| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ting Zhang, Bai-Shen Pan, Guang-Chun Sun, Xiao Sun, Feng-Yan Su. Diabetes synergistically exacerbates poststroke dementia and tau abnormality in brain. Neurochemistry international. vol 56. issue 8. 2010-11-29. PMID:20398714. |
moreover, we found that diabetes further increased at8, a marker of hyperphosphorylated tau, protein and immunopositive stained cells in the hippocampus of rats following mcao while reduced the level of phosphorylated glycogen synthase kinase 3-beta at serine-9 residues (p-ser9-gsk-3beta), indicating activation of gsk-3beta. |
2010-11-29 |
2023-08-12 |
rat |
| Ying Chen, Cui-Ping Cao, Chun-Ri Li, Wei Wang, Dan Zhang, Ling-Ling Han, Xiao-Qing Zhang, Andre Kim, Suhkmann Kim, Guo-Liang Li. Ghrelin modulates insulin sensitivity and tau phosphorylation in high glucose-induced hippocampal neurons. Biological & pharmaceutical bulletin. vol 33. issue 7. 2010-11-26. PMID:20606308. |
ghrelin modulates insulin sensitivity and tau phosphorylation in high glucose-induced hippocampal neurons. |
2010-11-26 |
2023-08-12 |
Not clear |
| Ying Chen, Cui-Ping Cao, Chun-Ri Li, Wei Wang, Dan Zhang, Ling-Ling Han, Xiao-Qing Zhang, Andre Kim, Suhkmann Kim, Guo-Liang Li. Ghrelin modulates insulin sensitivity and tau phosphorylation in high glucose-induced hippocampal neurons. Biological & pharmaceutical bulletin. vol 33. issue 7. 2010-11-26. PMID:20606308. |
the aim of this study was to investigate whether ghrelin increased high glucose-induced hippocampal neuron insulin sensitivity, and further modulated tau phosphorylation. |
2010-11-26 |
2023-08-12 |
Not clear |
| Gurdeep Marwarha, Bhanu Dasari, Jaya Prasanthi Rantham Prabhakara, Jared Schommer, Othman Ghrib. β-Amyloid regulates leptin expression and tau phosphorylation through the mTORC1 signaling pathway. Journal of neurochemistry. vol 115. issue 2. 2010-11-22. PMID:20670375. |
in this study, we show that incubation of organotypic slices from rabbit hippocampus with aβ down-regulates leptin expression, inhibits akt, activates gsk-3β, increases tau phosphorylation, and inactivates mtorc1. |
2010-11-22 |
2023-08-12 |
rabbit |
| Jesús Avila, Elena Gómez de Barreda, Tobias Engel, Jose J Lucas, Félix Hernánde. Tau phosphorylation in hippocampus results in toxic gain-of-function. Biochemical Society transactions. vol 38. issue 4. 2010-11-12. PMID:20658988. |
tau phosphorylation in hippocampus results in toxic gain-of-function. |
2010-11-12 |
2023-08-12 |
mouse |
| Kunie Ando, Karelle Leroy, Céline Heraud, Anna Kabova, Zehra Yilmaz, Michèle Authelet, Valèrie Suain, Robert De Decker, Jean-Pierre Brio. Deletion of murine tau gene increases tau aggregation in a human mutant tau transgenic mouse model. Biochemical Society transactions. vol 38. issue 4. 2010-11-12. PMID:20658993. |
whereas tg30xtauko mice express fewer tau proteins compared with tg30tau, they exhibit augmented sarkosyl-insoluble tau in the brain and an increased number of gallyas-positive nfts in the hippocampus. |
2010-11-12 |
2023-08-12 |
mouse |
| Jie Yan, Xiao-Bo Sun, Hong-Quan Wang, Hong Zhao, Xiao-Yan Zhao, Yu-Xia Xu, Jing-Chun Guo, Cui-Qing Zh. Chronic restraint stress alters the expression and distribution of phosphorylated tau and MAP2 in cortex and hippocampus of rat brain. Brain research. vol 1347. 2010-11-02. PMID:20513368. |
chronic restraint stress alters the expression and distribution of phosphorylated tau and map2 in cortex and hippocampus of rat brain. |
2010-11-02 |
2023-08-12 |
rat |
| Jie Yan, Xiao-Bo Sun, Hong-Quan Wang, Hong Zhao, Xiao-Yan Zhao, Yu-Xia Xu, Jing-Chun Guo, Cui-Qing Zh. Chronic restraint stress alters the expression and distribution of phosphorylated tau and MAP2 in cortex and hippocampus of rat brain. Brain research. vol 1347. 2010-11-02. PMID:20513368. |
robust hyperphosphorylated tau immunolabeling was observed both in cortex and hippocampus of stressed animals and mainly located to perikaryal/dendritic elements. |
2010-11-02 |
2023-08-12 |
rat |
| C Köhler, P Bista, J Götz, H Schröde. Analysis of the cholinergic pathology in the P301L tau transgenic pR5 model of tauopathy. Brain research. vol 1347. 2010-11-02. PMID:20513372. |
to test the suitability of the pr5 model as a model of alzheimer's disease concerning the cholinergic innervation of the telencephalon, we determined the expression of the human tau transgene and the presence of neurofibrillary changes in the basal nucleus of meynert, the septal nuclei and the diagonal band of broca, sources of cholinergic innervation of the cerebral cortex and hippocampus. |
2010-11-02 |
2023-08-12 |
mouse |
| Niall M Corcoran, Daniel Martin, Birgit Hutter-Paier, Manfred Windisch, Thanh Nguyen, Lina Nheu, Lars E Sundstrom, Anthony J Costello, Christopher M Hoven. Sodium selenate specifically activates PP2A phosphatase, dephosphorylates tau and reverses memory deficits in an Alzheimer's disease model. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 17. issue 8. 2010-10-19. PMID:20537899. |
sodium selenate-treated transgenic tau441 mice had significantly lower levels of phospho- and total tau levels in the hippocampus and amygdala compared with controls and exhibited significantly improved spatial learning and memory on the morris water maze task. |
2010-10-19 |
2023-08-12 |
mouse |
| Kimiaki Hashiguchi, Takato Morioka, Nobuya Murakami, Satoshi O Suzuki, Akio Hiwatashi, Takashi Yoshiura, Tomio Sasak. Utility of 3-T FLAIR and 3D short tau inversion recovery MR imaging in the preoperative diagnosis of hippocampal sclerosis: direct comparison with 1.5-T FLAIR MR imaging. Epilepsia. vol 51. issue 9. 2010-10-15. PMID:20738382. |
utility of 3-t flair and 3d short tau inversion recovery mr imaging in the preoperative diagnosis of hippocampal sclerosis: direct comparison with 1.5-t flair mr imaging. |
2010-10-15 |
2023-08-12 |
Not clear |
| Kimiaki Hashiguchi, Takato Morioka, Nobuya Murakami, Satoshi O Suzuki, Akio Hiwatashi, Takashi Yoshiura, Tomio Sasak. Utility of 3-T FLAIR and 3D short tau inversion recovery MR imaging in the preoperative diagnosis of hippocampal sclerosis: direct comparison with 1.5-T FLAIR MR imaging. Epilepsia. vol 51. issue 9. 2010-10-15. PMID:20738382. |
to examine the utility of fluid-attenuated inversion recovery (flair) imaging and three-dimensional short tau inversion recovery (3dstir) imaging using a 3-tesla (3-t) magnetic resonance (mr) imager in the preoperative evaluation of hippocampal sclerosis (hs). |
2010-10-15 |
2023-08-12 |
Not clear |
| Osamu Yokota, Yvonne Davidson, Eileen H Bigio, Hideki Ishizu, Seishi Terada, Tetsuaki Arai, Masato Hasegawa, Haruhiko Akiyama, Stephen Sikkink, Stuart Pickering-Brown, David M A Man. Phosphorylated TDP-43 pathology and hippocampal sclerosis in progressive supranuclear palsy. Acta neuropathologica. vol 120. issue 1. 2010-10-14. PMID:20512649. |
tdp-43 and tau were frequently colocalized in the amygdala, but not in the hippocampal dentate gyrus. |
2010-10-14 |
2023-08-12 |
Not clear |
| Miao-Kun Sun, Daniel L Alko. Pharmacology of protein kinase C activators: cognition-enhancing and antidementic therapeutics. Pharmacology & therapeutics. vol 127. issue 1. 2010-10-07. PMID:20382181. |
pkc activators not only increase activity of pkc isozymes and thereby restore pkc signaling activity, including neurotrophic activity, synaptic/structural remodeling, and synaptogenesis in the hippocampus and related cortical areas, but also reduce the accumulation of neurotoxic amyloid and tau protein hyperphosphorylation in the brain. |
2010-10-07 |
2023-08-12 |
Not clear |
| Johanne Bertrand, Patrick Sénéchal, Mathieu Zummo-Soucy, Vanessa Plouffe, Nicole Lecler. The formation of tau pathological phospho-epitopes in the axon is prevented by the dephosphorylation of selective sites in primary hippocampal neurons over-expressing human tau. Journal of neurochemistry. vol 114. issue 5. 2010-09-13. PMID:20550628. |
the formation of tau pathological phospho-epitopes in the axon is prevented by the dephosphorylation of selective sites in primary hippocampal neurons over-expressing human tau. |
2010-09-13 |
2023-08-12 |
human |
| Johanne Bertrand, Patrick Sénéchal, Mathieu Zummo-Soucy, Vanessa Plouffe, Nicole Lecler. The formation of tau pathological phospho-epitopes in the axon is prevented by the dephosphorylation of selective sites in primary hippocampal neurons over-expressing human tau. Journal of neurochemistry. vol 114. issue 5. 2010-09-13. PMID:20550628. |
in primary hippocampal neurons where human tau was over-expressed both in the somato-dendritic compartment and the axon, the pathological epitopes recognized by the antibodies at8 (s199/s202/t205), at100 (t212/s214/t217), and at180 (t231/s235) were found in the somato-dendritic compartment but not in the axon where tau was either not phosphorylated (t205 and t217) or not simultaneously phosphorylated (t231 and s235) at sites included in the above epitopes. |
2010-09-13 |
2023-08-12 |
human |
| Johanne Bertrand, Patrick Sénéchal, Mathieu Zummo-Soucy, Vanessa Plouffe, Nicole Lecler. The formation of tau pathological phospho-epitopes in the axon is prevented by the dephosphorylation of selective sites in primary hippocampal neurons over-expressing human tau. Journal of neurochemistry. vol 114. issue 5. 2010-09-13. PMID:20550628. |
expression of tau mutants where one phosphorylation site included in the above epitopes was mutated in alanine showed that the formation of one of these epitopes was not required for the formation of the two others in primary hippocampal neurons. |
2010-09-13 |
2023-08-12 |
human |
| Jiqing Xu, Shinji Sato, Satoshi Okuyama, Russell J Swan, Michael T Jacobsen, Elena Strunk, Tsuneya Ikez. Tau-tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP-17 tau-mutant mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 24. issue 8. 2010-09-07. PMID:20354135. |
the bigenic mice show enhanced tau phosphorylation at multiple sites (at8, 12e8, phf-1, and ps422), tauc3-immunoreactive tau fragmentation, and accumulation of tau aggregates in cortical and hippocampal neurons at 12-13 mo of age. |
2010-09-07 |
2023-08-12 |
mouse |
| Juan Deng, Cheng Shen, Yan-Jiang Wang, Meng Zhang, Jing Li, Zhi-Qiang Xu, Chang-Yue Gao, Chuan-Qing Fang, Hua-Dong Zho. Nicotine exacerbates tau phosphorylation and cognitive impairment induced by amyloid-beta 25-35 in rats. European journal of pharmacology. vol 637. issue 1-3. 2010-09-07. PMID:20363218. |
the present study investigated the effect of nicotine on tau phosphorylation and cognitive impairment induced by hippocampus injections of amyloid-beta (abeta) 25-35. |
2010-09-07 |
2023-08-12 |
rat |
| Juan Deng, Cheng Shen, Yan-Jiang Wang, Meng Zhang, Jing Li, Zhi-Qiang Xu, Chang-Yue Gao, Chuan-Qing Fang, Hua-Dong Zho. Nicotine exacerbates tau phosphorylation and cognitive impairment induced by amyloid-beta 25-35 in rats. European journal of pharmacology. vol 637. issue 1-3. 2010-09-07. PMID:20363218. |
the data show that nicotine (1mg/kg in base weight) treatment significantly exacerbates cognitive impairment and tau phosphorylation at ser-202 and thr-231 in the hippocampus compared with abeta25-35 injection groups in the abeta rat model of alzheimer's disease. |
2010-09-07 |
2023-08-12 |
rat |