| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Schwab, V Bondada, D L Sparks, L D Cahan, J W Gedde. Postmortem changes in the levels and localization of microtubule-associated proteins (tau, MAP2 and MAP1B) in the rat and human hippocampus. Hippocampus vol 4 issue 2 1994 7951696 |
postmortem changes in the levels and localization of microtubule-associated proteins (tau, map2 and map1b) in the rat and human hippocampus. |
1994-12-20 |
2023-01-24 |
rat |
| C Schwab, V Bondada, D L Sparks, L D Cahan, J W Gedde. Postmortem changes in the levels and localization of microtubule-associated proteins (tau, MAP2 and MAP1B) in the rat and human hippocampus. Hippocampus vol 4 issue 2 1994 7951696 |
immunohistochemistry and immunoblots were used to examine the microtubule-associated proteins tau, map2, and map1b in the rat hippocampus at various times after death. |
1994-12-20 |
2023-01-24 |
rat |
| R W Shin, V M Lee, J Q Trojanowsk. Aluminum modifies the properties of Alzheimer's disease PHF tau proteins in vivo and in vitro. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 14 issue 11 Pt 2 1994 7525898 |
to determine if aluminum salts interact directly and specifically with phf tau in situ, we pretreated sections of ad hippocampus with 10 mm alcl3 and then probed these sections by immunohistochemistry with antibodies to phf tau as well as to a number of other plaque and tangle components. |
1994-12-02 |
2023-01-24 |
rat |
| H Braak, E Braak, M Strothjohan. Abnormally phosphorylated tau protein related to the formation of neurofibrillary tangles and neuropil threads in the cerebral cortex of sheep and goat. Neuroscience letters vol 171 issue 1-2 1994 7521944 |
frontal sections including temporal isocortex, entorhinal region and hippocampus from aged domestic animals (dog, cat, horse, sheep and goat) were studied for alzheimer-related changes using immunostaining with the at8 antibody for abnormally phosphorylated tau protein and selective silver techniques for a4 amyloid and neurofibrillary changes of the alzheimer type. |
1994-10-10 |
2023-01-24 |
human |
| J W Geddes, C Schwab, S Craddock, J L Wilson, L C Pettigre. Alterations in tau immunostaining in the rat hippocampus following transient cerebral ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism vol 14 issue 4 1994 7516935 |
alterations in tau immunostaining in the rat hippocampus following transient cerebral ischemia. |
1994-07-27 |
2023-01-24 |
rat |
| J Q Trojanowski, M Mawal-Dewan, M L Schmidt, J Martin, V M Le. Localization of the mitogen activated protein kinase ERK2 in Alzheimer's disease neurofibrillary tangles and senile plaque neurites. Brain research vol 618 issue 2 1993 8374766 |
since erk2 was detected in neurofibrillary tangles and senile plaque neurites in the ad hippocampus, erk2 is positioned to phosphorylate normal tau and could play a role in the generation of phfs in ad. |
1993-10-21 |
2023-01-24 |
Not clear |
| R W Shin, G T Bramblett, V M Lee, J Q Trojanowsk. Alzheimer disease A68 proteins injected into rat brain induce codeposits of beta-amyloid, ubiquitin, and alpha 1-antichymotrypsin. Proceedings of the National Academy of Sciences of the United States of America vol 90 issue 14 1993 8393578 |
to probe the biological properties of a68 in vivo, and to assess interactions of a68 with endogenous proteins in the rodent brain, we injected a68, dephosphorylated a68 (dep-a68), and normal adult human tau protein into the hippocampus and neocortex of rats. |
1993-08-30 |
2023-01-24 |
rat |
| E M Elliott, M P Mattson, P Vanderklish, G Lynch, I Chang, R M Sapolsk. Corticosterone exacerbates kainate-induced alterations in hippocampal tau immunoreactivity and spectrin proteolysis in vivo. Journal of neurochemistry vol 61 issue 1 1993 8515288 |
corticosterone exacerbates kainate-induced alterations in hippocampal tau immunoreactivity and spectrin proteolysis in vivo. |
1993-07-22 |
2023-01-24 |
rat |
| L W Duchen, M Poulter, A E Hardin. Dementia associated with a 216 base pair insertion in the prion protein gene. Clinical and neuropathological features. Brain : a journal of neurology vol 116 ( Pt 3) issue 1993 8513392 |
in some places plaques bore a resemblance to senile neuritic plaques and in the hippocampus there were abundant typical neuritic plaques giving positive staining reactions for beta-amyloid protein and tau protein, but not prp. |
1993-07-21 |
2023-01-24 |
Not clear |
| M P Mattson, M A Lovell, W D Ehmann, W R Markesber. Comparison of the effects of elevated intracellular aluminum and calcium levels on neuronal survival and tau immunoreactivity. Brain research vol 602 issue 1 1993 8448655 |
we examined the effects of experimentally elevated intraneuronal levels of aluminum ([al]i) and/or calcium ([ca2+]i) on neuronal degeneration and antigenic alterations in the microtubule-associated protein tau in cell cultures of rat hippocampus and human cerebral cortex. |
1993-04-12 |
2023-01-24 |
rat |
| N Taleghany, M M Oblinge. Regional distribution and biochemical characteristics of high molecular weight tau in the nervous system. Journal of neuroscience research vol 33 issue 2 1993 1453489 |
another tau isoform of slightly smaller size (90-100 kda), termed mid-molecular weight (mmw) tau, was present in abundant quantity in optic nerve samples and detectable in several other cns regions, including hippocampus and cerebellum. |
1993-01-06 |
2023-01-23 |
Not clear |
| C F Lippa, T W Smit. The indusium griseum in Alzheimer's disease: an immunocytochemical study. Journal of the neurological sciences vol 111 issue 1 1992 1328542 |
the immunocytochemical features of the indusium griseum (ig) were compared with the corresponding hippocampus in 5 patients with alzheimer's disease (ad) and 5 age-matched nondemented individuals using antibodies against beta-amyloid, the a68 protein (alz-50 antibody), tau, ubiquitin and synapsin i. beta-amyloid-positive plaques were prominent in the ad hippocampus but were not present in the ig. |
1992-11-12 |
2023-01-23 |
Not clear |
| C F Lippa, T W Smit. The indusium griseum in Alzheimer's disease: an immunocytochemical study. Journal of the neurological sciences vol 111 issue 1 1992 1328542 |
numerous alz-50, tau and ubiquitin-positive neurofibrillary tangles and dystrophic neurites were observed in the ad hippocampus but were infrequent in the ig. |
1992-11-12 |
2023-01-23 |
Not clear |
| S Simler, L Ciesielski, J Clement, A Rastegar, P Mande. Involvement of synaptosomal neurotransmitter amino acids in audiogenic seizure-susceptibility and -severity of Rb mice. Neurochemical research vol 17 issue 9 1992 1357566 |
low levels of tau, gaba, and ser in hippocampus, gly in amygdala, glu in hippocampus, inferior colliculus and pons, gln and asp in inferior colliculus appeared to correlate with seizure-susceptibility. |
1992-11-02 |
2023-01-23 |
mouse |
| S Simler, L Ciesielski, J Clement, A Rastegar, P Mande. Involvement of synaptosomal neurotransmitter amino acids in audiogenic seizure-susceptibility and -severity of Rb mice. Neurochemical research vol 17 issue 9 1992 1357566 |
a strong involvement of hippocampus (tau, gaba, ser, glu, and gln) and inferior colliculus (asp, glu, gln) in audiogenic seizure-susceptibility, and of olfactory bulb (gaba, asp) in seizure-severity and/or -diversity is suggested. |
1992-11-02 |
2023-01-23 |
mouse |
| M P Mattso. Effects of microtubule stabilization and destabilization on tau immunoreactivity in cultured hippocampal neurons. Brain research vol 582 issue 1 1992 1354011 |
previous data indicated that calcium influx can cause antigenic changes in tau in cultured rat hippocampal and human cortical neurons similar to those seen in nft. |
1992-09-14 |
2023-01-23 |
rat |
| K Kolasa, R S Jope, M S Baird, G V Johnso. Alterations of choline acetyltransferase, phosphoinositide hydrolysis, and cytoskeletal proteins in rat brain in response to colchicine administration. Experimental brain research vol 89 issue 3 1992 1322821 |
the concentrations of tau and tubulin in the hippocampus were unaltered by colchicine treatment, and map-2 and spectrin were only slightly reduced 4 weeks after colchicine. |
1992-09-08 |
2023-01-23 |
rat |
| H Arai, M L Schmidt, V M Lee, H I Hurtig, B D Greenberg, C H Adler, J Q Trojanowsk. Epitope analysis of senile plaque components in the hippocampus of patients with Parkinson's disease. Neurology vol 42 issue 7 1992 1377804 |
as in the ad hippocampus, the sps detected by conventional stains in five of the 10 demented subjects contained the beta-ap and flanking domains in beta-apps as well as epitopes in tau, neurofilament proteins, and synaptophysin. |
1992-08-06 |
2023-01-23 |
human |
| Y Gache, J Guilleminot, F Ricolfi, G Theiss, J Nune. A tau-related protein of 130 kDa is present in Alzheimer brain. Journal of neurochemistry vol 58 issue 6 1992 1374115 |
two abnormal entities of 69 and 130 kda, immunologically related to the microtubule-associated tau proteins, are present in the hippocampus and the frontal cortex of the alzheimer brain, which contain a large number of neurofibrillary tangles (nfts), but are absent in the cerebellum, which does not contain these structures. |
1992-06-04 |
2023-01-23 |
Not clear |
| R W Shin, T Iwaki, T Kitamoto, Y Sato, J Tateish. Massive accumulation of modified tau and severe depletion of normal tau characterize the cerebral cortex and white matter of Alzheimer's disease. Demonstration using the hydrated autoclaving method. The American journal of pathology vol 140 issue 4 1992 1373272 |
using the hydrated autoclaving method, a new immunohistochemical procedure to enhance tau immunoreactivity in formalin-fixed brain tissue, the authors recently reported that tau protein is detected in neuronal cell bodies and proximal dendrites, gray matter neuropil, axons, and glial cells in normal human hippocampus and neocortex. |
1992-05-11 |
2023-01-23 |
human |