| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wen-Fei Tan, Xue-Zhao Cao, Jun-Ke Wang, Huang-Wei Lv, Bin-Yang Wu, Hong M. Protective effects of lithium treatment for spatial memory deficits induced by tau hyperphosphorylation in splenectomized rats. Clinical and experimental pharmacology & physiology. vol 37. issue 10. 2011-09-02. PMID:20659131. |
splenectomy was associated with learning and memory impairment 3 days later, as well as a rapid and massive hyperphosphorylation of hippocampal tau at thr-205 and ser-396, activated gsk-3β, and increased il-1β and tnf-α expression. |
2011-09-02 |
2023-08-12 |
rat |
| Ignacio Camacho-Arroyo, Aliesha González-Arenas, Judith Espinosa-Raya, Ana Gabriela Piña-Medina, Ofir Picaz. Short- and long-term treatment with estradiol or progesterone modifies the expression of GFAP, MAP2 and Tau in prefrontal cortex and hippocampus. Life sciences. vol 89. issue 3-4. 2011-08-30. PMID:21683086. |
short- and long-term treatment with estradiol or progesterone modifies the expression of gfap, map2 and tau in prefrontal cortex and hippocampus. |
2011-08-30 |
2023-08-12 |
Not clear |
| Ignacio Camacho-Arroyo, Aliesha González-Arenas, Judith Espinosa-Raya, Ana Gabriela Piña-Medina, Ofir Picaz. Short- and long-term treatment with estradiol or progesterone modifies the expression of GFAP, MAP2 and Tau in prefrontal cortex and hippocampus. Life sciences. vol 89. issue 3-4. 2011-08-30. PMID:21683086. |
we analyzed the effects of the short- and long-term administration of estradiol (e2) or progesterone (p4) after ovariectomy on the expression of map2, tau and gfap in prefrontal cortex and hippocampus. |
2011-08-30 |
2023-08-12 |
Not clear |
| D S Kern, K N Maclean, H Jiang, E Y Synder, J R Sladek, K B Bjugsta. Neural stem cells reduce hippocampal tau and reelin accumulation in aged Ts65Dn Down syndrome mice. Cell transplantation. vol 20. issue 3. 2011-08-23. PMID:20875225. |
neural stem cells reduce hippocampal tau and reelin accumulation in aged ts65dn down syndrome mice. |
2011-08-23 |
2023-08-12 |
mouse |
| Leora M Fox, Christopher M William, David H Adamowicz, Rose Pitstick, George A Carlson, Tara L Spires-Jones, Bradley T Hyma. Soluble tau species, not neurofibrillary aggregates, disrupt neural system integration in a tau transgenic model. Journal of neuropathology and experimental neurology. vol 70. issue 7. 2011-08-22. PMID:21666499. |
we interpret these data to indicate that soluble tau contributes to impairment of hippocampal function, although tangles do not preclude neurons from responding in a functional circuit. |
2011-08-22 |
2023-08-12 |
mouse |
| Lili C Kudo, Liubov Parfenova, Guijie Ren, Nancy Vi, Maria Hui, Zhongcai Ma, Kimbley Lau, Michelle Gray, Fawzia Bardag-Gorce, Martina Wiedau-Pazos, Koon-Sea Hui, Stanislav L Karste. Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in hPSA/TAU(P301L) double-transgenic mice. Human molecular genetics. vol 20. issue 9. 2011-08-15. PMID:21320871. |
double-transgenic animals for hpsa and tau(p301l) transgenes demonstrated a distinct trend for delayed paralysis and showed significantly improved motor neuron counts, no gliosis and markedly reduced levels of total and hyperphosphorylated tau in the spinal cord, brain stem, cortex, hippocampus and cerebellum of adult and aged animals when compared with tau(p301l) mice. |
2011-08-15 |
2023-08-12 |
mouse |
| Jack Reifert, DeeAnn Hartung-Cranston, Stuart C Feinstei. Amyloid beta-mediated cell death of cultured hippocampal neurons reveals extensive Tau fragmentation without increased full-length tau phosphorylation. The Journal of biological chemistry. vol 286. issue 23. 2011-08-05. PMID:21482827. |
amyloid beta-mediated cell death of cultured hippocampal neurons reveals extensive tau fragmentation without increased full-length tau phosphorylation. |
2011-08-05 |
2023-08-12 |
rat |
| Jack Reifert, DeeAnn Hartung-Cranston, Stuart C Feinstei. Amyloid beta-mediated cell death of cultured hippocampal neurons reveals extensive Tau fragmentation without increased full-length tau phosphorylation. The Journal of biological chemistry. vol 286. issue 23. 2011-08-05. PMID:21482827. |
to better understand molecular mechanisms involved in aβ-mediated neuronal cell death, we have treated primary rat hippocampal cultures with aβ oligomers and examined the resulting cellular changes occurring before and during the induction of cell death with a focus on altered tau biochemistry. |
2011-08-05 |
2023-08-12 |
rat |
| Yifan Lu, Tong Li, Hamid Y Qureshi, Dong Han, Hemant K Paude. Early growth response 1 (Egr-1) regulates phosphorylation of microtubule-associated protein tau in mammalian brain. The Journal of biological chemistry. vol 286. issue 23. 2011-08-05. PMID:21489990. |
in this study, we found that lentivirus-mediated overexpression of egr-1 in rat brain hippocampus and primary neurons in culture activates proline-directed kinase cdk5, inactivates pp1, promotes tau phosphorylation at both proline-directed ser(396/404) and non-proline-directed ser(262) sites, and destabilizes microtubules. |
2011-08-05 |
2023-08-12 |
mouse |
| Ioannis Sotiropoulos, Caterina Catania, Lucilia G Pinto, Rui Silva, G Elizabeth Pollerberg, Akihiko Takashima, Nuno Sousa, Osborne F X Almeid. Stress acts cumulatively to precipitate Alzheimer's disease-like tau pathology and cognitive deficits. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 21. 2011-08-04. PMID:21613497. |
results from healthy, wild-type, middle-aged rats show that chronic stress and gc induce abnormal hyperphosphorylation of tau in the hippocampus and prefrontal cortex (pfc), with contemporaneous impairments of hippocampus- and pfc-dependent behaviors. |
2011-08-04 |
2023-08-12 |
rat |
| Ann Van der Jeugd, Tariq Ahmed, Sylvie Burnouf, Karim Belarbi, Malika Hamdame, Marie-Eve Grosjean, Sandrine Humez, Detlef Balschun, David Blum, Luc Buée, Rudi D'Hoog. Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission. Neurobiology of learning and memory. vol 95. issue 3. 2011-08-03. PMID:21167950. |
hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission. |
2011-08-03 |
2023-08-12 |
mouse |
| Ann Van der Jeugd, Tariq Ahmed, Sylvie Burnouf, Karim Belarbi, Malika Hamdame, Marie-Eve Grosjean, Sandrine Humez, Detlef Balschun, David Blum, Luc Buée, Rudi D'Hoog. Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission. Neurobiology of learning and memory. vol 95. issue 3. 2011-08-03. PMID:21167950. |
we evaluated various forms of hippocampus-dependent learning and memory, and hippocampal synaptic plasticity in thy-tau22 transgenic mice, a murine tauopathy model that expresses double-mutated 4-repeat human tau, and shows neuropathological tau hyperphosphorylation and aggregation throughout the brain. |
2011-08-03 |
2023-08-12 |
mouse |
| Ann Van der Jeugd, Tariq Ahmed, Sylvie Burnouf, Karim Belarbi, Malika Hamdame, Marie-Eve Grosjean, Sandrine Humez, Detlef Balschun, David Blum, Luc Buée, Rudi D'Hoog. Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission. Neurobiology of learning and memory. vol 95. issue 3. 2011-08-03. PMID:21167950. |
focussing on hippocampus, immunohistochemical studies in aged thy-tau22 mice revealed prominent hyper- and abnormal phosphorylation of tau in ca1 region, and an increase in glial fibrillary acidic protein (gfap) in hippocampus, but without signs of neuronal loss. |
2011-08-03 |
2023-08-12 |
mouse |
| Zhongsen Qu, Zongxian Jiao, Xiaojiang Sun, Yuwu Zhao, Jinpeng Ren, Guogang X. Effects of streptozotocin-induced diabetes on tau phosphorylation in the rat brain. Brain research. vol 1383. 2011-08-02. PMID:21281610. |
the phosphorylation of tau in the rat hippocampus was detected with specific antibodies. |
2011-08-02 |
2023-08-12 |
rat |
| Zhongsen Qu, Zongxian Jiao, Xiaojiang Sun, Yuwu Zhao, Jinpeng Ren, Guogang X. Effects of streptozotocin-induced diabetes on tau phosphorylation in the rat brain. Brain research. vol 1383. 2011-08-02. PMID:21281610. |
we observed that rat hippocampus tau was hyperphosphorylated at ser(396)/ser(404) (phf-1 sites) in stz-induced dm model, accompanied by lowered phosphorylation levels of akt, gsk-3 and pp-2a. |
2011-08-02 |
2023-08-12 |
rat |
| Zhongsen Qu, Zongxian Jiao, Xiaojiang Sun, Yuwu Zhao, Jinpeng Ren, Guogang X. Effects of streptozotocin-induced diabetes on tau phosphorylation in the rat brain. Brain research. vol 1383. 2011-08-02. PMID:21281610. |
these findings strongly suggest that stz-induced hyperglycemia may cause disorder of akt/gsk-3/pp-2a regulations in rat brain and further lead to abnormal phosphorylation of hippocampus tau. |
2011-08-02 |
2023-08-12 |
rat |
| Robert A Whittington, László Virág, François Marcouiller, Marie-Amélie Papon, Noura B El Khoury, Carl Julien, Françoise Morin, Charles W Emala, Emmanuel Plane. Propofol directly increases tau phosphorylation. PloS one. vol 6. issue 1. 2011-08-02. PMID:21304998. |
we investigated the effects of a general anesthetic dose of propofol on levels of phosphorylated tau in the mouse hippocampus and cortex under normothermic conditions. |
2011-08-02 |
2023-08-12 |
mouse |
| Robert A Whittington, László Virág, François Marcouiller, Marie-Amélie Papon, Noura B El Khoury, Carl Julien, Françoise Morin, Charles W Emala, Emmanuel Plane. Propofol directly increases tau phosphorylation. PloS one. vol 6. issue 1. 2011-08-02. PMID:21304998. |
thirty min following the administration of propofol 250 mg/kg i.p., significant increases in tau phosphorylation were observed at the at8, cp13, and phf-1 phosphoepitopes in the hippocampus, as well as at at8, phf-1, mc6, ps262, and ps422 epitopes in the cortex. |
2011-08-02 |
2023-08-12 |
mouse |
| Kyoko Itoh, Maki Mitani, Kunihiko Kawamoto, Naonobu Futamura, Itaru Funakawa, Kenji Jinnai, Shinji Fushik. Neuropathology does not Correlate with Regional Differences in the Extent of Expansion of CTG Repeats in the Brain with Myotonic Dystrophy Type 1. Acta histochemica et cytochemica. vol 43. issue 6. 2011-07-14. PMID:21245981. |
the neuropathological changes included état criblé in the cerebral deep white matter and neurofibrillary tangles immunoreactive for phosphorylated tau in the hippocampus and entorhinal cortex, both of which were compatible with the subcortical dementia in dm1 patients. |
2011-07-14 |
2023-08-12 |
human |
| Erzsebet Kovesdi, Andrea B Gyorgy, Sook-Kyung C Kwon, Daniel L Wingo, Alaa Kamnaksh, Joseph B Long, Christine E Kasper, Denes V Agosto. The effect of enriched environment on the outcome of traumatic brain injury; a behavioral, proteomics, and histological study. Frontiers in neuroscience. vol 5. 2011-07-14. PMID:21503146. |
vegf and tau protein but not interleukin-6 (il-6) levels were normalized in the dorsal hippocampus (dhc) of een rats while all three markers remained elevated in nh rats. |
2011-07-14 |
2023-08-12 |
rat |