| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vanessa J De-Paula, Evelin L Schaeffer, Leda L Talib, Wagner F Gattaz, Orestes V Forlenz. Inhibition of phospholipase A2 increases tau phosphorylation at Ser214 in embryonic rat hippocampal neurons. Prostaglandins, leukotrienes, and essential fatty acids. vol 82. issue 1. 2010-04-26. PMID:19726172. |
inhibition of phospholipase a2 increases tau phosphorylation at ser214 in embryonic rat hippocampal neurons. |
2010-04-26 |
2023-08-12 |
rat |
| Chun Lai Nie, Yan Wei, Xinyong Chen, Yan Ying Liu, Wen Dui, Ying Liu, Martyn C Davies, Saul J B Tendler, Rong Giao H. Formaldehyde at low concentration induces protein tau into globular amyloid-like aggregates in vitro and in vivo. PloS one. vol 2. issue 7. 2010-04-23. PMID:17637844. |
our previous results show that neuronal tau aggregates in formaldehyde solution and that aggregated tau induces apoptosis of sh-sy5y and hippocampal cells. |
2010-04-23 |
2023-08-12 |
cattle |
| Karelle Leroy, Kunie Ando, Céline Héraud, Zehra Yilmaz, Michèle Authelet, Jean-Marie Boeynaems, Luc Buée, Robert De Decker, Jean-Pierre Brio. Lithium treatment arrests the development of neurofibrillary tangles in mutant tau transgenic mice with advanced neurofibrillary pathology. Journal of Alzheimer's disease : JAD. vol 19. issue 2. 2010-04-06. PMID:20110614. |
nevertheless, this study indicates that even a relatively short-term per os treatment leading to high blood concentration of lithium is effective in arresting the formation of nfts in the hippocampus and the spinal cord of a tau transgenic model. |
2010-04-06 |
2023-08-12 |
mouse |
| Yang-Yang Yin, Hao Liu, Xiao-Bin Cong, Zhao Liu, Qun Wang, Jian-Zhi Wang, Ling-Qiang Zh. Acetyl-L-carnitine attenuates okadaic acid induced tau hyperphosphorylation and spatial memory impairment in rats. Journal of Alzheimer's disease : JAD. vol 19. issue 2. 2010-04-06. PMID:20110616. |
inhibition of pp2a through hippocampal injection of okadaic acid (oa) induces tau hyperphosphorylation and memory impairment of rats. |
2010-04-06 |
2023-08-12 |
rat |
| Tomasz Jaworski, Ilse Dewachter, Benoit Lechat, Sophie Croes, Annelies Termont, David Demedts, Peter Borghgraef, Herman Devijver, Robert K Filipkowski, Leszek Kaczmarek, Sebastian Kügler, Fred Van Leuve. AAV-tau mediates pyramidal neurodegeneration by cell-cycle re-entry without neurofibrillary tangle formation in wild-type mice. PloS one. vol 4. issue 10. 2010-03-12. PMID:19794916. |
here, we approached the problem in non-transgenic models by intracerebral injection of adeno-associated viral vectors to express protein tau or amyloid precursor protein in the hippocampus in vivo. |
2010-03-12 |
2023-08-12 |
mouse |
| Masatake Fujimura, Fusako Usuki, Masumi Sawada, Akihiko Takashim. Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-N-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain. Neurotoxicology. vol 30. issue 6. 2010-03-09. PMID:19666049. |
methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-n-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain. |
2010-03-09 |
2023-08-12 |
mouse |
| Masatake Fujimura, Fusako Usuki, Masumi Sawada, Akihiko Takashim. Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-N-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain. Neurotoxicology. vol 30. issue 6. 2010-03-09. PMID:19666049. |
neither neuropathological changes nor tau hyperphosphorylation was detected in the hippocampus in this study although the mercury concentration here was twice that in the cerebral cortex. |
2010-03-09 |
2023-08-12 |
mouse |
| Masatake Fujimura, Fusako Usuki, Masumi Sawada, Akihiko Takashim. Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-N-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain. Neurotoxicology. vol 30. issue 6. 2010-03-09. PMID:19666049. |
these findings suggest that mehg exposure induces tau hyperphosphorylation at specific sites of tau mainly through the activation of jnk pathways, leading to neuropathological changes in the cerebral cortex selectively, but not in the hippocampus of mouse brain. |
2010-03-09 |
2023-08-12 |
mouse |
| M T Capucchio, M Márquez, P Pregel, L Foradada, M Bravo, G Mattutino, C Torre, D Schiffer, D Catalano, F Valenza, F Guarda, M Pumarol. Parenchymal and vascular lesions in ageing equine brains: histological and immunohistochemical studies. Journal of comparative pathology. vol 142. issue 1. 2010-02-25. PMID:19744668. |
some lesions described here, including some vascular changes, the presence of diffuse plaques and tau accumulation in hippocampal neurons, have not been described previously in the horse. |
2010-02-25 |
2023-08-12 |
Not clear |
| L Lecanu, G Rammouz, A McCourty, E K Sidahmed, J Greeson, V Papadopoulo. Caprospinol reduces amyloid deposits and improves cognitive function in a rat model of Alzheimer's disease. Neuroscience. vol 165. issue 2. 2010-02-24. PMID:19850110. |
this recovery of cognitive function was accompanied by a reduction in hippocampal amyloid deposits, astrogliosis, neurodegeneration and tau protein phopshorylation. |
2010-02-24 |
2023-08-12 |
rat |
| Masaoki Takano, Mieko Otani, Akiko Sakai, Keiichi Kadoyama, Shogo Matsuyama, Akira Matsumoto, Mariko Takenokuchi, Miho Sumida, Taizo Taniguch. Use of a phosphosensor dye in proteomic analysis of human mutant tau transgenic mice. Neuroreport. vol 20. issue 18. 2010-02-01. PMID:19898260. |
to investigate how tau dysfunctions cause these features, we examined the expression and phosphorylation levels in sjlb mouse hippocampal proteins using a phosphosensor dye in two-dimensional poly acrylamide gel electrophoresis analysis and mass spectrometry. |
2010-02-01 |
2023-08-12 |
mouse |
| Bhumsoo Kim, Carey Backus, Sangsu Oh, John M Hayes, Eva L Feldma. Increased tau phosphorylation and cleavage in mouse models of type 1 and type 2 diabetes. Endocrinology. vol 150. issue 12. 2010-01-19. PMID:19819959. |
tau phosphorylation is increased in the cortex and hippocampus of db/db mice compared with db+ control mouse brain. |
2010-01-19 |
2023-08-12 |
mouse |
| Steffen Albrecht, Nenad Bogdanovic, Bernardino Ghetti, Bengt Winblad, Andréa C LeBlan. Caspase-6 activation in familial alzheimer disease brains carrying amyloid precursor protein or presenilin i or presenilin II mutations. Journal of neuropathology and experimental neurology. vol 68. issue 12. 2009-12-22. PMID:19915487. |
to determine whether casp-6 is also activated in familial ad, we performed an immunohistochemical analysis of active casp-6 and tau cleaved by casp-6 in temporal cortex and hippocampal tissue sections from cases of familial ad. |
2009-12-22 |
2023-08-12 |
Not clear |
| Robert A Rissma. Stress-induced tau phosphorylation: functional neuroplasticity or neuronal vulnerability? Journal of Alzheimer's disease : JAD. vol 18. issue 2. 2009-12-17. PMID:19584431. |
despite its association with disease, tau phosphorylation (tau-p) also plays an important role in neuroplasticity, such as dendritic/synaptic remodeling seen in the hippocampus in response to environmental challenges, such as stress. |
2009-12-17 |
2023-08-12 |
Not clear |
| Zheng Jing, John Caltagarone, Robert Bowse. Altered subcellular distribution of c-Abl in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 17. issue 2. 2009-12-16. PMID:19363261. |
activated isoforms of c-abl were most abundant in ad hippocampus and co-localized with ad pathology, including granulovacuolar degeneration bodies, c-abl interacts with phosphorylated tau in ad brain and may contribute to the formation of tau pathology. |
2009-12-16 |
2023-08-12 |
human |
| Christian Tackenberg, Roland Brand. Divergent pathways mediate spine alterations and cell death induced by amyloid-beta, wild-type tau, and R406W tau. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 46. 2009-12-11. PMID:19923278. |
to determine whether synaptic changes and neurodegeneration share common pathways, we established an ex vivo model using organotypic hippocampal slice cultures from amyloid precursor protein transgenic mice combined with virus-mediated expression of egfp-tagged tau constructs. |
2009-12-11 |
2023-08-12 |
mouse |
| Stephanie J Adams, Richard J P Crook, Michael Deture, Suzanne J Randle, Amy E Innes, Xin Z Yu, Wen-Lang Lin, Brittany N Dugger, Melinda McBride, Mike Hutton, Dennis W Dickson, Eileen McGowa. Overexpression of wild-type murine tau results in progressive tauopathy and neurodegeneration. The American journal of pathology. vol 175. issue 4. 2009-12-09. PMID:19717642. |
in contrast, older mice show a decrease in tau pathology levels, which may represent hippocampal neuronal loss occurring in this wild-type model. |
2009-12-09 |
2023-08-12 |
mouse |
| J Vogel, V S Anand, B Ludwig, S Nawoschik, J Dunlop, S P Braithwait. The JNK pathway amplifies and drives subcellular changes in tau phosphorylation. Neuropharmacology. vol 57. issue 5-6. 2009-12-04. PMID:19628001. |
to model this pathology, okadaic acid (oa) has been used in primary cultured hippocampal neurons to investigate effects on tau, and the role of the jnk pathway in tau phosphorylation. |
2009-12-04 |
2023-08-12 |
Not clear |
| L Serenó, M Coma, M Rodríguez, P Sánchez-Ferrer, M B Sánchez, I Gich, J M Agulló, M Pérez, J Avila, C Guardia-Laguarta, J Clarimón, A Lleó, T Gómez-Isl. A novel GSK-3beta inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo. Neurobiology of disease. vol 35. issue 3. 2009-12-03. PMID:19523516. |
treatment with this thiadiazolidinone compound resulted in lower levels of tau phosphorylation, decreased amyloid deposition and plaque-associated astrocytic proliferation, protection of neurons in the entorhinal cortex and ca1 hippocampal subfield against cell death, and prevention of memory deficits in this transgenic mouse model. |
2009-12-03 |
2023-08-12 |
mouse |
| Pu Chen, Aiguo Shen, Wei Zhao, Seong-Joon Baek, Hua Yuan, Jiming H. Raman signature from brain hippocampus could aid Alzheimer's disease diagnosis. Applied optics. vol 48. issue 24. 2009-11-04. PMID:19696863. |
the biochemical changes of brain hippocampus tissue including the deposit of beta-amyloid (abeta) protein, the increase of cholesterol, and hyperphosphorylated tau are observed through mrs when ad occurs. |
2009-11-04 |
2023-08-12 |
rat |