| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Sugaya, M Reeves, M McKinne. Topographic associations between DNA fragmentation and Alzheimer's disease neuropathology in the hippocampus. Neurochemistry international vol 31 issue 2 1997 9220460 |
to identify whether the process of apoptosis bears a topographic relationship to selected aspects of alzheimer's disease (ad) pathology, we used an in situ nick translation method (tunel) to map dna fragmentation in hippocampal sections immunostained for abnormally phosphorylated tau, which exists in the neurofibrillary tangles (nfts) and in the dystrophic neurites associated with senile plaques. |
1997-09-02 |
2023-01-24 |
human |
| E A Irving, J McCulloch, D Dewa. The effect of postmortem delay on the distribution of microtubule-associated proteins tau, MAP2, and MAP5 in the rat. Molecular and chemical neuropathology vol 30 issue 3 1997 9165490 |
in this study, the distribution of tau, map2, and map5 immunohistochemistry was examined following postmortem intervals of 0-72 h in the rat cerebral cortex, corpus callosum, caudate nucleus, and hippocampus. |
1997-07-18 |
2023-01-24 |
rat |
| K Imahori, T Uchid. Physiology and pathology of tau protein kinases in relation to Alzheimer's disease. Journal of biochemistry vol 121 issue 2 1997 9089387 |
when a primary culture of embryonic rat hippocampus was treated with 20 microm a beta, induction of tpki, extensive phosphorylation of tau and then programmed cell death were observed, indicating that tpki induced by a beta phosphorylates tau, followed by disruption of axonal transportation and finally cell death. |
1997-07-11 |
2023-01-24 |
rat |
| U S Kayyali, W Zhang, A G Yee, J G Seidman, H Potte. Cytoskeletal changes in the brains of mice lacking calcineurin A alpha. Journal of neurochemistry vol 68 issue 4 1997 9084440 |
the increase in phosphorylated tau content occurred primarily in the mossy fibers of the cna alpha -/- hippocampus, which contained the highest level of calcineurin in brains of wild-type mice. |
1997-04-28 |
2023-01-24 |
mouse |
| C Duyckaerts, M Bennecib, Y Grignon, F Piette, J J Hau. [Is the topography of Alzheimer's disease lesions a clue to their pathogenesis?]. Bulletin de l'Academie nationale de medecine vol 180 issue 7 1997 9102152 |
tau positive neurofibrillary changes were present in the hippocampus and in the parahippocampal gyrus even in intellectually normal cases. |
1997-04-11 |
2023-01-24 |
Not clear |
| T Kimura, T Ono, J Takamatsu, H Yamamoto, K Ikegami, A Kondo, M Hasegawa, Y Ihara, E Miyamoto, T Miyakaw. Sequential changes of tau-site-specific phosphorylation during development of paired helical filaments. Dementia (Basel, Switzerland) vol 7 issue 4 1997 8835879 |
we investigated the phosphorylation of tau in the hippocampus of nondemented patients and alzheimer's disease patients by immunostaining with five site-specific antibodies against phosphorylated tau. |
1997-01-30 |
2023-01-24 |
human |
| K T Wong, I V Allen, S McQuaid, R McConnel. An immunohistochemical study of neurofibrillary tangle formation in post-encephalitic Parkinsonism. Clinical neuropathology vol 15 issue 1 1997 8998852 |
staining patterns for tau protein, ubiquitin and beta/a4 amyloid protein were studied in frontal lobe, hippocampus, and midbrain in 2 classical cases of pep, 2 cases of ad and 2 controls matched for age and sex. |
1997-01-17 |
2023-01-24 |
Not clear |
| C M Kondratick, D D Vandr\\xc3\\xa. Alzheimer's disease neurofibrillary tangles contain mitosis-specific phosphoepitopes. Journal of neurochemistry vol 67 issue 6 1996 8931473 |
to determine if similar mitosis-associated phosphoepitopes appeared in ad, sections of hippocampal tissue were stained for immunoreactivity with antibodies recognizing both tau and mitotic phosphoepitopes. |
1996-12-23 |
2023-01-24 |
rat |
| L Bu\\xc3\\xa9e, J P\\xc3\\xa9rez-Tur, B Leveugle, V Bu\\xc3\\xa9e-Scherrer, E J Mufson, A J Loerzel, M C Chartier-Harlin, D P Perl, A Delacourte, P R Ho. Apolipoprotein E in Guamanian amyotrophic lateral sclerosis/parkinsonism-dementia complex: genotype analysis and relationships to neuropathological changes. Acta neuropathologica vol 91 issue 3 1996 8834536 |
compared to tau protein immunoreactivity, there were generally fewer apo e-immunoreactive neurofibrillary tangles, particularly in the deep layers of the neocortex and in the hippocampus. |
1996-12-10 |
2023-01-24 |
Not clear |
| L Ferhat, N Chevassus au Louis, I Jorquera, J Niquet, M Khrestchatisky, Y Ben-Ari, A Repres. Transient increase of tenascin-C in immature hippocampus: astroglial and neuronal expression. Journal of neurocytology vol 25 issue 1 1996 8852938 |
double labelling experiments performed with a tenascin-c antibody or tenascin-c probes combined with specific markers of astrocytes (gfap) or neurons (map2 and tau) allowed us to demonstrate that tenascin-c is expressed by both immature astrocytes and neurons in immature hippocampus. |
1996-12-06 |
2023-01-24 |
rat |
| K Niizato, K Iked. Long-term antipsychotic medication of schizophrenics does not promote the development of Alzheimer's disease brain pathology. Journal of the neurological sciences vol 138 issue 1-2 1996 8791256 |
immunohistological staining of the hippocampal region with anti-human tau antibody was used to examine the degree of ad pathology in seven schizophrenic patients who had received long-term antipsychotic medication and in seven controls. |
1996-12-03 |
2023-01-24 |
Not clear |
| E B Mukaetova-Ladinska, C R Harrington, M Roth, C M Wischi. Alterations in tau protein metabolism during normal aging. Dementia (Basel, Switzerland) vol 7 issue 2 1996 8866683 |
we have examined phf-bound and normal tau fractions in frontal, temporal, parietal and occipital neocortex, cerebellum, hippocampus and entorhinal cortex in 15 cognitively unimpaired individuals aged 19-88 years at death. |
1996-12-03 |
2023-01-24 |
Not clear |
| E B Mukaetova-Ladinska, C R Harrington, M Roth, C M Wischi. Alterations in tau protein metabolism during normal aging. Dementia (Basel, Switzerland) vol 7 issue 2 1996 8866683 |
frontal grey matter and hippocampus were most vulnerable to age-related tau loss, decreasing by as much as 90% in the older subgroup. |
1996-12-03 |
2023-01-24 |
Not clear |
| E Bednarski, G Lync. Cytosolic proteolysis of tau by cathepsin D in hippocampus following suppression of cathepsins B and L. Journal of neurochemistry vol 67 issue 5 1996 8863489 |
cytosolic proteolysis of tau by cathepsin d in hippocampus following suppression of cathepsins b and l. incubation of cultured hippocampal slices with an inhibitor [n-cbz-l-phenylalanyl-l-alanine-diazomethyl ketone (zpad)] of cathepsins b and l resulted in the degradation of high molecular weight isoforms of tau protein and the production of a 29-kda tau fragment (tau 29). |
1996-12-02 |
2023-01-24 |
Not clear |
| P Vermersch, N Sergeant, M M Ruchoux, H Hofmann-Radvanyi, A Wattez, H Petit, P Dwailly, A Delacourt. Specific tau variants in the brains of patients with myotonic dystrophy. Neurology vol 47 issue 3 1996 8797469 |
as in ad brain homogenates, pathologic tau proteins, named tau 55, 64, and 69, were exclusively immunodetected in the dm cases in the hippocampus, the entorhinal cortex, and in most of the temporal areas. |
1996-11-22 |
2023-01-24 |
Not clear |
| J A Ogeng'o, D L Cohen, J G Sayi, W B Matuja, H M Chande, J N Kitinya, J K Kimani, R P Friedland, H Mori, R N Kalari. Cerebral amyloid beta protein deposits and other Alzheimer lesions in non-demented elderly east Africans. Brain pathology (Zurich, Switzerland) vol 6 issue 2 1996 8737923 |
tau protein reactive neurofibrillary tangles (nft) were also evident in the hippocampus of 4 subjects. |
1996-11-08 |
2023-01-24 |
human |
| R Layfield, J Fergusson, A Aitken, J Lowe, M Landon, R J Maye. Neurofibrillary tangles of Alzheimer's disease brains contain 14-3-3 proteins. Neuroscience letters vol 209 issue 1 1996 8734909 |
the localisation of 14-3-3 proteins compared to that of tau and ubiquitin-protein conjugates in sections of hippocampus from alzheimer's disease (ad) brains was examined by immunohistochemistry. |
1996-10-04 |
2023-01-24 |
Not clear |
| A Takashima, K Noguchi, G Michel, M Mercken, M Hoshi, K Ishiguro, K Imahor. Exposure of rat hippocampal neurons to amyloid beta peptide (25-35) induces the inactivation of phosphatidyl inositol-3 kinase and the activation of tau protein kinase I/glycogen synthase kinase-3 beta. Neuroscience letters vol 203 issue 1 1996 8742040 |
wortmannin, an inhibitor of pi-3 kinase, also activated tpk i/gsk-3 beta, leading to an enhancement of tau phosphorylation and neuronal death in hippocampal culture. |
1996-09-26 |
2023-01-24 |
rat |
| M L Schmidt, R Huang, J A Martin, J Henley, M Mawal-Dewan, H I Hurtig, V M Lee, J Q Trojanowsk. Neurofibrillary tangles in progressive supranuclear palsy contain the same tau epitopes identified in Alzheimer's disease PHFtau. Journal of neuropathology and experimental neurology vol 55 issue 5 1996 8627344 |
the immunohistochemical studies showed that all of the tau epitopes detected in brainstem psp nfts also were found in hippocampal ad nfts and vice versa. |
1996-06-25 |
2023-01-24 |
Not clear |
| M Hoshi, A Takashima, K Noguchi, M Murayama, M Sato, S Kondo, Y Saitoh, K Ishiguro, T Hoshino, K Imahor. Regulation of mitochondrial pyruvate dehydrogenase activity by tau protein kinase I/glycogen synthase kinase 3beta in brain. Proceedings of the National Academy of Sciences of the United States of America vol 93 issue 7 1996 8610107 |
in rat hippocampal culture, betaa exposure activates tau protein kinase i/glycogen synthase kinase 3beta (tpki/gsk-3beta), which phosphorylates tau protein into alzheimer disease-like forms, resulting in neuronal death. |
1996-05-24 |
2023-01-24 |
rat |