol administration on rat retina, optic nerve and brain amino acids and monoamines. Nutritional neuroscience vol 6 issue 4 2003 12887142 |
beta-ala administration reduced taurine (tau) levels in plasma, hippocampus and posterior cortex, but not in retina and optic nerve. |
2003-09-03 |
2023-01-24 |
rat |
| A Gonz\\xc3\\xa1lez-Quevedo, F Obreg\\xc3\\xb3n, M Urbina, T Rouss\\xc3\\xb3, L Lim. Effects of taurine deficiency and chronic methanol administration on rat retina, optic nerve and brain amino acids and monoamines. Nutritional neuroscience vol 6 issue 4 2003 12887142 |
on the other hand, in the hippocampus, asp metabolism could be affected by tau depletion with beta-ala. |
2003-09-03 |
2023-01-24 |
rat |
| Michael D Devou. Functional brain imaging in the dementias: role in early detection, differential diagnosis, and longitudinal studies. European journal of nuclear medicine and molecular imaging vol 29 issue 12 2003 12458405 |
even greater predictive ability for progression to ad is obtained by combining measures of perfusion or metabolism with risk factors, tau protein levels, hippocampal n-acetyl aspartate concentrations, or hippocampal volume measures. |
2003-08-15 |
2023-01-24 |
human |
| Kelly L Krass, Veronica Colinayo, Anatole Ghazalpour, Harry V Vinters, Aldons J Lusis, Thomas A Drak. Genetic loci contributing to age-related hippocampal lesions in mice. Neurobiology of disease vol 13 issue 2 2003 12828934 |
c57bl/6j mice develop genetically determined age-related hippocampal granular deposits that have some similarities to lesions seen in the brains of human patients with tau protein related neurodegenerative disorders ("tauopathies"). |
2003-08-08 |
2023-01-24 |
mouse |
| Kelly L Krass, Veronica Colinayo, Anatole Ghazalpour, Harry V Vinters, Aldons J Lusis, Thomas A Drak. Genetic loci contributing to age-related hippocampal lesions in mice. Neurobiology of disease vol 13 issue 2 2003 12828934 |
hippocampal lesions were shown to be pas positive, h and e negative, and immunoreactive for tau protein and alpha synuclein, but not to abeta 1-40 or abeta 1-42, or for ubiquitin. |
2003-08-08 |
2023-01-24 |
mouse |