| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Koping Chang, Alexander Barrett, Khoa Pham, Juan C Troncos. Lateral geniculate body is spared of tau pathology in Pick disease. Journal of neuropathology and experimental neurology. 2024-02-27. PMID:38412343. |
using immunohistochemistry for phospho-tau (at8) and 3r tau isoform, all pid cases demonstrated extensive lesions involving the hippocampus and neocortex. |
2024-02-27 |
2024-03-01 |
Not clear |
| Abigail Alexander, Victor E Alvarez, Bertrand R Huber, Michael L Alosco, Jesse Mez, Yorghos Tripodis, Raymond Nicks, Douglas I Katz, Brigid Dwyer, Daniel H Daneshvar, Brett Martin, Joseph Palmisano, Lee E Goldstein, John F Crary, Christopher Nowinski, Robert C Cantu, Neil W Kowall, Robert A Stern, Ivana Delalle, Ann C McKee, Thor D Stei. Cortical-sparing chronic traumatic encephalopathy (CSCTE): a distinct subtype of CTE. Acta neuropathologica. vol 147. issue 1. 2024-02-26. PMID:38407651. |
cross-sectional studies suggest that tau inclusions follow a stereotyped pattern that begins in the neocortex in low stage disease, followed by involvement of the medial temporal lobe and subcortical regions with significant neocortical burden in high stage cte. |
2024-02-26 |
2024-02-28 |
human |
| Abigail Alexander, Victor E Alvarez, Bertrand R Huber, Michael L Alosco, Jesse Mez, Yorghos Tripodis, Raymond Nicks, Douglas I Katz, Brigid Dwyer, Daniel H Daneshvar, Brett Martin, Joseph Palmisano, Lee E Goldstein, John F Crary, Christopher Nowinski, Robert C Cantu, Neil W Kowall, Robert A Stern, Ivana Delalle, Ann C McKee, Thor D Stei. Cortical-sparing chronic traumatic encephalopathy (CSCTE): a distinct subtype of CTE. Acta neuropathologica. vol 147. issue 1. 2024-02-26. PMID:38407651. |
cscte had less overall tau pathology severity, but a proportional increase of disease burden in medial temporal lobe and brainstem regions compared to the neocortex (p's < 0.001). |
2024-02-26 |
2024-02-28 |
human |
| Ya-Lan Chang, Chan-Chih Yang, Yun-Yu Huang, Yi-An Chen, Chia-Wei Yang, Chia-Yu Liao, Hsun Li, Ching-Shyi Wu, Chin-Hsien Lin, Shu-Chun Ten. The HSP40 family chaperone isoform DNAJB6b prevents neuronal cells from tau aggregation. BMC biology. vol 21. issue 1. 2023-12-19. PMID:38110916. |
the pathologic hallmarks of ad include tau neurofibrillary tangles and amyloid plaque depositions in the hippocampus and associated neocortex. |
2023-12-19 |
2023-12-21 |
Not clear |
| Meixiang Huang, Carolyn Tallon, Xiaolei Zhu, Kaitlyn D J Huizar, Silvia Picciolini, Ajit G Thomas, Lukas Tenora, Wathsala Liyanage, Francesca Rodà, Alice Gualerzi, Rangaramanujam M Kannan, Marzia Bedoni, Rana Rais, Barbara S Slushe. Microglial-Targeted nSMase2 Inhibitor Fails to Reduce Tau Propagation in PS19 Mice. Pharmaceutics. vol 15. issue 9. 2023-09-28. PMID:37765332. |
the progression of alzheimer's disease (ad) correlates with the propagation of hyperphosphorylated tau (ptau) from the entorhinal cortex to the hippocampus and neocortex. |
2023-09-28 |
2023-10-07 |
mouse |
| Feng Han, JiaQie Lee, Xi Chen, Jacob Ziontz, Tyler Ward, Susan M Landau, Suzanne L Baker, Theresa M Harrison, William J Jagus. Global brain activity and its coupling with cerebrospinal fluid flow is related to tau pathology. bioRxiv : the preprint server for biology. 2023-09-25. PMID:37745434. |
cortical tau deposits first in the entorhinal cortex and hippocampus and then propagates to neocortex in an aβ-dependent manner. |
2023-09-25 |
2023-10-07 |
human |
| Leon M Aksman, Neil P Oxtoby, Marzia A Scelsi, Peter A Wijeratne, Alexandra L Young, Isadora Lopes Alves, Lyduine E Collij, Jacob W Vogel, Frederik Barkhof, Daniel C Alexander, Andre Altman. A data-driven study of Alzheimer's disease related amyloid and tau pathology progression. Brain : a journal of neurology. 2023-07-11. PMID:37433038. |
amyloid-beta is thought to facilitate the spread of tau throughout the neocortex in alzheimer's disease, though how this occurs is not well understood. |
2023-07-11 |
2023-08-14 |
Not clear |
| Leon M Aksman, Neil P Oxtoby, Marzia A Scelsi, Peter A Wijeratne, Alexandra L Young, Isadora Lopes Alves, Lyduine E Collij, Jacob W Vogel, Frederik Barkhof, Daniel C Alexander, Andre Altman. A data-driven study of Alzheimer's disease related amyloid and tau pathology progression. Brain : a journal of neurology. 2023-07-11. PMID:37433038. |
this is because of the spatial discordance between amyloid-beta, which accumulates in the neocortex, and tau, which accumulates in the medial temporal lobe during aging. |
2023-07-11 |
2023-08-14 |
Not clear |
| Manuel Schweighauser, Holly J Garringer, Therése Klingstedt, K Peter R Nilsson, Masami Masuda-Suzukake, Jill R Murrell, Shannon L Risacher, Ruben Vidal, Sjors H W Scheres, Michel Goedert, Bernardino Ghetti, Kathy L Newel. Mutation ∆K281 in MAPT causes Pick's disease. Acta neuropathologica. 2023-06-23. PMID:37351604. |
at autopsy, numerous inclusions of hyperphosphorylated 3r tau were present in neurons and glial cells of neocortex and some subcortical regions, including hippocampus, caudate/putamen and globus pallidus. |
2023-06-23 |
2023-08-14 |
Not clear |
| Gemma Shireby, Emma L Dempster, Stefania Policicchio, Rebecca G Smith, Ehsan Pishva, Barry Chioza, Jonathan P Davies, Joe Burrage, Katie Lunnon, Dorothea Seiler Vellame, Seth Love, Alan Thomas, Keeley Brookes, Kevin Morgan, Paul Francis, Eilis Hannon, Jonathan Mil. DNA methylation signatures of Alzheimer's disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types. Nature communications. vol 13. issue 1. 2022-09-24. PMID:36153390. |
alzheimer's disease (ad) is a chronic neurodegenerative disease characterized by the progressive accumulation of amyloid-beta and neurofibrillary tangles of tau in the neocortex. |
2022-09-24 |
2023-08-14 |
Not clear |
| Ejlal Abu-El-Rub, Ramada R Khasawneh, Fatimah A Almahasneh, Basma Milad Aloud, Hana M Zegalla. The molecular and functional changes of Neural stem cells in Alzheimer's disease: Can they be reinvigorated to conduct Neurogenesis. Current stem cell research & therapy. 2022-09-01. PMID:36045542. |
ad's previously known pathological basis is the deposition of amyloid β (aβ) aggregates and the formation of neurofibrillary tangles by tau hyperphosphorylation in the cell bodies of neurons that are located in the hippocampus, neocortex, and certain other regions of the cerebral hemispheres and limbic system. |
2022-09-01 |
2023-08-14 |
Not clear |
| Isidro Ferrer, Pol Andrés-Benito, Karina Ausín, Paz Cartas-Cejudo, Mercedes Lachén-Montes, José Antonio Del Rio, Joaquín Fernández-Irigoyen, Enrique Santamarí. Dysregulated Protein Phosphorylation in a Mouse Model of FTLD-Tau. Journal of neuropathology and experimental neurology. 2022-07-18. PMID:35848963. |
the neocortex of p301s mice, used as a model of fronto-temporal lobar degeneration linked to tau mutation (ftld-tau), and wild-type mice, both aged 9 months, were analyzed with conventional label-free phosphoproteomics and swath-ms (sequential window acquisition of all theoretical fragment ion spectra mass spectrometry) to assess the (phospho)proteomes. |
2022-07-18 |
2023-08-14 |
mouse |
| Michael S Pollanen, Sylvester Onzivua, Paul M McKeever, Janice Robertson, Ian R Mackenzie, Gabor G Kovacs, Francis Olwa, David L Kitara, Amanda Fon. The spectrum of disease and tau pathology of nodding syndrome in Uganda. Brain : a journal of neurology. 2022-04-12. PMID:35411378. |
all cases showed some degree of tau pathology in the neocortex and in the locus coeruleus with frequent involvement of the substantia nigra and tegmental nuclei and lesser involvement of other grey matter sites, but there was a lack of glial tau pathology. |
2022-04-12 |
2023-08-13 |
Not clear |
| Michael S Pollanen, Sylvester Onzivua, Paul M McKeever, Janice Robertson, Ian R Mackenzie, Gabor G Kovacs, Francis Olwa, David L Kitara, Amanda Fon. The spectrum of disease and tau pathology of nodding syndrome in Uganda. Brain : a journal of neurology. 2022-04-12. PMID:35411378. |
the tau pathology in the neocortex showed a multifocal superficial laminar pattern. |
2022-04-12 |
2023-08-13 |
Not clear |
| Michael Rullmann, Matthias Brendel, Matthias L Schroeter, Dorothee Saur, Johannes Levin, Robert G Perneczky, Solveig Tiepolt, Marianne Patt, Andre Mueller, Victor L Villemagne, Joseph Classen, Andrew W Stephens, Osama Sabri, Henryk Barthel, On Behalf Of The German Imaging Initiative For Tauopathies Gii . Multicenter Biomolecules. vol 12. issue 3. 2022-03-25. PMID:35327650. |
multicenter tau aggregates accumulate in the alzheimer's disease (ad) brain according to the established braak staging scheme and spread from transentorhinal over limbic regions to the neocortex. |
2022-03-25 |
2023-08-13 |
Not clear |
| Shinobu Kawakatsu, Ryota Kobayashi, Hiroshi Hayashi, Daichi Morioka, Aya Utsunomiya, Takanobu Kabasawa, Rintaro Ohe, Koichi Otan. Clinicopathological heterogeneity of Alzheimer's disease with pure Alzheimer's disease pathology: Cases associated with dementia with Lewy bodies, very early-onset dementia, and primary progressive aphasia. Neuropathology : official journal of the Japanese Society of Neuropathology. 2021-11-24. PMID:34816507. |
tau deposits were also abundant in the cerebral neocortex, hippocampus, basal ganglia, and brain stem. |
2021-11-24 |
2023-08-13 |
Not clear |
| Christine W Fung, Jia Guo, Hongjun Fu, Helen Y Figueroa, Elisa E Konofagou, Karen E Duf. Atrophy associated with tau pathology precedes overt cell death in a mouse model of progressive tauopathy. Science advances. vol 6. issue 42. 2021-11-17. PMID:33067235. |
tau pathology in alzheimer's disease (ad) first develops in the entorhinal cortex (ec), then spreads to the hippocampus, followed by the neocortex. |
2021-11-17 |
2023-08-13 |
mouse |
| Alexander J Ehrenberg, Kun Leng, Kaitlyn N Letourneau, Israel Hernandez, Caroline Lew, William W Seeley, Salvatore Spina, Bruce Miller, Helmut Heinsen, Martin Kampmann, Kenneth S Kosik, Lea T Grinber. Patterns of neuronal Rhes as a novel hallmark of tauopathies. Acta neuropathologica. vol 141. issue 5. 2021-11-16. PMID:33677647. |
we examined histological slides of allocortex and neocortex from multiple postmortem cases in five different tauopathies, ftld-tdp, and healthy controls using immunofluorescence for rhes, several tau post-translational modifications, and phospho-tdp-43. |
2021-11-16 |
2023-08-13 |
Not clear |
| D Boche, J A R Nicol. Invited Review - Understanding cause and effect in Alzheimer's pathophysiology: Implications for clinical trials. Neuropathology and applied neurobiology. vol 46. issue 7. 2021-10-28. PMID:32643143. |
therefore, a sequence of (i) neocortical aβ accumulation followed by (ii) a microglial inflammatory reaction to aβ, causing neuritic dystrophy which promotes (iii) spread of tau from the limbic system to the neocortex with (iv) progressive tau accumulation and spread resulting in (v) neurodegeneration, explains the evidence. |
2021-10-28 |
2023-08-13 |
human |
| Tharick A Pascoal, Andrea L Benedet, Nicholas J Ashton, Min Su Kang, Joseph Therriault, Mira Chamoun, Melissa Savard, Firoza Z Lussier, Cécile Tissot, Thomas K Karikari, Julie Ottoy, Sulantha Mathotaarachchi, Jenna Stevenson, Gassan Massarweh, Michael Schöll, Mony J de Leon, Jean-Paul Soucy, Paul Edison, Kaj Blennow, Henrik Zetterberg, Serge Gauthier, Pedro Rosa-Net. Microglial activation and tau propagate jointly across Braak stages. Nature medicine. vol 27. issue 9. 2021-10-08. PMID:34446931. |
compelling experimental evidence suggests that microglial activation is involved in the spread of tau tangles over the neocortex in alzheimer's disease (ad). |
2021-10-08 |
2023-08-13 |
human |