All Relations between microtubule-associated protein tau and hippocampus

Publication Sentence Publish Date Extraction Date Species
Yunfang Su, Ningning Liu, Ruiqin Sun, Jinlian Ma, Zhonghua Li, Pan Wang, Huifen Ma, Yiran Sun, Junying Song, Zhenqiang Zhan. Radix Rehmanniae Praeparata (Shu Dihuang) exerts neuroprotective effects on ICV-STZ-induced Alzheimer's disease mice through modulation of INSR/IRS-1/AKT/GSK-3β signaling pathway and intestinal microbiota. Frontiers in pharmacology. vol 14. 2023-02-27. PMID:36843923. the pharmacological effects of rrp were evaluated by behavioral tests, brain tissue h&e staining and hippocampal tau protein phosphorylation levels. 2023-02-27 2023-08-14 mouse
Yunfang Su, Ningning Liu, Ruiqin Sun, Jinlian Ma, Zhonghua Li, Pan Wang, Huifen Ma, Yiran Sun, Junying Song, Zhenqiang Zhan. Radix Rehmanniae Praeparata (Shu Dihuang) exerts neuroprotective effects on ICV-STZ-induced Alzheimer's disease mice through modulation of INSR/IRS-1/AKT/GSK-3β signaling pathway and intestinal microbiota. Frontiers in pharmacology. vol 14. 2023-02-27. PMID:36843923. the results showed that rrp ameliorated cognitive dysfunction and neuronal pathological changes of brain tissue in icv-stz mice, reduced tau protein hyperphosphorylation, insr, irs-1, pser473-akt/akt, and pser9-gsk-3β/gsk-3β levels in hippocampal and cortical tissues. 2023-02-27 2023-08-14 mouse
Hiromitsu Tanaka, Hiroaki Matsushita, Keizo Tokuhiro, Atsushi Fukunari, Yukio And. Ingestion of Soybean Sprouts Containing a HASPIN Inhibitor Improves Condition in a Mouse Model of Alzheimer's Disease. Biology. vol 12. issue 2. 2023-02-25. PMID:36829593. the results showed that haspin was expressed in the hippocampus and phosphorylated tau protein, while the ingestion of soybean sprouts containing coumestrol suppressed the development of spatial cognitive dysfunction in 5xfad. 2023-02-25 2023-08-14 mouse
b' Samo Ribari\\xc4\\x8. Detecting Early Cognitive Decline in Alzheimer\'s Disease with Brain Synaptic Structural and Functional Evaluation. Biomedicines. vol 11. issue 2. 2023-02-25. PMID:36830892.' ad dysregulation of aβ and tau metabolism progressively disrupt normal synaptic function, leading to loss of synapses, decreased hippocampal synaptic density and early hippocampal atrophy. 2023-02-25 2023-08-14 Not clear
Taku Homma, Yoko Mochizuki, Shinsuke Tobisawa, Takashi Komori, Kazushi Takahash. Differential immunophenotypes of neuronal cytoplasmic inclusions in the dentate gyrus of multiple system atrophy and their association with clinicopathological features. Journal of neuropathology and experimental neurology. 2023-02-25. PMID:36840692. we investigated hippocampal nci pathology in 18 msa patient autopsies, focusing on phosphorylated α-synuclein (pas)- and phosphorylated tau (pt)-positive dntncis. 2023-02-25 2023-08-14 Not clear
Bo Pang, Lu-Lu Zhang, Bin Li, Feng-Xian Sun, Zhi-Da Wan. The sodium glucose co-transporter 2 inhibitor ertugliflozin for Alzheimer's disease: inhibition of brain insulin signaling disruption-induced tau hyperphosphorylation. Physiology & behavior. 2023-02-22. PMID:36809844. importantly, we found that the hyperphosphorylation of tau in the hippocampus of stz/i.c.v rats was decreased after oral administration of ertugliflozin, which was accompanied by decreased phospho.irs-1 2023-02-22 2023-08-14 rat
Elisabeth Black, Abbey Rasch, Tyler Wimmer, Alivia Li, Amanda Araujo, Steve Cieslak, Kevin S Steed, Rajan D Adhikari, Jonathan J Wisco, Bre Anna Hutchinso. The Effects of Age, Genotype, and Diet on Hippocampal Subfield Iron Dysregulation and Alzheimer's Disease Biomarkers in an ApoE Mouse Model. The European journal of neuroscience. 2023-02-13. PMID:36775930. we stained for ferritin, ferroportin, hyper-phosphorylated tau, and β-amyloid proteins in the hippocampal region of apolipoprotein e2 (apoe2), apoe3, or apoe4 mice fed a control diet or a hypothesized inflammation-inducing methionine diet and euthanized at 3, 6, 9, or 12 months. 2023-02-13 2023-08-14 mouse
Elisabeth Black, Abbey Rasch, Tyler Wimmer, Alivia Li, Amanda Araujo, Steve Cieslak, Kevin S Steed, Rajan D Adhikari, Jonathan J Wisco, Bre Anna Hutchinso. The Effects of Age, Genotype, and Diet on Hippocampal Subfield Iron Dysregulation and Alzheimer's Disease Biomarkers in an ApoE Mouse Model. The European journal of neuroscience. 2023-02-13. PMID:36775930. additionally, there were non-significant trends in each hippocampal subfield of increasing ferroportin and hyper-phosphorylated tau after 6 months of age, and decreasing β-amyloid and ferritin with age. 2023-02-13 2023-08-14 mouse
Danny Baltissen, Charlotte S Bold, Lena Rehra, Marija Banićević, Justus Fricke, Jennifer Just, Susann Ludewig, Christian J Buchholz, Martin Korte, Ulrike C Mülle. APPsα rescues CDK5 and GSK3β dysregulation and restores normal spine density in Tau transgenic mice. Frontiers in cellular neuroscience. vol 17. 2023-02-13. PMID:36779015. immunohistochemistry revealed a dramatic increase in pathologically phosphorylated (at8 and at180) or misfolded tau species (mc1) in the hippocampus of thy-tau22 mice between 3 and 12 months of age. 2023-02-13 2023-08-14 mouse
Danny Baltissen, Charlotte S Bold, Lena Rehra, Marija Banićević, Justus Fricke, Jennifer Just, Susann Ludewig, Christian J Buchholz, Martin Korte, Ulrike C Mülle. APPsα rescues CDK5 and GSK3β dysregulation and restores normal spine density in Tau transgenic mice. Frontiers in cellular neuroscience. vol 17. 2023-02-13. PMID:36779015. using a highly sensitive radioactive kinase assay with recombinant human tau as a substrate and immunoblotting, we demonstrate an increase in gsk3β and cdk5 activity in the hippocampus of thy-tau22 mice. 2023-02-13 2023-08-14 mouse
Xiuli Zhang, Shivakumar Subbanna, Colin R O Williams, Stefanie Canals-Baker, John F Smiley, Donald A Wilson, Bhaskar C Das, Mariko Sait. Anti-inflammatory Action of BT75, a Novel RARα Agonist, in Cultured Microglia and in an Experimental Mouse Model of Alzheimer's Disease. Neurochemical research. 2023-02-13. PMID:36781685. western blot results showed that bt75 decreased levels of neuronal nitric oxide synthase (nnos), gfap, and phosphorylated tau, and increased levels of synaptophysin in the hippocampus of icv-stz mice. 2023-02-13 2023-08-14 mouse
Yi-Ying Li, Kai-Yue Yu, Yu-Jia Cui, Zhao-Jun Wang, Hong-Yan Cai, Ji-Min Cao, Mei-Na W. Orexin-A aggravates cognitive deficits in 3xTg-AD mice by exacerbating synaptic plasticity impairment and affecting amyloid β metabolism. Neurobiology of aging. vol 124. 2023-02-09. PMID:36758468. the results showed that oxa aggravated memory impairments and circadian rhythm disturbance, exacerbated hippocampal ltp depression, and increased aβ and tau pathologies in 3xtg-ad mice by affecting bace1 and nep expression. 2023-02-09 2023-08-14 mouse
Xiao-Hui Li, Hong-Can Zhu, Xue-Min Cui, Wang Wang, Lin Yang, Li-Bo Wang, Neng-Wei Hu, Dong-Xiao Dua. Death-associated protein kinase 1 is associated with cognitive dysfunction in major depressive disorder. Neural regeneration research. vol 18. issue 8. 2023-02-08. PMID:36751808. exercise and treatment with the antidepressant drug citalopram decreased dapk1 expression and tau protein phosphorylation in hippocampal tissue and improved both depressive symptoms and cognitive dysfunction. 2023-02-08 2023-08-14 mouse
Ying-Ying Yang, Yan-Tao Ren, Meng-Yu Jia, Chen-Yang Bai, Xiu-Ting Liang, Hui-Ling Gao, Man-Li Zhong, Tao Wang, Chuang Gu. The human islet amyloid polypeptide reduces hippocampal tauopathy and behavioral impairments in P301S mice without inducing neurotoxicity or seeding amyloid aggregation. Experimental neurology. 2023-02-07. PMID:36750170. here, we found that long-term h-iapp treatment attenuated tau hyperphosphorylation levels and induced neuroinflammation and oxidative damage, prevented synaptic loss and neuronal degeneration in the hippocampus, and alleviated behavioral deficits in p301s transgenic mice (a mouse model of tauopathy). 2023-02-07 2023-08-14 mouse
Amber M Tetlow, Brianna M Jackman, Mohammed M Alhadidy, Patricia Muskus, David G Morgan, Marcia N Gordo. Neural atrophy produced by AAV tau injections into hippocampus and anterior cortex of middle-aged mice. Neurobiology of aging. vol 124. 2023-02-05. PMID:36739619. neural atrophy produced by aav tau injections into hippocampus and anterior cortex of middle-aged mice. 2023-02-05 2023-08-14 mouse
Raffaella Franciotti, Davide Nardini, Mirella Russo, Marco Onofrj, Stefano L Sens. Comparison of Machine Learning-based approaches to predict the conversion to Alzheimer's disease from Mild Cognitive Impairment. Neuroscience. 2023-02-03. PMID:36736612. finally, the feature selection procedure indicated that the most critical variables in the respective classes were the adas-cog-13 scale, the medial temporal lobe and hippocampus atrophy, and the ratio between phosphorylated tau and aβ42 proteins. 2023-02-03 2023-08-14 human
Ling-Ling Ye, Yuan-Lu Huang, Xiao-E Cheng, Yin-Qi Shi, Zi-Ye Liu, Ying-Fen Xion. Effect of neurotropin on Alzheimer's disease-like changes and cognitive function in rats with chronic cerebral hypoperfusion. Neuroreport. 2023-01-31. PMID:36719834. subsequently, an elisa was applied to detect amyloid-β (aβ) 1-40 and aβ1-42 levels in rat hippocampal tissues, quantitative reverse transcription pcr assays were used to detect the mrna expression levels of brain-derived neurotrophic factor (bdnf) and trk b, and western blots were used to detect the protein expression levels of bace1, tau, p-tau, and protein kinase b (akt)/glycogen synthase kinase 3β (gsk3β) pathway-related proteins. 2023-01-31 2023-08-14 rat
Ling-Ling Ye, Yuan-Lu Huang, Xiao-E Cheng, Yin-Qi Shi, Zi-Ye Liu, Ying-Fen Xion. Effect of neurotropin on Alzheimer's disease-like changes and cognitive function in rats with chronic cerebral hypoperfusion. Neuroreport. 2023-01-31. PMID:36719834. ntp treatment greatly ameliorated the cognitive disability, reduced aβ1-40 and aβ1-42 levels and tau phosphorylation, and upregulated bace1, trk b, and bdnf expression in the hippocampus of 2vo rats. 2023-01-31 2023-08-14 rat
Ling-Ling Ye, Yuan-Lu Huang, Xiao-E Cheng, Yin-Qi Shi, Zi-Ye Liu, Ying-Fen Xion. Effect of neurotropin on Alzheimer's disease-like changes and cognitive function in rats with chronic cerebral hypoperfusion. Neuroreport. 2023-01-31. PMID:36719834. ntp can ameliorate cognitive disability in cch rats possibly by reducing aβ accumulation and tau phosphorylation in the hippocampus. 2023-01-31 2023-08-14 rat
Miriam Zamorano, Jenolyn F Alexander, Desiree Catania, Shruti Dharmaraj, Annemieke Kavelaars, Cobi J Heijne. Nasal administration of mesenchymal stem cells prevents accelerated age-related tauopathy after chemotherapy in mice. Immunity & ageing : I & A. vol 20. issue 1. 2023-01-26. PMID:36698170. we showed recently that treatment of 9-month-old male mice with cisplatin causes cognitive deficits that are associated with formation of tau deposits in the hippocampus. 2023-01-26 2023-08-14 mouse