| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Julie Allyson, Eve Dontigny, Yves Auberson, Michel Cyr, Guy Massicott. Blockade of NR2A-containing NMDA receptors induces Tau phosphorylation in rat hippocampal slices. Neural plasticity. vol 2010. 2010-08-24. PMID:20508838. |
blockade of nr2a-containing nmda receptors induces tau phosphorylation in rat hippocampal slices. |
2010-08-24 |
2023-08-12 |
rat |
| Julie Allyson, Eve Dontigny, Yves Auberson, Michel Cyr, Guy Massicott. Blockade of NR2A-containing NMDA receptors induces Tau phosphorylation in rat hippocampal slices. Neural plasticity. vol 2010. 2010-08-24. PMID:20508838. |
we observed, in acute hippocampal slice preparations, that blockade of nr2a-containing nmda receptors by the nr2a antagonist nvp-aam077 provoked the hyperphosphorylation of a residue located in the proline-rich domain of tau (i.e., ser199). |
2010-08-24 |
2023-08-12 |
rat |
| J Bertrand, V Plouffe, P Sénéchal, N Lecler. The pattern of human tau phosphorylation is the result of priming and feedback events in primary hippocampal neurons. Neuroscience. vol 168. issue 2. 2010-08-19. PMID:20394726. |
the pattern of human tau phosphorylation is the result of priming and feedback events in primary hippocampal neurons. |
2010-08-19 |
2023-08-12 |
human |
| J Bertrand, V Plouffe, P Sénéchal, N Lecler. The pattern of human tau phosphorylation is the result of priming and feedback events in primary hippocampal neurons. Neuroscience. vol 168. issue 2. 2010-08-19. PMID:20394726. |
in the present study, human tau mutants in which disease-related sites associated with either an early (at8, t231 and s262) or intermediate (t217) stage of tau pathology were mutated in alanine to inhibit their phosphorylation were overexpressed in primary hippocampal neurons to examine their impact on the phosphorylation of other disease-related sites. |
2010-08-19 |
2023-08-12 |
human |
| J Bertrand, V Plouffe, P Sénéchal, N Lecler. The pattern of human tau phosphorylation is the result of priming and feedback events in primary hippocampal neurons. Neuroscience. vol 168. issue 2. 2010-08-19. PMID:20394726. |
all together, our data show that the sites forming the at8 epitope could play a central role in regulating the phosphorylation of tau at disease-associated sites and that priming and feedback events take place to regulate the overall level of tau phosphorylation in rat hippocampal neurons. |
2010-08-19 |
2023-08-12 |
human |
| Giovanni B Frison. Alzheimer's disease neuroimaging initiative in Europe. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 6. issue 3. 2010-08-11. PMID:20451877. |
because the adni platform was first imported in europe, thanks to the pilot european adni, several adni-related initiatives have flourished, funded by the european commission's 7th framework programme, national governments, and the alzheimer's association aimed at: (i) collecting fresh data adni style (fp7 addneuromed, innovative medicine initiative pharma-cog/european adni, swedish adni, and italian adni); (ii) developing standard operational procedures for the collection of markers (international harmonization of csf abeta42 and tau, and european alzheimer's disease consortium-adni harmonization of hippocampal volumetry); and (iii) developing infrastructures for the treatment of adni data (fp7 neugrid and outgrid, and the french centre pour l'acquisition et le traitement de l'image). |
2010-08-11 |
2023-08-12 |
Not clear |
| N Li, Z L Yu, L Wang, Y T Zheng, J X Jia, Q Wang, M J Zhu, X L Liu, X Xia, W J L. Increased tau phosphorylation and beta amyloid in the hipocampus of mouse pups by early life lead exposure. Acta biologica Hungarica. vol 61. issue 2. 2010-08-10. PMID:20519167. |
the aim of this study was to investigate the effects of maternal lead exposure on the learning and memory ability and expression of tau protein phosphorylation (p-tau) and beta amyloid protein (abeta) in hippocampus of mice offspring. |
2010-08-10 |
2023-08-12 |
mouse |
| N Li, Z L Yu, L Wang, Y T Zheng, J X Jia, Q Wang, M J Zhu, X L Liu, X Xia, W J L. Increased tau phosphorylation and beta amyloid in the hipocampus of mouse pups by early life lead exposure. Acta biologica Hungarica. vol 61. issue 2. 2010-08-10. PMID:20519167. |
tau hyper-phosphorylation and abeta increase in the hippocampus of pups may contribute to the impairment of learning and memory associated with maternal pb exposure. |
2010-08-10 |
2023-08-12 |
mouse |
| Juan Perucho, Isabel Rubio, Maria J Casarejos, Ana Gomez, Jose A Rodriguez-Navarro, Rosa M Solano, Justo Garcia De Yébenes, Maria A Men. Anesthesia with isoflurane increases amyloid pathology in mice models of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 19. issue 4. 2010-07-22. PMID:20308791. |
we have investigated the effects of repetitive anesthesia, twice a week, for 3 months, from 7 to 10 months of age, with isoflurane on survival, behavior, apoptosis in hippocampal cells, amyloid-beta (abeta) peptide and tau patterns, chaperones and autophagy in wt and abetapp{swe} mice. |
2010-07-22 |
2023-08-12 |
mouse |
| Yuan-Shih Hu, Peng Xu, Gustavo Pigino, Scott T Brady, John Larson, Orly Lazaro. Complex environment experience rescues impaired neurogenesis, enhances synaptic plasticity, and attenuates neuropathology in familial Alzheimer's disease-linked APPswe/PS1DeltaE9 mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 24. issue 6. 2010-07-21. PMID:20086049. |
enhanced neurogenesis was accompanied by a significant reduction in levels of hyperphosphorylated tau and oligomeric abeta, the precursors of ad hallmarks, in the hippocampus and cortex of enriched mice. |
2010-07-21 |
2023-08-12 |
mouse |
| Luis Escribano, Ana-María Simón, Esther Gimeno, Mar Cuadrado-Tejedor, Rakel López de Maturana, Ana García-Osta, Ana Ricobaraza, Alberto Pérez-Mediavilla, Joaquín Del Río, Diana Frechill. Rosiglitazone rescues memory impairment in Alzheimer's transgenic mice: mechanisms involving a reduced amyloid and tau pathology. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 7. 2010-07-09. PMID:20336061. |
in the hippocampus, neuropil threads containing phosphorylated tau, probably corresponding to dystrophic neurites, were also decreased by the drug. |
2010-07-09 |
2023-08-12 |
mouse |
| Ayodeji A Asuni, V Hugh Perry, Vincent O'Conno. Change in tau phosphorylation associated with neurodegeneration in the ME7 model of prion disease. Biochemical Society transactions. vol 38. issue 2. 2010-06-11. PMID:20298219. |
we have investigated the expression of hyperphosphorylated tau in the hippocampus of mice infected with the me7 prion agent. |
2010-06-11 |
2023-08-12 |
mouse |
| Gang Li, Nga Bien-Ly, Yaisa Andrews-Zwilling, Qin Xu, Aubrey Bernardo, Karen Ring, Brian Halabisky, Changhui Deng, Robert W Mahley, Yadong Huan. GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice. Cell stem cell. vol 5. issue 6. 2010-06-04. PMID:19951691. |
tau phosphorylation, an alzheimer's disease characteristic, and levels of neurotoxic apoe fragments were both elevated in apoe4-ki hippocampal neurons concomitant with decreased gabaergic interneuron survival. |
2010-06-04 |
2023-08-12 |
mouse |
| Fa-Fa Tian, Chang Zeng, Yun-Feng Ma, Ting-Hui Guo, Jin-Mei Chen, Ying Chen, Xiao-Feng Cai, Feng-Rong Li, Xin-Hua Wang, Wen-Jiao Huang, Yu-Zhong Wan. Potential roles of Cdk5/p35 and tau protein in hippocampal mossy fiber sprouting in the PTZ kindling model. Clinical laboratory. vol 56. issue 3-4. 2010-06-03. PMID:20476644. |
potential roles of cdk5/p35 and tau protein in hippocampal mossy fiber sprouting in the ptz kindling model. |
2010-06-03 |
2023-08-12 |
Not clear |
| Tohru Hasegawa, Nobuyuki Mikoda, Masashi Kitazawa, Frank M LaFerl. Treatment of Alzheimer's disease with anti-homocysteic acid antibody in 3xTg-AD male mice. PloS one. vol 5. issue 1. 2010-05-20. PMID:20098691. |
four-month-old prepathological 3xtg-ad mice exhibited higher levels of ha in the hippocampus than did age-matched nontransgenic mice, suggesting that ha accumulation may precede both abeta and tau pathologies. |
2010-05-20 |
2023-08-12 |
mouse |
| Silvia Josefina López-Pérez, Mónica Elisa Ureña-Guerrero, Alberto Morales-Villagrá. Monosodium glutamate neonatal treatment as a seizure and excitotoxic model. Brain research. vol 1317. 2010-05-19. PMID:20043888. |
glu levels and hippocampal total content of related amino acids (asp, glu, gln, gly, tau, ala and gaba) were estimated before, immediately and after each injection. |
2010-05-19 |
2023-08-12 |
rat |
| Alberto Serrano-Pozo, Christopher M William, Isidro Ferrer, Emmanuelle Uro-Coste, Marie-Bernadette Delisle, Claude-Alain Maurage, Christoph Hock, Roger M Nitsch, Eliezer Masliah, John H Growdon, Matthew P Frosch, Bradley T Hyma. Beneficial effect of human anti-amyloid-beta active immunization on neurite morphology and tau pathology. Brain : a journal of neurology. vol 133. issue Pt 5. 2010-05-17. PMID:20360050. |
anti-amyloid-beta immunization might also ameliorate the hippocampal tau pathology through a decrease in tau phosphorylation. |
2010-05-17 |
2023-08-12 |
human |
| Naoto Oikawa, Nobuyuki Kimura, Katsuhiko Yanagisaw. Alzheimer-type tau pathology in advanced aged nonhuman primate brains harboring substantial amyloid deposition. Brain research. vol 1315. 2010-05-06. PMID:20004650. |
to examine the accumulation of deposited abeta, phosphorylated tau accumulation, intracellular tau accumulation, and neurofibrillary tangle formation, the brains, mainly temporal cortex and hippocampus, of 34 cynomolgus monkeys aged 6 to 36 years were studied by biochemical and histochemical analyses. |
2010-05-06 |
2023-08-12 |
monkey |
| Naoto Oikawa, Nobuyuki Kimura, Katsuhiko Yanagisaw. Alzheimer-type tau pathology in advanced aged nonhuman primate brains harboring substantial amyloid deposition. Brain research. vol 1315. 2010-05-06. PMID:20004650. |
histologically, intraneuronal and intraoligodendroglial tau accumulation was observed in temporal cortex and hippocampus of animals before the age of 20. |
2010-05-06 |
2023-08-12 |
monkey |
| Balu Chakravarthy, Chantal Gaudet, Michel Ménard, Trevor Atkinson, Leslie Brown, Frank M Laferla, Ubaldo Armato, James Whitfiel. Amyloid-beta peptides stimulate the expression of the p75(NTR) neurotrophin receptor in SHSY5Y human neuroblastoma cells and AD transgenic mice. Journal of Alzheimer's disease : JAD. vol 19. issue 3. 2010-05-05. PMID:20157247. |
specifically, the level of the p75(ntr) receptor in the hippocampal membranes from 12-15 month old ad-triple transgenic mice (3xtg-ad) harboring ps1 (m146v), abetapp (swe), and tau (p301l) was nearly twice that in hippocampal membranes from age-matched wild-type mice. |
2010-05-05 |
2023-08-12 |
mouse |