| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Garth F Hall, Brian A Patut. Is tau ready for admission to the prion club? Prion. vol 6. issue 3. 2013-01-02. PMID:22561167. |
in particular, we consider (1) the possibility that prionoid behavior of misprocessed tau in neurodegenerative disease may involve other aggregation-prone proteins, including prp itself, and (2) whether "prionlike" tau lesion propagation might include mechanisms other than protein-protein templating. |
2013-01-02 |
2023-08-12 |
human |
| P Piccardo, J Cervenak, O Yakovleva, L Gregori, K Pomeroy, A Cook, F S Muhammad, T Seuberlich, L Cervenakova, D M Ashe. Squirrel monkeys (Saimiri sciureus) infected with the agent of bovine spongiform encephalopathy develop tau pathology. Journal of comparative pathology. vol 147. issue 1. 2012-10-02. PMID:22018806. |
constant neuropathological features included spongiform degeneration, gliosis, deposition of abnormal prion protein (prp(tse)) and many deposits of abnormally phosphorylated tau protein (p-tau) in several areas of the cerebrum and cerebellum. |
2012-10-02 |
2023-08-12 |
human |
| Nadia Canu, Ilaria Filesi, Andrea Pristerà, Maria Teresa Ciotti, Silvia Biocc. Altered intracellular distribution of PrPC and impairment of proteasome activity in tau overexpressing cortical neurons. Journal of Alzheimer's disease : JAD. vol 27. issue 3. 2012-08-20. PMID:21841253. |
we have investigated the fate of normal cellular prion protein (prp(c)) in primary cortical neurons overexpressing tau protein. |
2012-08-20 |
2023-08-12 |
Not clear |
| Nadia Canu, Ilaria Filesi, Andrea Pristerà, Maria Teresa Ciotti, Silvia Biocc. Altered intracellular distribution of PrPC and impairment of proteasome activity in tau overexpressing cortical neurons. Journal of Alzheimer's disease : JAD. vol 27. issue 3. 2012-08-20. PMID:21841253. |
we found that overexpression of tau reduces prp(c) expression at the cell surface and causes its accumulation and aggregation in the cell body but does not affect its maturation and glycosylation. |
2012-08-20 |
2023-08-12 |
Not clear |
| Nadia Canu, Ilaria Filesi, Andrea Pristerà, Maria Teresa Ciotti, Silvia Biocc. Altered intracellular distribution of PrPC and impairment of proteasome activity in tau overexpressing cortical neurons. Journal of Alzheimer's disease : JAD. vol 27. issue 3. 2012-08-20. PMID:21841253. |
interestingly, co-transfection of tau gene in cortical neurons with a proteasome activity reporter, consisting of a short peptide degron fused to the carboxyl-terminus of green fluorescent protein (gfp-cl1), results in down-regulation of the proteasome system, suggesting a possible mechanism that contributes to intracellular prp(c) accumulation. |
2012-08-20 |
2023-08-12 |
Not clear |
| Katarzyna M Osiecka, Hanna Nieznanska, Krzysztof J Skowronek, Jolanta Jozwiak, Krzysztof Nieznansk. Tau inhibits tubulin oligomerization induced by prion protein. Biochimica et biophysica acta. vol 1813. issue 10. 2011-11-07. PMID:21763357. |
tau protein, a major neuronal member of the maps family, reduces the effect of prp. |
2011-11-07 |
2023-08-12 |
Not clear |
| Katarzyna M Osiecka, Hanna Nieznanska, Krzysztof J Skowronek, Jolanta Jozwiak, Krzysztof Nieznansk. Tau inhibits tubulin oligomerization induced by prion protein. Biochimica et biophysica acta. vol 1813. issue 10. 2011-11-07. PMID:21763357. |
we propose that the binding of tau stabilizes tubulin in a conformation less susceptible to oligomerization by prp. |
2011-11-07 |
2023-08-12 |
Not clear |
| Ainhoa Alzualde, Begoña Indakoetxea, Isidre Ferrer, Fermin Moreno, Myriam Barandiaran, Ana Gorostidi, Ainara Estanga, Irune Ruiz, Miguel Calero, Fred W van Leeuwen, Begoña Atares, Ramón Juste, Ana Belén Rodriguez-Martínez, Adolfo López de Munai. A novel PRNP Y218N mutation in Gerstmann-Sträussler-Scheinker disease with neurofibrillary degeneration. Journal of neuropathology and experimental neurology. vol 69. issue 8. 2010-08-27. PMID:20613639. |
neuropathologic analysis revealed deposition of proteinase k-resistant prion protein (prp(res)), widespread hyperphosphorylated tau pathology, abnormal accumulation of mitochondria in the vicinity of prp deposits, and expression of mutant ubiquitin (ubb(+1)) in neurofibrillary tangles and dystrophic neurites. |
2010-08-27 |
2023-08-12 |
Not clear |
| Poh K Teng, David Eisenber. Short protein segments can drive a non-fibrillizing protein into the amyloid state. Protein engineering, design & selection : PEDS. vol 22. issue 8. 2009-10-28. PMID:19602569. |
we applied the 3d profile method to identify fibril-forming segments within the amyloid-forming human proteins tau, alpha-synuclein, prp prion and amyloid-beta. |
2009-10-28 |
2023-08-12 |
human |
| G Giaccone, M Mangieri, R Capobianco, L Limido, J J Hauw, S Haïk, P Fociani, O Bugiani, F Tagliavin. Tauopathy in human and experimental variant Creutzfeldt-Jakob disease. Neurobiology of aging. vol 29. issue 12. 2009-01-23. PMID:17560687. |
these findings suggest that the abnormal forms of prp associated with vcjd trigger a tauopathy, and provide a paradigm for the early stages of tau pathology associated with cerebral amyloidoses, including alzheimer disease. |
2009-01-23 |
2023-08-12 |
mouse |
| Huan Wang, Martin L Duennwald, Blake E Roberts, Leslie M Rozeboom, Yingxin L Zhang, Andrew D Steele, Rajaraman Krishnan, Linhui Julie Su, Drees Griffin, Samrat Mukhopadhyay, Edward J Hennessy, Peter Weigele, Barbara J Blanchard, Jonathan King, Ashok A Deniz, Stephen L Buchwald, Vernon M Ingram, Susan Lindquist, James Shorte. Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 20. 2008-06-24. PMID:18480256. |
here, we show that daph-1 and select derivatives are ineffective against several amyloidogenic proteins, including tau, alpha-synuclein, ure2, and prp, but antagonize the yeast prion protein, sup35, in vitro and in vivo. |
2008-06-24 |
2023-08-12 |
Not clear |
| Xiao-Fan Wang, Chen-Fang Dong, Jin Zhang, Yan-Zhen Wan, Feng Li, Yin-Xia Huang, Lu Han, Bing Shan, Chen Gao, Jun Han, Xiao-Ping Don. Human tau protein forms complex with PrP and some GSS- and fCJD-related PrP mutants possess stronger binding activities with tau in vitro. Molecular and cellular biochemistry. vol 310. issue 1-2. 2008-06-20. PMID:18038270. |
human tau protein forms complex with prp and some gss- and fcjd-related prp mutants possess stronger binding activities with tau in vitro. |
2008-06-20 |
2023-08-12 |
human |
| Xiao-Fan Wang, Chen-Fang Dong, Jin Zhang, Yan-Zhen Wan, Feng Li, Yin-Xia Huang, Lu Han, Bing Shan, Chen Gao, Jun Han, Xiao-Ping Don. Human tau protein forms complex with PrP and some GSS- and fCJD-related PrP mutants possess stronger binding activities with tau in vitro. Molecular and cellular biochemistry. vol 310. issue 1-2. 2008-06-20. PMID:18038270. |
using gst pull down, co-immunoprecipitation assay and tau-coated elisa, the molecular interaction between tau protein and prp was confirmed in the context of the full-length human tau. |
2008-06-20 |
2023-08-12 |
human |
| Xiao-Fan Wang, Chen-Fang Dong, Jin Zhang, Yan-Zhen Wan, Feng Li, Yin-Xia Huang, Lu Han, Bing Shan, Chen Gao, Jun Han, Xiao-Ping Don. Human tau protein forms complex with PrP and some GSS- and fCJD-related PrP mutants possess stronger binding activities with tau in vitro. Molecular and cellular biochemistry. vol 310. issue 1-2. 2008-06-20. PMID:18038270. |
the n terminus (amino acids 1-91) and tandem repeats region (amino acids 186-283) of tau protein were responsible for the interaction with prp. |
2008-06-20 |
2023-08-12 |
human |
| Xiao-Fan Wang, Chen-Fang Dong, Jin Zhang, Yan-Zhen Wan, Feng Li, Yin-Xia Huang, Lu Han, Bing Shan, Chen Gao, Jun Han, Xiao-Ping Don. Human tau protein forms complex with PrP and some GSS- and fCJD-related PrP mutants possess stronger binding activities with tau in vitro. Molecular and cellular biochemistry. vol 310. issue 1-2. 2008-06-20. PMID:18038270. |
the octapeptide repeats within prp directly affected the binding activity of prp with tau. |
2008-06-20 |
2023-08-12 |
human |
| Xiao-Fan Wang, Chen-Fang Dong, Jin Zhang, Yan-Zhen Wan, Feng Li, Yin-Xia Huang, Lu Han, Bing Shan, Chen Gao, Jun Han, Xiao-Ping Don. Human tau protein forms complex with PrP and some GSS- and fCJD-related PrP mutants possess stronger binding activities with tau in vitro. Molecular and cellular biochemistry. vol 310. issue 1-2. 2008-06-20. PMID:18038270. |
gss-related mutant prp102l and fcjd- related mutants with two and seven extra octarepeats showed more active binding capacity with tau than wild-type prp. |
2008-06-20 |
2023-08-12 |
human |
| Xiao-Fan Wang, Chen-Fang Dong, Jin Zhang, Yan-Zhen Wan, Feng Li, Yin-Xia Huang, Lu Han, Bing Shan, Chen Gao, Jun Han, Xiao-Ping Don. Human tau protein forms complex with PrP and some GSS- and fCJD-related PrP mutants possess stronger binding activities with tau in vitro. Molecular and cellular biochemistry. vol 310. issue 1-2. 2008-06-20. PMID:18038270. |
the molecular interactions between prp and tau protein highlight a potential role of tau in the biological function of prp and the pathogenesis of tse. |
2008-06-20 |
2023-08-12 |
human |
| Joao P Lopes, Catarina R Oliveira, Paula Agostinh. Role of cyclin-dependent kinase 5 in the neurodegenerative process triggered by amyloid-Beta and prion peptides: implications for Alzheimer's disease and prion-related encephalopathies. Cellular and molecular neurobiology. vol 27. issue 7. 2008-03-10. PMID:17965932. |
moreover, abeta 1-40 and prp 106-126 increased the levels of tau protein phosphorylated at ser202/thr205. |
2008-03-10 |
2023-08-12 |
rat |
| Joao P Lopes, Catarina R Oliveira, Paula Agostinh. Role of cyclin-dependent kinase 5 in the neurodegenerative process triggered by amyloid-Beta and prion peptides: implications for Alzheimer's disease and prion-related encephalopathies. Cellular and molecular neurobiology. vol 27. issue 7. 2008-03-10. PMID:17965932. |
cdk5 (roscovitine) and calpain (mdl28170) inhibitors reverted tau hyperphosphorylation and prevented neuronal death caused by abeta 1-40 and prp 106-126. |
2008-03-10 |
2023-08-12 |
rat |
| Michael R Sawaya, Shilpa Sambashivan, Rebecca Nelson, Magdalena I Ivanova, Stuart A Sievers, Marcin I Apostol, Michael J Thompson, Melinda Balbirnie, Jed J W Wiltzius, Heather T McFarlane, Anders Ø Madsen, Christian Riekel, David Eisenber. Atomic structures of amyloid cross-beta spines reveal varied steric zippers. Nature. vol 447. issue 7143. 2007-06-07. PMID:17468747. |
these include segments from the alzheimer's amyloid-beta and tau proteins, the prp prion protein, insulin, islet amyloid polypeptide (iapp), lysozyme, myoglobin, alpha-synuclein and beta(2)-microglobulin, suggesting that common structural features are shared by amyloid diseases at the molecular level. |
2007-06-07 |
2023-08-12 |
Not clear |