| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jennifer Rodríguez-Vázquez, Ignacio Camacho-Arroyo, Javier Velázquez-Moctezum. Differential impact of REM sleep deprivation on cytoskeletal proteins of brain regions involved in sleep regulation. Neuropsychobiology. vol 65. issue 3. 2012-08-27. PMID:22456537. |
results showed an increase in tau content in the pons, preoptic area and hippocampus after 24 h of remsd, while in the frontal cortex a significant increase in tau content was observed after 72 h of remsd. |
2012-08-27 |
2023-08-12 |
rat |
| Jennifer Rodríguez-Vázquez, Ignacio Camacho-Arroyo, Javier Velázquez-Moctezum. Differential impact of REM sleep deprivation on cytoskeletal proteins of brain regions involved in sleep regulation. Neuropsychobiology. vol 65. issue 3. 2012-08-27. PMID:22456537. |
a tau content decrease was observed in the hippocampus after 48 h of remsd. |
2012-08-27 |
2023-08-12 |
rat |
| Jiejie Li, Jiao Deng, Wenli Sheng, Zhiyi Zu. Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice. Pharmacology, biochemistry, and behavior. vol 101. issue 4. 2012-08-23. PMID:22425595. |
activated/phosphorylated c-jun n-terminal kinase (jnk), a tau kinase, was increased in the db/db mouse hippocampus. |
2012-08-23 |
2023-08-12 |
mouse |
| Lindsay C Reese, Giulio Taglialatel. A role for calcineurin in Alzheimer's disease. Current neuropharmacology. vol 9. issue 4. 2012-08-23. PMID:22654726. |
this bellwether symptom suggests involvement of the hippocampus -- a brain region responsible for memory formation -- and coincidentally an area heavily burdened by hyperphosphorylated tau and neuritic plaques of amyloid beta (aβ). |
2012-08-23 |
2023-08-12 |
Not clear |
| Wei Wei, Ying-Hua Liu, Chang-E Zhang, Qun Wang, Zelan Wei, Darrell D Mousseau, Jian-Zhi Wang, Qing Tian, Gong-Ping Li. Folate/vitamin-B12 prevents chronic hyperhomocysteinemia-induced tau hyperphosphorylation and memory deficits in aged rats. Journal of Alzheimer's disease : JAD. vol 27. issue 3. 2012-08-20. PMID:21860088. |
we found that hyperhomocysteinemia induced tau hyperphosphorylation and accumulation in hippocampus and cortex. |
2012-08-20 |
2023-08-12 |
rat |
| María Llorens-Martin, Cátia M Teixeira, Almudena Fuster-Matanzo, Jerónimo Jurado-Arjona, Víctor Borrell, Eduardo Soriano, Jesús Avila, Félix Hernánde. Tau isoform with three microtubule binding domains is a marker of new axons generated from the subgranular zone in the hippocampal dentate gyrus: implications for Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 29. issue 4. 2012-08-17. PMID:22337826. |
tau isoform with three microtubule binding domains is a marker of new axons generated from the subgranular zone in the hippocampal dentate gyrus: implications for alzheimer's disease. |
2012-08-17 |
2023-08-12 |
mouse |
| Jonathan Brouillette, Raphaëlle Caillierez, Nadège Zommer, Claire Alves-Pires, Iryna Benilova, David Blum, Bart De Strooper, Luc Bué. Neurotoxicity and memory deficits induced by soluble low-molecular-weight amyloid-β1-42 oligomers are revealed in vivo by using a novel animal model. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 23. 2012-08-09. PMID:22674261. |
using a novel in vivo approach, we found that repeated hippocampal injections of small soluble aβ(1-42) oligomers in awake, freely moving mice were able to induce marked neuronal loss, tau hyperphosphorylation, and deficits in hippocampus-dependent memory. |
2012-08-09 |
2023-08-12 |
mouse |
| P Korhonen, T van Groen, A Thornell, S Kyrylenko, M-L Soininen, J Ojala, E Peltomaa, H Tanila, A Salminen, E M Mandelkow, H Soinine. Characterization of a novel transgenic rat carrying human tau with mutation P301L. Neurobiology of aging. vol 32. issue 12. 2012-08-08. PMID:20097445. |
the htau-40/p301l rats expressed human tau mrna and protein in the limbic cortex and associated white matter, hippocampus and spinal cord. |
2012-08-08 |
2023-08-12 |
human |
| Byeong Tak Jeon, Eun Ae Jeong, Hyun Joo Shin, Younghyurk Lee, Dong Hoon Lee, Hyun Joon Kim, Sang Soo Kang, Gyeong Jae Cho, Wan Sung Choi, Gu Seob Ro. Resveratrol attenuates obesity-associated peripheral and central inflammation and improves memory deficit in mice fed a high-fat diet. Diabetes. vol 61. issue 6. 2012-07-25. PMID:22362175. |
choline acetyltransferase was increased, and the phosphorylation of tau was decreased in the hippocampus of hfd-fed mice upon res treatment. |
2012-07-25 |
2023-08-12 |
mouse |
| Yasumasa Yoshiyama, Ayako Kojima, Kimiko Itoh, Tomoyuki Uchiyama, Kimihito Ara. Anticholinergics boost the pathological process of neurodegeneration with increased inflammation in a tauopathy mouse model. Neurobiology of disease. vol 45. issue 1. 2012-07-23. PMID:21889983. |
tau pathology, synaptic loss, and neurodegeneration in the hippocampal region, as well as tau insolubility and phosphorylation, were markedly increased in tp-treated mice and mildly increased in pp-treated mice. |
2012-07-23 |
2023-08-12 |
mouse |
| Johannes Brettschneider, David J Libon, Jon B Toledo, Sharon X Xie, Leo McCluskey, Lauren Elman, Felix Geser, Virginia M Y Lee, Murray Grossman, John Q Trojanowsk. Microglial activation and TDP-43 pathology correlate with executive dysfunction in amyotrophic lateral sclerosis. Acta neuropathologica. vol 123. issue 3. 2012-07-23. PMID:22210083. |
a lower mmse score correlated with tau pathology in hippocampus and smt gyrus, and with aβ pathology in limbic and most cortical regions. |
2012-07-23 |
2023-08-12 |
Not clear |
| K Belarbi, S Burnouf, F-J Fernandez-Gomez, J Desmercières, L Troquier, J Brouillette, L Tsambou, M-E Grosjean, R Caillierez, D Demeyer, M Hamdane, K Schindowski, D Blum, L Bué. Loss of medial septum cholinergic neurons in THY-Tau22 mouse model: what links with tau pathology? Current Alzheimer research. vol 8. issue 6. 2012-07-19. PMID:21605043. |
the present study aimed to investigate the relationship between neurofibrillary degeneration and cholinergic defects in ad using thy-tau22 transgenic mouse model exhibiting a major hippocampal ad-like tau pathology and hyperphosphorylated tau species in the septohippocampal pathway. |
2012-07-19 |
2023-08-12 |
mouse |
| Robert A Rissman, Michael A Staup, Allyson Roe Lee, Nicholas J Justice, Kenner C Rice, Wylie Vale, Paul E Sawchenk. Corticotropin-releasing factor receptor-dependent effects of repeated stress on tau phosphorylation, solubility, and aggregation. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 16. 2012-07-12. PMID:22451915. |
although the basis for such a link remains unclear, we previously reported differential involvement of corticotropin-releasing factor receptor (crfr) 1 and 2 in acute stress-induced tau phosphorylation (tau-p) and solubility in the hippocampus. |
2012-07-12 |
2023-08-12 |
mouse |
| Robert A Rissman, Michael A Staup, Allyson Roe Lee, Nicholas J Justice, Kenner C Rice, Wylie Vale, Paul E Sawchenk. Corticotropin-releasing factor receptor-dependent effects of repeated stress on tau phosphorylation, solubility, and aggregation. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 16. 2012-07-12. PMID:22451915. |
using histochemical approaches in a transgenic crfr1 reporter mouse line, we found substantial overlap between hippocampal crfr1 expression and cells positive for phosphorylated tau after exposure to repeated stress. |
2012-07-12 |
2023-08-12 |
mouse |
| Yong-Kun Li, Xiao-Chun Chen, Yuan-Gui Zhu, Xiao-Song Peng, Yu-Qi Zeng, Jie Sheng, Tian-Wen Huan. [Ginsenoside Rb1 attenuates okadaic acid-induced Tau protein hyperphosphorylation in rat hippocampal neurons]. Sheng li xue bao : [Acta physiologica Sinica]. vol 57. issue 2. 2012-06-28. PMID:15830099. |
[ginsenoside rb1 attenuates okadaic acid-induced tau protein hyperphosphorylation in rat hippocampal neurons]. |
2012-06-28 |
2023-08-12 |
rat |
| Yong-Kun Li, Xiao-Chun Chen, Yuan-Gui Zhu, Xiao-Song Peng, Yu-Qi Zeng, Jie Sheng, Tian-Wen Huan. [Ginsenoside Rb1 attenuates okadaic acid-induced Tau protein hyperphosphorylation in rat hippocampal neurons]. Sheng li xue bao : [Acta physiologica Sinica]. vol 57. issue 2. 2012-06-28. PMID:15830099. |
the present study was aimed to investigate the effects of ginsenoside rb1 on okadaic acid (oa)-induced tau hyperphosphorylation in hippocampal neurons of sparague-dawley rat and to explore its possible mechanism. |
2012-06-28 |
2023-08-12 |
rat |
| Yong-Kun Li, Xiao-Chun Chen, Yuan-Gui Zhu, Xiao-Song Peng, Yu-Qi Zeng, Jie Sheng, Tian-Wen Huan. [Ginsenoside Rb1 attenuates okadaic acid-induced Tau protein hyperphosphorylation in rat hippocampal neurons]. Sheng li xue bao : [Acta physiologica Sinica]. vol 57. issue 2. 2012-06-28. PMID:15830099. |
on the thirteen day of pretreatment, animals in rb1 pretreatment group as well as animals in oa group received a bolus injection of 0.483 microg of oa (1.5 microl of solution in dmso) at right dorsal aspect of hippocampus to induce tau hyperphosphrylation. |
2012-06-28 |
2023-08-12 |
rat |
| Yong-Kun Li, Xiao-Chun Chen, Yuan-Gui Zhu, Xiao-Song Peng, Yu-Qi Zeng, Jie Sheng, Tian-Wen Huan. [Ginsenoside Rb1 attenuates okadaic acid-induced Tau protein hyperphosphorylation in rat hippocampal neurons]. Sheng li xue bao : [Acta physiologica Sinica]. vol 57. issue 2. 2012-06-28. PMID:15830099. |
these results indicate that oa-induced hyperphosphorylation of tau protein in rat hippocampal neurons can be attenuated by the pretreatment of ginsenoside rb1. |
2012-06-28 |
2023-08-12 |
rat |
| Qian Chen, Zhou Zhou, Lei Zhang, Yuan Wang, Yan-wen Zhang, Min Zhong, Shang-cheng Xu, Chun-hai Chen, Li Li, Zheng-ping Y. Tau protein is involved in morphological plasticity in hippocampal neurons in response to BDNF. Neurochemistry international. vol 60. issue 3. 2012-06-25. PMID:22226842. |
tau protein is involved in morphological plasticity in hippocampal neurons in response to bdnf. |
2012-06-25 |
2023-08-12 |
rat |
| Qian Chen, Zhou Zhou, Lei Zhang, Yuan Wang, Yan-wen Zhang, Min Zhong, Shang-cheng Xu, Chun-hai Chen, Li Li, Zheng-ping Y. Tau protein is involved in morphological plasticity in hippocampal neurons in response to BDNF. Neurochemistry international. vol 60. issue 3. 2012-06-25. PMID:22226842. |
stimulation of the cultured rat hippocampal neurons with bdnf resulted in increased tau protein expression, as detected by western blotting. |
2012-06-25 |
2023-08-12 |
rat |