| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jorge A Sierra-Fonseca, Minerva Rodriguez, Anapaula Themann, Omar Lira, Francisco J Flores-Ramirez, Javier Vargas-Medrano, Bharathi S Gadad, Sergio D Iñigue. Autophagy Induction and Accumulation of Phosphorylated Tau in the Hippocampus and Prefrontal Cortex of Adult C57BL/6 Mice Subjected to Adolescent Fluoxetine Treatment. Journal of Alzheimer's disease : JAD. vol 83. issue 4. 2021-11-24. PMID:34420960. |
autophagy induction and accumulation of phosphorylated tau in the hippocampus and prefrontal cortex of adult c57bl/6 mice subjected to adolescent fluoxetine treatment. |
2021-11-24 |
2023-08-13 |
mouse |
| Wei Wang, Qing Cao, Tao Tan, Fengwei Yang, Jamal B Williams, Zhen Ya. Epigenetic treatment of behavioral and physiological deficits in a tauopathy mouse model. Aging cell. vol 20. issue 10. 2021-11-09. PMID:34547169. |
here, we show that the euchromatic histone-lysine n-methyltransferase 2 (ehmt2) is significantly elevated in the prefrontal cortex (pfc) of p301s tau mice (5-7 months old), leading to the increased repressive histone mark, h3k9me2, which is reversed by treatment with the selective ehmt inhibitor unc0642. |
2021-11-09 |
2023-08-13 |
mouse |
| Wei Wang, Qing Cao, Tao Tan, Fengwei Yang, Jamal B Williams, Zhen Ya. Epigenetic treatment of behavioral and physiological deficits in a tauopathy mouse model. Aging cell. vol 20. issue 10. 2021-11-09. PMID:34547169. |
concomitantly, the diminished pfc neuronal excitability and glutamatergic synaptic transmission in p301s tau mice are also normalized by unc0642 treatment. |
2021-11-09 |
2023-08-13 |
mouse |
| Wei Wang, Qing Cao, Tao Tan, Fengwei Yang, Jamal B Williams, Zhen Ya. Epigenetic treatment of behavioral and physiological deficits in a tauopathy mouse model. Aging cell. vol 20. issue 10. 2021-11-09. PMID:34547169. |
in addition, ehmt inhibition dramatically attenuates the hyperphosphorylated tau level in pfc of p301s tau mice. |
2021-11-09 |
2023-08-13 |
mouse |
| Wei Wang, Qing Cao, Tao Tan, Fengwei Yang, Jamal B Williams, Zhen Ya. Epigenetic treatment of behavioral and physiological deficits in a tauopathy mouse model. Aging cell. vol 20. issue 10. 2021-11-09. PMID:34547169. |
transcriptomic analysis reveals that unc0642 treatment of p301s tau mice has normalized a number of dysregulated genes in pfc, which are enriched in cytoskeleton and extracellular matrix organization, ion channels and transporters, receptor signaling, and stress responses. |
2021-11-09 |
2023-08-13 |
mouse |
| Juciano Gasparotto, Mario Roberto Senger, Emilio Telles de Sá Moreira, Pedro Ozorio Brum, Flávio Gabriel Carazza Kessler, Daniel Oppermann Peixoto, Alana Castro Panzenhagen, Lin Kooi Ong, Marlene Campos Soares, Patricia Alves Reis, Giuliana Viegas Schirato, Walter César Góes Valente, Bogar Omar Araújo Montoya, Floriano P Silva, José Claudio Fonseca Moreira, Felipe Dal-Pizzol, Hugo C Castro-Faria-Neto, Daniel Pens Gelai. Neurological impairment caused by Schistosoma mansoni systemic infection exhibits early features of idiopathic neurodegenerative disease. The Journal of biological chemistry. vol 297. issue 2. 2021-10-29. PMID:34303703. |
we observed that systemic infection with s. mansoni led to astrocyte and microglia activation, expression of oxidative stress-induced transcription factor nrf2, oxidative damage, tau phosphorylation, and amyloid-β peptide accumulation in the prefrontal cortex of infected animals. |
2021-10-29 |
2023-08-13 |
Not clear |
| Dibyadeep Datta, John F Enwright, Dominique Arion, Constantinos D Paspalas, Yury M Morozov, David A Lewis, Amy F T Arnste. Mapping Phosphodiesterase 4D (PDE4D) in Macaque Dorsolateral Prefrontal Cortex: Postsynaptic Compartmentalization in Layer III Pyramidal Cell Circuits. Frontiers in neuroanatomy. vol 14. 2021-10-12. PMID:33328902. |
camp signaling has powerful, negative effects on cognitive functions of the primate dorsolateral prefrontal cortex (dlpfc), opening potassium channels to reduce firing and impair working memory, and increasing tau phosphorylation in aging neurons. |
2021-10-12 |
2023-08-13 |
human |
| Michelle Lima Garcez, Ricardo Chiengo Sapalo Cassoma, Francielle Mina, Tatiani Bellettini-Santos, Aline Pereira da Luz, Gustavo Luis Schiavo, Eduarda Behenck Medeiros, Ana Carolina Brunatto Falchetti Campos, Sabrina da Silva, Lisienny Campoli Tono Rempel, Amanda Valnier Steckert, Tatiana Barichello, Josiane Budn. Folic acid prevents habituation memory impairment and oxidative stress in an aging model induced by D-galactose. Metabolic brain disease. vol 36. issue 2. 2021-10-05. PMID:33219893. |
d-gal induced synaptophysin and bcl-2 decrease in the hippocampus and phosphorylated tau increase in the prefrontal cortex. |
2021-10-05 |
2023-08-13 |
rat |
| Sharay E Setti, Miranda N Ree. Network activity changes in the pathophysiology of Alzheimer's disease: the role of aging and early entorhinal cortex dysfunction. Metabolic brain disease. 2021-09-30. PMID:34591222. |
this review focuses on evidence in the literature that describes how one potential age-related change, that of glutamate-mediated increases in neuronal activity, may ultimately increase the risk of developing ad and promote the spread of tau pathology in ad-affected brains from the ec to later regions such as the hippocampus and prefrontal cortex. |
2021-09-30 |
2023-08-13 |
Not clear |
| Josephine Labus, Kian-Fritz Röhrs, Jana Ackmann, Hristo Varbanov, Franziska E Müller, Shaobo Jia, Kathrin Jahreis, Anna-Lena Vollbrecht, Malte Butzlaff, Yvonne Schill, Daria Guseva, Katrin Böhm, Rahul Kaushik, Monika Bijata, Philippe Marin, Séverine Chaumont-Dubel, Andre Zeug, Alexander Dityatev, Evgeni Ponimaski. Amelioration of Tau pathology and memory deficits by targeting 5-HT7 receptor. Progress in neurobiology. vol 197. 2021-06-11. PMID:32841723. |
moreover, 5-ht7r knockdown in the prefrontal cortex fully abrogates tau[r406w]-induced ltp deficits and memory impairments. |
2021-06-11 |
2023-08-13 |
mouse |
| Michael G Friedrich, Amanda Skora, Sarah E Hancock, Todd W Mitchell, Paul L Else, Roger J W Truscot. Tau Is Truncated in Five Regions of the Normal Adult Human Brain. International journal of molecular sciences. vol 22. issue 7. 2021-05-10. PMID:33805376. |
antibodies to the c-terminal and n-terminal regions of tau were employed to examine tau cleavage in five human brain regions: the entorhinal cortex, prefrontal cortex, motor cortex, hippocampus, and cerebellum. |
2021-05-10 |
2023-08-13 |
human |
| Michael Ohene-Nyako, Sara R Nass, Yun K Hahn, Pamela E Knapp, Kurt F Hause. Morphine and HIV-1 Tat interact to cause region-specific hyperphosphorylation of tau in transgenic mice. Neuroscience letters. vol 741. 2021-05-04. PMID:33202259. |
the pathological phospho-isotypes of tau (pser396, pser404, pthr205, pser202, and pthr181) and the tau kinases gsk3β and cdk5/p35 were explored in the striatum, hippocampus, and prefrontal cortex of inducible male and female hiv-1 tat-transgenic mice, with some receiving escalating doses of morphine for 2 weeks. |
2021-05-04 |
2023-08-13 |
mouse |
| G Siano, M Varisco, A Scarlatti, M C Caiazza, K Dunville, F Cremisi, M Costa, L Pancrazi, C Di Primio, A Cattane. Gene Expression of Disease-related Genes in Alzheimer's Disease is Impaired by Tau Aggregation. Journal of molecular biology. vol 432. issue 24. 2021-03-04. PMID:33058882. |
together, this evidence links the altered glutamatergic function in the pfc during ad progression to the newly discovered function of nuclear tau. |
2021-03-04 |
2023-08-13 |
Not clear |
| Zuntao Wu, Lin Bai, Runqi Tu, Lijie Zhang, Yue Ba, Huizhen Zhang, Xing Li, Xuemin Cheng, Wenjie Li, Hui Huan. Disruption of synaptic expression pattern and age-related DNA oxidation in a neuronal model of lead-induced toxicity. Environmental toxicology and pharmacology. vol 76. 2020-12-04. PMID:32058320. |
furthermore, the expression of bace1 protein and tau phosphorylation level in pfc and hippocampus increased, app mrnas in pfc and prolonged induction of bace1 in hippocampus. |
2020-12-04 |
2023-08-13 |
mouse |
| Mercedes A Hernández-Sapiéns, Edwin E Reza-Zaldívar, Ricardo R Cevallos, Ana L Márquez-Aguirre, Karlen Gazarian, Alejandro A Canales-Aguirr. A Three-Dimensional Alzheimer's Disease Cell Culture Model Using iPSC-Derived Neurons Carrying A246E Mutation in PSEN1. Frontiers in cellular neuroscience. vol 14. 2020-09-28. PMID:32655369. |
alzheimer's disease (ad) is a chronic brain disorder characterized by progressive intellectual decline and memory and neuronal loss, caused mainly by extracellular deposition of amyloid-β (aβ) and intracellular accumulation of hyperphosphorylated tau protein, primarily in areas implicated in memory and learning as prefrontal cortex and hippocampus. |
2020-09-28 |
2023-08-13 |
Not clear |
| Emily L Munger, Melissa K Edler, William D Hopkins, John J Ely, Joseph M Erwin, Daniel P Perl, Elliott J Mufson, Patrick R Hof, Chet C Sherwood, Mary Ann Raghant. Astrocytic changes with aging and Alzheimer's disease-type pathology in chimpanzees. The Journal of comparative neurology. vol 527. issue 7. 2020-09-16. PMID:30578640. |
both prefrontal cortex layer i and hippocampal astrocytes exhibit a high degree of astrogliosis that is positively correlated with accumulation of amyloid beta and tau proteins. |
2020-09-16 |
2023-08-13 |
chimpanzee |
| Yang Zhao, Haiyan Deng, Kun Li, Lijun Wang, Yongkang Wu, Xianwen Dong, Xingyu Wang, Yongjun Chen, Ying X. Trans-cinnamaldehyde improves neuroinflammation-mediated NMDA receptor dysfunction and memory deficits through blocking NF-κB pathway in presenilin1/2 conditional double knockout mice. Brain, behavior, and immunity. vol 82. 2020-08-25. PMID:31376499. |
we observed that tca treatment reversed abnormal expression of synaptic proteins and tau hyperphosphorylation in the hippocampus and prefrontal cortex of ps cdko mice. |
2020-08-25 |
2023-08-13 |
mouse |
| Geoffrey Canet, Fanny Pineau, Charleine Zussy, Célia Hernandez, Hazel Hunt, Nathalie Chevallier, Véronique Perrier, Joan Torrent, Joseph K Belanoff, Onno C Meijer, Catherine Desrumaux, Laurent Givaloi. Glucocorticoid receptors signaling impairment potentiates amyloid-β oligomers-induced pathology in an acute model of Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 1. 2020-07-20. PMID:31914623. |
deregulation of the hpa axis and a feed-forward effect on pfc gr sensitivity could participate in the etiology of ad, in perturbing aβ and tau homeostasis. |
2020-07-20 |
2023-08-13 |
Not clear |
| Jessica L Hoffman, Sara Faccidomo, Michelle Kim, Seth M Taylor, Abigail E Agoglia, Ashley M May, Evan N Smith, L C Wong, Clyde W Hodg. Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease. International review of neurobiology. vol 148. 2020-05-11. PMID:31733664. |
multiplex immunoassay conducted on brain lysates showed that alcohol drinking upregulated primary markers of ad pathology in 3xtg-ad mice: aβ 42/40 ratio in the lateral entorhinal and prefrontal cortex and total tau expression in the lateral entorhinal cortex, medial prefrontal cortex, and amygdala at 1-month post alcohol exposure. |
2020-05-11 |
2023-08-13 |
mouse |
| Chinnakkaruppan Adaikkan, Steven J Middleton, Asaf Marco, Ping-Chieh Pao, Hansruedi Mathys, David Nam-Woo Kim, Fan Gao, Jennie Z Young, Ho-Jun Suk, Edward S Boyden, Thomas J McHugh, Li-Huei Tsa. Gamma Entrainment Binds Higher-Order Brain Regions and Offers Neuroprotection. Neuron. vol 102. issue 5. 2020-03-23. PMID:31076275. |
here, we demonstrate that genus can entrain gamma oscillations in the visual cortex, hippocampus, and prefrontal cortex in tau p301s and ck-p25 mouse models of neurodegeneration. |
2020-03-23 |
2023-08-13 |
mouse |