All Relations between microtubule-associated protein tau and nucleus prepositus

Reference Sentence Publish Date Extraction Date Species
Sandeep K Rai, Roopali Khanna, Anamika Avni, Samrat Mukhopadhya. Heterotypic electrostatic interactions control complex phase separation of tau and prion into multiphasic condensates and co-aggregates. Proceedings of the National Academy of Sciences of the United States of America vol 120 issue 2 2023 36595668 the acidic n-terminal segment of tau interacts electrostatically with the polybasic n-terminal intrinsically disordered segment of the prion protein (prp). 2023-01-03 2023-01-05 Not clear
Sandeep K Rai, Roopali Khanna, Anamika Avni, Samrat Mukhopadhya. Heterotypic electrostatic interactions control complex phase separation of tau and prion into multiphasic condensates and co-aggregates. Proceedings of the National Academy of Sciences of the United States of America vol 120 issue 2 2023 36595668 we also show that upon aging, tau:prp droplets gradually convert into solid-like co-assemblies by sequestration of persistent intermolecular interactions. 2023-01-03 2023-01-05 Not clear
Sandeep K Rai, Roopali Khanna, Anamika Avni, Samrat Mukhopadhya. Heterotypic electrostatic interactions control complex phase separation of tau and prion into multiphasic condensates and co-aggregates. Proceedings of the National Academy of Sciences of the United States of America vol 120 issue 2 2023 36595668 our findings provide mechanistic underpinnings of overlapping neuropathology involving tau and prp and highlight a broader biological role of complex phase transitions in physiology and disease. 2023-01-03 2023-01-05 Not clear
Daniel Ojeda-Ju\\xc3\\xa1rez, Jessica A Lawrence, Katrin Soldau, Donald P Pizzo, Emily Wheeler, Patricia Aguilar-Calvo, Helen Khuu, Joy Chen, Adela Malik, Gail Funk, Percival Nam, Henry Sanchez, Michael D Geschwind, Chengbiao Wu, Gene W Yeo, Xu Chen, Gentry N Patrick, Christina J Sigurdso. Prions induce an early Arc response and a subsequent reduction in mGluR5 in the hippocampus. Neurobiology of disease vol 172 issue 2022 35905927 amyloid-\xce\xb2, tau, prion, and \xce\xb1-synuclein oligomers bind to the cellular prion protein (prp 2022-08-12 2022-08-15 Not clear
Heidi G Standke, Allison Krau. Seed amplification and RT-QuIC assays to investigate protein seed structures and strains. Cell and tissue research vol issue 2022 35258712 first shown for prp prions and prion diseases, it is now recognized that self-propagating misfolded proteins occur broadly in neurodegenerative diseases and include amyloid-\xce\xb2 (a\xce\xb2) and tau in alzheimer's disease (ad), tau in chronic traumatic encephalopathy (cte), pick's disease (pid), corticobasal degeneration (cbd), and progressive supranuclear palsy (psp), and \xce\xb1-synuclein (\xce\xb1-syn) in parkinson's disease (pd) and lewy body dementias (lbd). 2022-03-08 2022-03-09 Not clear
Nikol Jankovska, Radoslav Matej, Tomas Oleja. Extracellular Prion Protein Aggregates in Nine Gerstmann-Str\\xc3\\xa4ussler-Scheinker Syndrome Subjects with Mutation P102L: A Micromorphological Study and Comparison with Literature Data. International journal of molecular sciences vol 22 issue 24 2021 34948096 co-expression with hyperphosphorylated protein tau protein or amyloid beta-peptide (a\xce\xb2) in gss prp plaques is generally a rare observation, even in cases with comorbid neuropathology. 2021-12-24 2022-01-13 Not clear
Nikol Jankovska, Radoslav Matej, Tomas Oleja. Extracellular Prion Protein Aggregates in Nine Gerstmann-Str\\xc3\\xa4ussler-Scheinker Syndrome Subjects with Mutation P102L: A Micromorphological Study and Comparison with Literature Data. International journal of molecular sciences vol 22 issue 24 2021 34948096 the dominant picture of the gss brain is small, condensed plaques, often multicentric, while presence of dystrophic neuritic changes accumulating hyperphosphorylated protein tau or a\xce\xb2 in the prp plaques are rare and, thus, their presence probably constitutes a trivial observation without any relationship to gss development and progression. 2021-12-24 2022-01-13 Not clear
Ivan Martinez-Valbuena, Rafael Valenti-Azcarate, Irene Amat-Villegas, Irene Marcilla, Gloria Marti-Andres, Maria-Cristina Caballero, Mario Riverol, Mar\\xc3\\xada-Teresa Tu\\xc3\\xb1on, Paul E Fraser, Mar\\xc3\\xada-Rosario Luqui. Mixed pathologies in pancreatic \\xce\\xb2 cells from subjects with neurodegenerative diseases and their interaction with prion protein. Acta neuropathologica communications vol 9 issue 1 2021 33832546 furthermore, we also assessed the pancreatic expression of prion protein (prp) in these subjects and its interaction, both in the pancreas and brain, with \xce\xb1-synuclein, tau, a\xce\xb2 and amylin. 2021-11-10 2022-01-14 Not clear
Ivan Martinez-Valbuena, Rafael Valenti-Azcarate, Irene Amat-Villegas, Irene Marcilla, Gloria Marti-Andres, Maria-Cristina Caballero, Mario Riverol, Mar\\xc3\\xada-Teresa Tu\\xc3\\xb1on, Paul E Fraser, Mar\\xc3\\xada-Rosario Luqui. Mixed pathologies in pancreatic \\xce\\xb2 cells from subjects with neurodegenerative diseases and their interaction with prion protein. Acta neuropathologica communications vol 9 issue 1 2021 33832546 our study shows, for the first time, that along with amylin, pancreatic \xce\xb1-synuclein, a\xce\xb2, prp and tau may contribute together to the complex pathophysiology of type two diabetes and in the appearance of insulin resistance in alzheimer's and parkinson's disease. 2021-11-10 2022-01-14 Not clear
Ivan Martinez-Valbuena, Rafael Valenti-Azcarate, Irene Amat-Villegas, Irene Marcilla, Gloria Marti-Andres, Maria-Cristina Caballero, Mario Riverol, Mar\\xc3\\xada-Teresa Tu\\xc3\\xb1on, Paul E Fraser, Mar\\xc3\\xada-Rosario Luqui. Mixed pathologies in pancreatic \\xce\\xb2 cells from subjects with neurodegenerative diseases and their interaction with prion protein. Acta neuropathologica communications vol 9 issue 1 2021 33832546 finally, we provide the first histological evidence of an interaction between prp and a\xce\xb2, \xce\xb1-synuclein, amylin or tau in the pancreas and locus coeruleus. 2021-11-10 2022-01-14 Not clear
Ryuichi Koizumi, Naohisa Ueda, Atsushi Mugita, Katsuo Kimura, Hitaru Kishida, Fumiaki Tanak. Case Report: Extremely Early Detection of Preclinical Magnetic Resonance Imaging Abnormality in Creutzfeldt-Jakob Disease With the V180I Mutation. Frontiers in neurology vol 12 issue 2021 34690919 the levels of total tau protein, 14-3-3 protein, and protease-resistant isoform of prion protein (prp 2021-10-26 2022-01-13 Not clear
Alan David Snow, Joel A Cummings, Thomas Lak. The Unifying Hypothesis of Alzheimer's Disease: Heparan Sulfate Proteoglycans/Glycosaminoglycans Are Key as First Hypothesized Over 30 Years Ago. Frontiers in aging neuroscience vol 13 issue 2021 34671250 neurons full of hs demonstrate marked accumulation and fibrillization of a\xce\xb2, tau, \xce\xb1-synuclein, and prion protein (prp) in mucopolysaccharidosis animal models demonstrating that hs gag accumulation is a precursor to a\xce\xb2 accumulation in neurons. 2021-10-22 2022-01-13 Not clear
Brent Race, Katie Williams, James F Striebel, Bruce Chesebr. Prion-associated cerebral amyloid angiopathy is not exacerbated by human phosphorylated tau aggregates in scrapie-infected mice expressing anchorless prion protein. Neurobiology of disease vol 144 issue 2021 32829029 in human genetic prion diseases, tau aggregates are detected in association with amyloid plaques consisting of prion protein (prp). 2021-09-24 2022-01-14 Not clear
Brent Race, Katie Williams, James F Striebel, Bruce Chesebr. Prion-associated cerebral amyloid angiopathy is not exacerbated by human phosphorylated tau aggregates in scrapie-infected mice expressing anchorless prion protein. Neurobiology of disease vol 144 issue 2021 32829029 however, the role of abnormal tau aggregates in prp amyloid disease remains unclear. 2021-09-24 2022-01-14 Not clear
Brent Race, Katie Williams, James F Striebel, Bruce Chesebr. Prion-associated cerebral amyloid angiopathy is not exacerbated by human phosphorylated tau aggregates in scrapie-infected mice expressing anchorless prion protein. Neurobiology of disease vol 144 issue 2021 32829029 previously we inoculated scrapie prions into transgenic mice expressing human tau, mouse tau, glycophosphatidylinositol (gpi) anchored prp, and anchorless prp. 2021-09-24 2022-01-14 Not clear
Brent Race, Katie Williams, James F Striebel, Bruce Chesebr. Prion-associated cerebral amyloid angiopathy is not exacerbated by human phosphorylated tau aggregates in scrapie-infected mice expressing anchorless prion protein. Neurobiology of disease vol 144 issue 2021 32829029 these mice developed both spongiform vacuolar pathology and prp amyloid pathology, and human tau was detected near prp amyloid plaques. 2021-09-24 2022-01-14 Not clear
Brent Race, Katie Williams, James F Striebel, Bruce Chesebr. Prion-associated cerebral amyloid angiopathy is not exacerbated by human phosphorylated tau aggregates in scrapie-infected mice expressing anchorless prion protein. Neurobiology of disease vol 144 issue 2021 32829029 these mice expressed human tau but lacked both mouse tau and gpi-anchored prp. 2021-09-24 2022-01-14 Not clear
Brent Race, Katie Williams, James F Striebel, Bruce Chesebr. Prion-associated cerebral amyloid angiopathy is not exacerbated by human phosphorylated tau aggregates in scrapie-infected mice expressing anchorless prion protein. Neurobiology of disease vol 144 issue 2021 32829029 nevertheless, the accumulation of aggregated, phosphorylated human tau and its association with prp amyloid plaques failed to alter the timing or course of the clinical disease observed. 2021-09-24 2022-01-14 Not clear
Brent Race, Katie Williams, James F Striebel, Bruce Chesebr. Prion-associated cerebral amyloid angiopathy is not exacerbated by human phosphorylated tau aggregates in scrapie-infected mice expressing anchorless prion protein. Neurobiology of disease vol 144 issue 2021 32829029 these data suggest that human tau does not contribute to the pathogenesis of mouse prp amyloid brain disease and raise the possibility that tau may also not be pathogenic in human prp amyloid disease. 2021-09-24 2022-01-14 Not clear
Kate\\xc5\\x99ina Men\\xc5\\xa1\\xc3\\xadkov\\xc3\\xa1, Radoslav Mat\\xc4\\x9bj, Eva Parobkov\\xc3\\xa1, Magdalena Sm\\xc4\\x9bt\\xc3\\xa1kov\\xc3\\xa1, Petr Ka\\xc5\\x88ovsk\\xc3\\xb. PART and ARTAG tauopathies at a relatively young age as a concomitant finding in sporadic Creutzfeldt-Jakob disease. Prion vol 15 issue 1 2021 34224311 interactions between prion protein (prp) and tau protein have long been discussed, especially in relation to the pathogenesis of neurodegenerative diseases. 2021-09-24 2022-01-13 Not clear
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