| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carolina Lucía Facal, Iván Fernández Bessone, Javier Andrés Muñiz, A Ezequiel Pereyra, Olivia Pedroncini, Indiana Páez-Paz, Ramiro Clerici-Delville, Cayetana Arnaiz, Leandro Urrutia, Germán Falasco, Carla Verónica Argañaraz, Trinidad Saez, Antonia Marin-Burgin, Mariano Soiza-Reilly, Tomás Falzone, María Elena Aval. Tau reduction with artificial microRNAs modulates neuronal physiology and improves tauopathy phenotypes in mice. Molecular therapy : the journal of the American Society of Gene Therapy. 2024-02-04. PMID:38310353. |
in the htau mouse model of tauopathy, we locally expressed artificial micrornas in the prefrontal cortex (pfc), an area particularly vulnerable to initiating tau pathology in this model. |
2024-02-04 |
2024-02-06 |
mouse |
| Carolina Lucía Facal, Iván Fernández Bessone, Javier Andrés Muñiz, A Ezequiel Pereyra, Olivia Pedroncini, Indiana Páez-Paz, Ramiro Clerici-Delville, Cayetana Arnaiz, Leandro Urrutia, Germán Falasco, Carla Verónica Argañaraz, Trinidad Saez, Antonia Marin-Burgin, Mariano Soiza-Reilly, Tomás Falzone, María Elena Aval. Tau reduction with artificial microRNAs modulates neuronal physiology and improves tauopathy phenotypes in mice. Molecular therapy : the journal of the American Society of Gene Therapy. 2024-02-04. PMID:38310353. |
tau knockdown prevented the accumulation of insoluble and hyperphosphorylated tau, modulated firing activity of putative pyramidal neurons, and improved glucose uptake in the pfc. |
2024-02-04 |
2024-02-06 |
mouse |
| Tiziana Petrozziello, Sommer S Huntress, Ayleen L Castillo-Torres, James P Quinn, Theresa R Connors, Corinne A Auger, Alexandra N Mills, Spencer E Kim, Sophia Liu, Farah Mahmood, Adel Boudi, Muzhou Wu, Ellen Sapp, Pia Kivisäkk, Shekar R Sunderesh, Mahmoud A Pouladi, Steven E Arnold, Bradley T Hyman, H Diana Rosas, Marian DiFiglia, Ricardo Mouro Pinto, Kimberly Kegel-Gleason, Ghazaleh Sadri-Vakil. Age-Dependent Increase in Tau Phosphorylation at Serine 396 in Huntington's Disease Prefrontal Cortex. Journal of Huntington's disease. 2023-09-11. PMID:37694372. |
age-dependent increase in tau phosphorylation at serine 396 in huntington's disease prefrontal cortex. |
2023-09-11 |
2023-10-07 |
mouse |
| Yuko Koshimori, Michael D Cusimano, Erica L Vieira, Pablo M Rusjan, Stephen J Kish, Neil Vasdev, Sho Moriguchi, Isabelle Boileau, Thomas Chao, Zahra Nasser, M Ishrat Husain, Khunsa Faiz, Joeffre Braga, Jeffrey H Meye. Astrogliosis marker 11C-SL2511.88 PET in traumatic brain injury with persistent symptoms. Brain : a journal of neurology. 2023-08-21. PMID:37602426. |
in participants scanned within two years of last tbi, pfc [11c]sl25.1188 vt correlated with serum glial fibrillary acid protein (r=0.51, p=0.037) and total tau (r=0.74, p=0.001). |
2023-08-21 |
2023-09-07 |
human |
| Rebecca L Winfree, Mabel Seto, Logan Dumitrescu, Vilas Menon, Philip De Jager, Yanling Wang, Julie Schneider, David A Bennett, Angela L Jefferson, Timothy J Hohma. TREM2 gene expression associations with Alzheimer's disease neuropathology are region-specific: implications for cortical versus subcortical microglia. Acta neuropathologica. 2023-03-25. PMID:36966244. |
trem2 gene expression of the dorsolateral prefrontal cortex, posterior cingulate cortex, and caudate nucleus was assessed with respect to core pathology of alzheimer's disease (amyloid-β, and tau), cerebrovascular pathology (cerebral infarcts, arteriolosclerosis, atherosclerosis, and cerebral amyloid angiopathy), microglial activation (proportion of activated microglia), and cognitive performance. |
2023-03-25 |
2023-08-14 |
Not clear |
| Jamal B Williams, Qing Cao, Wei Wang, Young-Ho Lee, Luye Qin, Ping Zhong, Yong Ren, Kaijie Ma, Zhen Ya. Inhibition of histone methyltransferase Smyd3 rescues NMDAR and cognitive deficits in a tauopathy mouse model. Nature communications. vol 14. issue 1. 2023-01-07. PMID:36609445. |
here we find that the histone methyltransferase smyd3, which catalyzes histone h3 lysine 4 trimethylation (h3k4me3) to activate gene transcription, is significantly elevated in prefrontal cortex (pfc) of ad patients and p301s tau mice, a model of tauopathies. |
2023-01-07 |
2023-08-14 |
mouse |
| Jamal B Williams, Qing Cao, Wei Wang, Young-Ho Lee, Luye Qin, Ping Zhong, Yong Ren, Kaijie Ma, Zhen Ya. Inhibition of histone methyltransferase Smyd3 rescues NMDAR and cognitive deficits in a tauopathy mouse model. Nature communications. vol 14. issue 1. 2023-01-07. PMID:36609445. |
a short treatment with the smyd3 inhibitor, bci-121, rescues cognitive behavioral deficits, and restores synaptic nmdar function and expression in pfc pyramidal neurons of p301s tau mice. |
2023-01-07 |
2023-08-14 |
mouse |
| Jamal B Williams, Qing Cao, Wei Wang, Young-Ho Lee, Luye Qin, Ping Zhong, Yong Ren, Kaijie Ma, Zhen Ya. Inhibition of histone methyltransferase Smyd3 rescues NMDAR and cognitive deficits in a tauopathy mouse model. Nature communications. vol 14. issue 1. 2023-01-07. PMID:36609445. |
fbxo2 knockdown in pfc leads to the recovery of nmdar function and cognitive behaviors in p301s tau mice. |
2023-01-07 |
2023-08-14 |
mouse |
| José Tiago Costa-Pereira, Rita Oliveira, Irene Guadilla, Maria Jose Guillén, Isaura Tavares, Pilar López-Larrubi. Neuroimaging uncovers neuronal and metabolic changes in pain modulatory brain areas in a rat model of chemotherapy-induced neuropathy - MEMRI and ex vivo spectroscopy studies. Brain research bulletin. 2022-11-03. PMID:36328144. |
furthermore, at t56 the paclitaxel-injected rats presented lower naa and higher taurine (tau) levels in the pfc. |
2022-11-03 |
2023-08-14 |
rat |
| Ana Dias-Carvalho, Mariana Ferreira, Ana Reis-Mendes, Rita Ferreira, Maria Lourdes Bastos, Eduarda Fernandes, Susana Isabel Sá, João Paulo Capela, Félix Carvalho, Vera Marisa Cost. Chemobrain: mitoxantrone-induced oxidative stress, apoptotic and autophagic neuronal death in adult CD-1 mice. Archives of toxicology. 2022-03-20. PMID:35306571. |
postsynaptic density protein 95 expression decreased in the whole brain, while hyperphosphorylation of tau was seen in pfc. |
2022-03-20 |
2023-08-13 |
mouse |
| Ping Zhong, Qing Cao, Zhen Ya. Selective impairment of circuits between prefrontal cortex glutamatergic neurons and basal forebrain cholinergic neurons in a tauopathy mouse model. Cerebral cortex (New York, N.Y. : 1991). 2022-03-02. PMID:35235649. |
on the other hand, optogenetic stimulation of cholinergic terminals from bf induced a persistent reduction of the excitability of pfc pyramidal neurons from tau mice, instead of the transient reduction exhibited in wild-type mice. |
2022-03-02 |
2023-08-13 |
mouse |
| Ashlyn G Johnson, James A Webster, Chadwick M Hale. Glial profiling of human tauopathy brain demonstrates enrichment of astrocytic transcripts in tau-related frontotemporal degeneration. Neurobiology of aging. vol 112. 2022-01-20. PMID:35051675. |
to understand how glia may be altered in frontotemporal degeneration with tau pathology (ftd-tau), we used a nanostring glial profiling panel to measure 770 transcripts related to glial biology in human control (n = 8), alzheimer's disease (ad) (n = 8), and ftd-tau (n = 8) dorsolateral prefrontal cortex. |
2022-01-20 |
2023-08-13 |
human |
| Shannon N Leslie, Jean Kanyo, Dibyadeep Datta, Rashaun S Wilson, Caroline Zeiss, Alvaro Duque, TuKiet T Lam, Amy F T Arnsten, Angus C Nair. Simple, Single-Shot Phosphoproteomic Analysis of Heat-Stable Tau Identifies Age-Related Changes in pS235- and pS396-Tau Levels in Non-human Primates. Frontiers in aging neuroscience. vol 13. 2021-12-07. PMID:34867294. |
this methodology is species independent; thus, while initially developed in a rodent model, we utilized this technique to analyze 36 phosphorylation sites on rhesus monkey tau from the prefrontal cortex (pfc), a region vulnerable to ad-linked degeneration. |
2021-12-07 |
2023-08-13 |
monkey |
| Shannon N Leslie, Jean Kanyo, Dibyadeep Datta, Rashaun S Wilson, Caroline Zeiss, Alvaro Duque, TuKiet T Lam, Amy F T Arnsten, Angus C Nair. Simple, Single-Shot Phosphoproteomic Analysis of Heat-Stable Tau Identifies Age-Related Changes in pS235- and pS396-Tau Levels in Non-human Primates. Frontiers in aging neuroscience. vol 13. 2021-12-07. PMID:34867294. |
we identified novel, age-related changes in tau phosphorylation in the rhesus monkey pfc and analyzed patterns of phosphorylation change across domains of the protein. |
2021-12-07 |
2023-08-13 |
monkey |
| Shannon N Leslie, Jean Kanyo, Dibyadeep Datta, Rashaun S Wilson, Caroline Zeiss, Alvaro Duque, TuKiet T Lam, Amy F T Arnsten, Angus C Nair. Simple, Single-Shot Phosphoproteomic Analysis of Heat-Stable Tau Identifies Age-Related Changes in pS235- and pS396-Tau Levels in Non-human Primates. Frontiers in aging neuroscience. vol 13. 2021-12-07. PMID:34867294. |
histology showed robust labeling for tau phosphorylated at these sites in vulnerable layer iii pyramidal cells in the pfc. |
2021-12-07 |
2023-08-13 |
monkey |
| M Jahanshahi, E Nikmahzar, S Gorgan. Taurine can Decrease Phosphorylated Tau Protein Levels in Alzheimer's Model Rats' Brains. Kathmandu University medical journal (KUMJ). vol 19. issue 74. 2021-11-26. PMID:34819436. |
objective since the protective and therapeutic effects of taurine on phosphorylated tau proteins level in the cerebellum and prefrontal cortex of rats induced by scopolamine have not been studied, we examined these effects. |
2021-11-26 |
2023-08-13 |
rat |
| M Jahanshahi, E Nikmahzar, S Gorgan. Taurine can Decrease Phosphorylated Tau Protein Levels in Alzheimer's Model Rats' Brains. Kathmandu University medical journal (KUMJ). vol 19. issue 74. 2021-11-26. PMID:34819436. |
the phosphorylated tau protein level in the cerebellum and prefrontal cortex was determined by the enzyme-linked immunosorbent assay (elisa) technique. |
2021-11-26 |
2023-08-13 |
rat |
| M Jahanshahi, E Nikmahzar, S Gorgan. Taurine can Decrease Phosphorylated Tau Protein Levels in Alzheimer's Model Rats' Brains. Kathmandu University medical journal (KUMJ). vol 19. issue 74. 2021-11-26. PMID:34819436. |
result pretreatment with three doses of taurine significantly decreased the phosphorylated tau protein level that increased by scopolamine in the prefrontal cortex (p < 0.001), as well as the cerebellum (p < 0.001). |
2021-11-26 |
2023-08-13 |
rat |
| M Jahanshahi, E Nikmahzar, S Gorgan. Taurine can Decrease Phosphorylated Tau Protein Levels in Alzheimer's Model Rats' Brains. Kathmandu University medical journal (KUMJ). vol 19. issue 74. 2021-11-26. PMID:34819436. |
moreover, high-dose administration of taurine (100 mg/kg/day) after scopolamine injection significantly decreased phosphorylated tau protein level in the cerebellum (p < 0.01), as well as the prefrontal cortex (p < 0.05). |
2021-11-26 |
2023-08-13 |
rat |
| M Jahanshahi, E Nikmahzar, S Gorgan. Taurine can Decrease Phosphorylated Tau Protein Levels in Alzheimer's Model Rats' Brains. Kathmandu University medical journal (KUMJ). vol 19. issue 74. 2021-11-26. PMID:34819436. |
however, there was not any significant change in the level of phosphorylated tau protein after taurine treatment (25 and 50 mg/kg/day) in the cerebellum and prefrontal cortex. |
2021-11-26 |
2023-08-13 |
rat |