All Relations between microtubule-associated protein tau and prefrontal cortex

Reference Sentence Publish Date Extraction Date Species
Jamal B Williams, Qing Cao, Wei Wang, Young-Ho Lee, Luye Qin, Ping Zhong, Yong Ren, Kaijie Ma, Zhen Ya. Inhibition of histone methyltransferase Smyd3 rescues NMDAR and cognitive deficits in a tauopathy mouse model. Nature communications vol 14 issue 1 2023 36609445 fbxo2 knockdown in pfc leads to the recovery of nmdar function and cognitive behaviors in p301s tau mice. 2023-01-07 2023-01-08 Not clear
Jamal B Williams, Qing Cao, Wei Wang, Young-Ho Lee, Luye Qin, Ping Zhong, Yong Ren, Kaijie Ma, Zhen Ya. Inhibition of histone methyltransferase Smyd3 rescues NMDAR and cognitive deficits in a tauopathy mouse model. Nature communications vol 14 issue 1 2023 36609445 here we find that the histone methyltransferase smyd3, which catalyzes histone h3 lysine 4 trimethylation (h3k4me3) to activate gene transcription, is significantly elevated in prefrontal cortex (pfc) of ad patients and p301s tau mice, a model of tauopathies. 2023-01-07 2023-01-08 Not clear
Jamal B Williams, Qing Cao, Wei Wang, Young-Ho Lee, Luye Qin, Ping Zhong, Yong Ren, Kaijie Ma, Zhen Ya. Inhibition of histone methyltransferase Smyd3 rescues NMDAR and cognitive deficits in a tauopathy mouse model. Nature communications vol 14 issue 1 2023 36609445 a short treatment with the smyd3 inhibitor, bci-121, rescues cognitive behavioral deficits, and restores synaptic nmdar function and expression in pfc pyramidal neurons of p301s tau mice. 2023-01-07 2023-01-08 Not clear
Jos\\xc3\\xa9 Tiago Costa-Pereira, Rita Oliveira, Irene Guadilla, Maria Jose Guill\\xc3\\xa9n, Isaura Tavares, Pilar L\\xc3\\xb3pez-Larrubi. Neuroimaging uncovers neuronal and metabolic changes in pain modulatory brain areas in a rat model of chemotherapy-induced neuropathy - MEMRI and ex vivo spectroscopy studies. Brain research bulletin vol issue 2022 36328144 furthermore, at t56 the paclitaxel-injected rats presented lower naa and higher taurine (tau) levels in the pfc. 2022-11-03 2022-11-08 Not clear
Ana Dias-Carvalho, Mariana Ferreira, Ana Reis-Mendes, Rita Ferreira, Maria Lourdes Bastos, Eduarda Fernandes, Susana Isabel S\\xc3\\xa1, Jo\\xc3\\xa3o Paulo Capela, F\\xc3\\xa9lix Carvalho, Vera Marisa Cost. Chemobrain: mitoxantrone-induced oxidative stress, apoptotic and autophagic neuronal death in adult CD-1 mice. Archives of toxicology vol issue 2022 35306571 postsynaptic density protein 95 expression decreased in the whole brain, while hyperphosphorylation of tau was seen in pfc. 2022-03-20 2022-04-14 Not clear
Ping Zhong, Qing Cao, Zhen Ya. Selective impairment of circuits between prefrontal cortex glutamatergic neurons and basal forebrain cholinergic neurons in a tauopathy mouse model. Cerebral cortex (New York, N.Y. : 1991) vol issue 2022 35235649 on the other hand, optogenetic stimulation of cholinergic terminals from bf induced a persistent reduction of the excitability of pfc pyramidal neurons from tau mice, instead of the transient reduction exhibited in wild-type mice. 2022-03-02 2022-03-05 Not clear
Shannon N Leslie, Jean Kanyo, Dibyadeep Datta, Rashaun S Wilson, Caroline Zeiss, Alvaro Duque, TuKiet T Lam, Amy F T Arnsten, Angus C Nair. Simple, Single-Shot Phosphoproteomic Analysis of Heat-Stable Tau Identifies Age-Related Changes in pS235- and pS396-Tau Levels in Non-human Primates. Frontiers in aging neuroscience vol 13 issue 2021 34867294 we identified novel, age-related changes in tau phosphorylation in the rhesus monkey pfc and analyzed patterns of phosphorylation change across domains of the protein. 2021-12-07 2022-01-13 Not clear
Shannon N Leslie, Jean Kanyo, Dibyadeep Datta, Rashaun S Wilson, Caroline Zeiss, Alvaro Duque, TuKiet T Lam, Amy F T Arnsten, Angus C Nair. Simple, Single-Shot Phosphoproteomic Analysis of Heat-Stable Tau Identifies Age-Related Changes in pS235- and pS396-Tau Levels in Non-human Primates. Frontiers in aging neuroscience vol 13 issue 2021 34867294 histology showed robust labeling for tau phosphorylated at these sites in vulnerable layer iii pyramidal cells in the pfc. 2021-12-07 2022-01-13 Not clear
Shannon N Leslie, Jean Kanyo, Dibyadeep Datta, Rashaun S Wilson, Caroline Zeiss, Alvaro Duque, TuKiet T Lam, Amy F T Arnsten, Angus C Nair. Simple, Single-Shot Phosphoproteomic Analysis of Heat-Stable Tau Identifies Age-Related Changes in pS235- and pS396-Tau Levels in Non-human Primates. Frontiers in aging neuroscience vol 13 issue 2021 34867294 this methodology is species independent; thus, while initially developed in a rodent model, we utilized this technique to analyze 36 phosphorylation sites on rhesus monkey tau from the prefrontal cortex (pfc), a region vulnerable to ad-linked degeneration. 2021-12-07 2022-01-13 Not clear
Wei Wang, Qing Cao, Tao Tan, Fengwei Yang, Jamal B Williams, Zhen Ya. Epigenetic treatment of behavioral and physiological deficits in a tauopathy mouse model. Aging cell vol 20 issue 10 2021 34547169 concomitantly, the diminished pfc neuronal excitability and glutamatergic synaptic transmission in p301s tau mice are also normalized by unc0642 treatment. 2021-11-09 2022-01-13 Not clear
Wei Wang, Qing Cao, Tao Tan, Fengwei Yang, Jamal B Williams, Zhen Ya. Epigenetic treatment of behavioral and physiological deficits in a tauopathy mouse model. Aging cell vol 20 issue 10 2021 34547169 transcriptomic analysis reveals that unc0642 treatment of p301s tau mice has normalized a number of dysregulated genes in pfc, which are enriched in cytoskeleton and extracellular matrix organization, ion channels and transporters, receptor signaling, and stress responses. 2021-11-09 2022-01-13 Not clear
Wei Wang, Qing Cao, Tao Tan, Fengwei Yang, Jamal B Williams, Zhen Ya. Epigenetic treatment of behavioral and physiological deficits in a tauopathy mouse model. Aging cell vol 20 issue 10 2021 34547169 here, we show that the euchromatic histone-lysine n-methyltransferase 2 (ehmt2) is significantly elevated in the prefrontal cortex (pfc) of p301s tau mice (5-7\xc2\xa0months old), leading to the increased repressive histone mark, h3k9me2, which is reversed by treatment with the selective ehmt inhibitor unc0642. 2021-11-09 2022-01-13 Not clear
Wei Wang, Qing Cao, Tao Tan, Fengwei Yang, Jamal B Williams, Zhen Ya. Epigenetic treatment of behavioral and physiological deficits in a tauopathy mouse model. Aging cell vol 20 issue 10 2021 34547169 in addition, ehmt inhibition dramatically attenuates the hyperphosphorylated tau level in pfc of p301s tau mice. 2021-11-09 2022-01-13 Not clear
G Siano, M Varisco, A Scarlatti, M C Caiazza, K Dunville, F Cremisi, M Costa, L Pancrazi, C Di Primio, A Cattane. Gene Expression of Disease-related Genes in Alzheimer's Disease is Impaired by Tau Aggregation. Journal of molecular biology vol 432 issue 24 2021 33058882 together, this evidence links the altered glutamatergic function in the pfc during ad progression to the newly discovered function of nuclear tau. 2021-03-04 2022-01-13 Not clear
Zuntao Wu, Lin Bai, Runqi Tu, Lijie Zhang, Yue Ba, Huizhen Zhang, Xing Li, Xuemin Cheng, Wenjie Li, Hui Huan. Disruption of synaptic expression pattern and age-related DNA oxidation in a neuronal model of lead-induced toxicity. Environmental toxicology and pharmacology vol 76 issue 2020 32058320 furthermore, the expression of bace1 protein and tau phosphorylation level in pfc and hippocampus increased, app mrnas in pfc and prolonged induction of bace1 in hippocampus. 2020-12-04 2022-01-13 Not clear
Geoffrey Canet, Fanny Pineau, Charleine Zussy, C\\xc3\\xa9lia Hernandez, Hazel Hunt, Nathalie Chevallier, V\\xc3\\xa9ronique Perrier, Joan Torrent, Joseph K Belanoff, Onno C Meijer, Catherine Desrumaux, Laurent Givaloi. Glucocorticoid receptors signaling impairment potentiates amyloid-\\xce\\xb2 oligomers-induced pathology in an acute model of Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol 34 issue 1 2020 31914623 deregulation of the hpa axis and a feed-forward effect on pfc gr sensitivity could participate in the etiology of ad, in perturbing a\xce\xb2 and tau homeostasis. 2020-07-20 2022-01-13 Not clear
Donghong Su, Wenlong Li, Xiaojun She, Xuewei Chen, Qingfeng Zhai, Bo Cui, Rui Wan. Chronic noise exposure exacerbates AD-like neuropathology in SAMP8 mice in relation to Wnt signaling in the PFC and hippocampus. Scientific reports vol 8 issue 1 2019 30279527 chronic noise exposure led to progressive overproduction of a\xce\xb2 and increased the hyperphosphorylation of tau at ser396, thr205, and thr231 sites in the hippocampus and the prefrontal cortex (pfc) in young samp8 mice, similar to that observed in aging samp8 mice. 2019-10-31 2022-01-13 Not clear
Donghong Su, Wenlong Li, Xiaojun She, Xuewei Chen, Qingfeng Zhai, Bo Cui, Rui Wan. Chronic noise exposure exacerbates AD-like neuropathology in SAMP8 mice in relation to Wnt signaling in the PFC and hippocampus. Scientific reports vol 8 issue 1 2019 30279527 these findings demonstrate that chronic noise stress exacerbated ad-like neuropathology, possibly by disrupting wnt signaling and triggering aberrant tau hyperphosphorylation and a\xce\xb2 in the pfc and hippocampus. 2019-10-31 2022-01-13 Not clear
Edna Maria Camelo Chaves, Jose Eduardo Ribeiro Hon\\xc3\\xb3rio-J\\xc3\\xbanior, Caren N\\xc3\\xa1dia Soares Sousa, Vald\\xc3\\xa9cio Silveira Monteiro, Dayanne Terra Ten\\xc3\\xb3rio Nonato, Leonardo Pimentel Dantas, Ana Silvia Suassuna Carneiro L\\xc3\\xbacio, Jos\\xc3\\xa9 Maria Barbosa-Filho, Manoel Cl\\xc3\\xa1udio Azevedo Patroc\\xc3\\xadnio, Glauce Socorro Barros Viana, Silv\\xc3\\xa2nia Maria Mendes Vasconcelo. The anxiolytic-like effect of 6-styryl-2-pyrone in mice involves GABAergic mechanism of action. Metabolic brain disease vol 33 issue 1 2019 29086102 after behavioral tests, these animals were sacrificed and had their prefrontal cortex (pfc), hippocampus (hc) and striatum (st) dissected for assaying amino acids (aspartate- asp, glutamate- glu, glycine- gly, taurine- tau and gamma-aminobutyric acid- gaba). 2019-01-31 2022-01-13 Not clear
Edna Maria Camelo Chaves, Jose Eduardo Ribeiro Hon\\xc3\\xb3rio-J\\xc3\\xbanior, Caren N\\xc3\\xa1dia Soares Sousa, Vald\\xc3\\xa9cio Silveira Monteiro, Dayanne Terra Ten\\xc3\\xb3rio Nonato, Leonardo Pimentel Dantas, Ana Silvia Suassuna Carneiro L\\xc3\\xbacio, Jos\\xc3\\xa9 Maria Barbosa-Filho, Manoel Cl\\xc3\\xa1udio Azevedo Patroc\\xc3\\xadnio, Glauce Socorro Barros Viana, Silv\\xc3\\xa2nia Maria Mendes Vasconcelo. The anxiolytic-like effect of 6-styryl-2-pyrone in mice involves GABAergic mechanism of action. Metabolic brain disease vol 33 issue 1 2019 29086102 the effects of the sty on amino acid concentration in pfc showed increased glu, gaba and tau concentrations. 2019-01-31 2022-01-13 Not clear
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