| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoqian Peng, Li Chen, Zijuan Wang, Yingying He, John Bosco Ruganzu, Hongsong Guo, Xiao Zhang, Shengfeng Ji, Liming Zheng, Weina Yan. Tanshinone IIA regulates glycogen synthase kinase-3\\xce\\xb2-related signaling pathway and ameliorates memory impairment in APP/PS1 transgenic mice. European journal of pharmacology vol issue 2022 35090935 |
additionally, tan iia markedly attenuated tau hyperphosphorylation and prevented neuronal loss and apoptosis in the parietal cortex and hippocampus. |
2022-01-29 |
2023-01-27 |
mouse |
| Maha A Hegazy, Doaa A Abdelmonsif, Teshreen M Zeitoun, Norhan S El-Sayed, Doaa M Sam. Swimming exercise versus L-carnosine supplementation for Alzheimer's dementia in rats: implication of circulating and hippocampal FNDC5/irisin. Journal of physiology and biochemistry vol issue 2022 35091983 |
hippocampal tissues were used to assess expression of fndc5/irisin, bdnf and proteins related to insulin signalling, in addition to \xce\xb2-amyloid peptide and phosphorylated tau protein levels. |
2022-01-29 |
2023-01-27 |
rat |
| Maha A Hegazy, Doaa A Abdelmonsif, Teshreen M Zeitoun, Norhan S El-Sayed, Doaa M Sam. Swimming exercise versus L-carnosine supplementation for Alzheimer's dementia in rats: implication of circulating and hippocampal FNDC5/irisin. Journal of physiology and biochemistry vol issue 2022 35091983 |
exercise and carnosine intake almost normalized hippocampal fndc5/irisin expression which was associated with reduced soluble \xce\xb2-amyloid peptide and phosphorylated tau protein, improved bdnf and insulin signalling proteins, with corresponding mitigated cognitive impairments. |
2022-01-29 |
2023-01-27 |
rat |
| Munehisa Maeshiba, Hiroshi Kajiya, Takashi Tsutsumi, Keisuke Migita, Kazuko Goto-T, Yuri Kono, Takashi Tsuzuki, Jun Ohn. Occlusal disharmony transiently decrease cognition via cognitive suppressor molecules and partially restores cognitive ability via clearance molecules. Biochemical and biophysical research communications vol 594 issue 2022 35078110 |
the expression levels of amyloid-\xce\xb2 and phosphorylated tau were significantly upregulated 1 week after hyperocclusal loading in the hippocampus of 2-month-old mice but were constant in 12-month-old mice. |
2022-01-25 |
2023-01-26 |
mouse |
| Anton Meinicke, Wolfgang H\\xc3\\xa4rtig, Karsten Winter, Joana Puchta, Bianca Mages, Dominik Michalski, Alexander Emmer, Markus Otto, Karl-Titus Hoffmann, Willi Reimann, Matthias Krause, Stefan Scho. Surfactant Protein-G in Wildtype and 3xTg-AD Mice: Localization in the Forebrain, Age-Dependent Hippocampal Dot-like Deposits and Brain Content. Biomolecules vol 12 issue 1 2022 35053244 |
exploring whether sp-g might play a role in alzheimer's disease (ad), 3xtg-ad mice were investigated and displayed age-dependent hippocampal deposits of \xce\xb2-amyloid and hyperphosphorylated tau separately from clustered, sp-g-containing dots with additional reelin-ir-which was used as established marker for disease progression in this specific context. |
2022-01-21 |
2023-01-26 |
mouse |
| Pol Andr\\xc3\\xa9s-Benito, Margarita Carmona, M\\xc3\\xb3nica Jord\\xc3\\xa1n, Joaqu\\xc3\\xadn Fern\\xc3\\xa1ndez-Irigoyen, Enrique Santamar\\xc3\\xada, Jos\\xc3\\xa9 Antoni Del Rio, Isidro Ferre. Host Tau Genotype Specifically Designs and Regulates Tau Seeding and Spreading and Host Tau Transformation Following Intrahippocampal Injection of Identical Tau AD Inoculum. International journal of molecular sciences vol 23 issue 2 2022 35054902 |
the brains of three adult murine genotypes expressing different forms of tau-wt (murine 4rtau), htau (homozygous transgenic mice knock-out for murine tau protein and heterozygous expressing human forms of 3rtau and 4rtau proteins), and mtwt (homozygous transgenic mice knock-out for murine tau protein)-were analyzed following unilateral hippocampal inoculation of sarkosyl-insoluble tau fractions from the same ad and control cases. |
2022-01-21 |
2023-01-26 |
human |
| Melanie Alpaugh, Maria Masnata, Aurelie de Rus Jacquet, Eva Lepinay, H\\xc3\\xa9l\\xc3\\xa8na L Denis, Martine Saint-Pierre, Peter Davies, Emmanuel Planel, Francesca Cicchett. Passive immunization against phosphorylated tau improves features of Huntington's disease pathology. Molecular therapy : the journal of the American Society of Gene Therapy vol issue 2022 35051614 |
after 12 weeks of treatment, motor impairments, cognitive performance and general health were improved in zq175 mice along with a significant reduction in hippocampal ps202 tau levels. |
2022-01-20 |
2023-01-26 |
mouse |
| Xue Mi, Haiqiao Du, Xinmeng Guo, Yan Wu, Long Shen, Yukun Luo, Dekun Wang, Qiuyue Su, Rong Xiang, Shijing Yue, Songgu Wu, Junbo Gong, Zhuo Yang, Yuying Zhang, Xiaoyue Ta. Asparagine endopeptidase-targeted Ultrasound-responsive Nanobubbles Alleviate Tau Cleavage and Amyloid-\\xce\\xb2 Deposition in an Alzheimer's Disease Model. Acta biomaterialia vol issue 2022 35045359 |
as a result, co-administration of nb(11a)-a and nb(11a)-r significantly promoted accumulation of rr-11a in the mouse brain, and substantially alleviated both tau cleavage and amyloid plaques deposition in the hippocampus. |
2022-01-19 |
2023-01-26 |
mouse |
| Xue Mi, Haiqiao Du, Xinmeng Guo, Yan Wu, Long Shen, Yukun Luo, Dekun Wang, Qiuyue Su, Rong Xiang, Shijing Yue, Songgu Wu, Junbo Gong, Zhuo Yang, Yuying Zhang, Xiaoyue Ta. Asparagine endopeptidase-targeted Ultrasound-responsive Nanobubbles Alleviate Tau Cleavage and Amyloid-\\xce\\xb2 Deposition in an Alzheimer's Disease Model. Acta biomaterialia vol issue 2022 35045359 |
our results indicated that, co-administration of the nb(11a)-a and nb(11a)-r significantly enhanced accumulation of rr-11a molecules at the ad lesion, alleviated both tau cleavage and amyloid plaques deposition in the hippocampus, and consequently restored cognitive function of the ad model mice. |
2022-01-19 |
2023-01-26 |
mouse |
| Hongxia Yu, Jianhong Shi, Yiyou Lin, Yehui Zhang, Qihang Luo, Suo Huang, Sichen Wang, Jiale Wei, Junhao Huang, Changyu Li, Liting J. Icariin Ameliorates Alzheimer's Disease Pathology by Alleviating Myelin Injury in 3\\xe2\\x80\\x89\\xc3\\x97\\xe2\\x80\\x89Tg-AD Mice. Neurochemical research vol issue 2022 35037164 |
tau protein phosphorylation and mbp protein expression in the hippocampus were further analyzed by western blotting. |
2022-01-17 |
2023-01-26 |
mouse |
| Hongxia Yu, Jianhong Shi, Yiyou Lin, Yehui Zhang, Qihang Luo, Suo Huang, Sichen Wang, Jiale Wei, Junhao Huang, Changyu Li, Liting J. Icariin Ameliorates Alzheimer's Disease Pathology by Alleviating Myelin Injury in 3\\xe2\\x80\\x89\\xc3\\x97\\xe2\\x80\\x89Tg-AD Mice. Neurochemical research vol issue 2022 35037164 |
we observed that ica treatment improved the learning and memory of 3\xe2\x80\x89\xc3\x97\xe2\x80\x89tg-ad mice and reduced a\xce\xb2 deposition and tau protein phosphorylation in the hippocampus. |
2022-01-17 |
2023-01-26 |
mouse |
| Steven G Fagan, Sibylle Bechet, Kumlesh K De. Fingolimod Rescues Memory and Improves Pathological Hallmarks in the 3xTg-AD Model of Alzheimer's Disease. Molecular neurobiology vol issue 2022 35031916 |
finally, treatment with fingolimod was shown to reduce phosphorylated tau and app levels in the hippocampus and cortex. |
2022-01-15 |
2023-01-26 |
Not clear |
| Xi-Chen Zhu, Lu Liu, Wen-Zhuo Dai, Tao M. Crry silencing alleviates Alzheimer's disease injury by regulating neuroinflammatory cytokines and the complement system. Neural regeneration research vol 17 issue 8 2022 35017447 |
we also found that crry protein expression in the hippocampus and cortex was significantly elevated in p301s mice (a mouse model widely used for investigating tau pathology) compared with that in wild-type mice. |
2022-01-12 |
2023-01-26 |
mouse |
| Ryszard Pluta, S\\xc5\\x82awomir Januszewski, Stanis\\xc5\\x82aw J Czuczwa. Post-Ischemic Neurodegeneration of the Hippocampus Resembling Alzheimer's Disease Proteinopathy. International journal of molecular sciences vol 23 issue 1 2022 35008731 |
in the hippocampus, studies have revealed dysregulation of the genes for the amyloid protein precursor metabolism and tau protein that is identical in nature to alzheimer's disease. |
2022-01-11 |
2023-01-26 |
Not clear |
| Ryszard Pluta, S\\xc5\\x82awomir Januszewski, Stanis\\xc5\\x82aw J Czuczwa. Post-Ischemic Neurodegeneration of the Hippocampus Resembling Alzheimer's Disease Proteinopathy. International journal of molecular sciences vol 23 issue 1 2022 35008731 |
data indicate that amyloid and tau protein, derived from brain tissue and blood due to increased permeability of the blood-brain barrier after ischemia, play a key role in post-ischemic neurodegeneration of the hippocampus, with concomitant development of full-blown dementia. |
2022-01-11 |
2023-01-26 |
Not clear |
| Adam P Mecca, Ming-Kai Chen, Ryan S O'Dell, Mika Naganawa, Takuya Toyonaga, Tyler A Godek, Joanna E Harris, Hugh H Bartlett, Wenzhen Zhao, Emmie R Banks, Gessica S Ni, Kelly Rogers, Jean Dominique Gallezot, Jim Ropchan, Paul R Emery, Nabeel B Nabulsi, Brent C Vander Wyk, Amy F T Arnsten, Yiyun Huang, Richard E Carson, Christopher H van Dyc. Association of entorhinal cortical tau deposition and hippocampal synaptic density in older individuals with normal cognition and early Alzheimer's disease. Neurobiology of aging vol 111 issue 2021 34963063 |
association of entorhinal cortical tau deposition and hippocampal synaptic density in older individuals with normal cognition and early alzheimer's disease. |
2021-12-28 |
2023-01-26 |
human |
| Xinping Song, Zijian Zhao, Yujuan Zhao, Qing Jin, Shengyu L. Protective effects of Journal of microbiology and biotechnology vol 32 issue 3 2021 34954699 |
we also found that supplementation of b. coagulans ja845 alleviated amyloid-beta deposits and hyperphosphorylated tau in hippocampus of d-gal/alcl3-induced ad model mice. |
2021-12-26 |
2023-01-26 |
mouse |
| Alireza Salami, Rolf Adolfsson, Micael Andersson, Kaj Blennow, Anders Lundquist, Annelie Nordin Adolfsson, Michael Sch\\xc3\\xb6ll, Henrik Zetterberg, Lars Nyber. Association of APOE \\xc9\\x9b4 and Plasma p-tau181 with Preclinical Alzheimer's Disease and Longitudinal Change in Hippocampus Function. Journal of Alzheimer's disease : JAD vol issue 2021 34924376 |
however, it remains unknown whether elevated tau accumulation on hippocampal functional changes would be more pronounced for apoe \xc9\x9b4 carriers. |
2021-12-20 |
2023-01-26 |
Not clear |
| YouJin Lee, Morgan R Miller, Marty A Fernandez, Elizabeth L Berg, Adriana M Prada, Qing Ouyang, Michael Schmidt, Jill L Silverman, Tracy L Young-Pearse, Eric M Morro. Early lysosome defects precede neurodegeneration with amyloid-\\xce\\xb2 and tau aggregation in NHE6-null rat brain. Brain : a journal of neurology vol issue 2021 34928329 |
importantly, we subsequently observe biochemical and in situ evidence of both a\xce\xb2 and tau aggregation in the aged nhe6-null hippocampus and cortex (but not in the cerebellum). |
2021-12-20 |
2023-01-26 |
rat |
| Kurt A Jellinge. Recent update on the heterogeneity of the Alzheimer's disease spectrum. Journal of neural transmission (Vienna, Austria : 1996) vol issue 2021 34919190 |
in addition to four major subtypes based on the distribution of tau pathology and brain atrophy (typical, limbic predominant, hippocampal sparing, and minimal atrophy), several other clinical variants (non-amnestic, corticobasal, behavioral/dysexecutive, posterior cortical variants, etc.) |
2021-12-17 |
2023-01-26 |
Not clear |