| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Erzsebet Kovesdi, Andrea B Gyorgy, Sook-Kyung C Kwon, Daniel L Wingo, Alaa Kamnaksh, Joseph B Long, Christine E Kasper, Denes V Agosto. The effect of enriched environment on the outcome of traumatic brain injury; a behavioral, proteomics, and histological study. Frontiers in neuroscience. vol 5. 2011-07-14. PMID:21503146. |
housing animals in een had no significant effect on vegf and tau protein levels in the ventral hippocampus (vhc) and the amygdala (ad). |
2011-07-14 |
2023-08-12 |
rat |
| Ming Jin, Nina Shepardson, Ting Yang, Gang Chen, Dominic Walsh, Dennis J Selko. Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 14. 2011-07-01. PMID:21421841. |
here, we isolated aβ dimers, the most abundant form of soluble oligomer detectable in the human brain, from the cortices of typical ad subjects and found that at subnanomolar concentrations, they first induced hyperphosphorylation of tau at ad-relevant epitopes in hippocampal neurons and then disrupted the microtubule cytoskeleton and caused neuritic degeneration, all in the absence of amyloid fibrils. |
2011-07-01 |
2023-08-12 |
human |
| Michelle T Fodero-Tavoletti, Nobuyuki Okamura, Shozo Furumoto, Rachel S Mulligan, Andrea R Connor, Catriona A McLean, Diana Cao, Angela Rigopoulos, Glenn A Cartwright, Graeme O'Keefe, Sylvia Gong, Paul A Adlard, Kevin J Barnham, Christopher C Rowe, Colin L Masters, Yukitsuka Kudo, Roberto Cappai, Kazuhiko Yanai, Victor L Villemagn. 18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease. Brain : a journal of neurology. vol 134. issue Pt 4. 2011-07-01. PMID:21436112. |
autoradiographic and histofluorescence analysis of human hippocampal serial sections with alzheimer's disease exhibited positive thk523 binding that co-localized with immunoreactive tau pathology, but failed to highlight β-amyloid plaques. |
2011-07-01 |
2023-08-12 |
mouse |
| Haruka Sudo, Peter W Baa. Strategies for diminishing katanin-based loss of microtubules in tauopathic neurodegenerative diseases. Human molecular genetics. vol 20. issue 4. 2011-06-14. PMID:21118899. |
using cultured rat hippocampal neurons, we pursued two potential therapies for fortifying axonal microtubules against excess severing by katanin, under conditions of tau depletion. |
2011-06-14 |
2023-08-12 |
rat |
| C Corona, F Masciopinto, E Silvestri, A Del Viscovo, R Lattanzio, R La Sorda, D Ciavardelli, F Goglia, M Piantelli, L M T Canzoniero, S L Sens. Dietary zinc supplementation of 3xTg-AD mice increases BDNF levels and prevents cognitive deficits as well as mitochondrial dysfunction. Cell death & disease. vol 1. 2011-06-14. PMID:21368864. |
we found that zn(2+) supplementation greatly delays hippocampal-dependent memory deficits and strongly reduces both aβ and tau pathology in the hippocampus. |
2011-06-14 |
2023-08-12 |
mouse |
| Ji-Kyung Choi, Isabel Carreras, Alpaslan Dedeoglu, Bruce G Jenkin. Detection of increased scyllo-inositol in brain with magnetic resonance spectroscopy after dietary supplementation in Alzheimer's disease mouse models. Neuropharmacology. vol 59. issue 4-5. 2011-06-07. PMID:20399219. |
in this manuscript we demonstrate using mrs, in two different mouse models of ad (app x ps1 and app x ps1 x tau), that we could detect increased scyllo-inositol in the hippocampus and frontal cortex in mice fed water supplemented with 16.5 mg/l of scyllo-inositol equivalent to about 3.3 mg/kg/day. |
2011-06-07 |
2023-08-12 |
mouse |
| Kunie Ando, Karelle Leroy, Céline Héraud, Zehra Yilmaz, Michèle Authelet, Valèrie Suain, Robert De Decker, Jean-Pierre Brio. Accelerated human mutant tau aggregation by knocking out murine tau in a transgenic mouse model. The American journal of pathology. vol 178. issue 2. 2011-05-23. PMID:21281813. |
although tg30xtau(-/-) mice express less tau protein compared with tg30, they exhibit signs of decreased survival, increased proportion of sarkosyl-insoluble tau in the brain and in the spinal cord, increased number of gallyas-positive neurofibrillary tangles in the hippocampus, increased number of inclusions in the spinal cord, and a more severe motor phenotype. |
2011-05-23 |
2023-08-12 |
mouse |
| Dewen Yang, Zhiyong Xie, Diane Stephenson, Daniel Morton, Carol D Hicks, Tracy M Brown, Renuka Sriram, Sharon O'Neill, David Raunig, Thomas Boca. Volumetric MRI and MRS provide sensitive measures of Alzheimer's disease neuropathology in inducible Tau transgenic mice (rTg4510). NeuroImage. vol 54. issue 4. 2011-05-02. PMID:21035554. |
immunohistochemistry and histology in the same animals verified previously published data showing elevation of hyperphosphorylated tau, glial activation and cortical and hippocampal neuronal loss. |
2011-05-02 |
2023-08-12 |
mouse |
| Xiao-Ping Hong, Cai-Xia Peng, Wei Wei, Qing Tian, Ying-Hua Liu, Fu-Yuan Cao, Qun Wang, Jian-Zhi Wan. Relationship of adult neurogenesis with tau phosphorylation and GSK-3β activity in subventricular zone. Neurochemical research. vol 36. issue 2. 2011-04-29. PMID:21061060. |
recent studies suggest that tau phosphorylation is essential for hippocampal neurogenesis, however, it is not known whether tau phosphorylation also play a role in neurogenesis of subventricular zone (svz), another main progenitor niche in the brain. |
2011-04-29 |
2023-08-12 |
mouse |
| Kurt A Jellinger, Anja Grazer, Katja Petrovic, Stefan Ropele, Günter Alpi, Peter Kapeller, Thomas Ströbel, Reinhold Schmid. Four-repeat tauopathy clinically presenting as posterior cortical atrophy: atypical corticobasal degeneration? Acta neuropathologica. vol 121. issue 2. 2011-04-27. PMID:20571819. |
histology revealed severe diffuse tauopathy with neuronal loss, neurofibrillary tangles, neuropil threads, and tau deposits in astroglia and oligodendroglia in parietal, temporal, occipital cortex, less in frontal cortex and hippocampus, putamen, claustrum, thalamus and subthalamus. |
2011-04-27 |
2023-08-12 |
Not clear |
| Olivia A Shipton, Julie R Leitz, Jenny Dworzak, Christine E J Acton, Elizabeth M Tunbridge, Franziska Denk, Hana N Dawson, Michael P Vitek, Richard Wade-Martins, Ole Paulsen, Mariana Vargas-Caballer. Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 5. 2011-04-01. PMID:21289177. |
tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation. |
2011-04-01 |
2023-08-12 |
mouse |
| Olivia A Shipton, Julie R Leitz, Jenny Dworzak, Christine E J Acton, Elizabeth M Tunbridge, Franziska Denk, Hana N Dawson, Michael P Vitek, Richard Wade-Martins, Ole Paulsen, Mariana Vargas-Caballer. Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 5. 2011-04-01. PMID:21289177. |
consequently, we asked whether tau protein is required for the robust phenomenon of aβ-induced impairment of hippocampal long-term potentiation (ltp), a widely accepted cellular model of memory. |
2011-04-01 |
2023-08-12 |
mouse |
| Olivia A Shipton, Julie R Leitz, Jenny Dworzak, Christine E J Acton, Elizabeth M Tunbridge, Franziska Denk, Hana N Dawson, Michael P Vitek, Richard Wade-Martins, Ole Paulsen, Mariana Vargas-Caballer. Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 5. 2011-04-01. PMID:21289177. |
together, these findings show that tau protein is required for aβ to impair synaptic plasticity in the hippocampus and suggest that the aβ-induced impairment of ltp is mediated by tau phosphorylation. |
2011-04-01 |
2023-08-12 |
mouse |
| Vikas Dhikav, Kuljeet Anan. Potential predictors of hippocampal atrophy in Alzheimer's disease. Drugs & aging. vol 28. issue 1. 2011-03-31. PMID:21174483. |
deposition of tau protein, formation of neurofibrillary tangles and accumulation of β-amyloid (aβ) contributes to hippocampal atrophy together with damage caused by several other factors. |
2011-03-31 |
2023-08-12 |
Not clear |
| Liana G Apostolova, Kristy S Hwang, John P Andrawis, Amity E Green, Sona Babakchanian, Jonathan H Morra, Jeffrey L Cummings, Arthur W Toga, John Q Trojanowski, Leslie M Shaw, Clifford R Jack, Ronald C Petersen, Paul S Aisen, William J Jagust, Robert A Koeppe, Chester A Mathis, Michael W Weiner, Paul M Thompso. 3D PIB and CSF biomarker associations with hippocampal atrophy in ADNI subjects. Neurobiology of aging. vol 31. issue 8. 2011-03-29. PMID:20538372. |
cerebrospinal fluid (csf) measures of ab and tau, pittsburgh compound b (pib) imaging and hippocampal atrophy are promising alzheimer's disease biomarkers yet the associations between them are not known. |
2011-03-29 |
2023-08-12 |
human |
| Liana G Apostolova, Kristy S Hwang, John P Andrawis, Amity E Green, Sona Babakchanian, Jonathan H Morra, Jeffrey L Cummings, Arthur W Toga, John Q Trojanowski, Leslie M Shaw, Clifford R Jack, Ronald C Petersen, Paul S Aisen, William J Jagust, Robert A Koeppe, Chester A Mathis, Michael W Weiner, Paul M Thompso. 3D PIB and CSF biomarker associations with hippocampal atrophy in ADNI subjects. Neurobiology of aging. vol 31. issue 8. 2011-03-29. PMID:20538372. |
we applied a validated, automated hippocampal labeling method and 3d radial distance mapping to the 1.5t structural magnetic resonance imaging (mri) data of 388 adni subjects with baseline csf ab(42), total tau (t-tau) and phosphorylated tau (p-tau(181)) and 98 subjects with positron emission tomography (pet) imaging using pib. |
2011-03-29 |
2023-08-12 |
human |
| A Caroli, G B Frison. The dynamics of Alzheimer's disease biomarkers in the Alzheimer's Disease Neuroimaging Initiative cohort. Neurobiology of aging. vol 31. issue 8. 2011-03-29. PMID:20538373. |
the aim of this study was to investigate the dynamics of four of the most validated biomarkers for alzheimer's disease (ad), cerebro-spinal fluid (csf) abeta 1-42, tau, hippocampal volume, and fdg-pet, in patients at different stage of ad. |
2011-03-29 |
2023-08-12 |
human |
| A Caroli, G B Frison. The dynamics of Alzheimer's disease biomarkers in the Alzheimer's Disease Neuroimaging Initiative cohort. Neurobiology of aging. vol 31. issue 8. 2011-03-29. PMID:20538373. |
csf tau and hippocampal volume changed later showing similar monotonous trends, reflecting disease progression. |
2011-03-29 |
2023-08-12 |
human |
| M Lorenzi, M Donohue, D Paternicò, C Scarpazza, S Ostrowitzki, O Blin, E Irving, G B Frison. Enrichment through biomarkers in clinical trials of Alzheimer's drugs in patients with mild cognitive impairment. Neurobiology of aging. vol 31. issue 8. 2011-03-29. PMID:20541287. |
markers for enrichment were hippocampal atrophy on magnetic resonance (mri), temporoparietal hypometabolism on fdg pet, cerebrospinal fluid (csf) biomarkers (abeta42, tau, and phospho-tau), and cortical amyloid deposition (11c-pib positron emission tomography (pet)). |
2011-03-29 |
2023-08-12 |
Not clear |
| Sarika Garg, Thomas Timm, Eva-Maria Mandelkow, Eckhard Mandelkow, Yipeng Wan. Cleavage of Tau by calpain in Alzheimer's disease: the quest for the toxic 17 kD fragment. Neurobiology of aging. vol 32. issue 1. 2011-03-14. PMID:20961659. |
however, overexpression of neither tau(45-230) nor tau(125-230) fragment is toxic to chinese hamster ovary (cho) cells, neuroblastoma cells (n2a) or primary hippocampal neurons. |
2011-03-14 |
2023-08-12 |
human |